PHB domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXT6_LEIMU

TriTrypDb:

LmxM.25.2040

Length:

383

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9AXT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXT6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.546
CLV_C14_Caspase3-7	97	101	PF00656	0.675
CLV_NRD_NRD_1	162	164	PF00675	0.413
CLV_NRD_NRD_1	234	236	PF00675	0.289
CLV_NRD_NRD_1	318	320	PF00675	0.510
CLV_PCSK_KEX2_1	134	136	PF00082	0.462
CLV_PCSK_KEX2_1	161	163	PF00082	0.386
CLV_PCSK_KEX2_1	168	170	PF00082	0.447
CLV_PCSK_KEX2_1	234	236	PF00082	0.289
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.462
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.450
CLV_PCSK_SKI1_1	234	238	PF00082	0.419
DEG_APCC_DBOX_1	356	364	PF00400	0.598
DEG_Kelch_Keap1_1	373	378	PF01344	0.494
DEG_Nend_UBRbox_3	1	3	PF02207	0.385
DOC_CYCLIN_RxL_1	231	238	PF00134	0.492
DOC_MAPK_gen_1	209	216	PF00069	0.459
DOC_MAPK_gen_1	239	249	PF00069	0.557
DOC_MAPK_gen_1	55	64	PF00069	0.586
DOC_PP1_RVXF_1	219	226	PF00149	0.524
DOC_PP1_RVXF_1	343	349	PF00149	0.543
DOC_PP4_FxxP_1	237	240	PF00568	0.513
DOC_PP4_FxxP_1	53	56	PF00568	0.627
DOC_USP7_MATH_1	243	247	PF00917	0.532
DOC_USP7_MATH_1	60	64	PF00917	0.523
DOC_WW_Pin1_4	62	67	PF00397	0.545
DOC_WW_Pin1_4	76	81	PF00397	0.577
LIG_14-3-3_CanoR_1	155	161	PF00244	0.492
LIG_14-3-3_CanoR_1	242	248	PF00244	0.555
LIG_14-3-3_CanoR_1	345	349	PF00244	0.560
LIG_BIR_III_4	274	278	PF00653	0.603
LIG_BRCT_BRCA1_1	9	13	PF00533	0.433
LIG_Clathr_ClatBox_1	145	149	PF01394	0.543
LIG_Clathr_ClatBox_1	222	226	PF01394	0.520
LIG_FHA_1	128	134	PF00498	0.575
LIG_FHA_1	196	202	PF00498	0.542
LIG_FHA_1	335	341	PF00498	0.574
LIG_FHA_1	59	65	PF00498	0.490
LIG_FHA_2	354	360	PF00498	0.521
LIG_FXI_DFP_1	222	226	PF00024	0.377
LIG_HP1_1	39	43	PF01393	0.331
LIG_LIR_Gen_1	147	154	PF02991	0.501
LIG_LIR_Gen_1	224	233	PF02991	0.503
LIG_LIR_Gen_1	34	43	PF02991	0.190
LIG_LIR_Gen_1	341	351	PF02991	0.585
LIG_LIR_Gen_1	69	78	PF02991	0.579
LIG_LIR_Nem_3	118	123	PF02991	0.549
LIG_LIR_Nem_3	147	151	PF02991	0.496
LIG_LIR_Nem_3	224	228	PF02991	0.461
LIG_LIR_Nem_3	291	296	PF02991	0.557
LIG_LIR_Nem_3	34	38	PF02991	0.207
LIG_LIR_Nem_3	341	346	PF02991	0.548
LIG_LIR_Nem_3	347	351	PF02991	0.483
LIG_LIR_Nem_3	69	73	PF02991	0.568
LIG_PCNA_PIPBox_1	2	11	PF02747	0.285
LIG_PCNA_PIPBox_1	42	51	PF02747	0.331
LIG_Pex14_2	195	199	PF04695	0.562
LIG_Pex14_2	228	232	PF04695	0.464
LIG_SH2_CRK	293	297	PF00017	0.562
LIG_SH2_NCK_1	297	301	PF00017	0.578
LIG_SH2_PTP2	219	222	PF00017	0.572
LIG_SH2_SRC	297	300	PF00017	0.572
LIG_SH2_STAP1	197	201	PF00017	0.523
LIG_SH2_STAP1	358	362	PF00017	0.522
LIG_SH2_STAT3	197	200	PF00017	0.528
