Peptidase C51 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXR1_LEIMU

TriTrypDb:

LmxM.25.1790

Length:

300

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 33
NetGPI	no	yes: 0, no: 34

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	25
GO:0110165	cellular anatomical entity	1	27
GO:0005737	cytoplasm	2	3

Expansion

Sequence features

E9AXR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXR1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016874	ligase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.532
CLV_NRD_NRD_1	173	175	PF00675	0.516
CLV_NRD_NRD_1	37	39	PF00675	0.663
CLV_NRD_NRD_1	91	93	PF00675	0.662
CLV_PCSK_KEX2_1	173	175	PF00082	0.552
CLV_PCSK_KEX2_1	91	93	PF00082	0.648
CLV_PCSK_SKI1_1	212	216	PF00082	0.598
CLV_PCSK_SKI1_1	5	9	PF00082	0.429
DEG_Nend_UBRbox_3	1	3	PF02207	0.396
DOC_CYCLIN_RxL_1	239	251	PF00134	0.335
DOC_MAPK_gen_1	173	179	PF00069	0.251
DOC_MAPK_gen_1	210	219	PF00069	0.396
DOC_PP1_RVXF_1	113	120	PF00149	0.366
DOC_PP1_RVXF_1	241	248	PF00149	0.309
DOC_PP4_FxxP_1	169	172	PF00568	0.378
DOC_USP7_UBL2_3	212	216	PF12436	0.280
DOC_WW_Pin1_4	48	53	PF00397	0.335
LIG_14-3-3_CanoR_1	99	107	PF00244	0.407
LIG_Actin_WH2_2	266	284	PF00022	0.430
LIG_deltaCOP1_diTrp_1	228	236	PF00928	0.333
LIG_DLG_GKlike_1	106	114	PF00625	0.338
LIG_eIF4E_1	112	118	PF01652	0.319
LIG_FHA_1	11	17	PF00498	0.368
LIG_FHA_1	129	135	PF00498	0.405
LIG_FHA_1	96	102	PF00498	0.413
LIG_FHA_2	106	112	PF00498	0.305
LIG_FHA_2	154	160	PF00498	0.278
LIG_FHA_2	249	255	PF00498	0.373
LIG_FHA_2	281	287	PF00498	0.305
LIG_FHA_2	39	45	PF00498	0.273
LIG_Integrin_isoDGR_2	89	91	PF01839	0.517
LIG_Integrin_RGD_1	92	94	PF01839	0.682
LIG_LIR_Apic_2	137	143	PF02991	0.277
LIG_LIR_Apic_2	166	172	PF02991	0.392
LIG_LIR_Apic_2	258	264	PF02991	0.265
LIG_LIR_Gen_1	156	164	PF02991	0.422
LIG_LIR_Nem_3	156	161	PF02991	0.399
LIG_LIR_Nem_3	41	46	PF02991	0.370
LIG_LIR_Nem_3	51	56	PF02991	0.309
LIG_LIR_Nem_3	74	80	PF02991	0.328
LIG_Pex14_1	150	154	PF04695	0.418
LIG_SH2_CRK	241	245	PF00017	0.295
LIG_SH2_CRK	43	47	PF00017	0.440
LIG_SH2_GRB2like	140	143	PF00017	0.393
LIG_SH2_GRB2like	66	69	PF00017	0.305
LIG_SH2_GRB2like	77	80	PF00017	0.332
LIG_SH2_NCK_1	158	162	PF00017	0.392
LIG_SH2_PTP2	261	264	PF00017	0.269
LIG_SH2_PTP2	80	83	PF00017	0.397
LIG_SH2_SRC	158	161	PF00017	0.389
LIG_SH2_SRC	261	264	PF00017	0.274
LIG_SH2_SRC	288	291	PF00017	0.362
LIG_SH2_STAP1	241	245	PF00017	0.306
LIG_SH2_STAP1	29	33	PF00017	0.332
LIG_SH2_STAT5	107	110	PF00017	0.304
LIG_SH2_STAT5	140	143	PF00017	0.334
LIG_SH2_STAT5	154	157	PF00017	0.421
LIG_SH2_STAT5	225	228	PF00017	0.334
LIG_SH2_STAT5	261	264	PF00017	0.397
LIG_SH2_STAT5	40	43	PF00017	0.478
LIG_SH2_STAT5	77	80	PF00017	0.378
LIG_SH3_1	140	146	PF00018	0.285
