FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dullard-like phosphatase domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXT5_LEIMU

TriTrypDb:

LmxM.25.2030

Length:

369

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXT5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016787	hydrolase activity	2	14
GO:0016788	hydrolase activity, acting on ester bonds	3	14
GO:0016791	phosphatase activity	5	14
GO:0042578	phosphoric ester hydrolase activity	4	14
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.601
CLV_C14_Caspase3-7	348	352	PF00656	0.375
CLV_NRD_NRD_1	183	185	PF00675	0.282
CLV_Separin_Metazoa	329	333	PF03568	0.333
DEG_Nend_UBRbox_2	1	3	PF02207	0.675
DEG_SCF_FBW7_1	78	83	PF00400	0.528
DEG_SPOP_SBC_1	66	70	PF00917	0.547
DOC_CDC14_PxL_1	331	339	PF14671	0.322
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.538
DOC_MAPK_gen_1	182	191	PF00069	0.327
DOC_MAPK_gen_1	263	272	PF00069	0.244
DOC_MAPK_MEF2A_6	182	191	PF00069	0.311
DOC_MAPK_MEF2A_6	205	214	PF00069	0.252
DOC_MAPK_MEF2A_6	216	224	PF00069	0.249
DOC_MAPK_NFAT4_5	184	192	PF00069	0.302
DOC_MAPK_RevD_3	171	185	PF00069	0.391
DOC_USP7_MATH_1	133	137	PF00917	0.552
DOC_USP7_MATH_1	169	173	PF00917	0.482
DOC_USP7_MATH_1	180	184	PF00917	0.447
DOC_USP7_MATH_1	317	321	PF00917	0.277
DOC_USP7_MATH_1	33	37	PF00917	0.687
DOC_USP7_MATH_1	41	45	PF00917	0.655
DOC_WW_Pin1_4	160	165	PF00397	0.484
DOC_WW_Pin1_4	301	306	PF00397	0.326
DOC_WW_Pin1_4	50	55	PF00397	0.736
DOC_WW_Pin1_4	62	67	PF00397	0.621
DOC_WW_Pin1_4	7	12	PF00397	0.665
DOC_WW_Pin1_4	70	75	PF00397	0.629
DOC_WW_Pin1_4	76	81	PF00397	0.594
LIG_APCC_ABBA_1	270	275	PF00400	0.333
LIG_FHA_1	144	150	PF00498	0.521
LIG_FHA_1	160	166	PF00498	0.448
LIG_FHA_1	245	251	PF00498	0.279
LIG_FHA_1	280	286	PF00498	0.357
LIG_FHA_1	73	79	PF00498	0.622
LIG_FHA_1	84	90	PF00498	0.506
LIG_FHA_2	250	256	PF00498	0.442
LIG_FHA_2	343	349	PF00498	0.326
LIG_LIR_Apic_2	251	256	PF02991	0.333
LIG_LIR_Gen_1	344	355	PF02991	0.339
LIG_LIR_Nem_3	12	18	PF02991	0.604
LIG_LIR_Nem_3	344	350	PF02991	0.344
LIG_LIR_Nem_3	351	356	PF02991	0.310
LIG_MYND_1	171	175	PF01753	0.469
LIG_SH2_CRK	353	357	PF00017	0.339
LIG_SH2_GRB2like	200	203	PF00017	0.249
LIG_SH2_STAP1	206	210	PF00017	0.389
LIG_SH2_STAT3	308	311	PF00017	0.299
LIG_SH2_STAT5	154	157	PF00017	0.498
LIG_SH2_STAT5	223	226	PF00017	0.319
LIG_SH2_STAT5	253	256	PF00017	0.302
LIG_SH2_STAT5	284	287	PF00017	0.299
LIG_SH2_STAT5	308	311	PF00017	0.267
LIG_SH3_2	51	56	PF14604	0.575
LIG_SH3_3	205	211	PF00018	0.333
LIG_SH3_3	48	54	PF00018	0.692
LIG_SUMO_SIM_anti_2	287	292	PF11976	0.251
LIG_SUMO_SIM_anti_2	296	302	PF11976	0.251
