Myotubularin phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXR2_LEIMU

TriTrypDb:

LmxM.25.1800

Length:

1013

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXR2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.612
CLV_C14_Caspase3-7	30	34	PF00656	0.693
CLV_C14_Caspase3-7	563	567	PF00656	0.703
CLV_NRD_NRD_1	309	311	PF00675	0.465
CLV_NRD_NRD_1	528	530	PF00675	0.449
CLV_NRD_NRD_1	554	556	PF00675	0.545
CLV_NRD_NRD_1	582	584	PF00675	0.520
CLV_NRD_NRD_1	678	680	PF00675	0.339
CLV_NRD_NRD_1	712	714	PF00675	0.559
CLV_NRD_NRD_1	777	779	PF00675	0.416
CLV_NRD_NRD_1	878	880	PF00675	0.405
CLV_NRD_NRD_1	938	940	PF00675	0.584
CLV_PCSK_FUR_1	710	714	PF00082	0.556
CLV_PCSK_KEX2_1	309	311	PF00082	0.465
CLV_PCSK_KEX2_1	527	529	PF00082	0.452
CLV_PCSK_KEX2_1	554	556	PF00082	0.545
CLV_PCSK_KEX2_1	582	584	PF00082	0.520
CLV_PCSK_KEX2_1	678	680	PF00082	0.339
CLV_PCSK_KEX2_1	712	714	PF00082	0.559
CLV_PCSK_KEX2_1	776	778	PF00082	0.419
CLV_PCSK_KEX2_1	878	880	PF00082	0.405
CLV_PCSK_KEX2_1	938	940	PF00082	0.558
CLV_PCSK_PC7_1	578	584	PF00082	0.528
CLV_PCSK_SKI1_1	309	313	PF00082	0.438
CLV_PCSK_SKI1_1	529	533	PF00082	0.466
CLV_PCSK_SKI1_1	660	664	PF00082	0.336
CLV_PCSK_SKI1_1	679	683	PF00082	0.343
CLV_PCSK_SKI1_1	837	841	PF00082	0.490
DEG_APCC_DBOX_1	308	316	PF00400	0.674
DEG_APCC_DBOX_1	776	784	PF00400	0.649
DEG_APCC_DBOX_1	809	817	PF00400	0.632
DEG_APCC_DBOX_1	962	970	PF00400	0.547
DEG_Nend_Nbox_1	1	3	PF02207	0.632
DEG_SPOP_SBC_1	123	127	PF00917	0.713
DEG_SPOP_SBC_1	457	461	PF00917	0.651
DEG_SPOP_SBC_1	467	471	PF00917	0.648
DOC_ANK_TNKS_1	100	107	PF00023	0.661
DOC_CDC14_PxL_1	44	52	PF14671	0.706
DOC_CDC14_PxL_1	864	872	PF14671	0.559
DOC_CKS1_1	684	689	PF01111	0.626
DOC_CYCLIN_RxL_1	306	316	PF00134	0.546
DOC_CYCLIN_RxL_1	660	671	PF00134	0.528
DOC_CYCLIN_yCln2_LP_2	547	553	PF00134	0.700
DOC_MAPK_gen_1	527	539	PF00069	0.660
DOC_MAPK_gen_1	582	588	PF00069	0.676
DOC_MAPK_gen_1	707	716	PF00069	0.325
DOC_MAPK_gen_1	747	757	PF00069	0.625
DOC_MAPK_gen_1	878	886	PF00069	0.567
DOC_MAPK_gen_1	967	977	PF00069	0.639
DOC_MAPK_MEF2A_6	372	381	PF00069	0.610
DOC_MAPK_MEF2A_6	532	539	PF00069	0.658
DOC_MAPK_MEF2A_6	750	757	PF00069	0.623
DOC_PP1_RVXF_1	308	315	PF00149	0.618
DOC_PP1_RVXF_1	805	812	PF00149	0.669
DOC_PP1_RVXF_1	89	96	PF00149	0.657
DOC_PP2B_LxvP_1	384	387	PF13499	0.654
DOC_PP2B_LxvP_1	547	550	PF13499	0.615
