Not1 N-terminal domain, CCR4-Not complex component-domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

General negative regulator of transcription subunit 5

Species:

Leishmania mexicana

UniProt:

E9AXR6_LEIMU

TriTrypDb:

LmxM.25.1840

Length:

647

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	8
GO:0005737	cytoplasm	2	8
GO:0030015	CCR4-NOT core complex	3	8
GO:0032991	protein-containing complex	1	8
GO:0043226	organelle	2	8
GO:0043227	membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043231	intracellular membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:0140535	intracellular protein-containing complex	2	8
GO:0000932	P-body	5	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0099080	supramolecular complex	2	1

Expansion

Sequence features

E9AXR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXR6

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	8
GO:0009889	regulation of biosynthetic process	4	8
GO:0010468	regulation of gene expression	5	8
GO:0010556	regulation of macromolecule biosynthetic process	5	8
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	8
GO:0019222	regulation of metabolic process	3	8
GO:0031323	regulation of cellular metabolic process	4	8
GO:0031326	regulation of cellular biosynthetic process	5	8
GO:0050789	regulation of biological process	2	8
GO:0050794	regulation of cellular process	3	8
GO:0051171	regulation of nitrogen compound metabolic process	4	8
GO:0051252	regulation of RNA metabolic process	5	8
GO:0060255	regulation of macromolecule metabolic process	4	8
GO:0065007	biological regulation	1	8
GO:0080090	regulation of primary metabolic process	4	8
GO:1903506	regulation of nucleic acid-templated transcription	7	8
GO:2001141	regulation of RNA biosynthetic process	6	8
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening	8	1
GO:0000956	nuclear-transcribed mRNA catabolic process	7	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006401	RNA catabolic process	5	1
GO:0006402	mRNA catabolic process	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010629	negative regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0048519	negative regulation of biological process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.636
CLV_C14_Caspase3-7	187	191	PF00656	0.449
CLV_C14_Caspase3-7	20	24	PF00656	0.657
CLV_NRD_NRD_1	131	133	PF00675	0.367
CLV_NRD_NRD_1	151	153	PF00675	0.406
CLV_NRD_NRD_1	416	418	PF00675	0.734
CLV_NRD_NRD_1	80	82	PF00675	0.406
CLV_PCSK_FUR_1	149	153	PF00082	0.406
CLV_PCSK_KEX2_1	151	153	PF00082	0.406
CLV_PCSK_KEX2_1	416	418	PF00082	0.699
CLV_PCSK_KEX2_1	49	51	PF00082	0.367
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.406
CLV_PCSK_SKI1_1	13	17	PF00082	0.406
CLV_PCSK_SKI1_1	384	388	PF00082	0.910
CLV_PCSK_SKI1_1	50	54	PF00082	0.379
CLV_PCSK_SKI1_1	583	587	PF00082	0.406
CLV_PCSK_SKI1_1	96	100	PF00082	0.406
DEG_COP1_1	440	449	PF00400	0.585
DEG_SCF_FBW7_1	472	478	PF00400	0.776
DEG_SPOP_SBC_1	285	289	PF00917	0.775
DEG_SPOP_SBC_1	462	466	PF00917	0.789
DEG_SPOP_SBC_1	606	610	PF00917	0.606
DOC_CKS1_1	472	477	PF01111	0.770
DOC_CYCLIN_yClb5_NLxxxL_5	514	523	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	308	311	PF00134	0.788
