Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXQ6_LEIMU

TriTrypDb:

LmxM.25.1740

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXQ6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	92	96	PF00656	0.757
CLV_NRD_NRD_1	156	158	PF00675	0.543
CLV_NRD_NRD_1	190	192	PF00675	0.693
CLV_NRD_NRD_1	195	197	PF00675	0.643
CLV_NRD_NRD_1	210	212	PF00675	0.520
CLV_NRD_NRD_1	230	232	PF00675	0.740
CLV_NRD_NRD_1	264	266	PF00675	0.677
CLV_NRD_NRD_1	274	276	PF00675	0.676
CLV_NRD_NRD_1	292	294	PF00675	0.741
CLV_PCSK_KEX2_1	195	197	PF00082	0.720
CLV_PCSK_KEX2_1	210	212	PF00082	0.505
CLV_PCSK_KEX2_1	230	232	PF00082	0.740
CLV_PCSK_KEX2_1	264	266	PF00082	0.674
CLV_PCSK_KEX2_1	274	276	PF00082	0.680
CLV_PCSK_KEX2_1	292	294	PF00082	0.741
CLV_PCSK_PC7_1	191	197	PF00082	0.704
CLV_PCSK_SKI1_1	103	107	PF00082	0.690
CLV_PCSK_SKI1_1	129	133	PF00082	0.541
CLV_PCSK_SKI1_1	151	155	PF00082	0.557
CLV_PCSK_SKI1_1	158	162	PF00082	0.519
DEG_Nend_UBRbox_1	1	4	PF02207	0.653
DEG_SPOP_SBC_1	235	239	PF00917	0.551
DOC_ANK_TNKS_1	283	290	PF00023	0.659
DOC_MAPK_gen_1	191	200	PF00069	0.616
DOC_PP4_FxxP_1	75	78	PF00568	0.770
DOC_USP7_MATH_1	212	216	PF00917	0.593
DOC_USP7_MATH_1	236	240	PF00917	0.781
DOC_USP7_MATH_1	296	300	PF00917	0.729
DOC_USP7_MATH_1	66	70	PF00917	0.598
DOC_WW_Pin1_4	74	79	PF00397	0.726
LIG_14-3-3_CanoR_1	191	195	PF00244	0.692
LIG_14-3-3_CanoR_1	300	305	PF00244	0.709
LIG_14-3-3_CanoR_1	42	49	PF00244	0.736
LIG_FHA_1	112	118	PF00498	0.610
LIG_FHA_1	121	127	PF00498	0.496
LIG_LIR_Apic_2	72	78	PF02991	0.772
LIG_LIR_Gen_1	130	139	PF02991	0.538
LIG_LIR_Gen_1	3	12	PF02991	0.590
LIG_LIR_Nem_3	130	135	PF02991	0.493
LIG_LIR_Nem_3	3	7	PF02991	0.579
LIG_SH2_SRC	173	176	PF00017	0.613
LIG_SH2_STAP1	36	40	PF00017	0.700
LIG_SH2_STAT5	173	176	PF00017	0.453
LIG_SH3_3	238	244	PF00018	0.804
LIG_SH3_3	75	81	PF00018	0.697
LIG_TRAF2_2	268	273	PF00917	0.719
LIG_WRC_WIRS_1	1	6	PF05994	0.583
MOD_CDK_SPK_2	74	79	PF00069	0.664
MOD_CK1_1	127	133	PF00069	0.494
MOD_CK1_1	215	221	PF00069	0.534
MOD_CK1_1	239	245	PF00069	0.780
MOD_CK1_1	280	286	PF00069	0.585
MOD_CK1_1	45	51	PF00069	0.713
MOD_CK1_1	5	11	PF00069	0.780
MOD_CK1_1	59	65	PF00069	0.669
MOD_CK1_1	69	75	PF00069	0.745
MOD_CK1_1	99	105	PF00069	0.587
MOD_Cter_Amidation	262	265	PF01082	0.840
MOD_GlcNHglycan	13	16	PF01048	0.767
MOD_GlcNHglycan	132	135	PF01048	0.531
MOD_GlcNHglycan	238	241	PF01048	0.843
MOD_GlcNHglycan	254	257	PF01048	0.703
MOD_GlcNHglycan	30	33	PF01048	0.522
MOD_GlcNHglycan	36	39	PF01048	0.639
MOD_GlcNHglycan	52	55	PF01048	0.813
MOD_GlcNHglycan	58	61	PF01048	0.735
MOD_GlcNHglycan	62	65	PF01048	0.646
MOD_GlcNHglycan	97	101	PF01048	0.674
MOD_GSK3_1	107	114	PF00069	0.534
MOD_GSK3_1	120	127	PF00069	0.492
MOD_GSK3_1	235	242	PF00069	0.709
MOD_GSK3_1	296	303	PF00069	0.709
MOD_GSK3_1	30	37	PF00069	0.645
MOD_GSK3_1	45	52	PF00069	0.597
MOD_GSK3_1	56	63	PF00069	0.632
MOD_N-GLC_1	280	285	PF02516	0.769
MOD_N-GLC_1	300	305	PF02516	0.815
MOD_N-GLC_1	49	54	PF02516	0.553
MOD_N-GLC_1	90	95	PF02516	0.657
MOD_NEK2_1	89	94	PF00069	0.478
MOD_NEK2_2	124	129	PF00069	0.477
MOD_PK_1	107	113	PF00069	0.537
MOD_PK_1	2	8	PF00069	0.706
MOD_PKA_2	190	196	PF00069	0.697
MOD_PKA_2	50	56	PF00069	0.817
MOD_PKA_2	69	75	PF00069	0.670
MOD_Plk_1	107	113	PF00069	0.585
MOD_Plk_1	300	306	PF00069	0.765
MOD_Plk_4	107	113	PF00069	0.537
MOD_Plk_4	127	133	PF00069	0.302
MOD_Plk_4	212	218	PF00069	0.567
MOD_ProDKin_1	74	80	PF00069	0.721
TRG_ER_diArg_1	194	196	PF00400	0.712
TRG_ER_diArg_1	210	212	PF00400	0.488
TRG_ER_diArg_1	291	293	PF00400	0.831

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H0	Leptomonas seymouri	45%	96%
A0A3S7WZ80	Leishmania donovani	91%	100%
A4HEG8	Leishmania braziliensis	71%	99%
A4I1M2	Leishmania infantum	91%	100%
Q4Q9R5	Leishmania major	91%	100%