ATP-grasp domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP-grasp domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXR0_LEIMU

TriTrypDb:

LmxM.25.1780

Length:

868

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXR0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0008716	D-alanine-D-alanine ligase activity	5	5
GO:0016740	transferase activity	2	5
GO:0016874	ligase activity	2	5
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	5
GO:0016881	acid-amino acid ligase activity	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0043169	cation binding	3	5
GO:0046872	metal ion binding	4	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.549
CLV_C14_Caspase3-7	318	322	PF00656	0.639
CLV_C14_Caspase3-7	402	406	PF00656	0.595
CLV_NRD_NRD_1	145	147	PF00675	0.812
CLV_NRD_NRD_1	223	225	PF00675	0.871
CLV_NRD_NRD_1	249	251	PF00675	0.738
CLV_NRD_NRD_1	304	306	PF00675	0.730
CLV_NRD_NRD_1	361	363	PF00675	0.604
CLV_NRD_NRD_1	642	644	PF00675	0.641
CLV_NRD_NRD_1	866	868	PF00675	0.762
CLV_PCSK_KEX2_1	136	138	PF00082	0.781
CLV_PCSK_KEX2_1	145	147	PF00082	0.705
CLV_PCSK_KEX2_1	151	153	PF00082	0.680
CLV_PCSK_KEX2_1	222	224	PF00082	0.856
CLV_PCSK_KEX2_1	249	251	PF00082	0.793
CLV_PCSK_KEX2_1	258	260	PF00082	0.752
CLV_PCSK_KEX2_1	304	306	PF00082	0.730
CLV_PCSK_KEX2_1	384	386	PF00082	0.596
CLV_PCSK_KEX2_1	733	735	PF00082	0.432
CLV_PCSK_KEX2_1	786	788	PF00082	0.727
CLV_PCSK_KEX2_1	811	813	PF00082	0.739
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.758
CLV_PCSK_PC1ET2_1	151	153	PF00082	0.733
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.812
CLV_PCSK_PC1ET2_1	304	306	PF00082	0.730
CLV_PCSK_PC1ET2_1	384	386	PF00082	0.596
CLV_PCSK_PC1ET2_1	733	735	PF00082	0.432
CLV_PCSK_PC1ET2_1	786	788	PF00082	0.727
CLV_PCSK_PC1ET2_1	811	813	PF00082	0.739
CLV_PCSK_PC7_1	218	224	PF00082	0.587
CLV_PCSK_PC7_1	807	813	PF00082	0.727
CLV_PCSK_SKI1_1	136	140	PF00082	0.817
CLV_PCSK_SKI1_1	145	149	PF00082	0.729
CLV_PCSK_SKI1_1	274	278	PF00082	0.713
CLV_PCSK_SKI1_1	363	367	PF00082	0.596
CLV_PCSK_SKI1_1	444	448	PF00082	0.323
CLV_PCSK_SKI1_1	515	519	PF00082	0.432
CLV_PCSK_SKI1_1	53	57	PF00082	0.713
CLV_PCSK_SKI1_1	565	569	PF00082	0.432
CLV_PCSK_SKI1_1	669	673	PF00082	0.621
CLV_PCSK_SKI1_1	726	730	PF00082	0.432
CLV_PCSK_SKI1_1	783	787	PF00082	0.748
