RMI1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXQ8_LEIMU

TriTrypDb:

LmxM.25.1760

Length:

482

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016604	nuclear body	2	1
GO:0031422	RecQ family helicase-topoisomerase III complex	3	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0032991	protein-containing complex	1	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AXQ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXQ8

Function

Biological processes
Term	Name	Level	Count
GO:0000712	resolution of meiotic recombination intermediates	4	1
GO:0000724	double-strand break repair via homologous recombination	7	1
GO:0000725	recombinational repair	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006281	DNA repair	5	1
GO:0006302	double-strand break repair	6	1
GO:0006310	DNA recombination	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0022402	cell cycle process	2	1
GO:0022414	reproductive process	1	1
GO:0033554	cellular response to stress	3	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0061982	meiosis I cell cycle process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1903046	meiotic cell cycle process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	132	136	PF00656	0.464
CLV_C14_Caspase3-7	168	172	PF00656	0.473
CLV_C14_Caspase3-7	280	284	PF00656	0.745
CLV_NRD_NRD_1	466	468	PF00675	0.448
CLV_PCSK_KEX2_1	466	468	PF00082	0.448
CLV_PCSK_SKI1_1	363	367	PF00082	0.512
DEG_ODPH_VHL_1	37	49	PF01847	0.524
DOC_ANK_TNKS_1	465	472	PF00023	0.418
DOC_CKS1_1	40	45	PF01111	0.491
DOC_CYCLIN_RxL_1	160	171	PF00134	0.453
DOC_CYCLIN_RxL_1	426	437	PF00134	0.448
DOC_MAPK_gen_1	96	104	PF00069	0.495
DOC_PP2B_LxvP_1	47	50	PF13499	0.665
DOC_PP4_FxxP_1	40	43	PF00568	0.538
DOC_USP7_MATH_1	285	289	PF00917	0.715
DOC_USP7_MATH_1	298	302	PF00917	0.541
DOC_WW_Pin1_4	342	347	PF00397	0.543
DOC_WW_Pin1_4	373	378	PF00397	0.386
DOC_WW_Pin1_4	388	393	PF00397	0.538
DOC_WW_Pin1_4	39	44	PF00397	0.528
LIG_14-3-3_CanoR_1	111	118	PF00244	0.463
LIG_14-3-3_CanoR_1	207	213	PF00244	0.499
LIG_14-3-3_CanoR_1	429	434	PF00244	0.445
LIG_14-3-3_CanoR_1	461	465	PF00244	0.537
LIG_APCC_ABBA_1	245	250	PF00400	0.516
LIG_APCC_ABBAyCdc20_2	63	69	PF00400	0.614
LIG_BRCT_BRCA1_1	169	173	PF00533	0.516
LIG_CtBP_PxDLS_1	197	203	PF00389	0.452
LIG_FHA_1	207	213	PF00498	0.495
LIG_FHA_1	331	337	PF00498	0.391
LIG_FHA_1	365	371	PF00498	0.473
LIG_FHA_1	407	413	PF00498	0.431
LIG_FHA_1	42	48	PF00498	0.499
LIG_FHA_1	442	448	PF00498	0.493
LIG_FHA_1	77	83	PF00498	0.348
LIG_LIR_Gen_1	170	179	PF02991	0.448
LIG_LIR_Gen_1	367	374	PF02991	0.366
LIG_LIR_Nem_3	170	176	PF02991	0.448
LIG_LIR_Nem_3	246	251	PF02991	0.378
LIG_LIR_Nem_3	367	371	PF02991	0.374
LIG_LIR_Nem_3	426	431	PF02991	0.367
LIG_MYND_1	35	39	PF01753	0.552
LIG_SH2_CRK	190	194	PF00017	0.488
LIG_SH2_CRK	368	372	PF00017	0.447
LIG_SH2_STAP1	368	372	PF00017	0.447
LIG_SH2_STAT3	272	275	PF00017	0.493
