Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXR4_LEIMU

TriTrypDb:

LmxM.25.1820

Length:

852

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0005930	axoneme	2	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AXR4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXR4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.773
CLV_C14_Caspase3-7	294	298	PF00656	0.768
CLV_C14_Caspase3-7	500	504	PF00656	0.771
CLV_C14_Caspase3-7	555	559	PF00656	0.780
CLV_C14_Caspase3-7	625	629	PF00656	0.568
CLV_C14_Caspase3-7	680	684	PF00656	0.735
CLV_NRD_NRD_1	112	114	PF00675	0.479
CLV_NRD_NRD_1	115	117	PF00675	0.466
CLV_NRD_NRD_1	123	125	PF00675	0.500
CLV_NRD_NRD_1	130	132	PF00675	0.403
CLV_NRD_NRD_1	135	137	PF00675	0.364
CLV_NRD_NRD_1	146	148	PF00675	0.477
CLV_NRD_NRD_1	170	172	PF00675	0.778
CLV_NRD_NRD_1	179	181	PF00675	0.744
CLV_NRD_NRD_1	255	257	PF00675	0.793
CLV_NRD_NRD_1	621	623	PF00675	0.621
CLV_NRD_NRD_1	746	748	PF00675	0.858
CLV_NRD_NRD_1	766	768	PF00675	0.533
CLV_NRD_NRD_1	775	777	PF00675	0.715
CLV_NRD_NRD_1	98	100	PF00675	0.525
CLV_PCSK_FUR_1	113	117	PF00082	0.697
CLV_PCSK_KEX2_1	111	113	PF00082	0.572
CLV_PCSK_KEX2_1	115	117	PF00082	0.603
CLV_PCSK_KEX2_1	129	131	PF00082	0.408
CLV_PCSK_KEX2_1	135	137	PF00082	0.364
CLV_PCSK_KEX2_1	146	148	PF00082	0.461
CLV_PCSK_KEX2_1	170	172	PF00082	0.752
CLV_PCSK_KEX2_1	255	257	PF00082	0.793
CLV_PCSK_KEX2_1	775	777	PF00082	0.838
CLV_PCSK_PC1ET2_1	775	777	PF00082	0.838
CLV_PCSK_PC7_1	107	113	PF00082	0.671
CLV_PCSK_PC7_1	131	137	PF00082	0.677
CLV_PCSK_SKI1_1	100	104	PF00082	0.652
CLV_PCSK_SKI1_1	130	134	PF00082	0.693
DEG_APCC_KENBOX_2	752	756	PF00400	0.561
DEG_SCF_FBW7_2	816	821	PF00400	0.653
DEG_SPOP_SBC_1	229	233	PF00917	0.852
DEG_SPOP_SBC_1	780	784	PF00917	0.769
DEG_SPOP_SBC_1	798	802	PF00917	0.530
DOC_CDC14_PxL_1	61	69	PF14671	0.759
DOC_USP7_MATH_1	163	167	PF00917	0.545
DOC_USP7_MATH_1	196	200	PF00917	0.782
DOC_USP7_MATH_1	235	239	PF00917	0.813
DOC_USP7_MATH_1	247	251	PF00917	0.713
DOC_USP7_MATH_1	303	307	PF00917	0.665
DOC_USP7_MATH_1	312	316	PF00917	0.733
DOC_USP7_MATH_1	381	385	PF00917	0.772
DOC_USP7_MATH_1	475	479	PF00917	0.573
DOC_USP7_MATH_1	491	495	PF00917	0.623
DOC_USP7_MATH_1	609	613	PF00917	0.577
DOC_USP7_MATH_1	618	622	PF00917	0.624
DOC_USP7_MATH_1	681	685	PF00917	0.671
DOC_USP7_MATH_1	734	738	PF00917	0.790
DOC_USP7_MATH_1	743	747	PF00917	0.782
DOC_USP7_MATH_1	780	784	PF00917	0.773