CLV_PCSK_SKI1_1	807	811	PF00082	0.724
DEG_SCF_FBW7_1	239	245	PF00400	0.638
DEG_SPOP_SBC_1	163	167	PF00917	0.719
DEG_SPOP_SBC_1	312	316	PF00917	0.586
DEG_SPOP_SBC_1	816	820	PF00917	0.693
DEG_SPOP_SBC_1	833	837	PF00917	0.642
DEG_SPOP_SBC_1	850	854	PF00917	0.559
DOC_CKS1_1	239	244	PF01111	0.735
DOC_CKS1_1	331	336	PF01111	0.610
DOC_CYCLIN_RxL_1	663	674	PF00134	0.623
DOC_CYCLIN_RxL_1	783	791	PF00134	0.728
DOC_CYCLIN_yCln2_LP_2	446	452	PF00134	0.632
DOC_MAPK_gen_1	301	310	PF00069	0.696
DOC_MAPK_gen_1	368	374	PF00069	0.399
DOC_MAPK_gen_1	381	390	PF00069	0.573
DOC_MAPK_gen_1	441	448	PF00069	0.615
DOC_MAPK_MEF2A_6	303	312	PF00069	0.655
DOC_MAPK_MEF2A_6	413	420	PF00069	0.511
DOC_MAPK_NFAT4_5	413	421	PF00069	0.601
DOC_PP1_RVXF_1	442	449	PF00149	0.520
DOC_PP1_RVXF_1	516	523	PF00149	0.632
DOC_PP1_RVXF_1	577	583	PF00149	0.632
DOC_PP1_RVXF_1	724	731	PF00149	0.632
DOC_PP1_RVXF_1	765	772	PF00149	0.646
DOC_PP2B_LxvP_1	32	35	PF13499	0.609
DOC_PP4_FxxP_1	771	774	PF00568	0.712
DOC_USP7_MATH_1	123	127	PF00917	0.613
DOC_USP7_MATH_1	163	167	PF00917	0.824
DOC_USP7_MATH_1	176	180	PF00917	0.605
DOC_USP7_MATH_1	193	197	PF00917	0.538
DOC_USP7_MATH_1	206	210	PF00917	0.588
DOC_USP7_MATH_1	242	246	PF00917	0.806
DOC_USP7_MATH_1	248	252	PF00917	0.765
DOC_USP7_MATH_1	282	286	PF00917	0.550
DOC_USP7_MATH_1	348	352	PF00917	0.600
DOC_USP7_MATH_1	74	78	PF00917	0.731
DOC_USP7_MATH_1	816	820	PF00917	0.769
DOC_USP7_MATH_1	833	837	PF00917	0.566
DOC_USP7_MATH_1	842	846	PF00917	0.686
DOC_USP7_MATH_1	850	854	PF00917	0.559
DOC_USP7_MATH_1	95	99	PF00917	0.825
DOC_USP7_UBL2_3	136	140	PF12436	0.817
DOC_USP7_UBL2_3	340	344	PF12436	0.644
DOC_USP7_UBL2_3	413	417	PF12436	0.594
DOC_USP7_UBL2_3	684	688	PF12436	0.713
DOC_WW_Pin1_4	185	190	PF00397	0.566
DOC_WW_Pin1_4	20	25	PF00397	0.717
DOC_WW_Pin1_4	204	209	PF00397	0.753
DOC_WW_Pin1_4	235	240	PF00397	0.708
DOC_WW_Pin1_4	330	335	PF00397	0.618
DOC_WW_Pin1_4	507	512	PF00397	0.632
LIG_14-3-3_CanoR_1	18	26	PF00244	0.519
LIG_14-3-3_CanoR_1	224	234	PF00244	0.814
LIG_14-3-3_CanoR_1	259	265	PF00244	0.778
LIG_14-3-3_CanoR_1	342	348	PF00244	0.620
LIG_14-3-3_CanoR_1	362	372	PF00244	0.270
LIG_14-3-3_CanoR_1	660	666	PF00244	0.607
LIG_14-3-3_CanoR_1	713	720	PF00244	0.632
LIG_BRCT_BRCA1_1	405	409	PF00533	0.612
LIG_BRCT_BRCA1_1	767	771	PF00533	0.647
LIG_deltaCOP1_diTrp_1	620	628	PF00928	0.599
