Rieske domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rieske [2Fe-2S] domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXT9_LEIMU

TriTrypDb:

LmxM.25.2070

Length:

543

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXT9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	12
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	12
GO:0051537	2 iron, 2 sulfur cluster binding	4	12
GO:0051540	metal cluster binding	2	12
GO:0003824	catalytic activity	1	2
GO:0016491	oxidoreductase activity	2	2
GO:0008942	nitrite reductase [NAD(P)H] activity	5	1
GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors	3	1
GO:0046857	oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor	4	1
GO:0098809	nitrite reductase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	243	245	PF00675	0.246
CLV_NRD_NRD_1	273	275	PF00675	0.654
CLV_NRD_NRD_1	303	305	PF00675	0.457
CLV_NRD_NRD_1	364	366	PF00675	0.515
CLV_PCSK_KEX2_1	14	16	PF00082	0.441
CLV_PCSK_KEX2_1	243	245	PF00082	0.448
CLV_PCSK_KEX2_1	273	275	PF00082	0.744
CLV_PCSK_KEX2_1	302	304	PF00082	0.477
CLV_PCSK_KEX2_1	364	366	PF00082	0.550
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.441
CLV_PCSK_SKI1_1	431	435	PF00082	0.594
CLV_PCSK_SKI1_1	78	82	PF00082	0.448
CLV_Separin_Metazoa	299	303	PF03568	0.524
DEG_APCC_DBOX_1	38	46	PF00400	0.475
DOC_CDC14_PxL_1	413	421	PF14671	0.566
DOC_CKS1_1	458	463	PF01111	0.516
DOC_CYCLIN_RxL_1	9	22	PF00134	0.475
DOC_CYCLIN_yCln2_LP_2	341	347	PF00134	0.535
DOC_MAPK_gen_1	110	118	PF00069	0.415
DOC_MAPK_gen_1	148	156	PF00069	0.553
DOC_MAPK_JIP1_4	150	156	PF00069	0.555
DOC_MAPK_MEF2A_6	148	156	PF00069	0.553
DOC_MAPK_MEF2A_6	339	347	PF00069	0.272
DOC_MAPK_MEF2A_6	451	459	PF00069	0.512
DOC_PP1_RVXF_1	12	19	PF00149	0.475
DOC_PP1_RVXF_1	367	373	PF00149	0.526
DOC_PP2B_LxvP_1	163	166	PF13499	0.684
DOC_PP2B_LxvP_1	266	269	PF13499	0.434
DOC_PP2B_LxvP_1	341	344	PF13499	0.560
DOC_PP4_FxxP_1	458	461	PF00568	0.482
DOC_USP7_MATH_1	103	107	PF00917	0.522
DOC_USP7_MATH_1	155	159	PF00917	0.455
DOC_USP7_MATH_1	217	221	PF00917	0.738
DOC_USP7_MATH_1	288	292	PF00917	0.679
DOC_USP7_MATH_1	495	499	PF00917	0.570
DOC_USP7_MATH_1	527	531	PF00917	0.552
DOC_USP7_MATH_1	73	77	PF00917	0.421
DOC_WW_Pin1_4	213	218	PF00397	0.784
DOC_WW_Pin1_4	220	225	PF00397	0.773
DOC_WW_Pin1_4	3	8	PF00397	0.488
DOC_WW_Pin1_4	377	382	PF00397	0.426
DOC_WW_Pin1_4	457	462	PF00397	0.597
DOC_WW_Pin1_4	473	478	PF00397	0.712
LIG_14-3-3_CanoR_1	150	155	PF00244	0.583
