TPR_MalT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tetratricopeptide repeat protein 29

Species:

Leishmania mexicana

UniProt:

E9AXS4_LEIMU

TriTrypDb:

LmxM.25.1920

Length:

494

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	4
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4
GO:0031514	motile cilium	5	3

Expansion

Sequence features

E9AXS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXS4

Function

Biological processes
Term	Name	Level	Count
GO:0003341	cilium movement	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.472
CLV_NRD_NRD_1	195	197	PF00675	0.354
CLV_NRD_NRD_1	9	11	PF00675	0.698
CLV_PCSK_KEX2_1	109	111	PF00082	0.591
CLV_PCSK_KEX2_1	195	197	PF00082	0.354
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.591
CLV_PCSK_SKI1_1	110	114	PF00082	0.464
CLV_PCSK_SKI1_1	171	175	PF00082	0.452
CLV_PCSK_SKI1_1	26	30	PF00082	0.686
CLV_Separin_Metazoa	192	196	PF03568	0.330
DEG_APCC_DBOX_1	482	490	PF00400	0.527
DEG_Nend_UBRbox_3	1	3	PF02207	0.637
DOC_CKS1_1	73	78	PF01111	0.616
DOC_MAPK_MEF2A_6	343	350	PF00069	0.333
DOC_MAPK_NFAT4_5	343	351	PF00069	0.333
DOC_PP1_RVXF_1	178	184	PF00149	0.341
DOC_PP2B_LxvP_1	403	406	PF13499	0.333
DOC_PP2B_LxvP_1	93	96	PF13499	0.600
DOC_PP4_FxxP_1	174	177	PF00568	0.340
DOC_PP4_FxxP_1	303	306	PF00568	0.390
DOC_USP7_MATH_1	13	17	PF00917	0.657
DOC_USP7_MATH_1	21	25	PF00917	0.650
DOC_USP7_MATH_1	419	423	PF00917	0.253
DOC_USP7_MATH_1	487	491	PF00917	0.541
DOC_USP7_UBL2_3	362	366	PF12436	0.152
DOC_WW_Pin1_4	34	39	PF00397	0.649
DOC_WW_Pin1_4	72	77	PF00397	0.700
LIG_14-3-3_CanoR_1	195	204	PF00244	0.334
LIG_14-3-3_CanoR_1	311	321	PF00244	0.285
LIG_14-3-3_CanoR_1	50	58	PF00244	0.673
LIG_14-3-3_CanoR_1	71	76	PF00244	0.733
LIG_Actin_WH2_2	286	304	PF00022	0.451
LIG_BRCT_BRCA1_1	133	137	PF00533	0.361
LIG_BRCT_BRCA1_1	169	173	PF00533	0.475
LIG_BRCT_BRCA1_1	73	77	PF00533	0.596
LIG_FHA_1	113	119	PF00498	0.710
LIG_FHA_1	34	40	PF00498	0.585
LIG_FHA_1	371	377	PF00498	0.340
LIG_FHA_1	411	417	PF00498	0.276
LIG_FHA_1	449	455	PF00498	0.412
LIG_FHA_1	53	59	PF00498	0.733
LIG_FHA_1	73	79	PF00498	0.643
LIG_FHA_1	88	94	PF00498	0.726
LIG_FHA_2	313	319	PF00498	0.346
LIG_FHA_2	390	396	PF00498	0.389
LIG_FHA_2	82	88	PF00498	0.635
LIG_Integrin_RGD_1	343	345	PF01839	0.389
LIG_Integrin_RGD_1	460	462	PF01839	0.472
LIG_LIR_Apic_2	300	306	PF02991	0.328
LIG_LIR_Gen_1	151	159	PF02991	0.305
LIG_LIR_Gen_1	198	208	PF02991	0.362
LIG_LIR_Nem_3	151	155	PF02991	0.297
LIG_LIR_Nem_3	170	176	PF02991	0.505
LIG_LIR_Nem_3	198	203	PF02991	0.350
LIG_MAD2	116	124	PF02301	0.566
LIG_Pex14_2	200	204	PF04695	0.341
LIG_Pex14_2	433	437	PF04695	0.301
LIG_SH2_CRK	333	337	PF00017	0.336
LIG_SH2_NCK_1	220	224	PF00017	0.430
LIG_SH2_NCK_1	313	317	PF00017	0.333
LIG_SH2_SRC	220	223	PF00017	0.459
