TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania mexicana

UniProt:

E9AXU3_LEIMU

TriTrypDb:

LmxM.25.2100

Length:

334

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 2
Pissara et al.	no	yes: 6

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXU3

Function

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	15
GO:0009987	cellular process	1	15

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0005488	binding	1	17
GO:0005515	protein binding	2	15
GO:0008270	zinc ion binding	6	9
GO:0030544	Hsp70 protein binding	4	15
GO:0031072	heat shock protein binding	3	15
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0046914	transition metal ion binding	5	9
GO:0051879	Hsp90 protein binding	4	15
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	102	106	PF00656	0.317
CLV_C14_Caspase3-7	132	136	PF00656	0.419
CLV_C14_Caspase3-7	30	34	PF00656	0.469
CLV_NRD_NRD_1	263	265	PF00675	0.477
CLV_NRD_NRD_1	327	329	PF00675	0.506
CLV_PCSK_FUR_1	327	331	PF00082	0.520
CLV_PCSK_KEX2_1	327	329	PF00082	0.508
CLV_PCSK_KEX2_1	8	10	PF00082	0.402
CLV_PCSK_KEX2_1	89	91	PF00082	0.518
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.511
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.335
CLV_PCSK_PC1ET2_1	89	91	PF00082	0.467
CLV_PCSK_SKI1_1	178	182	PF00082	0.271
CLV_PCSK_SKI1_1	276	280	PF00082	0.554
DOC_CYCLIN_RxL_1	160	172	PF00134	0.492
DOC_MAPK_gen_1	62	70	PF00069	0.372
DOC_USP7_MATH_1	260	264	PF00917	0.561
DOC_USP7_MATH_1	290	294	PF00917	0.565
DOC_USP7_MATH_1	302	306	PF00917	0.536
DOC_USP7_MATH_1	53	57	PF00917	0.387
DOC_USP7_UBL2_3	223	227	PF12436	0.463
DOC_USP7_UBL2_3	241	245	PF12436	0.520
LIG_14-3-3_CanoR_1	276	285	PF00244	0.575
LIG_14-3-3_CanoR_1	299	307	PF00244	0.523
LIG_14-3-3_CanoR_1	90	98	PF00244	0.359
LIG_Actin_WH2_2	212	229	PF00022	0.425
LIG_BIR_II_1	1	5	PF00653	0.397
LIG_FHA_1	151	157	PF00498	0.566
LIG_FHA_1	235	241	PF00498	0.471
LIG_FHA_1	248	254	PF00498	0.494
LIG_FHA_1	273	279	PF00498	0.553
LIG_FHA_1	280	286	PF00498	0.464
LIG_FHA_1	34	40	PF00498	0.442
LIG_FHA_2	108	114	PF00498	0.348
LIG_FHA_2	172	178	PF00498	0.550
LIG_FHA_2	264	270	PF00498	0.481
LIG_LIR_Gen_1	231	240	PF02991	0.384
LIG_LIR_Gen_1	24	32	PF02991	0.406
LIG_LIR_Gen_1	308	315	PF02991	0.547
LIG_LIR_Gen_1	48	59	PF02991	0.405
LIG_LIR_Nem_3	231	236	PF02991	0.383
LIG_LIR_Nem_3	24	29	PF02991	0.406
LIG_LIR_Nem_3	308	312	PF02991	0.496
LIG_LIR_Nem_3	48	54	PF02991	0.405
LIG_LIR_Nem_3	95	100	PF02991	0.467
LIG_PTB_Apo_2	105	112	PF02174	0.323
LIG_PTB_Phospho_1	105	111	PF10480	0.323
LIG_RPA_C_Fungi	180	192	PF08784	0.320
LIG_RPA_C_Fungi	259	271	PF08784	0.569
LIG_SH2_CRK	233	237	PF00017	0.374
LIG_SH2_CRK	51	55	PF00017	0.282
LIG_SH2_NCK_1	26	30	PF00017	0.316
LIG_SH2_NCK_1	91	95	PF00017	0.372
LIG_SH2_NCK_1	98	102	PF00017	0.364
LIG_SH2_SRC	111	114	PF00017	0.340
LIG_SH2_SRC	155	158	PF00017	0.354
LIG_SH2_STAP1	139	143	PF00017	0.342
LIG_SH2_STAT5	111	114	PF00017	0.455
LIG_SH2_STAT5	155	158	PF00017	0.433
