KIF-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

KIF-binding protein

Gene product:

KIF-1 binding protein C terminal, putative

Species:

Leishmania mexicana

UniProt:

E9AXU4_LEIMU

TriTrypDb:

LmxM.25.2110

Length:

601

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005856	cytoskeleton	5	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AXU4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXU4

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	257	259	PF00675	0.459
CLV_NRD_NRD_1	415	417	PF00675	0.232
CLV_NRD_NRD_1	464	466	PF00675	0.332
CLV_NRD_NRD_1	484	486	PF00675	0.298
CLV_PCSK_FUR_1	413	417	PF00082	0.307
CLV_PCSK_KEX2_1	415	417	PF00082	0.232
CLV_PCSK_SKI1_1	158	162	PF00082	0.319
CLV_PCSK_SKI1_1	322	326	PF00082	0.180
CLV_PCSK_SKI1_1	444	448	PF00082	0.238
CLV_PCSK_SKI1_1	473	477	PF00082	0.322
CLV_PCSK_SKI1_1	579	583	PF00082	0.327
DEG_APCC_DBOX_1	310	318	PF00400	0.468
DEG_APCC_DBOX_1	443	451	PF00400	0.412
DEG_APCC_DBOX_1	578	586	PF00400	0.420
DEG_Nend_UBRbox_2	1	3	PF02207	0.381
DOC_CKS1_1	534	539	PF01111	0.493
DOC_CYCLIN_RxL_1	441	449	PF00134	0.412
DOC_CYCLIN_RxL_1	59	70	PF00134	0.383
DOC_CYCLIN_yClb1_LxF_4	142	148	PF00134	0.380
DOC_MAPK_MEF2A_6	204	212	PF00069	0.313
DOC_PP1_RVXF_1	551	558	PF00149	0.426
DOC_USP7_MATH_1	126	130	PF00917	0.360
DOC_USP7_MATH_1	236	240	PF00917	0.383
DOC_USP7_MATH_1	381	385	PF00917	0.441
DOC_USP7_MATH_1	569	573	PF00917	0.492
DOC_USP7_MATH_1	98	102	PF00917	0.349
DOC_USP7_UBL2_3	370	374	PF12436	0.468
DOC_WW_Pin1_4	533	538	PF00397	0.507
LIG_14-3-3_CanoR_1	258	262	PF00244	0.441
LIG_14-3-3_CanoR_1	422	430	PF00244	0.433
LIG_14-3-3_CanoR_1	485	489	PF00244	0.519
LIG_14-3-3_CanoR_1	499	509	PF00244	0.513
LIG_14-3-3_CterR_2	598	601	PF00244	0.542
LIG_APCC_ABBA_1	45	50	PF00400	0.451
LIG_BRCT_BRCA1_1	23	27	PF00533	0.599
LIG_BRCT_BRCA1_1	272	276	PF00533	0.443
LIG_deltaCOP1_diTrp_1	170	175	PF00928	0.388
LIG_eIF4E_1	403	409	PF01652	0.459
LIG_FHA_1	195	201	PF00498	0.445
LIG_FHA_1	217	223	PF00498	0.323
LIG_FHA_1	261	267	PF00498	0.426
LIG_FHA_1	388	394	PF00498	0.412
LIG_FHA_1	422	428	PF00498	0.380
LIG_FHA_1	501	507	PF00498	0.494
LIG_FHA_1	94	100	PF00498	0.356
LIG_FHA_2	118	124	PF00498	0.343
LIG_FHA_2	157	163	PF00498	0.360
LIG_FHA_2	323	329	PF00498	0.507
LIG_FHA_2	358	364	PF00498	0.414
LIG_FHA_2	534	540	PF00498	0.507
LIG_FHA_2	68	74	PF00498	0.285
LIG_GBD_Chelix_1	442	450	PF00786	0.212
LIG_LIR_Apic_2	496	501	PF02991	0.412
LIG_LIR_Apic_2	531	537	PF02991	0.493