LIG_SH2_STAT5	197	200	PF00017	0.558
LIG_SH2_STAT5	219	222	PF00017	0.581
LIG_SH2_STAT5	331	334	PF00017	0.599
LIG_SH2_STAT5	343	346	PF00017	0.608
LIG_SH2_STAT5	49	52	PF00017	0.329
LIG_SH2_STAT5	72	75	PF00017	0.528
LIG_SH3_3	305	311	PF00018	0.710
LIG_SH3_3	33	39	PF00018	0.331
LIG_TYR_ITIM	217	222	PF00017	0.590
LIG_TYR_ITSM	289	296	PF00017	0.554
LIG_WRC_WIRS_1	201	206	PF05994	0.556
LIG_WRC_WIRS_1	32	37	PF05994	0.167
LIG_WRC_WIRS_1	67	72	PF05994	0.557
LIG_WW_3	177	181	PF00397	0.482
LIG_WW_3	239	243	PF00397	0.542
MOD_CK1_1	282	288	PF00069	0.642
MOD_CK2_1	178	184	PF00069	0.597
MOD_CK2_1	254	260	PF00069	0.584
MOD_CK2_1	353	359	PF00069	0.576
MOD_CK2_1	90	96	PF00069	0.560
MOD_GlcNHglycan	348	351	PF01048	0.352
MOD_GSK3_1	178	185	PF00069	0.644
MOD_GSK3_1	195	202	PF00069	0.439
MOD_GSK3_1	261	268	PF00069	0.657
MOD_GSK3_1	278	285	PF00069	0.626
MOD_GSK3_1	58	65	PF00069	0.561
MOD_GSK3_1	7	14	PF00069	0.465
MOD_GSK3_1	72	79	PF00069	0.447
MOD_NEK2_1	199	204	PF00069	0.491
MOD_NEK2_1	265	270	PF00069	0.561
MOD_NEK2_1	344	349	PF00069	0.504
MOD_PKA_2	127	133	PF00069	0.542
MOD_PKA_2	344	350	PF00069	0.563
MOD_PKB_1	169	177	PF00069	0.603
MOD_Plk_1	288	294	PF00069	0.571
MOD_Plk_2-3	284	290	PF00069	0.431
MOD_Plk_4	127	133	PF00069	0.559
MOD_Plk_4	16	22	PF00069	0.382
MOD_Plk_4	182	188	PF00069	0.580
MOD_Plk_4	243	249	PF00069	0.579
MOD_Plk_4	376	382	PF00069	0.601
MOD_Plk_4	66	72	PF00069	0.610
MOD_Plk_4	90	96	PF00069	0.567
MOD_ProDKin_1	62	68	PF00069	0.541
MOD_ProDKin_1	76	82	PF00069	0.572
MOD_SUMO_for_1	133	136	PF00179	0.561
MOD_SUMO_rev_2	316	322	PF00179	0.660
TRG_AP2beta_CARGO_1	226	235	PF09066	0.523
TRG_DiLeu_BaEn_2	181	187	PF01217	0.587
TRG_DiLeu_BaEn_4	302	308	PF01217	0.628
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.590
TRG_DiLeu_BaLyEn_6	63	68	PF01217	0.508
TRG_ENDOCYTIC_2	219	222	PF00928	0.585
TRG_ENDOCYTIC_2	293	296	PF00928	0.624
TRG_ENDOCYTIC_2	297	300	PF00928	0.650
TRG_ENDOCYTIC_2	343	346	PF00928	0.571
TRG_ENDOCYTIC_2	49	52	PF00928	0.301
TRG_ER_diArg_1	160	163	PF00400	0.588
TRG_ER_diArg_1	233	235	PF00400	0.488
TRG_NES_CRM1_1	212	226	PF08389	0.422
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.337
TRG_Pf-PMV_PEXEL_1	234	238	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	361	365	PF00026	0.376

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I861	Leptomonas seymouri	63%	99%
A0A0S4JNZ4	Bodo saltans	30%	100%
A0A1X0NY60	Trypanosomatidae	38%	100%
A0A3R7MC60	Trypanosoma rangeli	37%	100%
A0A3S7WZB8	Leishmania donovani	93%	100%
A4HEA6	Leishmania braziliensis	87%	100%
A4I1Q2	Leishmania infantum	93%	100%
C9ZKA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q9N5	Leishmania major	92%	100%
V5BHZ5	Trypanosoma cruzi	36%	100%