LIG_SH2_STAT5	189	192	PF00017	0.531
LIG_SH2_STAT5	309	312	PF00017	0.398
LIG_TRAF2_1	266	269	PF00917	0.489
LIG_TRAF2_1	83	86	PF00917	0.461
MOD_CK1_1	171	177	PF00069	0.510
MOD_CK1_1	183	189	PF00069	0.349
MOD_CK1_1	24	30	PF00069	0.386
MOD_CK1_1	263	269	PF00069	0.559
MOD_CK1_1	305	311	PF00069	0.634
MOD_CK1_1	92	98	PF00069	0.344
MOD_CK1_1	99	105	PF00069	0.329
MOD_CK2_1	107	113	PF00069	0.335
MOD_CK2_1	151	157	PF00069	0.500
MOD_CK2_1	171	177	PF00069	0.417
MOD_CK2_1	24	30	PF00069	0.337
MOD_CK2_1	263	269	PF00069	0.474
MOD_CK2_1	316	322	PF00069	0.414
MOD_GlcNHglycan	129	132	PF01048	0.539
MOD_GlcNHglycan	14	17	PF01048	0.353
MOD_GlcNHglycan	185	188	PF01048	0.318
MOD_GlcNHglycan	196	200	PF01048	0.348
MOD_GlcNHglycan	23	26	PF01048	0.385
MOD_GlcNHglycan	304	307	PF01048	0.614
MOD_GlcNHglycan	47	50	PF01048	0.283
MOD_GSK3_1	168	175	PF00069	0.499
MOD_GSK3_1	272	279	PF00069	0.635
MOD_GSK3_1	298	305	PF00069	0.729
MOD_GSK3_1	53	60	PF00069	0.170
MOD_GSK3_1	92	99	PF00069	0.477
MOD_LATS_1	274	280	PF00433	0.418
MOD_N-GLC_1	183	188	PF02516	0.315
MOD_N-GLC_1	313	318	PF02516	0.532
MOD_N-GLC_1	45	50	PF02516	0.276
MOD_N-GLC_2	311	313	PF02516	0.536
MOD_NEK2_1	150	155	PF00069	0.484
MOD_NEK2_1	288	293	PF00069	0.436
MOD_NEK2_1	96	101	PF00069	0.532
MOD_PKA_1	328	334	PF00069	0.546
MOD_PKA_1	89	95	PF00069	0.293
MOD_PKA_2	263	269	PF00069	0.530
MOD_PKA_2	283	289	PF00069	0.331
MOD_PKA_2	298	304	PF00069	0.613
MOD_PKA_2	89	95	PF00069	0.544
MOD_PKB_1	270	278	PF00069	0.470
MOD_Plk_1	139	145	PF00069	0.483
MOD_Plk_1	208	214	PF00069	0.413
MOD_Plk_1	247	253	PF00069	0.334
MOD_Plk_1	92	98	PF00069	0.324
MOD_Plk_2-3	33	39	PF00069	0.170
MOD_Plk_4	107	113	PF00069	0.441
MOD_Plk_4	151	157	PF00069	0.550
MOD_Plk_4	92	98	PF00069	0.506
MOD_SUMO_rev_2	130	136	PF00179	0.519
MOD_SUMO_rev_2	2	10	PF00179	0.540
TRG_DiLeu_BaEn_1	177	182	PF01217	0.485
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.344
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.427
TRG_ENDOCYTIC_2	233	236	PF00928	0.385
TRG_ENDOCYTIC_2	26	29	PF00928	0.273
TRG_ENDOCYTIC_2	309	312	PF00928	0.537
TRG_ENDOCYTIC_2	51	54	PF00928	0.339
TRG_ENDOCYTIC_2	97	100	PF00928	0.376
TRG_ER_diArg_1	326	328	PF00400	0.499
TRG_ER_diArg_1	330	333	PF00400	0.523
TRG_ER_diArg_1	39	42	PF00400	0.282
TRG_NLS_MonoExtC_3	327	332	PF00514	0.509
TRG_NLS_MonoExtN_4	327	333	PF00514	0.508
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTR8	Leptomonas seymouri	25%	100%
A0A0N1IBD2	Leptomonas seymouri	63%	100%
A0A0S4JRK3	Bodo saltans	34%	95%
A0A1X0NZH9	Trypanosomatidae	38%	91%
A0A3Q8IJP8	Leishmania donovani	22%	100%
A0A3R7LE97	Trypanosoma rangeli	41%	94%
A0A3S7WZC1	Leishmania donovani	95%	100%
A4HEB3	Leishmania braziliensis	85%	100%
A4I1Q9	Leishmania infantum	95%	100%
A4ICY0	Leishmania infantum	22%	100%
C9ZKB4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	96%
E9ASC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
Q4Q271	Leishmania major	23%	100%
Q4Q9M8	Leishmania major	95%	100%
V5BCJ3	Trypanosoma cruzi	41%	94%