LIG_LIR_Gen_1	245	256	PF02991	0.318
LIG_LIR_Gen_1	279	287	PF02991	0.459
LIG_LIR_Gen_1	384	393	PF02991	0.478
LIG_LIR_Gen_1	477	488	PF02991	0.484
LIG_LIR_Nem_3	245	251	PF02991	0.317
LIG_LIR_Nem_3	279	285	PF02991	0.497
LIG_LIR_Nem_3	343	347	PF02991	0.415
LIG_LIR_Nem_3	384	388	PF02991	0.383
LIG_LIR_Nem_3	435	439	PF02991	0.472
LIG_LIR_Nem_3	477	483	PF02991	0.457
LIG_LIR_Nem_3	539	544	PF02991	0.412
LIG_LIR_Nem_3	591	596	PF02991	0.310
LIG_LIR_Nem_3	78	84	PF02991	0.512
LIG_LYPXL_SIV_4	277	285	PF13949	0.507
LIG_LYPXL_SIV_4	438	446	PF13949	0.507
LIG_LYPXL_yS_3	439	442	PF13949	0.412
LIG_MYND_1	351	355	PF01753	0.427
LIG_Pex14_2	27	31	PF04695	0.486
LIG_Pex14_2	494	498	PF04695	0.420
LIG_Pex14_2	6	10	PF04695	0.325
LIG_Rb_LxCxE_1	384	398	PF01857	0.341
LIG_REV1ctd_RIR_1	516	524	PF16727	0.426
LIG_SH2_CRK	138	142	PF00017	0.336
LIG_SH2_CRK	248	252	PF00017	0.284
LIG_SH2_CRK	320	324	PF00017	0.468
LIG_SH2_CRK	403	407	PF00017	0.443
LIG_SH2_CRK	534	538	PF00017	0.457
LIG_SH2_CRK	541	545	PF00017	0.413
LIG_SH2_NCK_1	278	282	PF00017	0.459
LIG_SH2_SRC	532	535	PF00017	0.352
LIG_SH2_STAP1	218	222	PF00017	0.326
LIG_SH2_STAP1	272	276	PF00017	0.412
LIG_SH2_STAP1	278	282	PF00017	0.412
LIG_SH2_STAP1	454	458	PF00017	0.468
LIG_SH2_STAP1	551	555	PF00017	0.493
LIG_SH2_STAT3	454	457	PF00017	0.460
LIG_SH2_STAT5	148	151	PF00017	0.298
LIG_SH2_STAT5	218	221	PF00017	0.319
LIG_SH2_STAT5	241	244	PF00017	0.296
LIG_SH2_STAT5	313	316	PF00017	0.418
LIG_SH3_1	345	351	PF00018	0.459
LIG_SH3_3	345	351	PF00018	0.435
LIG_SH3_3	352	358	PF00018	0.415
LIG_SUMO_SIM_par_1	63	70	PF11976	0.237
LIG_TRAF2_1	537	540	PF00917	0.426
LIG_TYR_ITIM	136	141	PF00017	0.331
LIG_TYR_ITIM	246	251	PF00017	0.265
LIG_UBA3_1	581	588	PF00899	0.433
LIG_WRC_WIRS_1	359	364	PF05994	0.412
MOD_CDK_SPK_2	533	538	PF00069	0.507
MOD_CK1_1	216	222	PF00069	0.448
MOD_CK1_1	260	266	PF00069	0.477
MOD_CK2_1	117	123	PF00069	0.341
MOD_CK2_1	127	133	PF00069	0.263
MOD_CK2_1	322	328	PF00069	0.507
MOD_CK2_1	358	364	PF00069	0.488
MOD_CK2_1	449	455	PF00069	0.539
MOD_CK2_1	533	539	PF00069	0.507
MOD_CK2_1	67	73	PF00069	0.280
MOD_CMANNOS	171	174	PF00535	0.304
MOD_GlcNHglycan	120	123	PF01048	0.528
MOD_GlcNHglycan	129	132	PF01048	0.498
MOD_GlcNHglycan	268	271	PF01048	0.212
MOD_GSK3_1	118	125	PF00069	0.541
MOD_GSK3_1	12	19	PF00069	0.261
MOD_GSK3_1	214	221	PF00069	0.297
MOD_GSK3_1	266	273	PF00069	0.412
MOD_N-GLC_1	117	122	PF02516	0.486
MOD_N-GLC_1	16	21	PF02516	0.463
MOD_NEK2_1	117	122	PF00069	0.443
