Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AXT1_LEIMU

TriTrypDb:

LmxM.25.1990

Length:

574

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXT1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXT1

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	427	429	PF00675	0.521
CLV_NRD_NRD_1	76	78	PF00675	0.250
CLV_NRD_NRD_1	8	10	PF00675	0.295
CLV_PCSK_KEX2_1	427	429	PF00082	0.521
CLV_PCSK_KEX2_1	76	78	PF00082	0.250
CLV_PCSK_SKI1_1	114	118	PF00082	0.299
CLV_PCSK_SKI1_1	132	136	PF00082	0.299
CLV_PCSK_SKI1_1	397	401	PF00082	0.514
CLV_PCSK_SKI1_1	428	432	PF00082	0.569
DEG_APCC_DBOX_1	113	121	PF00400	0.292
DEG_Nend_UBRbox_2	1	3	PF02207	0.355
DOC_ANK_TNKS_1	75	82	PF00023	0.276
DOC_CDC14_PxL_1	431	439	PF14671	0.538
DOC_CKS1_1	140	145	PF01111	0.276
DOC_CKS1_1	160	165	PF01111	0.135
DOC_CKS1_1	200	205	PF01111	0.236
DOC_CYCLIN_RxL_1	394	404	PF00134	0.459
DOC_CYCLIN_yClb3_PxF_3	395	403	PF00134	0.461
DOC_MAPK_gen_1	132	141	PF00069	0.280
DOC_MAPK_gen_1	76	84	PF00069	0.236
DOC_MAPK_MEF2A_6	76	84	PF00069	0.259
DOC_USP7_MATH_1	256	260	PF00917	0.682
DOC_USP7_MATH_1	274	278	PF00917	0.451
DOC_USP7_MATH_1	449	453	PF00917	0.498
DOC_USP7_MATH_1	454	458	PF00917	0.510
DOC_USP7_MATH_1	480	484	PF00917	0.702
DOC_USP7_MATH_1	502	506	PF00917	0.503
DOC_USP7_MATH_1	520	524	PF00917	0.479
DOC_USP7_MATH_1	538	542	PF00917	0.562
DOC_USP7_UBL2_3	276	280	PF12436	0.616
DOC_USP7_UBL2_3	6	10	PF12436	0.258
DOC_WW_Pin1_4	139	144	PF00397	0.351
DOC_WW_Pin1_4	159	164	PF00397	0.135
DOC_WW_Pin1_4	181	186	PF00397	0.235
DOC_WW_Pin1_4	199	204	PF00397	0.278
DOC_WW_Pin1_4	252	257	PF00397	0.679
DOC_WW_Pin1_4	258	263	PF00397	0.689
DOC_WW_Pin1_4	331	336	PF00397	0.254
DOC_WW_Pin1_4	450	455	PF00397	0.587
DOC_WW_Pin1_4	473	478	PF00397	0.573
DOC_WW_Pin1_4	500	505	PF00397	0.693
LIG_14-3-3_CanoR_1	363	370	PF00244	0.406
LIG_14-3-3_CanoR_1	427	431	PF00244	0.628
LIG_14-3-3_CanoR_1	479	487	PF00244	0.668
LIG_14-3-3_CanoR_1	537	547	PF00244	0.578
LIG_Actin_WH2_2	347	365	PF00022	0.292
LIG_APCC_ABBAyCdc20_2	34	40	PF00400	0.152
LIG_BRCT_BRCA1_1	238	242	PF00533	0.532
LIG_Clathr_ClatBox_1	36	40	PF01394	0.152
LIG_FHA_1	111	117	PF00498	0.287
LIG_FHA_1	124	130	PF00498	0.242
LIG_FHA_1	446	452	PF00498	0.611
LIG_FHA_1	65	71	PF00498	0.322
LIG_FHA_2	291	297	PF00498	0.236
LIG_FHA_2	301	307	PF00498	0.236
LIG_FHA_2	363	369	PF00498	0.338
LIG_FHA_2	427	433	PF00498	0.752
LIG_FHA_2	561	567	PF00498	0.555
LIG_LIR_Apic_2	202	208	PF02991	0.278