DOC_CYCLIN_yCln2_LP_2	467	473	PF00134	0.793
DOC_CYCLIN_yCln2_LP_2	487	493	PF00134	0.539
DOC_MAPK_gen_1	229	236	PF00069	0.749
DOC_MAPK_gen_1	72	79	PF00069	0.657
DOC_MAPK_MEF2A_6	229	236	PF00069	0.743
DOC_PP2B_LxvP_1	308	311	PF13499	0.788
DOC_PP2B_LxvP_1	467	470	PF13499	0.780
DOC_PP4_FxxP_1	223	226	PF00568	0.657
DOC_SPAK_OSR1_1	351	355	PF12202	0.569
DOC_USP7_MATH_1	285	289	PF00917	0.834
DOC_USP7_MATH_1	290	294	PF00917	0.817
DOC_USP7_MATH_1	36	40	PF00917	0.606
DOC_USP7_MATH_1	455	459	PF00917	0.795
DOC_USP7_MATH_1	479	483	PF00917	0.858
DOC_USP7_MATH_1	61	65	PF00917	0.613
DOC_USP7_UBL2_3	250	254	PF12436	0.808
DOC_USP7_UBL2_3	49	53	PF12436	0.606
DOC_USP7_UBL2_3	502	506	PF12436	0.741
DOC_USP7_UBL2_3	72	76	PF12436	0.606
DOC_WW_Pin1_4	245	250	PF00397	0.742
DOC_WW_Pin1_4	254	259	PF00397	0.755
DOC_WW_Pin1_4	264	269	PF00397	0.748
DOC_WW_Pin1_4	286	291	PF00397	0.832
DOC_WW_Pin1_4	312	317	PF00397	0.762
DOC_WW_Pin1_4	377	382	PF00397	0.791
DOC_WW_Pin1_4	400	405	PF00397	0.815
DOC_WW_Pin1_4	440	445	PF00397	0.767
DOC_WW_Pin1_4	471	476	PF00397	0.816
DOC_WW_Pin1_4	501	506	PF00397	0.685
LIG_14-3-3_CanoR_1	615	621	PF00244	0.606
LIG_BIR_II_1	1	5	PF00653	0.675
LIG_BIR_III_2	538	542	PF00653	0.601
LIG_BRCT_BRCA1_1	348	352	PF00533	0.792
LIG_BRCT_BRCA1_1	616	620	PF00533	0.606
LIG_EVH1_1	491	495	PF00568	0.819
LIG_FHA_1	257	263	PF00498	0.795
LIG_FHA_1	362	368	PF00498	0.735
LIG_FHA_1	383	389	PF00498	0.899
LIG_FHA_1	462	468	PF00498	0.809
LIG_FHA_1	483	489	PF00498	0.811
LIG_FHA_1	520	526	PF00498	0.599
LIG_FHA_2	335	341	PF00498	0.779
LIG_FHA_2	606	612	PF00498	0.610
LIG_FHA_2	617	623	PF00498	0.595
LIG_FHA_2	7	13	PF00498	0.582
LIG_Integrin_isoDGR_2	147	149	PF01839	0.406
LIG_LIR_Apic_2	221	226	PF02991	0.657
LIG_LIR_Gen_1	218	228	PF02991	0.569
LIG_LIR_Gen_1	23	33	PF02991	0.569
LIG_LIR_Gen_1	555	565	PF02991	0.606
LIG_LIR_Gen_1	617	623	PF02991	0.606
LIG_LIR_Nem_3	218	223	PF02991	0.569
LIG_LIR_Nem_3	23	28	PF02991	0.569
LIG_LIR_Nem_3	563	569	PF02991	0.581
LIG_LIR_Nem_3	575	579	PF02991	0.606
LIG_LIR_Nem_3	617	623	PF02991	0.570
LIG_LIR_Nem_3	638	642	PF02991	0.603
LIG_LIR_Nem_3	89	94	PF02991	0.606
LIG_PCNA_PIPBox_1	559	568	PF02747	0.592
LIG_PCNA_yPIPBox_3	554	566	PF02747	0.592
LIG_Pex14_2	623	627	PF04695	0.567
LIG_PTAP_UEV_1	446	451	PF05743	0.578
LIG_PTB_Apo_2	65	72	PF02174	0.606
LIG_PTB_Phospho_1	65	71	PF10480	0.606
LIG_REV1ctd_RIR_1	172	180	PF16727	0.657
LIG_SH2_NCK_1	531	535	PF00017	0.606
LIG_SH2_SRC	531	534	PF00017	0.606
LIG_SH2_STAT3	140	143	PF00017	0.606
LIG_SH2_STAT3	542	545	PF00017	0.606
LIG_SH2_STAT3	570	573	PF00017	0.567
LIG_SH2_STAT5	542	545	PF00017	0.606
LIG_SH2_STAT5	579	582	PF00017	0.567
LIG_SH2_STAT5	618	621	PF00017	0.606
LIG_SH2_STAT5	641	644	PF00017	0.629
LIG_SH3_1	229	235	PF00018	0.741
LIG_SH3_1	399	405	PF00018	0.810
LIG_SH3_1	527	533	PF00018	0.606
LIG_SH3_3	229	235	PF00018	0.763
LIG_SH3_3	385	391	PF00018	0.781
LIG_SH3_3	399	405	PF00018	0.771
LIG_SH3_3	441	447	PF00018	0.803
LIG_SH3_3	469	475	PF00018	0.838
LIG_SH3_3	487	493	PF00018	0.818
LIG_SH3_3	527	533	PF00018	0.586
LIG_SH3_3	538	544	PF00018	0.538
LIG_SUMO_SIM_anti_2	210	216	PF11976	0.657
LIG_TRAF2_1	127	130	PF00917	0.657
LIG_TRAF2_1	395	398	PF00917	0.810