LIG_SH2_STAT5	12	15	PF00017	0.619
LIG_SH3_2	306	311	PF14604	0.481
LIG_SH3_3	151	157	PF00018	0.516
LIG_SH3_3	25	31	PF00018	0.580
LIG_SH3_3	279	285	PF00018	0.536
LIG_SH3_3	303	309	PF00018	0.425
LIG_SH3_3	319	325	PF00018	0.337
LIG_SH3_3	418	424	PF00018	0.466
LIG_SH3_3	476	482	PF00018	0.440
LIG_SUMO_SIM_anti_2	439	444	PF11976	0.420
LIG_SUMO_SIM_anti_2	79	84	PF11976	0.495
LIG_SUMO_SIM_par_1	175	181	PF11976	0.474
LIG_TRAF2_1	140	143	PF00917	0.477
MOD_CDK_SPxxK_3	388	395	PF00069	0.488
MOD_CK1_1	106	112	PF00069	0.587
MOD_CK1_1	183	189	PF00069	0.495
MOD_CK1_1	55	61	PF00069	0.732
MOD_CK1_1	72	78	PF00069	0.467
MOD_CK2_1	431	437	PF00069	0.478
MOD_GlcNHglycan	113	116	PF01048	0.295
MOD_GlcNHglycan	157	160	PF01048	0.315
MOD_GlcNHglycan	180	185	PF01048	0.315
MOD_GlcNHglycan	289	292	PF01048	0.636
MOD_GlcNHglycan	54	57	PF01048	0.701
MOD_GlcNHglycan	74	77	PF01048	0.492
MOD_GSK3_1	103	110	PF00069	0.550
MOD_GSK3_1	2	9	PF00069	0.675
MOD_GSK3_1	208	215	PF00069	0.482
MOD_GSK3_1	258	265	PF00069	0.617
MOD_GSK3_1	283	290	PF00069	0.673
MOD_GSK3_1	330	337	PF00069	0.447
MOD_GSK3_1	342	349	PF00069	0.539
MOD_GSK3_1	386	393	PF00069	0.634
MOD_GSK3_1	55	62	PF00069	0.739
MOD_GSK3_1	68	75	PF00069	0.496
MOD_NEK2_1	103	108	PF00069	0.495
MOD_NEK2_1	208	213	PF00069	0.456
MOD_NEK2_1	257	262	PF00069	0.586
MOD_NEK2_1	287	292	PF00069	0.632
MOD_NEK2_1	366	371	PF00069	0.435
MOD_NEK2_1	431	436	PF00069	0.426
MOD_PIKK_1	381	387	PF00454	0.538
MOD_PIKK_1	55	61	PF00454	0.615
MOD_PKA_2	110	116	PF00069	0.550
MOD_PKA_2	155	161	PF00069	0.474
MOD_PKA_2	206	212	PF00069	0.499
MOD_PKA_2	262	268	PF00069	0.654
MOD_PKA_2	33	39	PF00069	0.508
MOD_PKA_2	381	387	PF00069	0.500
MOD_PKA_2	460	466	PF00069	0.448
MOD_Plk_1	134	140	PF00069	0.509
MOD_Plk_1	213	219	PF00069	0.463
MOD_Plk_1	6	12	PF00069	0.573
MOD_Plk_1	90	96	PF00069	0.448
MOD_Plk_2-3	406	412	PF00069	0.343
MOD_Plk_4	366	372	PF00069	0.430
MOD_Plk_4	78	84	PF00069	0.283
MOD_ProDKin_1	342	348	PF00069	0.552
MOD_ProDKin_1	373	379	PF00069	0.387
MOD_ProDKin_1	388	394	PF00069	0.541
MOD_ProDKin_1	39	45	PF00069	0.531
TRG_DiLeu_BaEn_1	397	402	PF01217	0.485
TRG_DiLeu_BaLyEn_6	28	33	PF01217	0.619
TRG_ENDOCYTIC_2	190	193	PF00928	0.488
TRG_ENDOCYTIC_2	248	251	PF00928	0.378
TRG_ENDOCYTIC_2	368	371	PF00928	0.451
TRG_ER_diArg_1	187	190	PF00400	0.494
TRG_ER_diArg_1	465	467	PF00400	0.395
TRG_ER_diArg_1	99	102	PF00400	0.495
TRG_NES_CRM1_1	168	181	PF08389	0.516
TRG_NES_CRM1_1	236	250	PF08389	0.516
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.315
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.315

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I876	Leptomonas seymouri	55%	100%
A0A3S7WZC3	Leishmania donovani	88%	96%
A0A422NGJ8	Trypanosoma rangeli	28%	100%
A4HEG6	Leishmania braziliensis	78%	99%
A4I1M4	Leishmania infantum	89%	96%
Q4Q9R3	Leishmania major	90%	100%
V5DIU3	Trypanosoma cruzi	33%	97%