LIG_FHA_1	260	266	PF00498	0.717
LIG_FHA_1	293	299	PF00498	0.791
LIG_FHA_1	31	37	PF00498	0.666
LIG_FHA_1	322	328	PF00498	0.635
LIG_FHA_1	58	64	PF00498	0.726
LIG_FHA_2	400	406	PF00498	0.566
LIG_FHA_2	746	752	PF00498	0.664
LIG_Integrin_RGD_1	702	704	PF01839	0.700
LIG_LIR_Apic_2	328	334	PF02991	0.624
LIG_LIR_Apic_2	768	774	PF02991	0.679
LIG_LIR_Gen_1	346	355	PF02991	0.605
LIG_LIR_Gen_1	367	376	PF02991	0.576
LIG_LIR_Gen_1	456	463	PF02991	0.632
LIG_LIR_Gen_1	529	535	PF02991	0.596
LIG_LIR_Gen_1	554	564	PF02991	0.580
LIG_LIR_Gen_1	590	598	PF02991	0.553
LIG_LIR_Gen_1	611	617	PF02991	0.522
LIG_LIR_Gen_1	743	754	PF02991	0.723
LIG_LIR_Nem_3	346	350	PF02991	0.600
LIG_LIR_Nem_3	356	361	PF02991	0.434
LIG_LIR_Nem_3	367	373	PF02991	0.405
LIG_LIR_Nem_3	456	461	PF02991	0.574
LIG_LIR_Nem_3	529	534	PF02991	0.596
LIG_LIR_Nem_3	544	550	PF02991	0.562
LIG_LIR_Nem_3	554	560	PF02991	0.516
LIG_LIR_Nem_3	590	596	PF02991	0.553
LIG_LIR_Nem_3	611	615	PF02991	0.524
LIG_LIR_Nem_3	743	749	PF02991	0.632
LIG_Pex14_2	534	538	PF04695	0.588
LIG_SH2_CRK	358	362	PF00017	0.605
LIG_SH2_CRK	458	462	PF00017	0.632
LIG_SH2_CRK	547	551	PF00017	0.562
LIG_SH2_CRK	557	561	PF00017	0.479
LIG_SH2_CRK	746	750	PF00017	0.650
LIG_SH2_NCK_1	458	462	PF00017	0.632
LIG_SH2_NCK_1	557	561	PF00017	0.497
LIG_SH2_STAP1	370	374	PF00017	0.560
LIG_SH2_STAP1	69	73	PF00017	0.713
LIG_SH2_STAT5	533	536	PF00017	0.615
LIG_SH2_STAT5	557	560	PF00017	0.501
LIG_SH2_STAT5	570	573	PF00017	0.579
LIG_SH2_STAT5	592	595	PF00017	0.556
LIG_SH2_STAT5	647	650	PF00017	0.502
LIG_SH3_3	202	208	PF00018	0.638
LIG_SH3_3	228	234	PF00018	0.826
LIG_SH3_3	236	242	PF00018	0.709
LIG_SH3_3	422	428	PF00018	0.524
LIG_SH3_3	505	511	PF00018	0.632
LIG_SH3_3	513	519	PF00018	0.539
LIG_SH3_3	766	772	PF00018	0.647
LIG_SUMO_SIM_par_1	28	33	PF11976	0.650
LIG_TRAF2_1	393	396	PF00917	0.597
LIG_TYR_ITAM	544	560	PF00017	0.632
LIG_TYR_ITIM	575	580	PF00017	0.632
LIG_TYR_ITIM	744	749	PF00017	0.707
MOD_CK1_1	110	116	PF00069	0.634
MOD_CK1_1	166	172	PF00069	0.729
MOD_CK1_1	179	185	PF00069	0.572
MOD_CK1_1	188	194	PF00069	0.642
MOD_CK1_1	195	201	PF00069	0.656
MOD_CK1_1	20	26	PF00069	0.516
MOD_CK1_1	214	220	PF00069	0.712
MOD_CK1_1	238	244	PF00069	0.713
MOD_CK1_1	261	267	PF00069	0.729
MOD_CK1_1	287	293	PF00069	0.714
MOD_CK1_1	75	81	PF00069	0.638