DOC_PP2B_LxvP_1	665	668	PF13499	0.535
DOC_PP2B_LxvP_1	725	728	PF13499	0.312
DOC_PP4_FxxP_1	40	43	PF00568	0.735
DOC_USP7_MATH_1	123	127	PF00917	0.703
DOC_USP7_MATH_1	151	155	PF00917	0.757
DOC_USP7_MATH_1	174	178	PF00917	0.702
DOC_USP7_MATH_1	428	432	PF00917	0.680
DOC_USP7_MATH_1	433	437	PF00917	0.672
DOC_USP7_MATH_1	445	449	PF00917	0.713
DOC_USP7_MATH_1	457	461	PF00917	0.631
DOC_USP7_MATH_1	468	472	PF00917	0.713
DOC_USP7_MATH_1	475	479	PF00917	0.672
DOC_USP7_MATH_1	518	522	PF00917	0.686
DOC_USP7_MATH_1	530	534	PF00917	0.712
DOC_USP7_MATH_1	621	625	PF00917	0.659
DOC_USP7_MATH_1	668	672	PF00917	0.507
DOC_USP7_MATH_1	721	725	PF00917	0.312
DOC_USP7_MATH_1	759	763	PF00917	0.668
DOC_USP7_MATH_1	902	906	PF00917	0.723
DOC_USP7_MATH_1	926	930	PF00917	0.669
DOC_USP7_MATH_1	952	956	PF00917	0.790
DOC_USP7_MATH_2	92	98	PF00917	0.695
DOC_WW_Pin1_4	119	124	PF00397	0.647
DOC_WW_Pin1_4	182	187	PF00397	0.816
DOC_WW_Pin1_4	293	298	PF00397	0.699
DOC_WW_Pin1_4	327	332	PF00397	0.686
DOC_WW_Pin1_4	573	578	PF00397	0.709
DOC_WW_Pin1_4	683	688	PF00397	0.657
LIG_14-3-3_CanoR_1	114	123	PF00244	0.621
LIG_14-3-3_CanoR_1	155	165	PF00244	0.618
LIG_14-3-3_CanoR_1	290	297	PF00244	0.609
LIG_14-3-3_CanoR_1	372	381	PF00244	0.722
LIG_14-3-3_CanoR_1	529	535	PF00244	0.686
LIG_14-3-3_CanoR_1	810	814	PF00244	0.630
LIG_14-3-3_CanoR_1	830	838	PF00244	0.582
LIG_14-3-3_CanoR_1	896	904	PF00244	0.635
LIG_14-3-3_CanoR_1	921	930	PF00244	0.700
LIG_14-3-3_CanoR_1	963	967	PF00244	0.551
LIG_Actin_WH2_2	300	315	PF00022	0.689
LIG_Actin_WH2_2	882	898	PF00022	0.541
LIG_BIR_III_4	188	192	PF00653	0.604
LIG_BIR_III_4	597	601	PF00653	0.685
LIG_BRCT_BRCA1_1	36	40	PF00533	0.667
LIG_FHA_1	196	202	PF00498	0.625
LIG_FHA_1	294	300	PF00498	0.689
LIG_FHA_1	340	346	PF00498	0.696
LIG_FHA_1	427	433	PF00498	0.595
LIG_FHA_1	487	493	PF00498	0.710
LIG_FHA_1	60	66	PF00498	0.708
LIG_FHA_1	703	709	PF00498	0.333
LIG_FHA_1	788	794	PF00498	0.681
LIG_FHA_1	80	86	PF00498	0.592
LIG_FHA_2	119	125	PF00498	0.621
LIG_FHA_2	561	567	PF00498	0.662
LIG_FHA_2	699	705	PF00498	0.214
LIG_FHA_2	898	904	PF00498	0.668
LIG_FHA_2	966	972	PF00498	0.636
LIG_HCF-1_HBM_1	350	353	PF13415	0.692
LIG_LIR_Apic_2	37	43	PF02991	0.705
LIG_LIR_Apic_2	624	628	PF02991	0.621
LIG_LIR_Apic_2	992	998	PF02991	0.557
LIG_LIR_Gen_1	366	373	PF02991	0.592
LIG_LIR_Gen_1	533	540	PF02991	0.678
LIG_LIR_LC3C_4	972	977	PF02991	0.542