LIG_14-3-3_CanoR_1	227	235	PF00244	0.515
LIG_14-3-3_CanoR_1	339	344	PF00244	0.368
LIG_14-3-3_CanoR_1	411	417	PF00244	0.329
LIG_Actin_WH2_2	241	258	PF00022	0.558
LIG_BIR_II_1	1	5	PF00653	0.707
LIG_FHA_1	223	229	PF00498	0.543
LIG_FHA_1	249	255	PF00498	0.402
LIG_FHA_1	28	34	PF00498	0.466
LIG_FHA_1	372	378	PF00498	0.493
LIG_FHA_1	450	456	PF00498	0.263
LIG_FHA_1	523	529	PF00498	0.510
LIG_FHA_2	294	300	PF00498	0.598
LIG_FHA_2	304	310	PF00498	0.378
LIG_LIR_Apic_2	456	461	PF02991	0.522
LIG_LIR_Gen_1	123	133	PF02991	0.434
LIG_LIR_Gen_1	137	146	PF02991	0.447
LIG_LIR_Gen_1	262	270	PF02991	0.571
LIG_LIR_Gen_1	315	324	PF02991	0.415
LIG_LIR_Gen_1	380	390	PF02991	0.380
LIG_LIR_Nem_3	123	128	PF02991	0.399
LIG_LIR_Nem_3	262	266	PF02991	0.551
LIG_LIR_Nem_3	315	320	PF02991	0.398
LIG_LIR_Nem_3	380	386	PF02991	0.397
LIG_LIR_Nem_3	85	91	PF02991	0.431
LIG_MYND_3	416	420	PF01753	0.481
LIG_Pex14_1	425	429	PF04695	0.544
LIG_PTB_Apo_2	37	44	PF02174	0.341
LIG_PTB_Phospho_1	37	43	PF10480	0.340
LIG_PTB_Phospho_1	44	50	PF10480	0.318
LIG_SH2_CRK	383	387	PF00017	0.405
LIG_SH2_PTP2	125	128	PF00017	0.444
LIG_SH2_PTP2	263	266	PF00017	0.515
LIG_SH2_STAT5	11	14	PF00017	0.449
LIG_SH2_STAT5	125	128	PF00017	0.421
LIG_SH2_STAT5	263	266	PF00017	0.503
LIG_SH2_STAT5	395	398	PF00017	0.687
LIG_SH2_STAT5	453	456	PF00017	0.385
LIG_SH2_STAT5	504	507	PF00017	0.529
LIG_SH2_STAT5	513	516	PF00017	0.490
LIG_SH2_STAT5	88	91	PF00017	0.572
LIG_SH3_3	340	346	PF00018	0.445
LIG_SH3_3	511	517	PF00018	0.405
LIG_SUMO_SIM_par_1	126	131	PF11976	0.424
LIG_SUMO_SIM_par_1	54	60	PF11976	0.475
LIG_UBA3_1	316	322	PF00899	0.421
MOD_CDK_SPxK_1	3	9	PF00069	0.478
MOD_CDK_SPxxK_3	220	227	PF00069	0.654
MOD_CK1_1	131	137	PF00069	0.574
MOD_CK1_1	2	8	PF00069	0.681
MOD_CK1_1	216	222	PF00069	0.804
MOD_CK1_1	223	229	PF00069	0.636
MOD_CK1_1	290	296	PF00069	0.716
MOD_CK1_1	315	321	PF00069	0.384
MOD_CK1_1	409	415	PF00069	0.500
MOD_CK1_1	441	447	PF00069	0.779
MOD_CK1_1	472	478	PF00069	0.727
MOD_CK1_1	522	528	PF00069	0.351
MOD_CK2_1	293	299	PF00069	0.614
MOD_Cter_Amidation	12	15	PF01082	0.449
MOD_GlcNHglycan	1	4	PF01048	0.730
MOD_GlcNHglycan	129	133	PF01048	0.527
MOD_GlcNHglycan	157	160	PF01048	0.496
MOD_GlcNHglycan	177	180	PF01048	0.573
MOD_GlcNHglycan	196	199	PF01048	0.693
MOD_GlcNHglycan	290	293	PF01048	0.676
MOD_GlcNHglycan	330	333	PF01048	0.481
MOD_GlcNHglycan	397	400	PF01048	0.623
MOD_GlcNHglycan	431	434	PF01048	0.657
MOD_GlcNHglycan	440	443	PF01048	0.724
