Putative helicase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

helicase-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXT7_LEIMU

TriTrypDb:

LmxM.25.2050

Length:

1044

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	1
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXT7

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004386	helicase activity	2	9
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0008094	ATP-dependent activity, acting on DNA	2	13
GO:0016491	oxidoreductase activity	2	12
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0051213	dioxygenase activity	3	12
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140097	catalytic activity, acting on DNA	3	13
GO:0140640	catalytic activity, acting on a nucleic acid	2	13
GO:0140657	ATP-dependent activity	1	13
GO:0140658	ATP-dependent chromatin remodeler activity	3	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003682	chromatin binding	2	1
GO:0005515	protein binding	2	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1
GO:0042393	histone binding	3	1
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1005	1009	PF00656	0.565
CLV_C14_Caspase3-7	1021	1025	PF00656	0.706
CLV_C14_Caspase3-7	1040	1044	PF00656	0.465
CLV_C14_Caspase3-7	138	142	PF00656	0.570
CLV_C14_Caspase3-7	645	649	PF00656	0.419
CLV_NRD_NRD_1	146	148	PF00675	0.532
CLV_NRD_NRD_1	379	381	PF00675	0.275
CLV_NRD_NRD_1	410	412	PF00675	0.254
CLV_NRD_NRD_1	437	439	PF00675	0.217
CLV_NRD_NRD_1	499	501	PF00675	0.248
CLV_NRD_NRD_1	740	742	PF00675	0.421
CLV_NRD_NRD_1	90	92	PF00675	0.533
CLV_NRD_NRD_1	977	979	PF00675	0.454
CLV_PCSK_KEX2_1	120	122	PF00082	0.730
CLV_PCSK_KEX2_1	146	148	PF00082	0.602
CLV_PCSK_KEX2_1	379	381	PF00082	0.377
CLV_PCSK_KEX2_1	407	409	PF00082	0.255
CLV_PCSK_KEX2_1	412	414	PF00082	0.235
CLV_PCSK_KEX2_1	499	501	PF00082	0.248
CLV_PCSK_KEX2_1	582	584	PF00082	0.557
CLV_PCSK_KEX2_1	90	92	PF00082	0.533
CLV_PCSK_KEX2_1	907	909	PF00082	0.548
CLV_PCSK_KEX2_1	977	979	PF00082	0.416
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.730
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.252
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.233
CLV_PCSK_PC1ET2_1	582	584	PF00082	0.454
CLV_PCSK_PC1ET2_1	907	909	PF00082	0.572
CLV_PCSK_PC7_1	408	414	PF00082	0.242
CLV_PCSK_SKI1_1	146	150	PF00082	0.542
CLV_PCSK_SKI1_1	17	21	PF00082	0.648
CLV_PCSK_SKI1_1	272	276	PF00082	0.493
CLV_PCSK_SKI1_1	371	375	PF00082	0.258