DOC_USP7_MATH_1	785	789	PF00917	0.725
DOC_USP7_MATH_1	798	802	PF00917	0.597
DOC_USP7_MATH_1	811	815	PF00917	0.632
DOC_USP7_MATH_1	820	824	PF00917	0.676
DOC_WW_Pin1_4	250	255	PF00397	0.589
DOC_WW_Pin1_4	308	313	PF00397	0.636
DOC_WW_Pin1_4	444	449	PF00397	0.564
DOC_WW_Pin1_4	46	51	PF00397	0.648
DOC_WW_Pin1_4	613	618	PF00397	0.613
DOC_WW_Pin1_4	738	743	PF00397	0.730
DOC_WW_Pin1_4	762	767	PF00397	0.849
DOC_WW_Pin1_4	814	819	PF00397	0.672
LIG_14-3-3_CanoR_1	12	17	PF00244	0.807
LIG_14-3-3_CanoR_1	158	162	PF00244	0.593
LIG_14-3-3_CanoR_1	305	312	PF00244	0.658
LIG_14-3-3_CanoR_1	37	45	PF00244	0.826
LIG_APCC_ABBA_1	394	399	PF00400	0.677
LIG_APCC_ABBA_1	82	87	PF00400	0.729
LIG_BIR_II_1	1	5	PF00653	0.808
LIG_BIR_III_4	443	447	PF00653	0.782
LIG_FHA_1	531	537	PF00498	0.629
LIG_FHA_1	656	662	PF00498	0.630
LIG_FHA_2	260	266	PF00498	0.595
LIG_FHA_2	279	285	PF00498	0.778
LIG_FHA_2	416	422	PF00498	0.832
LIG_FHA_2	445	451	PF00498	0.652
LIG_FHA_2	457	463	PF00498	0.761
LIG_FHA_2	529	535	PF00498	0.738
LIG_FHA_2	537	543	PF00498	0.650
LIG_FHA_2	573	579	PF00498	0.615
LIG_FHA_2	654	660	PF00498	0.696
LIG_FHA_2	698	704	PF00498	0.572
LIG_HCF-1_HBM_1	225	228	PF13415	0.851
LIG_KLC1_Yacidic_2	279	284	PF13176	0.776
LIG_LIR_Apic_2	567	571	PF02991	0.583
LIG_LIR_Apic_2	692	696	PF02991	0.573
LIG_LIR_Nem_3	55	61	PF02991	0.713
LIG_MYND_1	91	95	PF01753	0.674
LIG_PTB_Apo_2	362	369	PF02174	0.555
LIG_RPA_C_Fungi	371	383	PF08784	0.564
LIG_SH2_NCK_1	568	572	PF00017	0.585
LIG_SH2_NCK_1	693	697	PF00017	0.574
LIG_SH2_SRC	20	23	PF00017	0.548
LIG_SH2_STAP1	39	43	PF00017	0.827
LIG_SH2_STAP1	426	430	PF00017	0.557
LIG_SH2_STAP1	525	529	PF00017	0.579
LIG_SH2_STAP1	650	654	PF00017	0.573
LIG_SH2_STAP1	844	848	PF00017	0.773
LIG_SH2_STAT5	228	231	PF00017	0.855
LIG_SH2_STAT5	261	264	PF00017	0.574
LIG_SH2_STAT5	282	285	PF00017	0.775
LIG_SH2_STAT5	393	396	PF00017	0.835
LIG_SH2_STAT5	458	461	PF00017	0.865
LIG_SH3_1	170	176	PF00018	0.825
LIG_SH3_3	170	176	PF00018	0.699
LIG_SH3_3	267	273	PF00018	0.855
LIG_SH3_3	283	289	PF00018	0.567
LIG_SH3_3	450	456	PF00018	0.767
LIG_SH3_3	611	617	PF00018	0.680
LIG_SH3_3	62	68	PF00018	0.612
LIG_SH3_3	736	742	PF00018	0.663
LIG_SH3_3	78	84	PF00018	0.677
LIG_SH3_3	784	790	PF00018	0.776
LIG_SxIP_EBH_1	158	168	PF03271	0.518
LIG_TRAF2_1	276	279	PF00917	0.852
LIG_TRAF2_1	407	410	PF00917	0.815
LIG_TRAF2_1	414	417	PF00917	0.690
LIG_TRAF2_1	418	421	PF00917	0.689
LIG_TRAF2_1	459	462	PF00917	0.793
