Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXS3_LEIMU

TriTrypDb:

LmxM.25.1910

Length:

349

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXS3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXS3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	266	270	PF00656	0.727
CLV_NRD_NRD_1	192	194	PF00675	0.790
CLV_NRD_NRD_1	294	296	PF00675	0.739
CLV_NRD_NRD_1	311	313	PF00675	0.381
CLV_PCSK_KEX2_1	192	194	PF00082	0.790
CLV_PCSK_KEX2_1	294	296	PF00082	0.739
CLV_PCSK_KEX2_1	311	313	PF00082	0.354
CLV_PCSK_SKI1_1	174	178	PF00082	0.734
CLV_PCSK_SKI1_1	21	25	PF00082	0.473
CLV_PCSK_SKI1_1	249	253	PF00082	0.416
CLV_PCSK_SKI1_1	69	73	PF00082	0.567
DEG_APCC_DBOX_1	227	235	PF00400	0.543
DEG_APCC_DBOX_1	248	256	PF00400	0.499
DOC_MAPK_MEF2A_6	121	130	PF00069	0.499
DOC_USP7_MATH_1	179	183	PF00917	0.687
DOC_USP7_MATH_1	207	211	PF00917	0.748
DOC_USP7_MATH_1	217	221	PF00917	0.621
DOC_USP7_MATH_1	3	7	PF00917	0.585
DOC_USP7_MATH_1	319	323	PF00917	0.546
DOC_USP7_MATH_1	98	102	PF00917	0.642
DOC_USP7_UBL2_3	174	178	PF12436	0.734
DOC_WW_Pin1_4	160	165	PF00397	0.759
DOC_WW_Pin1_4	197	202	PF00397	0.771
DOC_WW_Pin1_4	302	307	PF00397	0.389
DOC_WW_Pin1_4	84	89	PF00397	0.784
DOC_WW_Pin1_4	91	96	PF00397	0.673
LIG_14-3-3_CanoR_1	21	26	PF00244	0.516
LIG_14-3-3_CanoR_1	228	232	PF00244	0.576
LIG_14-3-3_CanoR_1	238	246	PF00244	0.464
LIG_14-3-3_CanoR_1	59	67	PF00244	0.492
LIG_Actin_WH2_2	219	235	PF00022	0.602
LIG_Actin_WH2_2	316	333	PF00022	0.572
LIG_DLG_GKlike_1	326	334	PF00625	0.468
LIG_eIF4E_1	25	31	PF01652	0.494
LIG_FHA_1	123	129	PF00498	0.544
LIG_FHA_1	137	143	PF00498	0.403
LIG_FHA_2	150	156	PF00498	0.722
LIG_FHA_2	39	45	PF00498	0.508
LIG_FHA_2	72	78	PF00498	0.622
LIG_LIR_Gen_1	184	194	PF02991	0.812
LIG_LIR_Gen_1	56	64	PF02991	0.458
LIG_LIR_Nem_3	184	190	PF02991	0.807
LIG_LIR_Nem_3	56	60	PF02991	0.425
LIG_PDZ_Class_3	344	349	PF00595	0.655
LIG_Pex14_1	28	32	PF04695	0.404
LIG_SH2_NCK_1	187	191	PF00017	0.740
LIG_SH2_STAP1	124	128	PF00017	0.581
LIG_SH2_STAT5	124	127	PF00017	0.542
LIG_SH2_STAT5	244	247	PF00017	0.515
LIG_SH2_STAT5	304	307	PF00017	0.294
LIG_SH3_3	198	204	PF00018	0.738
LIG_SH3_3	213	219	PF00018	0.712
LIG_SH3_3	283	289	PF00018	0.620
LIG_SH3_3	85	91	PF00018	0.751
LIG_SH3_3	92	98	PF00018	0.736
LIG_SUMO_SIM_par_1	124	129	PF11976	0.585
LIG_TRAF2_1	276	279	PF00917	0.609
MOD_CDK_SPK_2	160	165	PF00069	0.656
MOD_CK1_1	259	265	PF00069	0.708
MOD_CK1_1	87	93	PF00069	0.730
MOD_CK2_1	149	155	PF00069	0.625
MOD_CK2_1	179	185	PF00069	0.697
MOD_CK2_1	38	44	PF00069	0.489
MOD_CK2_1	71	77	PF00069	0.578
MOD_CK2_1	87	93	PF00069	0.606
MOD_GlcNHglycan	105	108	PF01048	0.570
MOD_GlcNHglycan	20	24	PF01048	0.501
MOD_GlcNHglycan	209	212	PF01048	0.766
MOD_GlcNHglycan	260	264	PF01048	0.776
MOD_GlcNHglycan	306	309	PF01048	0.518
MOD_GlcNHglycan	317	320	PF01048	0.475
MOD_GSK3_1	122	129	PF00069	0.488
MOD_GSK3_1	160	167	PF00069	0.723
MOD_GSK3_1	203	210	PF00069	0.801
MOD_GSK3_1	234	241	PF00069	0.442
MOD_GSK3_1	315	322	PF00069	0.516
MOD_GSK3_1	59	66	PF00069	0.534
MOD_GSK3_1	71	78	PF00069	0.621
MOD_GSK3_1	87	94	PF00069	0.656
MOD_GSK3_1	98	105	PF00069	0.594
MOD_N-GLC_2	141	143	PF02516	0.660
MOD_NEK2_1	1	6	PF00069	0.644
MOD_NEK2_1	71	76	PF00069	0.546
MOD_PIKK_1	59	65	PF00454	0.572
MOD_PKA_2	164	170	PF00069	0.820
MOD_PKA_2	227	233	PF00069	0.487
MOD_PKA_2	58	64	PF00069	0.510
MOD_PKB_1	19	27	PF00069	0.512
MOD_Plk_4	172	178	PF00069	0.705
MOD_Plk_4	227	233	PF00069	0.567
MOD_Plk_4	319	325	PF00069	0.510
MOD_ProDKin_1	160	166	PF00069	0.759
MOD_ProDKin_1	197	203	PF00069	0.772
MOD_ProDKin_1	302	308	PF00069	0.392
MOD_ProDKin_1	84	90	PF00069	0.785
MOD_ProDKin_1	91	97	PF00069	0.667
MOD_SUMO_rev_2	169	176	PF00179	0.758
TRG_DiLeu_BaEn_1	185	190	PF01217	0.799
TRG_DiLeu_BaEn_1	227	232	PF01217	0.571
TRG_DiLeu_BaEn_1	281	286	PF01217	0.519
TRG_DiLeu_BaEn_4	283	289	PF01217	0.630
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.580
TRG_ENDOCYTIC_2	187	190	PF00928	0.793
TRG_ER_diArg_1	192	194	PF00400	0.794
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.558

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I869	Leptomonas seymouri	49%	100%
A0A3Q8IFE5	Leishmania donovani	87%	100%
A0A3S5ISQ2	Trypanosoma rangeli	27%	100%
A4HE93	Leishmania braziliensis	66%	100%
A4I1N9	Leishmania infantum	86%	100%
C9ZK88	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
Q4Q9P8	Leishmania major	84%	98%
V5BHX9	Trypanosoma cruzi	28%	100%