CLV_PCSK_SKI1_1	407	411	PF00082	0.245
CLV_PCSK_SKI1_1	438	442	PF00082	0.226
CLV_PCSK_SKI1_1	780	784	PF00082	0.406
CLV_PCSK_SKI1_1	831	835	PF00082	0.536
DEG_Nend_UBRbox_3	1	3	PF02207	0.647
DEG_SPOP_SBC_1	126	130	PF00917	0.749
DEG_SPOP_SBC_1	193	197	PF00917	0.678
DEG_SPOP_SBC_1	207	211	PF00917	0.479
DEG_SPOP_SBC_1	801	805	PF00917	0.427
DOC_CKS1_1	397	402	PF01111	0.426
DOC_MAPK_FxFP_2	466	469	PF00069	0.417
DOC_MAPK_gen_1	389	397	PF00069	0.426
DOC_MAPK_gen_1	407	418	PF00069	0.439
DOC_MAPK_gen_1	499	509	PF00069	0.432
DOC_MAPK_MEF2A_6	365	372	PF00069	0.437
DOC_MAPK_MEF2A_6	411	420	PF00069	0.519
DOC_MAPK_MEF2A_6	500	509	PF00069	0.437
DOC_MAPK_NFAT4_5	502	510	PF00069	0.420
DOC_PP1_RVXF_1	235	242	PF00149	0.310
DOC_PP1_RVXF_1	617	624	PF00149	0.448
DOC_PP2B_LxvP_1	507	510	PF13499	0.417
DOC_PP4_FxxP_1	466	469	PF00568	0.417
DOC_USP7_MATH_1	1022	1026	PF00917	0.742
DOC_USP7_MATH_1	135	139	PF00917	0.645
DOC_USP7_MATH_1	193	197	PF00917	0.622
DOC_USP7_MATH_1	328	332	PF00917	0.522
DOC_USP7_MATH_1	384	388	PF00917	0.547
DOC_USP7_MATH_1	432	436	PF00917	0.522
DOC_USP7_MATH_1	44	48	PF00917	0.649
DOC_USP7_MATH_1	573	577	PF00917	0.455
DOC_USP7_MATH_1	666	670	PF00917	0.481
DOC_USP7_MATH_1	976	980	PF00917	0.461
DOC_USP7_UBL2_3	48	52	PF12436	0.491
DOC_USP7_UBL2_3	789	793	PF12436	0.467
DOC_USP7_UBL2_3	9	13	PF12436	0.544
DOC_WW_Pin1_4	188	193	PF00397	0.611
DOC_WW_Pin1_4	194	199	PF00397	0.599
DOC_WW_Pin1_4	396	401	PF00397	0.426
DOC_WW_Pin1_4	448	453	PF00397	0.448
DOC_WW_Pin1_4	54	59	PF00397	0.639
DOC_WW_Pin1_4	62	67	PF00397	0.636
DOC_WW_Pin1_4	768	773	PF00397	0.485
DOC_WW_Pin1_4	77	82	PF00397	0.507
DOC_WW_Pin1_4	856	861	PF00397	0.615
LIG_14-3-3_CanoR_1	152	161	PF00244	0.406
LIG_14-3-3_CanoR_1	413	419	PF00244	0.537
LIG_14-3-3_CanoR_1	438	446	PF00244	0.443
LIG_14-3-3_CanoR_1	548	557	PF00244	0.421
LIG_14-3-3_CanoR_1	640	645	PF00244	0.481
LIG_14-3-3_CanoR_1	977	983	PF00244	0.431
LIG_Actin_WH2_2	258	274	PF00022	0.502
LIG_BIR_III_2	934	938	PF00653	0.314
LIG_BIR_III_4	953	957	PF00653	0.370
LIG_BRCT_BRCA1_1	667	671	PF00533	0.417
LIG_BRCT_BRCA1_1	938	942	PF00533	0.330
LIG_Clathr_ClatBox_1	402	406	PF01394	0.442
LIG_deltaCOP1_diTrp_1	459	466	PF00928	0.417
LIG_DLG_GKlike_1	640	647	PF00625	0.481
LIG_FHA_1	1002	1008	PF00498	0.701
LIG_FHA_1	325	331	PF00498	0.439
LIG_FHA_1	358	364	PF00498	0.441
LIG_FHA_1	397	403	PF00498	0.426
LIG_FHA_1	415	421	PF00498	0.505
LIG_FHA_1	516	522	PF00498	0.469
LIG_FHA_1	625	631	PF00498	0.417
LIG_FHA_1	689	695	PF00498	0.426