MOD_CK1_1	760	766	PF00069	0.643
MOD_CK1_1	814	820	PF00069	0.728
MOD_CK1_1	821	827	PF00069	0.762
MOD_CK1_1	832	838	PF00069	0.585
MOD_CK1_1	844	850	PF00069	0.607
MOD_CK1_1	851	857	PF00069	0.525
MOD_CK1_1	860	866	PF00069	0.578
MOD_CK1_1	98	104	PF00069	0.825
MOD_CK2_1	431	437	PF00069	0.560
MOD_CK2_1	860	866	PF00069	0.737
MOD_GlcNHglycan	102	105	PF01048	0.745
MOD_GlcNHglycan	109	112	PF01048	0.630
MOD_GlcNHglycan	120	123	PF01048	0.527
MOD_GlcNHglycan	125	128	PF01048	0.625
MOD_GlcNHglycan	160	163	PF01048	0.751
MOD_GlcNHglycan	168	171	PF01048	0.771
MOD_GlcNHglycan	178	181	PF01048	0.610
MOD_GlcNHglycan	185	188	PF01048	0.531
MOD_GlcNHglycan	190	193	PF01048	0.579
MOD_GlcNHglycan	195	198	PF01048	0.534
MOD_GlcNHglycan	199	202	PF01048	0.549
MOD_GlcNHglycan	213	216	PF01048	0.523
MOD_GlcNHglycan	244	247	PF01048	0.779
MOD_GlcNHglycan	265	268	PF01048	0.796
MOD_GlcNHglycan	288	292	PF01048	0.702
MOD_GlcNHglycan	321	324	PF01048	0.626
MOD_GlcNHglycan	422	425	PF01048	0.419
MOD_GlcNHglycan	455	458	PF01048	0.432
MOD_GlcNHglycan	74	77	PF01048	0.748
MOD_GlcNHglycan	821	824	PF01048	0.793
MOD_GlcNHglycan	825	828	PF01048	0.744
MOD_GlcNHglycan	831	834	PF01048	0.646
MOD_GlcNHglycan	844	847	PF01048	0.587
MOD_GlcNHglycan	853	856	PF01048	0.661
MOD_GlcNHglycan	859	862	PF01048	0.597
MOD_GlcNHglycan	92	95	PF01048	0.604
MOD_GlcNHglycan	98	101	PF01048	0.816
MOD_GSK3_1	103	110	PF00069	0.669
MOD_GSK3_1	158	165	PF00069	0.839
MOD_GSK3_1	172	179	PF00069	0.590
MOD_GSK3_1	188	195	PF00069	0.554
MOD_GSK3_1	204	211	PF00069	0.596
MOD_GSK3_1	238	245	PF00069	0.680
MOD_GSK3_1	248	255	PF00069	0.663
MOD_GSK3_1	259	266	PF00069	0.793
MOD_GSK3_1	280	287	PF00069	0.764
MOD_GSK3_1	30	37	PF00069	0.649
MOD_GSK3_1	313	320	PF00069	0.610
MOD_GSK3_1	399	406	PF00069	0.517
MOD_GSK3_1	431	438	PF00069	0.631
MOD_GSK3_1	453	460	PF00069	0.588
MOD_GSK3_1	47	54	PF00069	0.584
MOD_GSK3_1	655	662	PF00069	0.622
MOD_GSK3_1	68	75	PF00069	0.816
MOD_GSK3_1	810	817	PF00069	0.738
MOD_GSK3_1	819	826	PF00069	0.682
MOD_GSK3_1	829	836	PF00069	0.539
MOD_GSK3_1	840	847	PF00069	0.653
MOD_GSK3_1	849	856	PF00069	0.547
MOD_GSK3_1	86	93	PF00069	0.552
MOD_GSK3_1	95	102	PF00069	0.808
MOD_N-GLC_2	375	377	PF02516	0.560
MOD_N-GLC_2	467	469	PF02516	0.307
MOD_NEK2_1	17	22	PF00069	0.571
MOD_NEK2_1	30	35	PF00069	0.608
MOD_NEK2_1	364	369	PF00069	0.598