LIG_LIR_Nem_3	221	227	PF02991	0.662
LIG_LIR_Nem_3	360	364	PF02991	0.623
LIG_LIR_Nem_3	366	370	PF02991	0.561
LIG_LIR_Nem_3	533	537	PF02991	0.714
LIG_LYPXL_yS_3	361	364	PF13949	0.652
LIG_LYPXL_yS_3	47	50	PF13949	0.701
LIG_MAD2	707	715	PF02301	0.304
LIG_Pex14_2	363	367	PF04695	0.591
LIG_RPA_C_Fungi	272	284	PF08784	0.481
LIG_SH2_CRK	625	629	PF00017	0.391
LIG_SH2_CRK	68	72	PF00017	0.653
LIG_SH2_PTP2	693	696	PF00017	0.340
LIG_SH2_STAT5	693	696	PF00017	0.352
LIG_SH3_2	577	582	PF14604	0.554
LIG_SH3_3	200	206	PF00018	0.606
LIG_SH3_3	207	213	PF00018	0.549
LIG_SH3_3	325	331	PF00018	0.584
LIG_SH3_3	489	495	PF00018	0.596
LIG_SH3_3	519	525	PF00018	0.746
LIG_SH3_3	534	540	PF00018	0.555
LIG_SH3_3	574	580	PF00018	0.690
LIG_SH3_3	681	687	PF00018	0.522
LIG_SH3_3	694	700	PF00018	0.329
LIG_SH3_3	72	78	PF00018	0.615
LIG_SH3_3	862	868	PF00018	0.566
LIG_SH3_3	877	883	PF00018	0.424
LIG_SUMO_SIM_anti_2	543	548	PF11976	0.595
LIG_SUMO_SIM_anti_2	782	788	PF11976	0.453
LIG_SUMO_SIM_par_1	192	198	PF11976	0.563
LIG_SUMO_SIM_par_1	782	788	PF11976	0.453
LIG_TYR_ITIM	691	696	PF00017	0.340
LIG_UBA3_1	673	682	PF00899	0.385
LIG_WRC_WIRS_1	786	791	PF05994	0.523
MOD_CDK_SPK_2	573	578	PF00069	0.569
MOD_CK1_1	122	128	PF00069	0.683
MOD_CK1_1	144	150	PF00069	0.613
MOD_CK1_1	231	237	PF00069	0.609
MOD_CK1_1	252	258	PF00069	0.705
MOD_CK1_1	263	269	PF00069	0.573
MOD_CK1_1	289	295	PF00069	0.536
MOD_CK1_1	329	335	PF00069	0.612
MOD_CK1_1	339	345	PF00069	0.655
MOD_CK1_1	34	40	PF00069	0.595
MOD_CK1_1	459	465	PF00069	0.588
MOD_CK1_1	471	477	PF00069	0.479
MOD_CK1_1	488	494	PF00069	0.784
MOD_CK1_1	561	567	PF00069	0.709
MOD_CK1_1	57	63	PF00069	0.691
MOD_CK1_1	611	617	PF00069	0.647
MOD_CK1_1	647	653	PF00069	0.492
MOD_CK1_1	849	855	PF00069	0.641
MOD_CK1_1	954	960	PF00069	0.568
MOD_CK2_1	275	281	PF00069	0.542
MOD_CK2_1	372	378	PF00069	0.472
MOD_CK2_1	5	11	PF00069	0.441
MOD_CK2_1	611	617	PF00069	0.647
MOD_CK2_1	698	704	PF00069	0.205
MOD_CK2_1	785	791	PF00069	0.453
MOD_CK2_1	869	875	PF00069	0.592
MOD_CK2_1	954	960	PF00069	0.604
MOD_CK2_1	965	971	PF00069	0.453
MOD_Cter_Amidation	307	310	PF01082	0.590
MOD_GlcNHglycan	132	135	PF01048	0.599
MOD_GlcNHglycan	143	146	PF01048	0.620
MOD_GlcNHglycan	159	162	PF01048	0.635
MOD_GlcNHglycan	165	168	PF01048	0.617
MOD_GlcNHglycan	172	175	PF01048	0.540
MOD_GlcNHglycan	251	254	PF01048	0.661