LIG_FHA_1	715	721	PF00498	0.410
LIG_FHA_1	769	775	PF00498	0.627
LIG_FHA_1	808	814	PF00498	0.593
LIG_FHA_1	845	851	PF00498	0.593
LIG_FHA_2	1019	1025	PF00498	0.524
LIG_FHA_2	499	505	PF00498	0.514
LIG_FHA_2	626	632	PF00498	0.522
LIG_FHA_2	685	691	PF00498	0.435
LIG_FHA_2	728	734	PF00498	0.356
LIG_FHA_2	773	779	PF00498	0.504
LIG_FHA_2	97	103	PF00498	0.499
LIG_Integrin_RGD_1	1034	1036	PF01839	0.469
LIG_LIR_Apic_2	465	469	PF02991	0.481
LIG_LIR_Gen_1	248	257	PF02991	0.458
LIG_LIR_Gen_1	4	11	PF02991	0.565
LIG_LIR_Gen_1	459	469	PF02991	0.447
LIG_LIR_Gen_1	643	648	PF02991	0.514
LIG_LIR_Gen_1	668	679	PF02991	0.417
LIG_LIR_Gen_1	939	950	PF02991	0.350
LIG_LIR_Nem_3	248	253	PF02991	0.354
LIG_LIR_Nem_3	4	10	PF02991	0.563
LIG_LIR_Nem_3	465	471	PF02991	0.480
LIG_LIR_Nem_3	643	647	PF02991	0.537
LIG_LIR_Nem_3	668	674	PF02991	0.417
LIG_LIR_Nem_3	939	945	PF02991	0.316
LIG_LYPXL_S_1	467	471	PF13949	0.239
LIG_LYPXL_yS_3	468	471	PF13949	0.481
LIG_NRBOX	160	166	PF00104	0.485
LIG_NRBOX	528	534	PF00104	0.442
LIG_PCNA_yPIPBox_3	519	533	PF02747	0.527
LIG_Pex14_2	253	257	PF04695	0.468
LIG_Pex14_2	466	470	PF04695	0.502
LIG_Pex14_2	695	699	PF04695	0.481
LIG_REV1ctd_RIR_1	254	264	PF16727	0.346
LIG_REV1ctd_RIR_1	407	417	PF16727	0.413
LIG_SH2_NCK_1	663	667	PF00017	0.466
LIG_SH2_PTP2	495	498	PF00017	0.481
LIG_SH2_STAT3	89	92	PF00017	0.571
LIG_SH2_STAT5	234	237	PF00017	0.464
LIG_SH2_STAT5	495	498	PF00017	0.481
LIG_SH2_STAT5	6	9	PF00017	0.662
LIG_SH2_STAT5	605	608	PF00017	0.522
LIG_SH2_STAT5	744	747	PF00017	0.429
LIG_SH2_STAT5	949	952	PF00017	0.333
LIG_SH2_STAT5	982	985	PF00017	0.292
LIG_SH3_3	187	193	PF00018	0.671
LIG_SH3_3	394	400	PF00018	0.439
LIG_SH3_3	510	516	PF00018	0.464
LIG_SH3_3	873	879	PF00018	0.404
LIG_SH3_3	896	902	PF00018	0.501
LIG_SUMO_SIM_anti_2	155	165	PF11976	0.613
LIG_SUMO_SIM_anti_2	627	634	PF11976	0.427
LIG_SUMO_SIM_par_1	278	286	PF11976	0.402
LIG_SUMO_SIM_par_1	37	43	PF11976	0.448
LIG_SUMO_SIM_par_1	416	422	PF11976	0.429
LIG_SUMO_SIM_par_1	528	534	PF11976	0.570
LIG_SUMO_SIM_par_1	627	634	PF11976	0.489
LIG_SUMO_SIM_par_1	690	696	PF11976	0.446
LIG_TRAF2_1	537	540	PF00917	0.442
LIG_TRAF2_1	730	733	PF00917	0.292
LIG_TRAF2_1	99	102	PF00917	0.658
LIG_TYR_ITIM	493	498	PF00017	0.481
LIG_UBA3_1	402	407	PF00899	0.442
LIG_UBA3_1	609	614	PF00899	0.522
LIG_UBA3_1	880	888	PF00899	0.328
LIG_WRC_WIRS_1	463	468	PF05994	0.472
LIG_WW_3	509	513	PF00397	0.459
LIG_WW_3	898	902	PF00397	0.452
MOD_CDC14_SPxK_1	859	862	PF00782	0.563
