(d)CMP kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

(d)CMP kinase

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXT4_LEIMU

TriTrypDb:

LmxM.25.2020

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXT4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXT4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	3
GO:0003824	catalytic activity	1	3
GO:0004127	cytidylate kinase activity	6	3
GO:0005488	binding	1	3
GO:0005524	ATP binding	5	3
GO:0016301	kinase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	3
GO:0016776	phosphotransferase activity, phosphate group as acceptor	4	3
GO:0017076	purine nucleotide binding	4	3
GO:0019205	nucleobase-containing compound kinase activity	5	3
GO:0030554	adenyl nucleotide binding	5	3
GO:0032553	ribonucleotide binding	3	3
GO:0032555	purine ribonucleotide binding	4	3
GO:0032559	adenyl ribonucleotide binding	5	3
GO:0035639	purine ribonucleoside triphosphate binding	4	3
GO:0036094	small molecule binding	2	3
GO:0043167	ion binding	2	3
GO:0043168	anion binding	3	3
GO:0050145	nucleoside monophosphate kinase activity	5	3
GO:0097159	organic cyclic compound binding	2	3
GO:0097367	carbohydrate derivative binding	2	3
GO:1901265	nucleoside phosphate binding	3	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.528
CLV_NRD_NRD_1	268	270	PF00675	0.381
CLV_NRD_NRD_1	43	45	PF00675	0.433
CLV_NRD_NRD_1	60	62	PF00675	0.514
CLV_PCSK_KEX2_1	169	171	PF00082	0.525
CLV_PCSK_KEX2_1	268	270	PF00082	0.381
CLV_PCSK_KEX2_1	43	45	PF00082	0.562
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.525
CLV_PCSK_SKI1_1	121	125	PF00082	0.451
CLV_PCSK_SKI1_1	126	130	PF00082	0.381
CLV_PCSK_SKI1_1	152	156	PF00082	0.537
CLV_PCSK_SKI1_1	169	173	PF00082	0.310
DEG_Nend_UBRbox_3	1	3	PF02207	0.666
DEG_SCF_FBW7_1	198	205	PF00400	0.440
DOC_AGCK_PIF_1	136	141	PF00069	0.379
DOC_CKS1_1	199	204	PF01111	0.462
DOC_MAPK_DCC_7	254	264	PF00069	0.512
DOC_MAPK_MEF2A_6	51	60	PF00069	0.441
DOC_MAPK_RevD_3	255	269	PF00069	0.387
DOC_PP1_RVXF_1	124	131	PF00149	0.403
DOC_PP1_RVXF_1	167	174	PF00149	0.409
DOC_PP2B_LxvP_1	257	260	PF13499	0.527
DOC_USP7_MATH_1	94	98	PF00917	0.568
DOC_USP7_UBL2_3	293	297	PF12436	0.428
DOC_WW_Pin1_4	198	203	PF00397	0.494
DOC_WW_Pin1_4	248	253	PF00397	0.377
DOC_WW_Pin1_4	69	74	PF00397	0.611
LIG_14-3-3_CanoR_1	137	142	PF00244	0.357
LIG_14-3-3_CanoR_1	170	174	PF00244	0.470
LIG_14-3-3_CanoR_1	242	247	PF00244	0.387
LIG_BIR_III_2	122	126	PF00653	0.479
LIG_BIR_III_2	70	74	PF00653	0.347
LIG_FHA_1	158	164	PF00498	0.407
LIG_FHA_1	186	192	PF00498	0.520