MOD_GlcNHglycan	497	500	PF01048	0.547
MOD_GlcNHglycan	529	532	PF01048	0.495
MOD_GSK3_1	212	219	PF00069	0.804
MOD_GSK3_1	286	293	PF00069	0.691
MOD_GSK3_1	323	330	PF00069	0.421
MOD_GSK3_1	386	393	PF00069	0.490
MOD_GSK3_1	429	436	PF00069	0.658
MOD_GSK3_1	437	444	PF00069	0.774
MOD_GSK3_1	459	466	PF00069	0.507
MOD_GSK3_1	468	475	PF00069	0.684
MOD_GSK3_1	477	484	PF00069	0.655
MOD_GSK3_1	533	540	PF00069	0.479
MOD_LATS_1	337	343	PF00433	0.290
MOD_N-GLC_1	19	24	PF02516	0.449
MOD_N-GLC_1	312	317	PF02516	0.522
MOD_N-GLC_1	386	391	PF02516	0.525
MOD_N-GLC_1	409	414	PF02516	0.554
MOD_N-GLC_1	495	500	PF02516	0.494
MOD_N-GLC_2	47	49	PF02516	0.328
MOD_N-GLC_2	479	481	PF02516	0.681
MOD_NEK2_1	1	6	PF00069	0.629
MOD_NEK2_1	16	21	PF00069	0.352
MOD_NEK2_1	228	233	PF00069	0.470
MOD_NEK2_1	286	291	PF00069	0.669
MOD_NEK2_1	371	376	PF00069	0.412
MOD_NEK2_1	385	390	PF00069	0.364
MOD_NEK2_2	217	222	PF00069	0.499
MOD_PIKK_1	325	331	PF00454	0.605
MOD_PIKK_1	463	469	PF00454	0.581
MOD_PK_1	339	345	PF00069	0.446
MOD_PKA_1	303	309	PF00069	0.427
MOD_PKA_2	303	309	PF00069	0.427
MOD_PKB_1	148	156	PF00069	0.553
MOD_Plk_1	337	343	PF00069	0.587
MOD_Plk_1	386	392	PF00069	0.539
MOD_Plk_1	409	415	PF00069	0.491
MOD_Plk_4	312	318	PF00069	0.484
MOD_Plk_4	390	396	PF00069	0.634
MOD_Plk_4	449	455	PF00069	0.486
MOD_ProDKin_1	213	219	PF00069	0.781
MOD_ProDKin_1	220	226	PF00069	0.761
MOD_ProDKin_1	3	9	PF00069	0.478
MOD_ProDKin_1	377	383	PF00069	0.426
MOD_ProDKin_1	457	463	PF00069	0.615
MOD_ProDKin_1	473	479	PF00069	0.711
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.580
TRG_DiLeu_BaLyEn_6	52	57	PF01217	0.328
TRG_ENDOCYTIC_2	125	128	PF00928	0.421
TRG_ENDOCYTIC_2	140	143	PF00928	0.445
TRG_ENDOCYTIC_2	263	266	PF00928	0.503
TRG_ENDOCYTIC_2	383	386	PF00928	0.381
TRG_ENDOCYTIC_2	88	91	PF00928	0.464
TRG_ER_diArg_1	242	244	PF00400	0.391
TRG_ER_diArg_1	273	275	PF00400	0.556
TRG_ER_diArg_1	301	304	PF00400	0.461
TRG_ER_diArg_1	363	365	PF00400	0.519
TRG_ER_diArg_1	489	492	PF00400	0.507
TRG_NES_CRM1_1	259	272	PF08389	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I7	Leptomonas seymouri	59%	100%
A0A0S4JP70	Bodo saltans	38%	100%
A0A1X0NYR2	Trypanosomatidae	37%	100%
A0A3S5ISQ1	Trypanosoma rangeli	35%	100%
A0A3S7WZH8	Leishmania donovani	88%	100%
A4HEA9	Leishmania braziliensis	72%	99%
A4I1Q5	Leishmania infantum	88%	100%
C9ZKA9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q9N2	Leishmania major	89%	100%
V5BS23	Trypanosoma cruzi	34%	100%