Phosphopantothenate--cysteine ligase (CTP)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphopantothenate--cysteine ligase, putative

Species:

Leishmania mexicana

UniProt:

E9AXS2_LEIMU

TriTrypDb:

LmxM.25.1900

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXS2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXS2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006163	purine nucleotide metabolic process	5	11
GO:0006164	purine nucleotide biosynthetic process	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006753	nucleoside phosphate metabolic process	4	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009117	nucleotide metabolic process	5	11
GO:0009150	purine ribonucleotide metabolic process	6	11
GO:0009152	purine ribonucleotide biosynthetic process	7	11
GO:0009165	nucleotide biosynthetic process	6	11
GO:0009259	ribonucleotide metabolic process	5	11
GO:0009260	ribonucleotide biosynthetic process	6	11
GO:0009987	cellular process	1	11
GO:0015936	coenzyme A metabolic process	6	11
GO:0015937	coenzyme A biosynthetic process	7	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0019637	organophosphate metabolic process	3	11
GO:0019693	ribose phosphate metabolic process	4	11
GO:0033865	nucleoside bisphosphate metabolic process	5	11
GO:0033866	nucleoside bisphosphate biosynthetic process	6	11
GO:0033875	ribonucleoside bisphosphate metabolic process	6	11
GO:0034030	ribonucleoside bisphosphate biosynthetic process	7	11
GO:0034032	purine nucleoside bisphosphate metabolic process	5	11
GO:0034033	purine nucleoside bisphosphate biosynthetic process	6	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046390	ribose phosphate biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0072521	purine-containing compound metabolic process	4	11
GO:0072522	purine-containing compound biosynthetic process	5	11
GO:0090407	organophosphate biosynthetic process	4	11
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901293	nucleoside phosphate biosynthetic process	5	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901566	organonitrogen compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004632	phosphopantothenate--cysteine ligase activity	5	2
GO:0016874	ligase activity	2	2
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	2
GO:0016881	acid-amino acid ligase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	281	285	PF00656	0.331
CLV_NRD_NRD_1	161	163	PF00675	0.314
CLV_NRD_NRD_1	330	332	PF00675	0.402
CLV_NRD_NRD_1	373	375	PF00675	0.466
CLV_NRD_NRD_1	54	56	PF00675	0.423
CLV_PCSK_KEX2_1	161	163	PF00082	0.317
CLV_PCSK_KEX2_1	330	332	PF00082	0.402
CLV_PCSK_KEX2_1	373	375	PF00082	0.559
CLV_PCSK_KEX2_1	54	56	PF00082	0.416
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.402
CLV_PCSK_SKI1_1	123	127	PF00082	0.295
CLV_PCSK_SKI1_1	161	165	PF00082	0.372
CLV_PCSK_SKI1_1	295	299	PF00082	0.400
DEG_Nend_Nbox_1	1	3	PF02207	0.552
DOC_CYCLIN_RxL_1	289	303	PF00134	0.329
DOC_MAPK_DCC_7	289	298	PF00069	0.152
DOC_MAPK_HePTP_8	286	298	PF00069	0.152
DOC_MAPK_MEF2A_6	289	298	PF00069	0.152
DOC_PP2B_LxvP_1	270	273	PF13499	0.385
DOC_PP4_MxPP_1	176	179	PF00568	0.322
DOC_USP7_MATH_1	20	24	PF00917	0.591
DOC_USP7_MATH_1	200	204	PF00917	0.364
DOC_USP7_MATH_1	263	267	PF00917	0.275
DOC_USP7_MATH_1	273	277	PF00917	0.275
DOC_USP7_MATH_1	39	43	PF00917	0.416
DOC_WW_Pin1_4	16	21	PF00397	0.593
DOC_WW_Pin1_4	195	200	PF00397	0.574
LIG_14-3-3_CanoR_1	80	89	PF00244	0.435
LIG_eIF4E_1	353	359	PF01652	0.359
LIG_FHA_1	112	118	PF00498	0.399
LIG_FHA_1	167	173	PF00498	0.295
LIG_FHA_1	215	221	PF00498	0.441
LIG_FHA_1	311	317	PF00498	0.303
LIG_FHA_2	226	232	PF00498	0.291
LIG_FHA_2	322	328	PF00498	0.308
LIG_FHA_2	81	87	PF00498	0.332
LIG_FHA_2	88	94	PF00498	0.309