MOD_CDK_SPxK_1	856	862	PF00069	0.604
MOD_CK1_1	1001	1007	PF00069	0.561
MOD_CK1_1	108	114	PF00069	0.574
MOD_CK1_1	130	136	PF00069	0.543
MOD_CK1_1	15	21	PF00069	0.754
MOD_CK1_1	224	230	PF00069	0.542
MOD_CK1_1	281	287	PF00069	0.530
MOD_CK1_1	354	360	PF00069	0.446
MOD_CK1_1	462	468	PF00069	0.470
MOD_CK1_1	531	537	PF00069	0.522
MOD_CK1_1	576	582	PF00069	0.571
MOD_CK1_1	624	630	PF00069	0.476
MOD_CK1_1	77	83	PF00069	0.683
MOD_CK1_1	799	805	PF00069	0.646
MOD_CK1_1	816	822	PF00069	0.604
MOD_CK1_1	993	999	PF00069	0.491
MOD_CK2_1	498	504	PF00069	0.401
MOD_CK2_1	727	733	PF00069	0.336
MOD_CK2_1	96	102	PF00069	0.612
MOD_CK2_1	996	1002	PF00069	0.537
MOD_GlcNHglycan	132	135	PF01048	0.719
MOD_GlcNHglycan	137	140	PF01048	0.705
MOD_GlcNHglycan	17	20	PF01048	0.744
MOD_GlcNHglycan	210	213	PF01048	0.575
MOD_GlcNHglycan	224	227	PF01048	0.352
MOD_GlcNHglycan	245	248	PF01048	0.567
MOD_GlcNHglycan	29	32	PF01048	0.577
MOD_GlcNHglycan	314	317	PF01048	0.250
MOD_GlcNHglycan	330	333	PF01048	0.179
MOD_GlcNHglycan	386	389	PF01048	0.283
MOD_GlcNHglycan	434	437	PF01048	0.242
MOD_GlcNHglycan	598	602	PF01048	0.338
MOD_GlcNHglycan	819	822	PF01048	0.640
MOD_GlcNHglycan	953	957	PF01048	0.613
MOD_GlcNHglycan	998	1001	PF01048	0.619
MOD_GSK3_1	1018	1025	PF00069	0.660
MOD_GSK3_1	105	112	PF00069	0.696
MOD_GSK3_1	125	132	PF00069	0.522
MOD_GSK3_1	188	195	PF00069	0.649
MOD_GSK3_1	220	227	PF00069	0.617
MOD_GSK3_1	324	331	PF00069	0.451
MOD_GSK3_1	351	358	PF00069	0.445
MOD_GSK3_1	40	47	PF00069	0.649
MOD_GSK3_1	428	435	PF00069	0.471
MOD_GSK3_1	621	628	PF00069	0.489
MOD_GSK3_1	684	691	PF00069	0.443
MOD_GSK3_1	768	775	PF00069	0.596
MOD_GSK3_1	793	800	PF00069	0.644
MOD_GSK3_1	813	820	PF00069	0.699
MOD_GSK3_1	97	104	PF00069	0.713
MOD_GSK3_1	990	997	PF00069	0.434
MOD_LATS_1	113	119	PF00433	0.582
MOD_LATS_1	638	644	PF00433	0.420
MOD_LATS_1	791	797	PF00433	0.464
MOD_N-GLC_1	15	20	PF02516	0.521
MOD_N-GLC_1	624	629	PF02516	0.217
MOD_NEK2_1	103	108	PF00069	0.609
MOD_NEK2_1	164	169	PF00069	0.633
MOD_NEK2_1	305	310	PF00069	0.411
MOD_NEK2_1	324	329	PF00069	0.415
MOD_NEK2_1	333	338	PF00069	0.448
MOD_NEK2_1	498	503	PF00069	0.429
MOD_NEK2_1	538	543	PF00069	0.517
MOD_NEK2_1	621	626	PF00069	0.423
MOD_NEK2_1	647	652	PF00069	0.467
MOD_NEK2_1	673	678	PF00069	0.440
MOD_NEK2_1	952	957	PF00069	0.432
MOD_NEK2_1	991	996	PF00069	0.467
MOD_NEK2_2	666	671	PF00069	0.481
MOD_NEK2_2	976	981	PF00069	0.446
MOD_OFUCOSY	980	985	PF10250	0.433