LIG_WRC_WIRS_1	220	225	PF05994	0.606
LIG_WRC_WIRS_1	62	67	PF05994	0.657
LIG_WRC_WIRS_1	88	93	PF05994	0.567
MOD_CDK_SPK_2	245	250	PF00069	0.796
MOD_CDK_SPK_2	269	274	PF00069	0.773
MOD_CDK_SPK_2	501	506	PF00069	0.746
MOD_CDK_SPxK_1	501	507	PF00069	0.737
MOD_CDK_SPxxK_3	377	384	PF00069	0.788
MOD_CK1_1	248	254	PF00069	0.782
MOD_CK1_1	482	488	PF00069	0.707
MOD_CK1_1	501	507	PF00069	0.406
MOD_CK2_1	115	121	PF00069	0.606
MOD_CK2_1	236	242	PF00069	0.764
MOD_CK2_1	269	275	PF00069	0.861
MOD_CK2_1	353	359	PF00069	0.762
MOD_CK2_1	36	42	PF00069	0.606
MOD_CK2_1	455	461	PF00069	0.867
MOD_CK2_1	605	611	PF00069	0.606
MOD_Cter_Amidation	130	133	PF01082	0.406
MOD_GlcNHglycan	109	112	PF01048	0.379
MOD_GlcNHglycan	117	120	PF01048	0.387
MOD_GlcNHglycan	348	351	PF01048	0.789
MOD_GlcNHglycan	361	364	PF01048	0.533
MOD_GlcNHglycan	38	41	PF01048	0.406
MOD_GlcNHglycan	447	450	PF01048	0.736
MOD_GlcNHglycan	456	460	PF01048	0.796
MOD_GlcNHglycan	481	484	PF01048	0.833
MOD_GSK3_1	215	222	PF00069	0.575
MOD_GSK3_1	254	261	PF00069	0.811
MOD_GSK3_1	264	271	PF00069	0.678
MOD_GSK3_1	286	293	PF00069	0.833
MOD_GSK3_1	346	353	PF00069	0.872
MOD_GSK3_1	361	368	PF00069	0.570
MOD_GSK3_1	471	478	PF00069	0.777
MOD_GSK3_1	605	612	PF00069	0.592
MOD_GSK3_1	97	104	PF00069	0.584
MOD_N-GLC_1	36	41	PF02516	0.374
MOD_NEK2_1	276	281	PF00069	0.680
MOD_NEK2_1	512	517	PF00069	0.672
MOD_NEK2_1	77	82	PF00069	0.606
MOD_NEK2_2	616	621	PF00069	0.606
MOD_PIKK_1	365	371	PF00454	0.760
MOD_PKA_2	350	356	PF00069	0.707
MOD_PKA_2	614	620	PF00069	0.606
MOD_Plk_1	215	221	PF00069	0.606
MOD_Plk_1	339	345	PF00069	0.757
MOD_Plk_1	512	518	PF00069	0.426
MOD_Plk_2-3	215	221	PF00069	0.606
MOD_Plk_4	176	182	PF00069	0.647
MOD_Plk_4	215	221	PF00069	0.606
MOD_Plk_4	463	469	PF00069	0.820
MOD_Plk_4	561	567	PF00069	0.582
MOD_Plk_4	61	67	PF00069	0.657
MOD_Plk_4	616	622	PF00069	0.606
MOD_ProDKin_1	245	251	PF00069	0.742
MOD_ProDKin_1	254	260	PF00069	0.753
MOD_ProDKin_1	264	270	PF00069	0.746
MOD_ProDKin_1	286	292	PF00069	0.829
MOD_ProDKin_1	312	318	PF00069	0.764
MOD_ProDKin_1	377	383	PF00069	0.790
MOD_ProDKin_1	400	406	PF00069	0.816
MOD_ProDKin_1	440	446	PF00069	0.765
MOD_ProDKin_1	471	477	PF00069	0.819
MOD_ProDKin_1	501	507	PF00069	0.676
MOD_SUMO_for_1	175	178	PF00179	0.657
MOD_SUMO_for_1	48	51	PF00179	0.606
MOD_SUMO_rev_2	221	230	PF00179	0.739
MOD_SUMO_rev_2	237	246	PF00179	0.770
MOD_SUMO_rev_2	380	386	PF00179	0.845
MOD_SUMO_rev_2	45	55	PF00179	0.606
MOD_SUMO_rev_2	633	642	PF00179	0.567
MOD_SUMO_rev_2	95	100	PF00179	0.606
TRG_DiLeu_BaEn_1	10	15	PF01217	0.567
TRG_DiLeu_LyEn_5	10	15	PF01217	0.567
TRG_ENDOCYTIC_2	220	223	PF00928	0.567
TRG_ENDOCYTIC_2	25	28	PF00928	0.567
TRG_ENDOCYTIC_2	557	560	PF00928	0.567
TRG_ENDOCYTIC_2	600	603	PF00928	0.606
TRG_ENDOCYTIC_2	618	621	PF00928	0.606
TRG_ENDOCYTIC_2	639	642	PF00928	0.567
TRG_ER_diArg_1	149	152	PF00400	0.606
TRG_ER_diArg_1	527	530	PF00400	0.601
TRG_NES_CRM1_1	199	215	PF08389	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMJ8	Leptomonas seymouri	67%	96%
A0A3S5H7F0	Leishmania donovani	93%	100%
A4HE86	Leishmania braziliensis	86%	99%
A4I1N2	Leishmania infantum	93%	100%
C9ZK81	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q9Q5	Leishmania major	93%	99%