TPM_phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TLP18.3, Psb32 and MOLO-1 founding proteins of phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AXR8_LEIMU

TriTrypDb:

LmxM.25.1860

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AXR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.472
CLV_NRD_NRD_1	41	43	PF00675	0.435
CLV_NRD_NRD_1	91	93	PF00675	0.392
CLV_PCSK_KEX2_1	107	109	PF00082	0.284
CLV_PCSK_KEX2_1	3	5	PF00082	0.472
CLV_PCSK_KEX2_1	378	380	PF00082	0.657
CLV_PCSK_KEX2_1	41	43	PF00082	0.435
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.284
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.657
CLV_PCSK_PC7_1	103	109	PF00082	0.359
CLV_PCSK_SKI1_1	103	107	PF00082	0.336
CLV_PCSK_SKI1_1	180	184	PF00082	0.341
CLV_PCSK_SKI1_1	206	210	PF00082	0.239
CLV_PCSK_SKI1_1	242	246	PF00082	0.369
CLV_PCSK_SKI1_1	311	315	PF00082	0.624
CLV_PCSK_SKI1_1	384	388	PF00082	0.502
CLV_PCSK_SKI1_1	397	401	PF00082	0.518
DEG_APCC_DBOX_1	396	404	PF00400	0.316
DEG_Nend_Nbox_1	1	3	PF02207	0.710
DEG_SPOP_SBC_1	28	32	PF00917	0.653
DOC_CKS1_1	149	154	PF01111	0.422
DOC_CYCLIN_yCln2_LP_2	403	409	PF00134	0.382
DOC_MAPK_gen_1	106	115	PF00069	0.538
DOC_MAPK_gen_1	239	247	PF00069	0.644
DOC_MAPK_MEF2A_6	136	143	PF00069	0.538
DOC_PP1_RVXF_1	250	256	PF00149	0.517
DOC_PP2B_LxvP_1	245	248	PF13499	0.541
DOC_PP4_FxxP_1	200	203	PF00568	0.486
DOC_USP7_MATH_1	28	32	PF00917	0.680
DOC_USP7_UBL2_3	370	374	PF12436	0.311
DOC_USP7_UBL2_3	428	432	PF12436	0.449
DOC_WW_Pin1_4	148	153	PF00397	0.425
DOC_WW_Pin1_4	32	37	PF00397	0.676
DOC_WW_Pin1_4	47	52	PF00397	0.540
LIG_14-3-3_CanoR_1	108	116	PF00244	0.428
LIG_14-3-3_CanoR_1	3	9	PF00244	0.671
LIG_14-3-3_CanoR_1	92	100	PF00244	0.623
LIG_BRCT_BRCA1_1	157	161	PF00533	0.423
LIG_deltaCOP1_diTrp_1	412	418	PF00928	0.339
LIG_FHA_1	108	114	PF00498	0.538
LIG_FHA_1	181	187	PF00498	0.462
LIG_FHA_1	22	28	PF00498	0.642
LIG_FHA_1	220	226	PF00498	0.448
LIG_FHA_1	279	285	PF00498	0.329
LIG_FHA_1	351	357	PF00498	0.360
LIG_FHA_1	363	369	PF00498	0.283
LIG_FHA_2	83	89	PF00498	0.575
LIG_LIR_Apic_2	146	152	PF02991	0.422
LIG_LIR_Apic_2	197	203	PF02991	0.483
LIG_LIR_Gen_1	137	147	PF02991	0.415
LIG_LIR_Gen_1	79	86	PF02991	0.573
LIG_LIR_Nem_3	137	143	PF02991	0.415
LIG_LIR_Nem_3	207	212	PF02991	0.428
LIG_LIR_Nem_3	412	418	PF02991	0.339
LIG_MLH1_MIPbox_1	157	161	PF16413	0.538
LIG_PDZ_Class_2	430	435	PF00595	0.447
LIG_Pex14_2	196	200	PF04695	0.428
LIG_PTB_Apo_2	154	161	PF02174	0.483
LIG_RPA_C_Insects	54	69	PF08784	0.474
LIG_SH2_CRK	149	153	PF00017	0.241
LIG_SH2_CRK	404	408	PF00017	0.491
LIG_SH2_CRK	416	420	PF00017	0.396
LIG_SH2_NCK_1	388	392	PF00017	0.479
LIG_SH2_PTP2	140	143	PF00017	0.242
LIG_SH2_SRC	227	230	PF00017	0.275
LIG_SH2_STAP1	364	368	PF00017	0.299
LIG_SH2_STAP1	416	420	PF00017	0.442
LIG_SH2_STAT5	140	143	PF00017	0.254
LIG_SH2_STAT5	149	152	PF00017	0.277
LIG_SH2_STAT5	195	198	PF00017	0.324
LIG_SH2_STAT5	269	272	PF00017	0.278
