Pyruvate dehydrogenase E1 component subunit beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pyruvate dehydrogenase E1 beta subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AXQ3_LEIMU

TriTrypDb:

LmxM.25.1710

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005967	mitochondrial pyruvate dehydrogenase complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045254	pyruvate dehydrogenase complex	4	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990204	oxidoreductase complex	3	1

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Expansion

Sequence features

E9AXQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXQ3

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	12
GO:0006084	acetyl-CoA metabolic process	5	12
GO:0006085	acetyl-CoA biosynthetic process	6	12
GO:0006086	acetyl-CoA biosynthetic process from pyruvate	7	12
GO:0006090	pyruvate metabolic process	7	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006164	purine nucleotide biosynthetic process	6	12
GO:0006637	acyl-CoA metabolic process	4	12
GO:0006725	cellular aromatic compound metabolic process	3	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004738	pyruvate dehydrogenase activity	4	12
GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity	5	12
GO:0016491	oxidoreductase activity	2	12
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	4	12
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.508
CLV_C14_Caspase3-7	308	312	PF00656	0.465
CLV_NRD_NRD_1	2	4	PF00675	0.527
CLV_PCSK_KEX2_1	2	4	PF00082	0.527
CLV_PCSK_KEX2_1	346	348	PF00082	0.387
CLV_PCSK_PC1ET2_1	346	348	PF00082	0.515
CLV_PCSK_SKI1_1	19	23	PF00082	0.494
CLV_PCSK_SKI1_1	227	231	PF00082	0.322
CLV_PCSK_SKI1_1	280	284	PF00082	0.275
CLV_PCSK_SKI1_1	346	350	PF00082	0.421

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5M5	Leptomonas seymouri	33%	95%
A0A0N0P8J5	Leptomonas seymouri	88%	100%
A0A0S4J2J6	Bodo saltans	73%	100%
A0A1X0NJN2	Trypanosomatidae	34%	95%
A0A1X0NY97	Trypanosomatidae	76%	100%
A0A3Q8IJ06	Leishmania donovani	34%	96%
A0A3S7WZ91	Leishmania donovani	97%	100%
A0A422N7P1	Trypanosoma rangeli	31%	96%
A0A422NGI4	Trypanosoma rangeli	78%	100%
A2CI50	Chlorokybus atmophyticus	41%	100%

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