MOD_GlcNHglycan	271	274	PF01048	0.558
MOD_GlcNHglycan	277	280	PF01048	0.588
MOD_GlcNHglycan	35	39	PF01048	0.584
MOD_GlcNHglycan	374	377	PF01048	0.427
MOD_GlcNHglycan	410	413	PF01048	0.562
MOD_GlcNHglycan	437	440	PF01048	0.625
MOD_GlcNHglycan	461	464	PF01048	0.567
MOD_GlcNHglycan	470	473	PF01048	0.548
MOD_GlcNHglycan	477	480	PF01048	0.550
MOD_GlcNHglycan	50	53	PF01048	0.521
MOD_GlcNHglycan	508	511	PF01048	0.601
MOD_GlcNHglycan	513	516	PF01048	0.604
MOD_GlcNHglycan	560	563	PF01048	0.585
MOD_GlcNHglycan	646	649	PF01048	0.527
MOD_GlcNHglycan	7	10	PF01048	0.432
MOD_GlcNHglycan	831	834	PF01048	0.621
MOD_GlcNHglycan	872	875	PF01048	0.578
MOD_GlcNHglycan	903	907	PF01048	0.663
MOD_GlcNHglycan	908	911	PF01048	0.626
MOD_GlcNHglycan	956	959	PF01048	0.579
MOD_GSK3_1	114	121	PF00069	0.675
MOD_GSK3_1	147	154	PF00069	0.752
MOD_GSK3_1	170	177	PF00069	0.572
MOD_GSK3_1	231	238	PF00069	0.683
MOD_GSK3_1	243	250	PF00069	0.634
MOD_GSK3_1	260	267	PF00069	0.696
MOD_GSK3_1	27	34	PF00069	0.614
MOD_GSK3_1	289	296	PF00069	0.656
MOD_GSK3_1	313	320	PF00069	0.500
MOD_GSK3_1	322	329	PF00069	0.697
MOD_GSK3_1	332	339	PF00069	0.596
MOD_GSK3_1	404	411	PF00069	0.681
MOD_GSK3_1	433	440	PF00069	0.565
MOD_GSK3_1	458	465	PF00069	0.559
MOD_GSK3_1	466	473	PF00069	0.581
MOD_GSK3_1	482	489	PF00069	0.709
MOD_GSK3_1	53	60	PF00069	0.604
MOD_GSK3_1	560	567	PF00069	0.668
MOD_GSK3_1	647	654	PF00069	0.492
MOD_GSK3_1	698	705	PF00069	0.205
MOD_GSK3_1	837	844	PF00069	0.663
MOD_GSK3_1	902	909	PF00069	0.637
MOD_LATS_1	241	247	PF00433	0.696
MOD_N-GLC_1	244	249	PF02516	0.527
MOD_N-GLC_1	269	274	PF02516	0.474
MOD_N-GLC_1	339	344	PF02516	0.613
MOD_N-GLC_1	357	362	PF02516	0.475
MOD_NEK2_1	181	186	PF00069	0.642
MOD_NEK2_1	195	200	PF00069	0.536
MOD_NEK2_1	260	265	PF00069	0.685
MOD_NEK2_1	336	341	PF00069	0.618
MOD_NEK2_1	408	413	PF00069	0.634
MOD_NEK2_1	437	442	PF00069	0.511
MOD_NEK2_1	466	471	PF00069	0.543
MOD_NEK2_1	54	59	PF00069	0.640
MOD_NEK2_1	692	697	PF00069	0.323
MOD_NEK2_1	702	707	PF00069	0.352
MOD_NEK2_1	869	874	PF00069	0.552
MOD_NEK2_1	87	92	PF00069	0.620
MOD_NEK2_1	895	900	PF00069	0.527
MOD_NEK2_2	639	644	PF00069	0.397
MOD_NEK2_2	651	656	PF00069	0.334
MOD_PIKK_1	252	258	PF00454	0.599
MOD_PIKK_1	54	60	PF00454	0.633
MOD_PIKK_1	611	617	PF00454	0.571
MOD_PIKK_1	770	776	PF00454	0.565
MOD_PIKK_1	94	100	PF00454	0.684
MOD_PKA_2	289	295	PF00069	0.507