LIG_LIR_Apic_2	268	274	PF02991	0.602
LIG_LIR_Apic_2	35	41	PF02991	0.276
LIG_LIR_Apic_2	544	550	PF02991	0.443
LIG_LIR_Gen_1	303	313	PF02991	0.270
LIG_LIR_Gen_1	350	358	PF02991	0.280
LIG_LIR_Gen_1	523	533	PF02991	0.442
LIG_LIR_Gen_1	566	574	PF02991	0.549
LIG_LIR_Nem_3	269	275	PF02991	0.593
LIG_LIR_Nem_3	303	308	PF02991	0.281
LIG_LIR_Nem_3	350	354	PF02991	0.280
LIG_LIR_Nem_3	429	434	PF02991	0.601
LIG_LIR_Nem_3	523	529	PF02991	0.432
LIG_LIR_Nem_3	566	570	PF02991	0.526
LIG_MYND_1	373	377	PF01753	0.438
LIG_Pex14_2	242	246	PF04695	0.537
LIG_SH2_CRK	272	276	PF00017	0.568
LIG_SH2_CRK	526	530	PF00017	0.428
LIG_SH2_CRK	547	551	PF00017	0.451
LIG_SH2_GRB2like	271	274	PF00017	0.582
LIG_SH2_NCK_1	305	309	PF00017	0.292
LIG_SH2_NCK_1	547	551	PF00017	0.451
LIG_SH2_STAP1	112	116	PF00017	0.236
LIG_SH2_STAP1	229	233	PF00017	0.471
LIG_SH2_STAP1	291	295	PF00017	0.236
LIG_SH2_STAP1	358	362	PF00017	0.351
LIG_SH2_STAT5	112	115	PF00017	0.296
LIG_SH2_STAT5	122	125	PF00017	0.284
LIG_SH2_STAT5	195	198	PF00017	0.375
LIG_SH2_STAT5	291	294	PF00017	0.236
LIG_SH2_STAT5	88	91	PF00017	0.318
LIG_SH2_STAT5	96	99	PF00017	0.309
LIG_SH3_3	157	163	PF00018	0.359
LIG_SH3_3	197	203	PF00018	0.278
LIG_SH3_3	333	339	PF00018	0.289
LIG_SH3_3	392	398	PF00018	0.681
LIG_SH3_3	440	446	PF00018	0.618
LIG_SH3_3	448	454	PF00018	0.568
LIG_SH3_3	496	502	PF00018	0.512
LIG_TYR_ITSM	301	308	PF00017	0.292
LIG_WRC_WIRS_1	348	353	PF05994	0.329
LIG_WW_1	263	266	PF00397	0.650
LIG_WW_3	394	398	PF00397	0.455
MOD_CDC14_SPxK_1	476	479	PF00782	0.569
MOD_CDK_SPK_2	181	186	PF00069	0.235
MOD_CDK_SPxK_1	159	165	PF00069	0.202
MOD_CDK_SPxK_1	473	479	PF00069	0.570
MOD_CDK_SPxxK_3	139	146	PF00069	0.351
MOD_CDK_SPxxK_3	181	188	PF00069	0.235
MOD_CK1_1	453	459	PF00069	0.623
MOD_CK1_1	495	501	PF00069	0.585
MOD_CK1_1	503	509	PF00069	0.621
MOD_CK1_1	512	518	PF00069	0.605
MOD_CK1_1	541	547	PF00069	0.631
MOD_CK1_1	556	562	PF00069	0.555
MOD_CK1_1	90	96	PF00069	0.364
MOD_CK2_1	238	244	PF00069	0.654
MOD_CK2_1	300	306	PF00069	0.236
MOD_CK2_1	362	368	PF00069	0.303
MOD_CK2_1	387	393	PF00069	0.735
MOD_CK2_1	512	518	PF00069	0.568
MOD_CK2_1	560	566	PF00069	0.575
MOD_GlcNHglycan	238	241	PF01048	0.716
MOD_GlcNHglycan	248	251	PF01048	0.534
MOD_GlcNHglycan	258	261	PF01048	0.637
MOD_GlcNHglycan	293	296	PF01048	0.318
MOD_GlcNHglycan	321	324	PF01048	0.292
MOD_GlcNHglycan	344	347	PF01048	0.306
MOD_GlcNHglycan	383	386	PF01048	0.638