LIG_SUMO_SIM_par_1	187	194	PF11976	0.328
LIG_SUMO_SIM_par_1	210	215	PF11976	0.335
LIG_UBA3_1	257	263	PF00899	0.333
MOD_CDC14_SPxK_1	53	56	PF00782	0.580
MOD_CDK_SPxK_1	50	56	PF00069	0.576
MOD_CK1_1	113	119	PF00069	0.723
MOD_CK1_1	136	142	PF00069	0.526
MOD_CK1_1	249	255	PF00069	0.271
MOD_CK1_1	68	74	PF00069	0.835
MOD_CK1_1	76	82	PF00069	0.526
MOD_CK2_1	322	328	PF00069	0.271
MOD_GlcNHglycan	101	104	PF01048	0.624
MOD_GlcNHglycan	112	116	PF01048	0.718
MOD_GlcNHglycan	117	121	PF01048	0.633
MOD_GlcNHglycan	166	170	PF01048	0.523
MOD_GlcNHglycan	18	21	PF01048	0.519
MOD_GlcNHglycan	35	38	PF01048	0.597
MOD_GSK3_1	165	172	PF00069	0.489
MOD_GSK3_1	191	198	PF00069	0.321
MOD_GSK3_1	244	251	PF00069	0.329
MOD_GSK3_1	275	282	PF00069	0.333
MOD_GSK3_1	33	40	PF00069	0.588
MOD_GSK3_1	62	69	PF00069	0.773
MOD_GSK3_1	70	77	PF00069	0.699
MOD_GSK3_1	79	86	PF00069	0.465
MOD_N-GLC_1	160	165	PF02516	0.419
MOD_N-GLC_1	7	12	PF02516	0.717
MOD_NEK2_1	195	200	PF00069	0.348
MOD_NEK2_1	246	251	PF00069	0.319
MOD_PIKK_1	21	27	PF00454	0.612
MOD_PIKK_1	83	89	PF00454	0.555
MOD_PKA_2	215	221	PF00069	0.310
MOD_PKA_2	37	43	PF00069	0.586
MOD_PKA_2	4	10	PF00069	0.791
MOD_Plk_1	191	197	PF00069	0.326
MOD_Plk_1	286	292	PF00069	0.304
MOD_Plk_2-3	342	348	PF00069	0.343
MOD_Plk_4	10	16	PF00069	0.590
MOD_Plk_4	169	175	PF00069	0.441
MOD_Plk_4	191	197	PF00069	0.328
MOD_Plk_4	275	281	PF00069	0.290
MOD_Plk_4	286	292	PF00069	0.237
MOD_Plk_4	317	323	PF00069	0.307
MOD_Plk_4	342	348	PF00069	0.303
MOD_Plk_4	80	86	PF00069	0.549
MOD_ProDKin_1	160	166	PF00069	0.489
MOD_ProDKin_1	301	307	PF00069	0.326
MOD_ProDKin_1	50	56	PF00069	0.740
MOD_ProDKin_1	62	68	PF00069	0.622
MOD_ProDKin_1	7	13	PF00069	0.664
MOD_ProDKin_1	70	76	PF00069	0.626
TRG_DiLeu_BaEn_1	329	334	PF01217	0.322
TRG_DiLeu_LyEn_5	329	334	PF01217	0.333
TRG_ENDOCYTIC_2	223	226	PF00928	0.291
TRG_ENDOCYTIC_2	347	350	PF00928	0.337
TRG_ENDOCYTIC_2	353	356	PF00928	0.333
TRG_ER_diArg_1	140	143	PF00400	0.516
TRG_ER_diArg_1	151	154	PF00400	0.383
TRG_ER_diArg_1	181	184	PF00400	0.300
TRG_Pf-PMV_PEXEL_1	293	297	PF00026	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG96	Leptomonas seymouri	68%	100%
A0A0S4IJH3	Bodo saltans	46%	100%
A0A3Q8IDG4	Leishmania donovani	94%	100%
A0A3S7WZH2	Leishmania donovani	51%	100%
A4HEA5	Leishmania braziliensis	86%	99%
A4HEM1	Leishmania braziliensis	50%	100%
A4I1Q1	Leishmania infantum	94%	100%
A4I1V3	Leishmania infantum	50%	100%
A4ICB8	Leishmania infantum	27%	100%
C9ZKA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	87%
E9AXZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	50%	100%
Q4Q9H6	Leishmania major	51%	100%
Q4Q9N6	Leishmania major	93%	99%