LIG_LIR_Apic_2	266	271	PF02991	0.275
LIG_LIR_Gen_1	143	151	PF02991	0.399
LIG_LIR_Gen_1	170	181	PF02991	0.296
LIG_LIR_Gen_1	355	360	PF02991	0.443
LIG_LIR_Nem_3	143	149	PF02991	0.399
LIG_LIR_Nem_3	266	272	PF02991	0.298
LIG_LIR_Nem_3	355	359	PF02991	0.446
LIG_NRP_CendR_1	393	394	PF00754	0.584
LIG_PCNA_PIPBox_1	62	71	PF02747	0.495
LIG_PCNA_yPIPBox_3	55	69	PF02747	0.357
LIG_Pex14_1	356	360	PF04695	0.431
LIG_Pex14_2	124	128	PF04695	0.353
LIG_PTAP_UEV_1	178	183	PF05743	0.457
LIG_SH2_CRK	226	230	PF00017	0.362
LIG_SH2_STAP1	226	230	PF00017	0.353
LIG_SH2_STAP1	69	73	PF00017	0.496
LIG_SH2_STAT5	11	14	PF00017	0.474
LIG_SH2_STAT5	223	226	PF00017	0.329
LIG_SH2_STAT5	269	272	PF00017	0.297
LIG_SH2_STAT5	360	363	PF00017	0.488
LIG_SH3_1	97	103	PF00018	0.499
LIG_SH3_3	176	182	PF00018	0.521
LIG_SH3_3	97	103	PF00018	0.496
LIG_SUMO_SIM_par_1	234	240	PF11976	0.372
LIG_SUMO_SIM_par_1	296	303	PF11976	0.387
LIG_SUMO_SIM_par_1	313	319	PF11976	0.407
LIG_SUMO_SIM_par_1	386	392	PF11976	0.430
LIG_TRAF2_1	324	327	PF00917	0.295
LIG_TYR_ITIM	224	229	PF00017	0.356
LIG_WRC_WIRS_1	317	322	PF05994	0.275
LIG_WRC_WIRS_1	88	93	PF05994	0.402
MOD_CK1_1	110	116	PF00069	0.316
MOD_CK1_1	180	186	PF00069	0.689
MOD_CK1_1	189	195	PF00069	0.672
MOD_CK1_1	22	28	PF00069	0.461
MOD_CK1_1	3	9	PF00069	0.572
MOD_CK1_1	74	80	PF00069	0.369
MOD_CK2_1	200	206	PF00069	0.475
MOD_CK2_1	225	231	PF00069	0.299
MOD_CK2_1	321	327	PF00069	0.307
MOD_CK2_1	349	355	PF00069	0.402
MOD_CK2_1	87	93	PF00069	0.394
MOD_GlcNHglycan	109	112	PF01048	0.292
MOD_GlcNHglycan	129	132	PF01048	0.224
MOD_GlcNHglycan	179	182	PF01048	0.625
MOD_GlcNHglycan	188	191	PF01048	0.689
MOD_GlcNHglycan	22	25	PF01048	0.458
MOD_GlcNHglycan	280	283	PF01048	0.299
MOD_GlcNHglycan	365	369	PF01048	0.500
MOD_GlcNHglycan	41	44	PF01048	0.732
MOD_GlcNHglycan	49	52	PF01048	0.568
MOD_GSK3_1	1	8	PF00069	0.551
MOD_GSK3_1	106	113	PF00069	0.273
MOD_GSK3_1	123	130	PF00069	0.302
MOD_GSK3_1	16	23	PF00069	0.512
MOD_GSK3_1	177	184	PF00069	0.530
MOD_GSK3_1	34	41	PF00069	0.435
MOD_GSK3_1	80	87	PF00069	0.437
MOD_N-GLC_1	126	131	PF02516	0.288
MOD_N-GLC_1	71	76	PF02516	0.328
MOD_NEK2_1	1	6	PF00069	0.452
MOD_NEK2_1	107	112	PF00069	0.278
MOD_NEK2_1	172	177	PF00069	0.236
MOD_NEK2_1	243	248	PF00069	0.420
MOD_NEK2_1	288	293	PF00069	0.393
MOD_NEK2_1	316	321	PF00069	0.434
MOD_NEK2_1	34	39	PF00069	0.439
MOD_NEK2_1	349	354	PF00069	0.371
MOD_NEK2_1	384	389	PF00069	0.363
MOD_PIKK_1	310	316	PF00454	0.402
MOD_PIKK_1	74	80	PF00454	0.481
MOD_PKA_1	374	380	PF00069	0.267
MOD_PKA_2	288	294	PF00069	0.250
MOD_PKA_2	79	85	PF00069	0.446
MOD_Plk_2-3	376	382	PF00069	0.419
MOD_Plk_4	225	231	PF00069	0.318
MOD_Plk_4	384	390	PF00069	0.404
MOD_Plk_4	84	90	PF00069	0.495
MOD_ProDKin_1	16	22	PF00069	0.591
MOD_ProDKin_1	195	201	PF00069	0.564
MOD_SUMO_for_1	320	323	PF00179	0.275
TRG_DiLeu_BaEn_1	231	236	PF01217	0.306
TRG_DiLeu_BaLyEn_6	312	317	PF01217	0.152
TRG_ENDOCYTIC_2	226	229	PF00928	0.319
TRG_ENDOCYTIC_2	269	272	PF00928	0.399
TRG_ER_diArg_1	160	162	PF00400	0.328
TRG_ER_diArg_1	372	374	PF00400	0.444
TRG_ER_diArg_1	53	55	PF00400	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I9	Leptomonas seymouri	65%	100%
A0A0S4JKM7	Bodo saltans	35%	100%
A0A1X0NYS8	Trypanosomatidae	43%	100%
A0A3Q8ICG6	Leishmania donovani	86%	100%
A0A3R7MC75	Trypanosoma rangeli	42%	100%
A4HE92	Leishmania braziliensis	77%	96%
A4I1N8	Leishmania infantum	85%	100%
C9ZK87	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
P40506	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q0J7N5	Oryza sativa subsp. japonica	35%	100%
Q4Q9P9	Leishmania major	85%	100%
Q8GXR5	Arabidopsis thaliana	34%	100%
Q9HAB8	Homo sapiens	32%	100%
Q9LZM3	Arabidopsis thaliana	32%	100%
Q9USK7	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
V5BS04	Trypanosoma cruzi	45%	100%