MOD_GlcNHglycan	389	392	PF01048	0.600
MOD_GlcNHglycan	456	459	PF01048	0.746
MOD_GlcNHglycan	464	467	PF01048	0.709
MOD_GlcNHglycan	482	485	PF01048	0.585
MOD_GlcNHglycan	489	492	PF01048	0.526
MOD_GlcNHglycan	494	497	PF01048	0.518
MOD_GlcNHglycan	540	543	PF01048	0.592
MOD_GlcNHglycan	555	558	PF01048	0.684
MOD_GlcNHglycan	89	92	PF01048	0.336
MOD_GSK3_1	195	202	PF00069	0.338
MOD_GSK3_1	236	243	PF00069	0.756
MOD_GSK3_1	252	259	PF00069	0.757
MOD_GSK3_1	285	292	PF00069	0.282
MOD_GSK3_1	296	303	PF00069	0.237
MOD_GSK3_1	381	388	PF00069	0.524
MOD_GSK3_1	401	408	PF00069	0.556
MOD_GSK3_1	445	452	PF00069	0.610
MOD_GSK3_1	485	492	PF00069	0.694
MOD_GSK3_1	505	512	PF00069	0.660
MOD_GSK3_1	549	556	PF00069	0.634
MOD_NEK2_1	123	128	PF00069	0.258
MOD_NEK2_1	251	256	PF00069	0.737
MOD_NEK2_1	265	270	PF00069	0.521
MOD_NEK2_1	362	367	PF00069	0.332
MOD_NEK2_1	487	492	PF00069	0.583
MOD_NEK2_1	560	565	PF00069	0.701
MOD_PKA_2	362	368	PF00069	0.303
MOD_PKA_2	426	432	PF00069	0.568
MOD_PKA_2	480	486	PF00069	0.683
MOD_PKA_2	536	542	PF00069	0.621
MOD_Plk_2-3	347	353	PF00069	0.243
MOD_Plk_4	274	280	PF00069	0.575
MOD_Plk_4	300	306	PF00069	0.266
MOD_Plk_4	347	353	PF00069	0.329
MOD_Plk_4	556	562	PF00069	0.543
MOD_ProDKin_1	139	145	PF00069	0.351
MOD_ProDKin_1	159	165	PF00069	0.135
MOD_ProDKin_1	181	187	PF00069	0.235
MOD_ProDKin_1	199	205	PF00069	0.278
MOD_ProDKin_1	252	258	PF00069	0.681
MOD_ProDKin_1	331	337	PF00069	0.254
MOD_ProDKin_1	450	456	PF00069	0.589
MOD_ProDKin_1	473	479	PF00069	0.575
MOD_ProDKin_1	500	506	PF00069	0.693
TRG_DiLeu_BaEn_2	346	352	PF01217	0.276
TRG_DiLeu_BaEn_2	565	571	PF01217	0.527
TRG_DiLeu_BaLyEn_6	432	437	PF01217	0.538
TRG_ENDOCYTIC_2	20	23	PF00928	0.351
TRG_ENDOCYTIC_2	272	275	PF00928	0.562
TRG_ENDOCYTIC_2	305	308	PF00928	0.338
TRG_ENDOCYTIC_2	526	529	PF00928	0.417
TRG_ER_diArg_1	185	188	PF00400	0.356
TRG_ER_diArg_1	529	532	PF00400	0.528
TRG_NES_CRM1_1	118	133	PF08389	0.351

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W2	Leptomonas seymouri	55%	96%
A0A1X0NYS1	Trypanosomatidae	41%	100%
A0A3S7WZA6	Leishmania donovani	90%	100%
A0A422P4L8	Trypanosoma rangeli	44%	100%
A4HEA1	Leishmania braziliensis	79%	99%
A4I1P7	Leishmania infantum	89%	99%
C9ZK98	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AKZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AWL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q1PFB9	Arabidopsis thaliana	24%	100%
Q4Q9P0	Leishmania major	90%	100%