BRO1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

BRO1-like domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXU8_LEIMU

TriTrypDb:

LmxM.25.2150

Length:

404

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXU8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXU8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.434
CLV_C14_Caspase3-7	84	88	PF00656	0.379
CLV_NRD_NRD_1	17	19	PF00675	0.250
CLV_NRD_NRD_1	54	56	PF00675	0.421
CLV_PCSK_KEX2_1	17	19	PF00082	0.283
CLV_PCSK_KEX2_1	276	278	PF00082	0.385
CLV_PCSK_KEX2_1	37	39	PF00082	0.364
CLV_PCSK_KEX2_1	43	45	PF00082	0.378
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.385
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.364
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.386
CLV_PCSK_SKI1_1	277	281	PF00082	0.432
CLV_PCSK_SKI1_1	77	81	PF00082	0.454
CLV_PCSK_SKI1_1	8	12	PF00082	0.388
DEG_APCC_DBOX_1	126	134	PF00400	0.364
DEG_Nend_Nbox_1	1	3	PF02207	0.647
DOC_MAPK_DCC_7	8	16	PF00069	0.448
DOC_MAPK_gen_1	187	193	PF00069	0.426
DOC_MAPK_gen_1	323	330	PF00069	0.323
DOC_MAPK_gen_1	42	50	PF00069	0.457
DOC_MAPK_gen_1	77	85	PF00069	0.287
DOC_MAPK_MEF2A_6	323	330	PF00069	0.317
DOC_MAPK_MEF2A_6	8	16	PF00069	0.516
DOC_MAPK_NFAT4_5	323	331	PF00069	0.265
DOC_PP2B_LxvP_1	326	329	PF13499	0.385
DOC_PP2B_LxvP_1	369	372	PF13499	0.367
DOC_USP7_MATH_1	194	198	PF00917	0.499
DOC_USP7_MATH_1	231	235	PF00917	0.442
DOC_USP7_UBL2_3	323	327	PF12436	0.369
DOC_WW_Pin1_4	379	384	PF00397	0.435
DOC_WW_Pin1_4	387	392	PF00397	0.604
DOC_WW_Pin1_4	97	102	PF00397	0.488
LIG_14-3-3_CanoR_1	152	156	PF00244	0.454
LIG_14-3-3_CanoR_1	17	24	PF00244	0.401
LIG_14-3-3_CanoR_1	240	248	PF00244	0.405
LIG_APCC_ABBA_1	206	211	PF00400	0.385
LIG_BRCT_BRCA1_1	172	176	PF00533	0.454
LIG_BRCT_BRCA1_1	289	293	PF00533	0.364
LIG_BRCT_BRCA1_1	381	385	PF00533	0.454
LIG_BRCT_BRCA1_2	289	295	PF00533	0.521
LIG_EH1_1	134	142	PF00400	0.339
LIG_FHA_1	236	242	PF00498	0.389
LIG_FHA_1	269	275	PF00498	0.469
LIG_FHA_1	331	337	PF00498	0.476
LIG_FHA_1	345	351	PF00498	0.363
LIG_FHA_1	393	399	PF00498	0.658
LIG_FHA_1	88	94	PF00498	0.383
LIG_FHA_2	259	265	PF00498	0.342
LIG_LIR_Gen_1	100	110	PF02991	0.523
LIG_LIR_Gen_1	125	135	PF02991	0.385
LIG_LIR_Gen_1	264	274	PF02991	0.387
LIG_LIR_Gen_1	278	288	PF02991	0.389
LIG_LIR_Gen_1	49	58	PF02991	0.342
LIG_LIR_LC3C_4	270	274	PF02991	0.283
LIG_LIR_Nem_3	100	106	PF02991	0.420
LIG_LIR_Nem_3	120	126	PF02991	0.280
LIG_LIR_Nem_3	164	169	PF02991	0.321
LIG_LIR_Nem_3	173	178	PF02991	0.321
LIG_LIR_Nem_3	264	269	PF02991	0.404
LIG_LIR_Nem_3	278	283	PF02991	0.389
LIG_LIR_Nem_3	333	338	PF02991	0.391
LIG_LIR_Nem_3	49	54	PF02991	0.358
LIG_MLH1_MIPbox_1	172	176	PF16413	0.454
LIG_Pex14_2	50	54	PF04695	0.442
LIG_SH2_CRK	166	170	PF00017	0.321
LIG_SH2_CRK	9	13	PF00017	0.397
LIG_SH2_GRB2like	134	137	PF00017	0.375