MOD_NEK2_1	419	424	PF00069	0.617
MOD_NEK2_1	68	73	PF00069	0.752
MOD_NEK2_1	757	762	PF00069	0.653
MOD_NEK2_2	348	353	PF00069	0.603
MOD_NEK2_2	35	40	PF00069	0.681
MOD_PKA_1	225	231	PF00069	0.859
MOD_PKA_1	258	264	PF00069	0.753
MOD_PKA_1	536	542	PF00069	0.632
MOD_PKA_1	810	816	PF00069	0.743
MOD_PKA_2	123	129	PF00069	0.745
MOD_PKA_2	17	23	PF00069	0.524
MOD_PKA_2	248	254	PF00069	0.734
MOD_PKA_2	258	264	PF00069	0.615
MOD_PKA_2	659	665	PF00069	0.601
MOD_PKA_2	712	718	PF00069	0.632
MOD_PKA_2	811	817	PF00069	0.750
MOD_PKA_2	86	92	PF00069	0.846
MOD_PKB_1	496	504	PF00069	0.632
MOD_Plk_1	348	354	PF00069	0.601
MOD_Plk_1	435	441	PF00069	0.489
MOD_Plk_1	740	746	PF00069	0.632
MOD_Plk_1	750	756	PF00069	0.530
MOD_Plk_2-3	740	746	PF00069	0.632
MOD_Plk_4	169	175	PF00069	0.542
MOD_Plk_4	498	504	PF00069	0.551
MOD_Plk_4	682	688	PF00069	0.590
MOD_ProDKin_1	185	191	PF00069	0.567
MOD_ProDKin_1	20	26	PF00069	0.716
MOD_ProDKin_1	204	210	PF00069	0.754
MOD_ProDKin_1	235	241	PF00069	0.710
MOD_ProDKin_1	330	336	PF00069	0.617
MOD_ProDKin_1	507	513	PF00069	0.632
MOD_SUMO_rev_2	378	386	PF00179	0.602
MOD_SUMO_rev_2	410	419	PF00179	0.605
MOD_SUMO_rev_2	529	539	PF00179	0.632
MOD_SUMO_rev_2	85	93	PF00179	0.569
TRG_DiLeu_BaLyEn_6	784	789	PF01217	0.734
TRG_ENDOCYTIC_2	358	361	PF00928	0.601
TRG_ENDOCYTIC_2	370	373	PF00928	0.368
TRG_ENDOCYTIC_2	458	461	PF00928	0.637
TRG_ENDOCYTIC_2	547	550	PF00928	0.562
TRG_ENDOCYTIC_2	557	560	PF00928	0.516
TRG_ENDOCYTIC_2	577	580	PF00928	0.632
TRG_ENDOCYTIC_2	746	749	PF00928	0.638
TRG_ER_diArg_1	145	147	PF00400	0.847
TRG_ER_diArg_1	222	224	PF00400	0.694
TRG_ER_diArg_1	305	308	PF00400	0.671
TRG_ER_diArg_1	495	498	PF00400	0.560
TRG_NLS_Bipartite_1	792	814	PF00514	0.705
TRG_NLS_MonoCore_2	223	228	PF00514	0.867
TRG_NLS_MonoCore_2	302	307	PF00514	0.728
TRG_NLS_MonoExtC_3	135	140	PF00514	0.735
TRG_NLS_MonoExtC_3	302	307	PF00514	0.728
TRG_NLS_MonoExtN_4	136	143	PF00514	0.812
TRG_NLS_MonoExtN_4	222	229	PF00514	0.855
TRG_NLS_MonoExtN_4	301	308	PF00514	0.721
TRG_NLS_MonoExtN_4	807	814	PF00514	0.728
TRG_Pf-PMV_PEXEL_1	635	639	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	787	791	PF00026	0.707

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WZE7	Leishmania donovani	93%	100%
A4HEJ2	Leishmania braziliensis	82%	100%
Q4Q9R1	Leishmania major	90%	100%