Sm domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

LSM domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXQ2_LEIMU

TriTrypDb:

LmxM.25.1705

Length:

131

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0005681	spliceosomal complex	3	2
GO:0005688	U6 snRNP	5	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	2
GO:0071011	precatalytic spliceosome	4	1
GO:0097525	spliceosomal snRNP complex	4	2
GO:0097526	spliceosomal tri-snRNP complex	5	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

E9AXQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXQ2

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	6	12	PF00089	0.210
CLV_NRD_NRD_1	6	8	PF00675	0.241
CLV_PCSK_KEX2_1	8	10	PF00082	0.221
CLV_PCSK_PC1ET2_1	8	10	PF00082	0.266
CLV_PCSK_SKI1_1	76	80	PF00082	0.179
DEG_APCC_DBOX_1	75	83	PF00400	0.369
DEG_Nend_Nbox_1	1	3	PF02207	0.263
DOC_CYCLIN_yClb5_NLxxxL_5	15	24	PF00134	0.504
DOC_MAPK_gen_1	7	15	PF00069	0.466
DOC_USP7_MATH_1	68	72	PF00917	0.456
LIG_14-3-3_CanoR_1	7	13	PF00244	0.414
LIG_Actin_WH2_2	78	95	PF00022	0.490
LIG_APCC_ABBA_1	103	108	PF00400	0.475
LIG_FHA_1	34	40	PF00498	0.440
LIG_MYND_3	79	83	PF01753	0.426
LIG_SH2_NCK_1	106	110	PF00017	0.496
LIG_SH2_SRC	106	109	PF00017	0.491
LIG_SH2_STAT5	5	8	PF00017	0.436
LIG_SUMO_SIM_par_1	11	16	PF11976	0.466
LIG_TRAF2_1	52	55	PF00917	0.426
LIG_TRAF2_1	81	84	PF00917	0.504
MOD_CK1_1	11	17	PF00069	0.422
MOD_CK1_1	71	77	PF00069	0.431
MOD_CK2_1	34	40	PF00069	0.417
MOD_GlcNHglycan	70	73	PF01048	0.284
MOD_GSK3_1	123	130	PF00069	0.560
MOD_GSK3_1	64	71	PF00069	0.447
MOD_PK_1	8	14	PF00069	0.410
MOD_PKA_1	8	14	PF00069	0.410
MOD_PKA_2	8	14	PF00069	0.410
MOD_Plk_2-3	50	56	PF00069	0.365
MOD_Plk_4	8	14	PF00069	0.410
TRG_ER_diArg_1	116	119	PF00400	0.413
TRG_ER_diArg_1	6	9	PF00400	0.455
TRG_NES_CRM1_1	4	16	PF08389	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X1	Leptomonas seymouri	71%	100%
A0A0S4J0G1	Bodo saltans	36%	100%
A0A1X0NYL8	Trypanosomatidae	48%	100%
A0A3Q8IFD7	Leishmania donovani	95%	100%
A0A3R7KAX5	Trypanosoma rangeli	50%	100%
A4HEH2	Leishmania braziliensis	83%	100%
A4I1L8	Leishmania infantum	94%	100%
C9ZK60	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
Q1ZXD5	Dictyostelium discoideum	28%	100%
Q4Q9R9	Leishmania major	91%	100%