Vacuolar protein sorting 55

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Vacuolar protein sorting 55, putative

Species:

Leishmania mexicana

UniProt:

E9AXS0_LEIMU

TriTrypDb:

LmxM.25.1880

Length:

139

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005768	endosome	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

E9AXS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXS0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0007034	vacuolar transport	4	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0032509	endosome transport via multivesicular body sorting pathway	5	1
GO:0032511	late endosome to vacuole transport via multivesicular body sorting pathway	6	1
GO:0045324	late endosome to vacuole transport	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0071985	multivesicular body sorting pathway	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.433
CLV_PCSK_KEX2_1	30	32	PF00082	0.313
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.313
DOC_MAPK_RevD_3	17	31	PF00069	0.152
DOC_PP2B_LxvP_1	122	125	PF13499	0.304
DOC_USP7_MATH_1	118	122	PF00917	0.419
DOC_USP7_MATH_1	35	39	PF00917	0.409
LIG_BIR_II_1	1	5	PF00653	0.351
LIG_BRCT_BRCA1_1	57	61	PF00533	0.303
LIG_BRCT_BRCA1_1	9	13	PF00533	0.345
LIG_EVH1_1	44	48	PF00568	0.152
LIG_EVH1_2	45	49	PF00568	0.152
LIG_FHA_1	72	78	PF00498	0.361
LIG_FHA_1	95	101	PF00498	0.480
LIG_LIR_Gen_1	10	21	PF02991	0.365
LIG_LIR_Gen_1	58	69	PF02991	0.268
LIG_LIR_Gen_1	70	79	PF02991	0.127
LIG_LIR_Nem_3	10	15	PF02991	0.365
LIG_LIR_Nem_3	58	64	PF02991	0.213
LIG_LIR_Nem_3	70	75	PF02991	0.191
LIG_MLH1_MIPbox_1	9	13	PF16413	0.327
LIG_PCNA_PIPBox_1	6	15	PF02747	0.327
LIG_PCNA_yPIPBox_3	5	13	PF02747	0.268
LIG_PDZ_Class_2	134	139	PF00595	0.425
LIG_SH2_CRK	42	46	PF00017	0.229
LIG_SH2_STAT5	42	45	PF00017	0.398
LIG_SH3_1	42	48	PF00018	0.152
LIG_SH3_3	42	48	PF00018	0.201
MOD_CK1_1	55	61	PF00069	0.180
MOD_GlcNHglycan	1	4	PF01048	0.596
MOD_GlcNHglycan	110	113	PF01048	0.350
MOD_GlcNHglycan	54	57	PF01048	0.343
MOD_GlcNHglycan	85	88	PF01048	0.331
MOD_GlcNHglycan	9	12	PF01048	0.352
MOD_NEK2_1	105	110	PF00069	0.251
MOD_NEK2_1	23	28	PF00069	0.193
MOD_NEK2_1	7	12	PF00069	0.315
MOD_NEK2_1	94	99	PF00069	0.286
MOD_Plk_4	23	29	PF00069	0.325
MOD_Plk_4	95	101	PF00069	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDL8	Leptomonas seymouri	65%	100%
A0A0S4JPU8	Bodo saltans	37%	100%
A0A1X0NY46	Trypanosomatidae	41%	100%
A0A3R7KZE9	Trypanosoma rangeli	38%	100%
A0A3S7WZC0	Leishmania donovani	90%	100%
A4HE90	Leishmania braziliensis	75%	100%
A4I1N6	Leishmania infantum	90%	100%
C9ZK85	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	89%
O89013	Mus musculus	35%	100%
Q3SYT0	Bos taurus	29%	100%
Q4Q9Q1	Leishmania major	86%	100%
Q561T9	Danio rerio	30%	100%
Q6PDU4	Rattus norvegicus	29%	100%
Q9JLS8	Rattus norvegicus	33%	100%