MOD_PIKK_1	133	139	PF00454	0.546
MOD_PIKK_1	164	170	PF00454	0.617
MOD_PIKK_1	56	62	PF00454	0.586
MOD_PIKK_1	573	579	PF00454	0.609
MOD_PIKK_1	819	825	PF00454	0.462
MOD_PKA_1	438	444	PF00069	0.439
MOD_PKA_2	227	233	PF00069	0.381
MOD_PKA_2	378	384	PF00069	0.454
MOD_PKA_2	498	504	PF00069	0.417
MOD_PKA_2	807	813	PF00069	0.536
MOD_PKA_2	962	968	PF00069	0.492
MOD_PKA_2	976	982	PF00069	0.318
MOD_Plk_1	101	107	PF00069	0.496
MOD_Plk_1	1035	1041	PF00069	0.666
MOD_Plk_1	25	31	PF00069	0.474
MOD_Plk_1	656	662	PF00069	0.411
MOD_Plk_2-3	1006	1012	PF00069	0.591
MOD_Plk_4	414	420	PF00069	0.484
MOD_Plk_4	462	468	PF00069	0.481
MOD_Plk_4	528	534	PF00069	0.521
MOD_Plk_4	605	611	PF00069	0.481
MOD_Plk_4	656	662	PF00069	0.424
MOD_Plk_4	688	694	PF00069	0.426
MOD_Plk_4	802	808	PF00069	0.511
MOD_ProDKin_1	188	194	PF00069	0.614
MOD_ProDKin_1	396	402	PF00069	0.426
MOD_ProDKin_1	448	454	PF00069	0.448
MOD_ProDKin_1	54	60	PF00069	0.642
MOD_ProDKin_1	62	68	PF00069	0.637
MOD_ProDKin_1	768	774	PF00069	0.472
MOD_ProDKin_1	77	83	PF00069	0.506
MOD_ProDKin_1	856	862	PF00069	0.604
TRG_DiLeu_BaEn_1	160	165	PF01217	0.487
TRG_DiLeu_BaEn_1	459	464	PF01217	0.426
TRG_DiLeu_BaEn_2	300	306	PF01217	0.377
TRG_DiLeu_BaLyEn_6	562	567	PF01217	0.351
TRG_DiLeu_BaLyEn_6	876	881	PF01217	0.411
TRG_DiLeu_BaLyEn_6	955	960	PF01217	0.496
TRG_ENDOCYTIC_2	468	471	PF00928	0.470
TRG_ENDOCYTIC_2	495	498	PF00928	0.481
TRG_ENDOCYTIC_2	644	647	PF00928	0.545
TRG_ENDOCYTIC_2	949	952	PF00928	0.327
TRG_ENDOCYTIC_2	966	969	PF00928	0.377
TRG_ER_diArg_1	146	148	PF00400	0.512
TRG_ER_diArg_1	379	382	PF00400	0.442
TRG_ER_diArg_1	410	413	PF00400	0.430
TRG_ER_diArg_1	477	480	PF00400	0.466
TRG_ER_diArg_1	498	500	PF00400	0.448
TRG_ER_diArg_1	758	761	PF00400	0.766
TRG_ER_diArg_1	89	91	PF00400	0.535
TRG_ER_diArg_1	976	978	PF00400	0.464
TRG_NLS_MonoExtN_4	408	415	PF00514	0.442
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	565	569	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	948	953	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE28	Leptomonas seymouri	65%	100%
A0A0S4JP66	Bodo saltans	41%	94%
A0A1X0NY53	Trypanosomatidae	55%	100%
A0A3S7WZF4	Leishmania donovani	92%	100%
A0A422P4R6	Trypanosoma rangeli	58%	100%
A4HEA7	Leishmania braziliensis	85%	100%
A4I1Q3	Leishmania infantum	92%	100%
C9ZKA7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AZN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
Q4Q9N4	Leishmania major	91%	100%
V5DIY2	Trypanosoma cruzi	55%	100%