Proteasome assembly chaperone 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXS1_LEIMU

TriTrypDb:

LmxM.25.1890

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXS1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXS1

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0022607	cellular component assembly	4	7
GO:0043248	proteasome assembly	6	7
GO:0043933	protein-containing complex organization	4	7
GO:0065003	protein-containing complex assembly	5	7
GO:0071840	cellular component organization or biogenesis	2	7

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	171	173	PF00675	0.411
CLV_NRD_NRD_1	22	24	PF00675	0.510
CLV_PCSK_FUR_1	169	173	PF00082	0.411
CLV_PCSK_KEX2_1	171	173	PF00082	0.411
CLV_PCSK_KEX2_1	22	24	PF00082	0.510
CLV_PCSK_SKI1_1	177	181	PF00082	0.411
CLV_PCSK_SKI1_1	198	202	PF00082	0.509
CLV_PCSK_SKI1_1	3	7	PF00082	0.466
CLV_PCSK_SKI1_1	60	64	PF00082	0.521
CLV_PCSK_SKI1_1	94	98	PF00082	0.558
DEG_APCC_DBOX_1	176	184	PF00400	0.411
DOC_CYCLIN_RxL_1	195	203	PF00134	0.584
DOC_MAPK_MEF2A_6	177	185	PF00069	0.411
DOC_MAPK_MEF2A_6	94	101	PF00069	0.545
DOC_MAPK_NFAT4_5	94	102	PF00069	0.552
DOC_PP1_RVXF_1	58	65	PF00149	0.593
DOC_PP4_FxxP_1	66	69	PF00568	0.624
DOC_USP7_MATH_1	26	30	PF00917	0.790
DOC_WW_Pin1_4	139	144	PF00397	0.485
DOC_WW_Pin1_4	215	220	PF00397	0.730
DOC_WW_Pin1_4	32	37	PF00397	0.794
DOC_WW_Pin1_4	42	47	PF00397	0.704
DOC_WW_Pin1_4	8	13	PF00397	0.655
LIG_14-3-3_CanoR_1	22	28	PF00244	0.686
LIG_14-3-3_CanoR_1	60	65	PF00244	0.503
LIG_BRCT_BRCA1_1	143	147	PF00533	0.411
LIG_eIF4E_1	204	210	PF01652	0.330
LIG_FHA_1	140	146	PF00498	0.485
LIG_FHA_1	157	163	PF00498	0.411
LIG_FHA_1	174	180	PF00498	0.411
LIG_FHA_1	9	15	PF00498	0.711
LIG_LIR_Apic_2	63	69	PF02991	0.599
LIG_LIR_Gen_1	106	112	PF02991	0.452
LIG_LIR_Gen_1	144	153	PF02991	0.411
LIG_LIR_Nem_3	106	110	PF02991	0.408
LIG_LIR_Nem_3	144	150	PF02991	0.411
LIG_SH2_CRK	126	130	PF00017	0.523
LIG_SH2_NCK_1	126	130	PF00017	0.624
LIG_SH2_PTP2	107	110	PF00017	0.427
LIG_SH2_STAT5	107	110	PF00017	0.444
LIG_SH3_3	213	219	PF00018	0.574
LIG_SH3_3	43	49	PF00018	0.647
LIG_TYR_ITIM	105	110	PF00017	0.463
LIG_UBA3_1	1	9	PF00899	0.636
MOD_CDC14_SPxK_1	218	221	PF00782	0.715
MOD_CDK_SPxK_1	215	221	PF00069	0.684
MOD_CK1_1	70	76	PF00069	0.651
MOD_GlcNHglycan	163	166	PF01048	0.450
MOD_GSK3_1	110	117	PF00069	0.503
MOD_GSK3_1	181	188	PF00069	0.411
MOD_GSK3_1	22	29	PF00069	0.714
MOD_GSK3_1	32	39	PF00069	0.654
MOD_GSK3_1	67	74	PF00069	0.621
MOD_N-GLC_1	192	197	PF02516	0.470
MOD_NEK2_1	1	6	PF00069	0.637
MOD_NEK2_1	161	166	PF00069	0.494
MOD_NEK2_1	181	186	PF00069	0.183
MOD_NEK2_1	192	197	PF00069	0.497
MOD_NEK2_1	97	102	PF00069	0.410
MOD_PKA_1	22	28	PF00069	0.517
MOD_PKA_2	21	27	PF00069	0.637
MOD_PKB_1	58	66	PF00069	0.531
MOD_Plk_2-3	141	147	PF00069	0.411
MOD_Plk_4	181	187	PF00069	0.411
MOD_ProDKin_1	139	145	PF00069	0.485
MOD_ProDKin_1	215	221	PF00069	0.684
MOD_ProDKin_1	32	38	PF00069	0.793
MOD_ProDKin_1	42	48	PF00069	0.700
MOD_ProDKin_1	8	14	PF00069	0.659
TRG_DiLeu_LyEn_5	175	180	PF01217	0.411
TRG_ENDOCYTIC_2	107	110	PF00928	0.444
TRG_ER_diArg_1	169	172	PF00400	0.411
TRG_ER_diArg_1	57	60	PF00400	0.509
TRG_Pf-PMV_PEXEL_1	3	8	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W5	Leptomonas seymouri	64%	100%
A0A3Q8IGP4	Leishmania donovani	91%	100%
A4HE91	Leishmania braziliensis	76%	100%
A4I1N7	Leishmania infantum	91%	100%
Q4Q9Q0	Leishmania major	90%	100%