LIG_SH3_3	140	146	PF00018	0.426
LIG_SUMO_SIM_anti_2	265	271	PF11976	0.396
LIG_TRAF2_1	287	290	PF00917	0.517
LIG_TYR_ITIM	21	26	PF00017	0.400
LIG_TYR_ITIM	78	83	PF00017	0.509
LIG_TYR_ITSM	154	161	PF00017	0.326
LIG_WRC_WIRS_1	107	112	PF05994	0.175
MOD_CK2_1	153	159	PF00069	0.329
MOD_CK2_1	248	254	PF00069	0.308
MOD_CMANNOS	116	119	PF00535	0.465
MOD_Cter_Amidation	89	92	PF01082	0.596
MOD_GlcNHglycan	150	153	PF01048	0.529
MOD_GSK3_1	44	51	PF00069	0.408
MOD_N-GLC_1	239	244	PF02516	0.395
MOD_NEK2_1	73	78	PF00069	0.409
MOD_NEK2_2	22	27	PF00069	0.568
MOD_PKA_1	38	44	PF00069	0.402
MOD_PKA_2	105	111	PF00069	0.444
MOD_Plk_1	146	152	PF00069	0.387
MOD_Plk_1	239	245	PF00069	0.336
MOD_Plk_2-3	159	165	PF00069	0.307
MOD_Plk_4	11	17	PF00069	0.325
MOD_Plk_4	22	28	PF00069	0.566
MOD_Plk_4	257	263	PF00069	0.314
MOD_Plk_4	73	79	PF00069	0.508
MOD_ProDKin_1	48	54	PF00069	0.409
MOD_SUMO_for_1	196	199	PF00179	0.455
MOD_SUMO_rev_2	160	169	PF00179	0.472
MOD_SUMO_rev_2	209	217	PF00179	0.557
MOD_SUMO_rev_2	67	74	PF00179	0.258
TRG_ENDOCYTIC_2	107	110	PF00928	0.373
TRG_ENDOCYTIC_2	158	161	PF00928	0.527
TRG_ENDOCYTIC_2	23	26	PF00928	0.503
TRG_ENDOCYTIC_2	241	244	PF00928	0.356
TRG_ENDOCYTIC_2	43	46	PF00928	0.516
TRG_ENDOCYTIC_2	80	83	PF00928	0.456
TRG_ER_diArg_1	172	174	PF00400	0.417
TRG_NLS_MonoExtN_4	212	219	PF00514	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I309	Leptomonas seymouri	62%	100%
A0A0N1I7J8	Leptomonas seymouri	27%	76%
A0A0N1PB04	Leptomonas seymouri	27%	84%
A0A0S4ITA7	Bodo saltans	25%	97%
A0A1X0NR96	Trypanosomatidae	26%	100%
A0A1X0NR98	Trypanosomatidae	27%	100%
A0A1X0NRB4	Trypanosomatidae	26%	88%
A0A1X0NY88	Trypanosomatidae	38%	100%
A0A1X0NYK9	Trypanosomatidae	37%	100%
A0A3R7KMG1	Trypanosoma rangeli	37%	92%
A0A3R7LYQ4	Trypanosoma rangeli	27%	97%
A0A3S7WZA9	Leishmania donovani	93%	100%
A0A3S7X769	Leishmania donovani	28%	100%
A0A3S7X774	Leishmania donovani	27%	74%
A0A422NKH5	Trypanosoma rangeli	25%	91%
A4HEJ1	Leishmania braziliensis	82%	100%
A4HLZ4	Leishmania braziliensis	29%	100%
A4HLZ6	Leishmania braziliensis	28%	79%
A4I1M7	Leishmania infantum	93%	100%
A4I9C4	Leishmania infantum	27%	81%
A4I9C6	Leishmania infantum	27%	74%
C9ZJ94	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZJ95	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZK72	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0A867	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9B4C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B4C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	78%
Q4Q3Q0	Leishmania major	29%	71%
Q4Q3Q2	Leishmania major	26%	92%
Q4Q9R0	Leishmania major	92%	100%
V5BF57	Trypanosoma cruzi	28%	91%
V5DB66	Trypanosoma cruzi	28%	97%
V5DIU8	Trypanosoma cruzi	38%	100%