LIG_TRAF2_1	480	483	PF00917	0.855
LIG_TRAF2_1	508	511	PF00917	0.570
LIG_TRAF2_1	633	636	PF00917	0.568
LIG_TRAF2_1	76	79	PF00917	0.752
LIG_TRFH_1	72	76	PF08558	0.748
MOD_CDC14_SPxK_1	253	256	PF00782	0.592
MOD_CDC14_SPxK_1	765	768	PF00782	0.856
MOD_CDK_SPK_2	250	255	PF00069	0.589
MOD_CDK_SPK_2	762	767	PF00069	0.779
MOD_CDK_SPxK_1	250	256	PF00069	0.590
MOD_CDK_SPxK_1	762	768	PF00069	0.851
MOD_CK1_1	166	172	PF00069	0.715
MOD_CK1_1	23	29	PF00069	0.829
MOD_CK1_1	231	237	PF00069	0.849
MOD_CK1_1	240	246	PF00069	0.718
MOD_CK1_1	250	256	PF00069	0.560
MOD_CK1_1	306	312	PF00069	0.835
MOD_CK1_1	313	319	PF00069	0.736
MOD_CK1_1	359	365	PF00069	0.775
MOD_CK1_1	384	390	PF00069	0.764
MOD_CK1_1	435	441	PF00069	0.833
MOD_CK1_1	604	610	PF00069	0.800
MOD_CK1_1	621	627	PF00069	0.620
MOD_CK1_1	729	735	PF00069	0.856
MOD_CK1_1	746	752	PF00069	0.573
MOD_CK1_1	779	785	PF00069	0.839
MOD_CK1_1	794	800	PF00069	0.583
MOD_CK1_1	801	807	PF00069	0.727
MOD_CK1_1	814	820	PF00069	0.532
MOD_CK2_1	415	421	PF00069	0.737
MOD_CK2_1	456	462	PF00069	0.783
MOD_CK2_1	528	534	PF00069	0.649
MOD_CK2_1	536	542	PF00069	0.592
MOD_CK2_1	572	578	PF00069	0.616
MOD_CK2_1	653	659	PF00069	0.652
MOD_CK2_1	697	703	PF00069	0.575
MOD_CK2_1	767	773	PF00069	0.560
MOD_CK2_1	801	807	PF00069	0.820
MOD_DYRK1A_RPxSP_1	46	50	PF00069	0.807
MOD_GlcNHglycan	181	184	PF01048	0.833
MOD_GlcNHglycan	233	236	PF01048	0.847
MOD_GlcNHglycan	239	242	PF01048	0.765
MOD_GlcNHglycan	25	28	PF01048	0.827
MOD_GlcNHglycan	379	382	PF01048	0.849
MOD_GlcNHglycan	388	391	PF01048	0.693
MOD_GlcNHglycan	41	44	PF01048	0.565
MOD_GlcNHglycan	434	437	PF01048	0.772
MOD_GlcNHglycan	46	49	PF01048	0.740
MOD_GlcNHglycan	558	561	PF01048	0.830
MOD_GlcNHglycan	607	610	PF01048	0.734
MOD_GlcNHglycan	611	614	PF01048	0.699
MOD_GlcNHglycan	683	686	PF01048	0.750
MOD_GlcNHglycan	732	735	PF01048	0.840
MOD_GlcNHglycan	736	739	PF01048	0.805
MOD_GlcNHglycan	778	781	PF01048	0.813
MOD_GlcNHglycan	783	786	PF01048	0.770
MOD_GlcNHglycan	793	796	PF01048	0.590
MOD_GlcNHglycan	813	816	PF01048	0.536
MOD_GSK3_1	12	19	PF00069	0.810
MOD_GSK3_1	157	164	PF00069	0.629
MOD_GSK3_1	171	178	PF00069	0.756
MOD_GSK3_1	227	234	PF00069	0.851
MOD_GSK3_1	235	242	PF00069	0.727
MOD_GSK3_1	246	253	PF00069	0.559
MOD_GSK3_1	301	308	PF00069	0.803
MOD_GSK3_1	310	317	PF00069	0.741
MOD_GSK3_1	372	379	PF00069	0.843
MOD_GSK3_1	381	388	PF00069	0.690
MOD_GSK3_1	431	438	PF00069	0.769
MOD_GSK3_1	46	53	PF00069	0.803
