Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXU1_LEIMU

TriTrypDb:

LmxM.25.2090

Length:

156

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AXU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXU1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.449
CLV_C14_Caspase3-7	26	30	PF00656	0.754
CLV_NRD_NRD_1	108	110	PF00675	0.355
CLV_NRD_NRD_1	14	16	PF00675	0.469
CLV_NRD_NRD_1	2	4	PF00675	0.467
CLV_PCSK_KEX2_1	110	112	PF00082	0.324
CLV_PCSK_KEX2_1	14	16	PF00082	0.503
CLV_PCSK_PC1ET2_1	110	112	PF00082	0.434
CLV_PCSK_SKI1_1	14	18	PF00082	0.471
DOC_PP4_FxxP_1	127	130	PF00568	0.491
DOC_PP4_FxxP_1	53	56	PF00568	0.647
DOC_WW_Pin1_4	48	53	PF00397	0.637
LIG_14-3-3_CanoR_1	3	8	PF00244	0.691
LIG_14-3-3_CanoR_1	45	54	PF00244	0.641
LIG_BRCT_BRCA1_1	140	144	PF00533	0.480
LIG_BRCT_BRCA1_1	49	53	PF00533	0.638
LIG_FHA_1	31	37	PF00498	0.601
LIG_FHA_1	98	104	PF00498	0.602
LIG_FHA_2	137	143	PF00498	0.477
LIG_FHA_2	24	30	PF00498	0.689
LIG_LIR_Apic_2	50	56	PF02991	0.632
LIG_LIR_Apic_2	68	72	PF02991	0.637
LIG_LIR_Gen_1	142	153	PF02991	0.398
LIG_LIR_Nem_3	142	148	PF02991	0.453
LIG_LIR_Nem_3	58	64	PF02991	0.641
LIG_LIR_Nem_3	68	73	PF02991	0.615
LIG_PDZ_Class_3	151	156	PF00595	0.412
LIG_SH2_STAP1	61	65	PF00017	0.640
LIG_SH2_STAT3	87	90	PF00017	0.543
LIG_SH2_STAT5	112	115	PF00017	0.354
LIG_SH2_STAT5	118	121	PF00017	0.344
LIG_SH2_STAT5	124	127	PF00017	0.312
LIG_SH2_STAT5	69	72	PF00017	0.642
LIG_SH3_3	143	149	PF00018	0.447
LIG_SUMO_SIM_par_1	99	108	PF11976	0.617
LIG_TRFH_1	126	130	PF08558	0.355
LIG_UBA3_1	103	110	PF00899	0.608
MOD_CK1_1	136	142	PF00069	0.449
MOD_DYRK1A_RPxSP_1	48	52	PF00069	0.634
MOD_GlcNHglycan	135	138	PF01048	0.597
MOD_N-GLC_1	30	35	PF02516	0.492
MOD_NEK2_1	2	7	PF00069	0.660
MOD_PK_1	3	9	PF00069	0.680
MOD_PKA_1	3	9	PF00069	0.718
MOD_PKA_2	2	8	PF00069	0.694
MOD_PKA_2	47	53	PF00069	0.638
MOD_Plk_1	131	137	PF00069	0.401
MOD_Plk_4	60	66	PF00069	0.649
MOD_ProDKin_1	48	54	PF00069	0.638
TRG_ENDOCYTIC_2	124	127	PF00928	0.325
TRG_ER_diArg_1	109	112	PF00400	0.535
TRG_NLS_Bipartite_1	93	113	PF00514	0.588

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8V9	Leptomonas seymouri	87%	100%
A0A0S4JP84	Bodo saltans	63%	100%
A0A1X0NYC2	Trypanosomatidae	76%	100%
A0A3R7P4M5	Trypanosoma rangeli	75%	100%
A0A3S7WZB6	Leishmania donovani	95%	100%
A4HEB1	Leishmania braziliensis	90%	100%
A4I1Q7	Leishmania infantum	95%	100%
C9ZKB2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	100%
Q4Q9N0	Leishmania major	96%	100%