LIG_SH2_STAP1	220	224	PF00017	0.359
LIG_SH2_STAP1	313	317	PF00017	0.333
LIG_SH2_STAT5	213	216	PF00017	0.318
LIG_SH2_STAT5	464	467	PF00017	0.370
LIG_SH2_STAT5	474	477	PF00017	0.364
LIG_SH2_STAT5	479	482	PF00017	0.369
LIG_SH3_1	32	38	PF00018	0.596
LIG_SH3_3	124	130	PF00018	0.617
LIG_SH3_3	27	33	PF00018	0.590
LIG_SH3_3	6	12	PF00018	0.675
LIG_SUMO_SIM_anti_2	189	195	PF11976	0.334
LIG_TRAF2_1	252	255	PF00917	0.449
LIG_TRAF2_1	392	395	PF00917	0.349
LIG_TYR_ITIM	331	336	PF00017	0.152
LIG_TYR_ITIM	477	482	PF00017	0.459
MOD_CDK_SPxxK_3	34	41	PF00069	0.714
MOD_CK1_1	3	9	PF00069	0.697
MOD_CK1_1	37	43	PF00069	0.754
MOD_CK1_1	64	70	PF00069	0.627
MOD_CK2_1	186	192	PF00069	0.333
MOD_CK2_1	195	201	PF00069	0.366
MOD_CK2_1	312	318	PF00069	0.306
MOD_CK2_1	389	395	PF00069	0.354
MOD_CK2_1	81	87	PF00069	0.636
MOD_GlcNHglycan	188	191	PF01048	0.325
MOD_GlcNHglycan	2	5	PF01048	0.743
MOD_GlcNHglycan	23	26	PF01048	0.722
MOD_GlcNHglycan	333	336	PF01048	0.303
MOD_GlcNHglycan	437	440	PF01048	0.344
MOD_GlcNHglycan	489	492	PF01048	0.555
MOD_GSK3_1	234	241	PF00069	0.482
MOD_GSK3_1	297	304	PF00069	0.312
MOD_GSK3_1	33	40	PF00069	0.739
MOD_GSK3_1	57	64	PF00069	0.709
MOD_NEK2_1	297	302	PF00069	0.326
MOD_NEK2_1	387	392	PF00069	0.389
MOD_NEK2_1	433	438	PF00069	0.333
MOD_NEK2_1	448	453	PF00069	0.253
MOD_NEK2_1	57	62	PF00069	0.718
MOD_NEK2_2	352	357	PF00069	0.463
MOD_NEK2_2	370	375	PF00069	0.286
MOD_PIKK_1	40	46	PF00454	0.552
MOD_PKA_1	195	201	PF00069	0.347
MOD_PKA_2	131	137	PF00069	0.524
MOD_PKA_2	195	201	PF00069	0.347
MOD_PKA_2	44	50	PF00069	0.656
MOD_Plk_1	238	244	PF00069	0.545
MOD_Plk_1	433	439	PF00069	0.333
MOD_Plk_4	148	154	PF00069	0.339
MOD_Plk_4	3	9	PF00069	0.456
MOD_ProDKin_1	34	40	PF00069	0.650
MOD_ProDKin_1	72	78	PF00069	0.701
MOD_SUMO_for_1	385	388	PF00179	0.389
TRG_DiLeu_BaEn_4	261	267	PF01217	0.461
TRG_DiLeu_BaEn_4	380	386	PF01217	0.389
TRG_ENDOCYTIC_2	152	155	PF00928	0.427
TRG_ENDOCYTIC_2	226	229	PF00928	0.328
TRG_ENDOCYTIC_2	250	253	PF00928	0.331
TRG_ENDOCYTIC_2	267	270	PF00928	0.310
TRG_ENDOCYTIC_2	333	336	PF00928	0.312
TRG_ENDOCYTIC_2	474	477	PF00928	0.379
TRG_ENDOCYTIC_2	479	482	PF00928	0.397
TRG_ER_diArg_1	194	196	PF00400	0.347
TRG_ER_diArg_1	420	423	PF00400	0.389
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.307

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PG68	Leptomonas seymouri	57%	93%
A0A1X0NYE0	Trypanosomatidae	49%	97%
A0A3Q8ICL8	Leishmania donovani	93%	100%
A0A3R7MX90	Trypanosoma rangeli	51%	100%
A4HE94	Leishmania braziliensis	78%	98%
A4I1P0	Leishmania infantum	94%	100%
C9ZK89	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q32NR4	Xenopus laevis	22%	100%
Q4Q9P7	Leishmania major	91%	100%
Q4R6M4	Macaca fascicularis	22%	100%
Q8NA56	Homo sapiens	22%	100%
V5B2E8	Trypanosoma cruzi	50%	100%