mRNA_triPase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Capping enzyme RNA triphosphatase 1

Species:

Leishmania mexicana

UniProt:

E9AXU2_LEIMU

TriTrypDb:

LmxM.25.2095

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	11
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

E9AXU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXU2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0016311	dephosphorylation	5	1
GO:0036260	RNA capping	7	1
GO:0098507	polynucleotide 5' dephosphorylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004651	polynucleotide 5'-phosphatase activity	6	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0003924	GTPase activity	7	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.643
CLV_NRD_NRD_1	174	176	PF00675	0.376
CLV_NRD_NRD_1	215	217	PF00675	0.490
CLV_NRD_NRD_1	218	220	PF00675	0.426
CLV_NRD_NRD_1	269	271	PF00675	0.404
CLV_PCSK_FUR_1	215	219	PF00082	0.475
CLV_PCSK_KEX2_1	113	115	PF00082	0.642
CLV_PCSK_KEX2_1	173	175	PF00082	0.389
CLV_PCSK_KEX2_1	215	217	PF00082	0.475
CLV_PCSK_KEX2_1	218	220	PF00082	0.426
CLV_PCSK_KEX2_1	269	271	PF00082	0.412
CLV_PCSK_KEX2_1	81	83	PF00082	0.731
CLV_PCSK_PC1ET2_1	173	175	PF00082	0.389
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.475
CLV_PCSK_PC1ET2_1	81	83	PF00082	0.764
CLV_PCSK_SKI1_1	200	204	PF00082	0.442
CLV_PCSK_SKI1_1	269	273	PF00082	0.386
CLV_PCSK_SKI1_1	59	63	PF00082	0.484
DOC_CKS1_1	24	29	PF01111	0.661
DOC_CKS1_1	4	9	PF01111	0.665
DOC_CYCLIN_yCln2_LP_2	24	30	PF00134	0.531
DOC_MAPK_gen_1	113	119	PF00069	0.522
DOC_MAPK_gen_1	173	181	PF00069	0.334
DOC_MAPK_HePTP_8	171	183	PF00069	0.449
DOC_MAPK_MEF2A_6	174	183	PF00069	0.415
DOC_MIT_MIM_1	266	274	PF04212	0.515
DOC_USP7_MATH_1	284	288	PF00917	0.724
DOC_USP7_MATH_1	83	87	PF00917	0.718
DOC_USP7_MATH_2	27	33	PF00917	0.671
DOC_WD40_RPTOR_TOS_1	244	249	PF00400	0.449
DOC_WW_Pin1_4	23	28	PF00397	0.460
DOC_WW_Pin1_4	3	8	PF00397	0.755
DOC_WW_Pin1_4	31	36	PF00397	0.766
DOC_WW_Pin1_4	38	43	PF00397	0.741
LIG_14-3-3_CanoR_1	154	158	PF00244	0.435
LIG_14-3-3_CanoR_1	191	199	PF00244	0.344
LIG_14-3-3_CanoR_1	218	227	PF00244	0.348
LIG_14-3-3_CanoR_1	72	77	PF00244	0.570
LIG_BIR_II_1	1	5	PF00653	0.773
LIG_BRCT_BRCA1_1	163	167	PF00533	0.475
LIG_FHA_1	143	149	PF00498	0.408
LIG_FHA_1	154	160	PF00498	0.396
LIG_FHA_2	24	30	PF00498	0.723
LIG_GBD_Chelix_1	264	272	PF00786	0.431
LIG_GBD_Chelix_1	50	58	PF00786	0.461
LIG_LIR_Gen_1	122	132	PF02991	0.427
LIG_LIR_Gen_1	228	236	PF02991	0.475
LIG_LIR_Nem_3	228	234	PF02991	0.475
LIG_LIR_Nem_3	238	244	PF02991	0.310
LIG_NRBOX	263	269	PF00104	0.420
LIG_Pex14_2	227	231	PF04695	0.449
LIG_SH2_NCK_1	157	161	PF00017	0.515
LIG_SH2_STAP1	155	159	PF00017	0.476
LIG_SH2_STAP1	188	192	PF00017	0.385
LIG_SH2_STAT5	130	133	PF00017	0.310
LIG_SH2_STAT5	155	158	PF00017	0.451
LIG_SH3_3	1	7	PF00018	0.725
LIG_SH3_3	178	184	PF00018	0.389
LIG_SH3_3	36	42	PF00018	0.555
LIG_UBA3_1	271	278	PF00899	0.511
LIG_UBA3_1	54	59	PF00899	0.495
LIG_ULM_U2AF65_1	215	221	PF00076	0.475
MOD_CK1_1	193	199	PF00069	0.348
MOD_CK1_1	41	47	PF00069	0.477
MOD_CK2_1	140	146	PF00069	0.544
MOD_CK2_1	23	29	PF00069	0.662
MOD_CK2_1	62	68	PF00069	0.436
MOD_GlcNHglycan	1	4	PF01048	0.761
MOD_GlcNHglycan	119	122	PF01048	0.474
MOD_GSK3_1	149	156	PF00069	0.497
MOD_NEK2_1	140	145	PF00069	0.542
MOD_NEK2_1	163	168	PF00069	0.184
MOD_NEK2_1	62	67	PF00069	0.476
MOD_NEK2_2	284	289	PF00069	0.444
MOD_PIKK_1	252	258	PF00454	0.477
MOD_PIKK_1	84	90	PF00454	0.691
MOD_PKA_1	218	224	PF00069	0.475
MOD_PKA_2	153	159	PF00069	0.414
MOD_PKA_2	190	196	PF00069	0.376
MOD_PKA_2	218	224	PF00069	0.330
MOD_PKB_1	216	224	PF00069	0.475
MOD_Plk_4	163	169	PF00069	0.410
MOD_Plk_4	50	56	PF00069	0.552
MOD_ProDKin_1	23	29	PF00069	0.460
MOD_ProDKin_1	3	9	PF00069	0.756
MOD_ProDKin_1	31	37	PF00069	0.766
MOD_ProDKin_1	38	44	PF00069	0.730
TRG_DiLeu_BaEn_4	133	139	PF01217	0.595
TRG_DiLeu_BaLyEn_6	267	272	PF01217	0.471
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.643
TRG_ENDOCYTIC_2	241	244	PF00928	0.262
TRG_ER_diArg_1	113	115	PF00400	0.642
TRG_ER_diArg_1	174	176	PF00400	0.475
TRG_ER_diArg_1	214	216	PF00400	0.475
TRG_ER_diArg_1	218	220	PF00400	0.409
TRG_ER_diArg_1	268	270	PF00400	0.404
TRG_NLS_MonoCore_2	215	220	PF00514	0.475
TRG_NLS_MonoExtN_4	215	221	PF00514	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I3	Leptomonas seymouri	57%	100%
A0A0S4JKB2	Bodo saltans	26%	100%
A0A1X0NZM4	Trypanosomatidae	34%	100%
A0A3S7WZD5	Leishmania donovani	84%	100%
A0A422P4J1	Trypanosoma rangeli	35%	100%
A4HEB2	Leishmania braziliensis	68%	100%
A4I1Q8	Leishmania infantum	84%	100%
C9ZKB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
Q4Q9M9	Leishmania major	85%	100%
V5BH28	Trypanosoma cruzi	33%	100%