LIG_SH2_STAP1	89	93	PF00017	0.321
LIG_SH2_STAT3	317	320	PF00017	0.221
LIG_SH2_STAT5	147	150	PF00017	0.413
LIG_SH2_STAT5	175	178	PF00017	0.333
LIG_SH2_STAT5	317	320	PF00017	0.481
LIG_SH2_STAT5	78	81	PF00017	0.499
LIG_SH2_STAT5	89	92	PF00017	0.390
LIG_SH3_1	9	15	PF00018	0.512
LIG_SH3_2	12	17	PF14604	0.454
LIG_SH3_3	193	199	PF00018	0.454
LIG_SH3_3	368	374	PF00018	0.451
LIG_SH3_3	394	400	PF00018	0.552
LIG_SH3_3	9	15	PF00018	0.474
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.410
LIG_SUMO_SIM_anti_2	81	87	PF11976	0.287
LIG_SUMO_SIM_par_1	197	203	PF11976	0.514
LIG_SUMO_SIM_par_1	81	87	PF11976	0.287
LIG_TYR_ITIM	247	252	PF00017	0.385
MOD_CDK_SPK_2	97	102	PF00069	0.331
MOD_CDK_SPxxK_3	379	386	PF00069	0.221
MOD_CK1_1	113	119	PF00069	0.464
MOD_CK1_1	234	240	PF00069	0.478
MOD_CK1_1	344	350	PF00069	0.298
MOD_CK1_1	392	398	PF00069	0.617
MOD_CK2_1	156	162	PF00069	0.364
MOD_CK2_1	23	29	PF00069	0.383
MOD_CK2_1	258	264	PF00069	0.379
MOD_CK2_1	30	36	PF00069	0.353
MOD_GlcNHglycan	172	175	PF01048	0.434
MOD_GlcNHglycan	391	394	PF01048	0.749
MOD_GlcNHglycan	71	74	PF01048	0.385
MOD_GSK3_1	109	116	PF00069	0.361
MOD_GSK3_1	231	238	PF00069	0.419
MOD_GSK3_1	93	100	PF00069	0.343
MOD_N-GLC_1	330	335	PF02516	0.508
MOD_N-GLC_1	339	344	PF02516	0.437
MOD_NEK2_1	209	214	PF00069	0.387
MOD_NEK2_1	248	253	PF00069	0.316
MOD_NEK2_1	318	323	PF00069	0.385
MOD_NEK2_1	330	335	PF00069	0.274
MOD_NEK2_1	338	343	PF00069	0.199
MOD_NEK2_1	69	74	PF00069	0.426
MOD_NEK2_1	93	98	PF00069	0.434
MOD_PIKK_1	23	29	PF00454	0.454
MOD_PIKK_1	302	308	PF00454	0.375
MOD_PIKK_1	316	322	PF00454	0.317
MOD_PK_1	61	67	PF00069	0.454
MOD_PKA_2	151	157	PF00069	0.454
MOD_PKA_2	16	22	PF00069	0.399
MOD_PKA_2	239	245	PF00069	0.389
MOD_Plk_1	267	273	PF00069	0.413
MOD_Plk_1	339	345	PF00069	0.276
MOD_Plk_4	156	162	PF00069	0.399
MOD_Plk_4	268	274	PF00069	0.326
MOD_Plk_4	299	305	PF00069	0.436
MOD_Plk_4	352	358	PF00069	0.350
MOD_ProDKin_1	379	385	PF00069	0.435
MOD_ProDKin_1	387	393	PF00069	0.613
MOD_ProDKin_1	97	103	PF00069	0.488
MOD_SUMO_rev_2	224	234	PF00179	0.385
MOD_SUMO_rev_2	63	70	PF00179	0.377
TRG_DiLeu_BaEn_1	268	273	PF01217	0.221
TRG_DiLeu_BaLyEn_6	394	399	PF01217	0.502
TRG_ENDOCYTIC_2	128	131	PF00928	0.344
TRG_ENDOCYTIC_2	134	137	PF00928	0.322
TRG_ENDOCYTIC_2	166	169	PF00928	0.321
TRG_ENDOCYTIC_2	175	178	PF00928	0.321
TRG_ENDOCYTIC_2	249	252	PF00928	0.537
TRG_ER_diArg_1	16	18	PF00400	0.221

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBN4	Leptomonas seymouri	67%	100%
A0A0S4JPD3	Bodo saltans	25%	93%
A0A1X0NY42	Trypanosomatidae	37%	100%
A0A3Q8ICM9	Leishmania donovani	92%	100%
A0A422P4K0	Trypanosoma rangeli	38%	97%
A4HEB8	Leishmania braziliensis	82%	100%
A4I1R3	Leishmania infantum	91%	100%
C9ZKB9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4Q9M3	Leishmania major	87%	100%