Acylphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Acylphosphatase

Gene product:

acylphosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AXS8_LEIMU

TriTrypDb:

LmxM.25.1960

Length:

212

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXS8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXS8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0003998	acylphosphatase activity	6	5
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.337
CLV_NRD_NRD_1	15	17	PF00675	0.524
CLV_NRD_NRD_1	22	24	PF00675	0.474
CLV_NRD_NRD_1	62	64	PF00675	0.538
CLV_PCSK_KEX2_1	15	17	PF00082	0.523
CLV_PCSK_KEX2_1	22	24	PF00082	0.474
CLV_PCSK_SKI1_1	15	19	PF00082	0.489
DOC_ANK_TNKS_1	140	147	PF00023	0.287
DOC_CKS1_1	42	47	PF01111	0.579
DOC_CYCLIN_yCln2_LP_2	186	189	PF00134	0.450
DOC_PP2B_LxvP_1	186	189	PF13499	0.450
DOC_PP4_FxxP_1	42	45	PF00568	0.525
DOC_USP7_MATH_1	193	197	PF00917	0.662
DOC_WW_Pin1_4	167	172	PF00397	0.287
DOC_WW_Pin1_4	41	46	PF00397	0.692
DOC_WW_Pin1_4	50	55	PF00397	0.579
LIG_14-3-3_CanoR_1	105	111	PF00244	0.384
LIG_14-3-3_CanoR_1	47	52	PF00244	0.527
LIG_14-3-3_CanoR_1	71	80	PF00244	0.589
LIG_Actin_WH2_2	114	132	PF00022	0.287
LIG_BIR_III_2	32	36	PF00653	0.384
LIG_FHA_1	107	113	PF00498	0.287
LIG_FHA_1	135	141	PF00498	0.287
LIG_FHA_1	154	160	PF00498	0.235
LIG_FHA_1	182	188	PF00498	0.465
LIG_FHA_1	80	86	PF00498	0.547
LIG_FHA_2	174	180	PF00498	0.287
LIG_FHA_2	85	91	PF00498	0.526
LIG_LIR_Nem_3	109	113	PF02991	0.287
LIG_SH2_CRK	126	130	PF00017	0.287
LIG_SH2_STAP1	108	112	PF00017	0.287
LIG_SH2_STAT5	106	109	PF00017	0.379
LIG_SH2_STAT5	126	129	PF00017	0.287
LIG_SH3_3	42	48	PF00018	0.666
LIG_WW_3	44	48	PF00397	0.518
MOD_CDK_SPK_2	167	172	PF00069	0.287
MOD_CDK_SPxK_1	41	47	PF00069	0.514
MOD_CDK_SPxxK_3	50	57	PF00069	0.534
MOD_CK1_1	50	56	PF00069	0.581
MOD_CK2_1	173	179	PF00069	0.238
MOD_GlcNHglycan	114	117	PF01048	0.366
MOD_GlcNHglycan	189	192	PF01048	0.527
MOD_GlcNHglycan	194	198	PF01048	0.540
MOD_GlcNHglycan	205	208	PF01048	0.591
MOD_GlcNHglycan	66	69	PF01048	0.623
MOD_GSK3_1	69	76	PF00069	0.736
MOD_LATS_1	61	67	PF00433	0.540
MOD_NEK2_1	101	106	PF00069	0.458
MOD_NEK2_1	134	139	PF00069	0.330
MOD_PIKK_1	181	187	PF00454	0.269
MOD_PIKK_1	69	75	PF00454	0.541
MOD_PKA_1	124	130	PF00069	0.287
MOD_PKA_1	63	69	PF00069	0.547
MOD_Plk_1	101	107	PF00069	0.451
MOD_Plk_1	181	187	PF00069	0.269
MOD_ProDKin_1	167	173	PF00069	0.287
MOD_ProDKin_1	41	47	PF00069	0.697
MOD_ProDKin_1	50	56	PF00069	0.580
MOD_SUMO_for_1	10	13	PF00179	0.506
TRG_DiLeu_BaEn_3	13	19	PF01217	0.475
TRG_ENDOCYTIC_2	110	113	PF00928	0.287
TRG_ENDOCYTIC_2	126	129	PF00928	0.287
TRG_ER_diArg_1	15	17	PF00400	0.490
TRG_ER_diArg_1	22	24	PF00400	0.474
TRG_Pf-PMV_PEXEL_1	141	145	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	57	62	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IDK0	Leishmania donovani	75%	100%
A4I1P4	Leishmania infantum	73%	92%
Q4Q9P3	Leishmania major	85%	100%