MOD_NEK2_1	147	152	PF00069	0.304
MOD_NEK2_1	214	219	PF00069	0.330
MOD_NEK2_1	266	271	PF00069	0.439
MOD_NEK2_1	340	345	PF00069	0.507
MOD_NEK2_1	40	45	PF00069	0.347
MOD_NEK2_1	494	499	PF00069	0.412
MOD_NEK2_1	66	71	PF00069	0.389
MOD_NEK2_2	218	223	PF00069	0.354
MOD_NEK2_2	242	247	PF00069	0.289
MOD_PIKK_1	236	242	PF00454	0.470
MOD_PKA_2	257	263	PF00069	0.317
MOD_PKA_2	40	46	PF00069	0.352
MOD_PKA_2	421	427	PF00069	0.460
MOD_PKA_2	484	490	PF00069	0.462
MOD_Plk_1	214	220	PF00069	0.369
MOD_Plk_1	333	339	PF00069	0.513
MOD_Plk_1	511	517	PF00069	0.483
MOD_Plk_2-3	449	455	PF00069	0.562
MOD_Plk_4	156	162	PF00069	0.360
MOD_Plk_4	218	224	PF00069	0.299
MOD_Plk_4	333	339	PF00069	0.407
MOD_Plk_4	40	46	PF00069	0.412
MOD_Plk_4	449	455	PF00069	0.530
MOD_Plk_4	67	73	PF00069	0.356
MOD_ProDKin_1	533	539	PF00069	0.507
MOD_SUMO_for_1	29	32	PF00179	0.481
MOD_SUMO_for_1	537	540	PF00179	0.426
MOD_SUMO_rev_2	24	31	PF00179	0.432
MOD_SUMO_rev_2	296	304	PF00179	0.453
TRG_DiLeu_BaEn_1	300	305	PF01217	0.493
TRG_DiLeu_BaEn_1	580	585	PF01217	0.426
TRG_DiLeu_BaEn_4	511	517	PF01217	0.484
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.388
TRG_ENDOCYTIC_2	138	141	PF00928	0.338
TRG_ENDOCYTIC_2	248	251	PF00928	0.310
TRG_ENDOCYTIC_2	320	323	PF00928	0.419
TRG_ENDOCYTIC_2	403	406	PF00928	0.412
TRG_ENDOCYTIC_2	439	442	PF00928	0.447
TRG_ENDOCYTIC_2	491	494	PF00928	0.461
TRG_ENDOCYTIC_2	541	544	PF00928	0.426
TRG_ENDOCYTIC_2	81	84	PF00928	0.451
TRG_ENDOCYTIC_2	88	91	PF00928	0.370
TRG_ER_diArg_1	413	416	PF00400	0.441
TRG_ER_diArg_1	458	461	PF00400	0.471
TRG_NES_CRM1_1	398	410	PF08389	0.459
TRG_NES_CRM1_1	566	580	PF08389	0.507
TRG_Pf-PMV_PEXEL_1	244	249	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	374	378	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	444	449	PF00026	0.226
TRG_Pf-PMV_PEXEL_1	55	59	PF00026	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFB1	Leptomonas seymouri	72%	100%
A0A1X0NY49	Trypanosomatidae	47%	100%
A0A3Q8IGQ4	Leishmania donovani	93%	100%
A0A3R7RTL1	Trypanosoma rangeli	46%	100%
A4HEB4	Leishmania braziliensis	84%	100%
A4I1R0	Leishmania infantum	93%	100%
A8WE67	Danio rerio	26%	95%
C9ZKB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q0IIZ5	Xenopus tropicalis	25%	98%
Q3SYS9	Bos taurus	27%	97%
Q4G074	Rattus norvegicus	27%	97%
Q4Q9M7	Leishmania major	93%	100%
Q5ZIL9	Gallus gallus	27%	100%
Q6ZPU9	Mus musculus	27%	97%
Q96EK5	Homo sapiens	26%	97%
Q9VMX1	Drosophila melanogaster	24%	100%
V5ASJ5	Trypanosoma cruzi	47%	97%