LIG_SH2_STAT5	318	321	PF00017	0.322
LIG_SH2_STAT5	364	367	PF00017	0.321
LIG_SH3_3	139	145	PF00018	0.262
LIG_SH3_3	205	211	PF00018	0.417
LIG_SH3_3	396	402	PF00018	0.403
LIG_SH3_3	8	14	PF00018	0.681
LIG_SUMO_SIM_par_1	140	146	PF11976	0.262
LIG_SUMO_SIM_par_1	243	249	PF11976	0.474
LIG_SUMO_SIM_par_1	405	412	PF11976	0.396
LIG_TRAF2_1	191	194	PF00917	0.285
LIG_UBA3_1	244	252	PF00899	0.465
LIG_UBA3_1	372	378	PF00899	0.395
LIG_UBA3_1	48	54	PF00899	0.498
LIG_WRC_WIRS_1	77	82	PF05994	0.466
MOD_CDK_SPK_2	148	153	PF00069	0.272
MOD_CDK_SPxxK_3	47	54	PF00069	0.510
MOD_CK1_1	188	194	PF00069	0.361
MOD_CK1_1	219	225	PF00069	0.292
MOD_CK1_1	31	37	PF00069	0.608
MOD_CK1_1	50	56	PF00069	0.414
MOD_CK2_1	188	194	PF00069	0.396
MOD_CK2_1	374	380	PF00069	0.420
MOD_CK2_1	82	88	PF00069	0.505
MOD_GlcNHglycan	18	21	PF01048	0.581
MOD_GlcNHglycan	187	190	PF01048	0.378
MOD_GSK3_1	130	137	PF00069	0.377
MOD_GSK3_1	143	150	PF00069	0.208
MOD_GSK3_1	27	34	PF00069	0.576
MOD_GSK3_1	422	429	PF00069	0.516
MOD_N-GLC_1	22	27	PF02516	0.660
MOD_N-GLC_2	323	325	PF02516	0.350
MOD_NEK2_1	155	160	PF00069	0.302
MOD_NEK2_1	275	280	PF00069	0.333
MOD_NEK2_1	288	293	PF00069	0.413
MOD_NEK2_1	37	42	PF00069	0.575
MOD_NEK2_1	386	391	PF00069	0.478
MOD_OFUCOSY	361	366	PF10250	0.330
MOD_PIKK_1	216	222	PF00454	0.417
MOD_PIKK_1	283	289	PF00454	0.498
MOD_PIKK_1	420	426	PF00454	0.504
MOD_PIKK_1	91	97	PF00454	0.437
MOD_PKA_1	107	113	PF00069	0.262
MOD_PKA_1	3	9	PF00069	0.528
MOD_PKA_1	384	390	PF00069	0.474
MOD_PKA_2	107	113	PF00069	0.262
MOD_PKA_2	3	9	PF00069	0.603
MOD_PKA_2	91	97	PF00069	0.454
MOD_Plk_1	180	186	PF00069	0.274
MOD_Plk_1	22	28	PF00069	0.713
MOD_Plk_1	305	311	PF00069	0.392
MOD_Plk_4	155	161	PF00069	0.262
MOD_Plk_4	338	344	PF00069	0.526
MOD_ProDKin_1	148	154	PF00069	0.259
MOD_ProDKin_1	32	38	PF00069	0.609
MOD_ProDKin_1	47	53	PF00069	0.416
MOD_SUMO_rev_2	58	67	PF00179	0.473
TRG_DiLeu_BaLyEn_6	33	38	PF01217	0.434
TRG_ENDOCYTIC_2	140	143	PF00928	0.242
TRG_ENDOCYTIC_2	318	321	PF00928	0.333
TRG_ENDOCYTIC_2	327	330	PF00928	0.348
TRG_ENDOCYTIC_2	404	407	PF00928	0.479
TRG_ENDOCYTIC_2	416	419	PF00928	0.381
TRG_ER_diArg_1	2	4	PF00400	0.605
TRG_ER_FFAT_2	360	369	PF00635	0.400
TRG_NLS_Bipartite_1	92	110	PF00514	0.396
TRG_NLS_MonoExtC_3	105	111	PF00514	0.362
TRG_NLS_MonoExtN_4	103	110	PF00514	0.365
TRG_Pf-PMV_PEXEL_1	405	410	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	59	64	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMC6	Leptomonas seymouri	82%	99%
A0A0S4JYA2	Bodo saltans	63%	100%
A0A1X0NZJ4	Trypanosomatidae	66%	88%
A0A3Q8IDD5	Leishmania donovani	96%	100%
A0A3R7N4K9	Trypanosoma rangeli	67%	94%
A4HE88	Leishmania braziliensis	88%	100%
A4I1N4	Leishmania infantum	96%	100%
C9ZK83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
C9ZK84	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
Q4Q9Q3	Leishmania major	96%	100%
V5BHX3	Trypanosoma cruzi	67%	99%