LIG_FHA_1	199	205	PF00498	0.466
LIG_FHA_1	3	9	PF00498	0.415
LIG_FHA_1	86	92	PF00498	0.426
LIG_FHA_2	181	187	PF00498	0.497
LIG_FHA_2	213	219	PF00498	0.413
LIG_LIR_Gen_1	138	147	PF02991	0.349
LIG_LIR_Gen_1	178	185	PF02991	0.398
LIG_LIR_Gen_1	233	239	PF02991	0.498
LIG_LIR_Nem_3	138	142	PF02991	0.338
LIG_LIR_Nem_3	233	238	PF02991	0.499
LIG_SH2_CRK	139	143	PF00017	0.372
LIG_SH2_CRK	235	239	PF00017	0.385
LIG_SH2_STAT5	139	142	PF00017	0.377
LIG_SH2_STAT5	248	251	PF00017	0.431
LIG_SUMO_SIM_anti_2	261	266	PF11976	0.437
LIG_TRAF2_1	286	289	PF00917	0.599
LIG_TRAF2_1	83	86	PF00917	0.495
LIG_UBA3_1	104	113	PF00899	0.463
LIG_UBA3_1	91	98	PF00899	0.412
MOD_CDC14_SPxK_1	251	254	PF00782	0.387
MOD_CDK_SPxK_1	248	254	PF00069	0.371
MOD_CDK_SPxxK_3	69	76	PF00069	0.592
MOD_CK2_1	162	168	PF00069	0.533
MOD_CK2_1	212	218	PF00069	0.417
MOD_CK2_1	282	288	PF00069	0.573
MOD_CK2_1	31	37	PF00069	0.455
MOD_CK2_1	80	86	PF00069	0.479
MOD_GlcNHglycan	108	111	PF01048	0.431
MOD_GlcNHglycan	230	233	PF01048	0.547
MOD_GlcNHglycan	284	287	PF01048	0.638
MOD_GlcNHglycan	65	68	PF01048	0.570
MOD_GlcNHglycan	82	85	PF01048	0.502
MOD_GSK3_1	108	115	PF00069	0.411
MOD_GSK3_1	194	201	PF00069	0.439
MOD_GSK3_1	203	210	PF00069	0.450
MOD_NEK2_1	1	6	PF00069	0.488
MOD_NEK2_1	108	113	PF00069	0.405
MOD_NEK2_1	185	190	PF00069	0.528
MOD_NEK2_1	203	208	PF00069	0.624
MOD_NEK2_1	282	287	PF00069	0.629
MOD_PIKK_1	212	218	PF00454	0.411
MOD_PIKK_1	240	246	PF00454	0.475
MOD_PKA_1	169	175	PF00069	0.526
MOD_PKA_2	169	175	PF00069	0.526
MOD_Plk_1	155	161	PF00069	0.441
MOD_Plk_2-3	157	163	PF00069	0.560
MOD_Plk_2-3	284	290	PF00069	0.558
MOD_Plk_4	137	143	PF00069	0.375
MOD_Plk_4	169	175	PF00069	0.481
MOD_Plk_4	180	186	PF00069	0.402
MOD_Plk_4	194	200	PF00069	0.379
MOD_ProDKin_1	198	204	PF00069	0.487
MOD_ProDKin_1	248	254	PF00069	0.371
MOD_ProDKin_1	69	75	PF00069	0.609
MOD_SUMO_for_1	174	177	PF00179	0.434
TRG_DiLeu_BaLyEn_6	199	204	PF01217	0.548
TRG_ENDOCYTIC_2	139	142	PF00928	0.355
TRG_ENDOCYTIC_2	235	238	PF00928	0.385
TRG_ER_diArg_1	42	44	PF00400	0.402
TRG_NES_CRM1_1	247	263	PF08389	0.475

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1G0	Leptomonas seymouri	78%	100%
A0A0S4IKR6	Bodo saltans	54%	100%
A0A1X0NZI5	Trypanosomatidae	57%	100%
A0A3S7WZD1	Leishmania donovani	96%	100%
A0A422P4M6	Trypanosoma rangeli	57%	100%
A4HEA4	Leishmania braziliensis	86%	100%
A4I1Q0	Leishmania infantum	96%	100%
C9ZKA2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	99%
Q4Q9N7	Leishmania major	94%	100%
V5BMH9	Trypanosoma cruzi	57%	100%