MOD_PKA_2	746	752	PF00069	0.477
MOD_PKA_2	809	815	PF00069	0.581
MOD_PKA_2	829	835	PF00069	0.461
MOD_PKA_2	895	901	PF00069	0.513
MOD_PKA_2	962	968	PF00069	0.417
MOD_PKB_1	77	85	PF00069	0.568
MOD_Plk_1	220	226	PF00069	0.566
MOD_Plk_1	269	275	PF00069	0.474
MOD_Plk_1	357	363	PF00069	0.555
MOD_Plk_1	651	657	PF00069	0.455
MOD_Plk_1	798	804	PF00069	0.532
MOD_Plk_2-3	31	37	PF00069	0.623
MOD_Plk_2-3	785	791	PF00069	0.453
MOD_Plk_4	322	328	PF00069	0.616
MOD_Plk_4	329	335	PF00069	0.510
MOD_Plk_4	518	524	PF00069	0.615
MOD_Plk_4	530	536	PF00069	0.614
MOD_Plk_4	605	611	PF00069	0.669
MOD_Plk_4	621	627	PF00069	0.529
MOD_Plk_4	631	637	PF00069	0.499
MOD_Plk_4	692	698	PF00069	0.207
MOD_Plk_4	721	727	PF00069	0.312
MOD_Plk_4	753	759	PF00069	0.592
MOD_Plk_4	798	804	PF00069	0.511
MOD_Plk_4	890	896	PF00069	0.430
MOD_Plk_4	990	996	PF00069	0.415
MOD_ProDKin_1	119	125	PF00069	0.555
MOD_ProDKin_1	182	188	PF00069	0.788
MOD_ProDKin_1	293	299	PF00069	0.627
MOD_ProDKin_1	327	333	PF00069	0.607
MOD_ProDKin_1	573	579	PF00069	0.636
MOD_ProDKin_1	683	689	PF00069	0.567
TRG_DiLeu_BaEn_1	971	976	PF01217	0.479
TRG_DiLeu_BaEn_2	35	41	PF01217	0.640
TRG_DiLeu_BaLyEn_6	190	195	PF01217	0.579
TRG_DiLeu_BaLyEn_6	307	312	PF01217	0.492
TRG_DiLeu_BaLyEn_6	812	817	PF01217	0.528
TRG_DiLeu_BaLyEn_6	865	870	PF01217	0.434
TRG_ENDOCYTIC_2	361	364	PF00928	0.560
TRG_ENDOCYTIC_2	47	50	PF00928	0.628
TRG_ENDOCYTIC_2	68	71	PF00928	0.653
TRG_ENDOCYTIC_2	693	696	PF00928	0.340
TRG_ER_diArg_1	309	311	PF00400	0.594
TRG_ER_diArg_1	526	529	PF00400	0.582
TRG_ER_diArg_1	554	557	PF00400	0.646
TRG_ER_diArg_1	581	583	PF00400	0.662
TRG_ER_diArg_1	677	679	PF00400	0.392
TRG_ER_diArg_1	712	714	PF00400	0.421
TRG_ER_diArg_1	750	753	PF00400	0.551
TRG_ER_diArg_1	775	778	PF00400	0.489
TRG_ER_diArg_1	878	880	PF00400	0.493
TRG_ER_diArg_1	920	923	PF00400	0.596
TRG_ER_diArg_1	937	939	PF00400	0.608
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	589	593	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	707	711	PF00026	0.351
TRG_Pf-PMV_PEXEL_1	778	782	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	967	971	PF00026	0.538
TRG_PTS2	1	20	PF00400	0.525

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8W8	Leptomonas seymouri	42%	98%
A0A3S7WZ87	Leishmania donovani	88%	98%
A4HEJ0	Leishmania braziliensis	66%	98%
A4I1M8	Leishmania infantum	88%	98%
Q4Q9Q9	Leishmania major	87%	100%