RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXS5_LEIMU

TriTrypDb:

LmxM.25.1930

Length:

218

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXS5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.472
CLV_NRD_NRD_1	199	201	PF00675	0.447
CLV_NRD_NRD_1	209	211	PF00675	0.483
CLV_PCSK_KEX2_1	116	118	PF00082	0.457
CLV_PCSK_KEX2_1	201	203	PF00082	0.459
CLV_PCSK_KEX2_1	209	211	PF00082	0.483
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.457
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.459
CLV_PCSK_PC7_1	113	119	PF00082	0.388
CLV_PCSK_SKI1_1	113	117	PF00082	0.483
CLV_PCSK_SKI1_1	37	41	PF00082	0.426
DOC_CYCLIN_RxL_1	177	187	PF00134	0.603
DOC_CYCLIN_yCln2_LP_2	107	110	PF00134	0.481
DOC_MAPK_gen_1	160	167	PF00069	0.467
DOC_PP2B_LxvP_1	107	110	PF13499	0.481
DOC_PP2B_LxvP_1	182	185	PF13499	0.677
DOC_USP7_MATH_1	79	83	PF00917	0.615
DOC_USP7_MATH_1	8	12	PF00917	0.459
DOC_USP7_MATH_1	89	93	PF00917	0.529
DOC_USP7_MATH_1	94	98	PF00917	0.481
LIG_14-3-3_CanoR_1	37	44	PF00244	0.431
LIG_Actin_WH2_2	100	115	PF00022	0.498
LIG_BIR_II_1	1	5	PF00653	0.577
LIG_FHA_1	17	23	PF00498	0.474
LIG_FHA_1	28	34	PF00498	0.490
LIG_FHA_1	48	54	PF00498	0.392
LIG_FHA_1	79	85	PF00498	0.616
LIG_HCF-1_HBM_1	121	124	PF13415	0.411
LIG_IRF3_LxIS_1	18	24	PF10401	0.451
LIG_LIR_Apic_2	51	57	PF02991	0.500
LIG_LIR_Apic_2	69	73	PF02991	0.468
LIG_LIR_Gen_1	121	131	PF02991	0.461
LIG_LIR_Nem_3	125	131	PF02991	0.424
LIG_LIR_Nem_3	24	29	PF02991	0.388
LIG_PDZ_Class_1	213	218	PF00595	0.441
LIG_SH2_CRK	54	58	PF00017	0.458
LIG_SH2_CRK	70	74	PF00017	0.534
LIG_SH2_GRB2like	54	57	PF00017	0.449
LIG_SH2_NCK_1	54	58	PF00017	0.497
LIG_SH2_NCK_1	70	74	PF00017	0.471
LIG_SH2_STAP1	124	128	PF00017	0.452
LIG_SH2_STAP1	29	33	PF00017	0.373
LIG_SH2_STAT5	128	131	PF00017	0.368
LIG_SH2_STAT5	134	137	PF00017	0.363
LIG_SH2_STAT5	29	32	PF00017	0.356
LIG_SH2_STAT5	38	41	PF00017	0.429
LIG_SH2_STAT5	54	57	PF00017	0.449
LIG_SH3_3	145	151	PF00018	0.452
LIG_SUMO_SIM_anti_2	19	24	PF11976	0.439
LIG_SUMO_SIM_par_1	18	24	PF11976	0.394
LIG_TRFH_1	70	74	PF08558	0.547
MOD_GlcNHglycan	11	14	PF01048	0.505
MOD_GlcNHglycan	206	209	PF01048	0.561
MOD_GlcNHglycan	211	214	PF01048	0.616
MOD_GlcNHglycan	215	218	PF01048	0.735
MOD_GlcNHglycan	23	26	PF01048	0.351
MOD_GlcNHglycan	75	78	PF01048	0.657
MOD_GlcNHglycan	81	84	PF01048	0.680
MOD_GlcNHglycan	97	100	PF01048	0.653
MOD_GSK3_1	135	142	PF00069	0.501
MOD_GSK3_1	209	216	PF00069	0.654
MOD_GSK3_1	48	55	PF00069	0.461
MOD_GSK3_1	90	97	PF00069	0.636
MOD_NEK2_1	203	208	PF00069	0.569
MOD_NEK2_1	21	26	PF00069	0.389
MOD_PIKK_1	135	141	PF00454	0.443
MOD_PKA_1	209	215	PF00069	0.620
MOD_PKA_2	139	145	PF00069	0.567
MOD_PKA_2	203	209	PF00069	0.566
MOD_PKB_1	200	208	PF00069	0.507
MOD_Plk_4	16	22	PF00069	0.374
TRG_DiLeu_BaLyEn_6	1	6	PF01217	0.525
TRG_ENDOCYTIC_2	124	127	PF00928	0.466
TRG_ENDOCYTIC_2	128	131	PF00928	0.408
TRG_ER_diArg_1	117	119	PF00400	0.390
TRG_ER_diArg_1	159	162	PF00400	0.602
TRG_ER_diArg_1	199	202	PF00400	0.492
TRG_NLS_MonoExtC_3	199	204	PF00514	0.447
TRG_NLS_MonoExtN_4	198	205	PF00514	0.515
TRG_Pf-PMV_PEXEL_1	37	41	PF00026	0.426

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I303	Leptomonas seymouri	67%	98%
A0A1X0NZI8	Trypanosomatidae	45%	86%
A0A3R7P4N9	Trypanosoma rangeli	48%	93%
A0A3S7WZA1	Leishmania donovani	92%	94%
A4HE95	Leishmania braziliensis	83%	100%
A4I1P1	Leishmania infantum	92%	94%
C9ZK90	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4Q9P6	Leishmania major	85%	100%