MOD_GSK3_1	491	498	PF00069	0.782
MOD_GSK3_1	601	608	PF00069	0.729
MOD_GSK3_1	609	616	PF00069	0.652
MOD_GSK3_1	726	733	PF00069	0.842
MOD_GSK3_1	734	741	PF00069	0.721
MOD_GSK3_1	776	783	PF00069	0.840
MOD_GSK3_1	794	801	PF00069	0.535
MOD_GSK3_1	820	827	PF00069	0.693
MOD_LATS_1	774	780	PF00433	0.768
MOD_NEK2_1	1	6	PF00069	0.722
MOD_NEK2_1	431	436	PF00069	0.836
MOD_NEK2_1	781	786	PF00069	0.836
MOD_NEK2_1	791	796	PF00069	0.656
MOD_NEK2_1	799	804	PF00069	0.533
MOD_PIKK_1	235	241	PF00454	0.579
MOD_PIKK_1	53	59	PF00454	0.715
MOD_PIKK_1	572	578	PF00454	0.588
MOD_PIKK_1	697	703	PF00454	0.610
MOD_PK_1	12	18	PF00069	0.808
MOD_PKA_1	495	501	PF00069	0.646
MOD_PKA_1	605	611	PF00069	0.743
MOD_PKA_1	730	736	PF00069	0.789
MOD_PKA_1	767	773	PF00069	0.611
MOD_PKA_1	776	782	PF00069	0.631
MOD_PKA_2	157	163	PF00069	0.661
MOD_PKA_2	179	185	PF00069	0.849
MOD_PKA_2	23	29	PF00069	0.829
MOD_PKA_2	621	627	PF00069	0.613
MOD_PKA_2	746	752	PF00069	0.740
MOD_Plk_1	16	22	PF00069	0.539
MOD_Plk_1	359	365	PF00069	0.845
MOD_Plk_1	70	76	PF00069	0.749
MOD_Plk_2-3	278	284	PF00069	0.848
MOD_Plk_2-3	424	430	PF00069	0.768
MOD_Plk_2-3	545	551	PF00069	0.777
MOD_Plk_2-3	670	676	PF00069	0.739
MOD_Plk_4	157	163	PF00069	0.591
MOD_Plk_4	278	284	PF00069	0.568
MOD_ProDKin_1	250	256	PF00069	0.590
MOD_ProDKin_1	308	314	PF00069	0.638
MOD_ProDKin_1	444	450	PF00069	0.566
MOD_ProDKin_1	46	52	PF00069	0.645
MOD_ProDKin_1	613	619	PF00069	0.615
MOD_ProDKin_1	738	744	PF00069	0.733
MOD_ProDKin_1	762	768	PF00069	0.851
MOD_ProDKin_1	814	820	PF00069	0.674
MOD_SUMO_for_1	339	342	PF00179	0.752
MOD_SUMO_rev_2	177	182	PF00179	0.770
MOD_SUMO_rev_2	366	373	PF00179	0.554
MOD_SUMO_rev_2	416	425	PF00179	0.772
MOD_SUMO_rev_2	534	539	PF00179	0.854
MOD_SUMO_rev_2	540	548	PF00179	0.747
MOD_SUMO_rev_2	659	664	PF00179	0.810
MOD_SUMO_rev_2	665	673	PF00179	0.730
TRG_DiLeu_BaEn_1	89	94	PF01217	0.679
TRG_DiLeu_BaEn_3	156	162	PF01217	0.585
TRG_DiLeu_BaEn_4	278	284	PF01217	0.778
TRG_ENDOCYTIC_2	85	88	PF00928	0.722
TRG_ER_diArg_1	111	113	PF00400	0.580
TRG_ER_diArg_1	114	116	PF00400	0.603
TRG_ER_diArg_1	129	131	PF00400	0.408
TRG_ER_diArg_1	170	172	PF00400	0.717
TRG_ER_diArg_1	254	256	PF00400	0.675
TRG_Pf-PMV_PEXEL_1	112	117	PF00026	0.695

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WZ94	Leishmania donovani	82%	100%
A4HE84	Leishmania braziliensis	63%	100%
A4I1N0	Leishmania infantum	81%	100%
Q4Q9Q7	Leishmania major	78%	97%