J domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXQ0_LEIMU

TriTrypDb:

LmxM.25.1690

Length:

284

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AXQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXQ0

Function

Biological processes
Term	Name	Level	Count
GO:0006790	sulfur compound metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016043	cellular component organization	3	11
GO:0016226	iron-sulfur cluster assembly	4	11
GO:0022607	cellular component assembly	4	11
GO:0031163	metallo-sulfur cluster assembly	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044571	[2Fe-2S] cluster assembly	5	11
GO:0071840	cellular component organization or biogenesis	2	11
GO:0043933	protein-containing complex organization	4	4
GO:0051259	protein complex oligomerization	6	4
GO:0065003	protein-containing complex assembly	5	4

Molecular functions
Term	Name	Level	Count
GO:0001671	ATPase activator activity	3	11
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0051087	protein-folding chaperone binding	3	11
GO:0098772	molecular function regulator activity	1	11
GO:0140677	molecular function activator activity	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	252	256	PF00656	0.491
CLV_NRD_NRD_1	11	13	PF00675	0.500
CLV_NRD_NRD_1	40	42	PF00675	0.748
CLV_PCSK_KEX2_1	11	13	PF00082	0.500
CLV_PCSK_KEX2_1	40	42	PF00082	0.749
CLV_PCSK_SKI1_1	11	15	PF00082	0.500
CLV_PCSK_SKI1_1	162	166	PF00082	0.516
CLV_PCSK_SKI1_1	189	193	PF00082	0.640
CLV_PCSK_SKI1_1	67	71	PF00082	0.396
DEG_Nend_Nbox_1	1	3	PF02207	0.628
DEG_SCF_FBW7_1	115	120	PF00400	0.442
DEG_SPOP_SBC_1	118	122	PF00917	0.663
DOC_MAPK_gen_1	11	19	PF00069	0.488
DOC_MAPK_gen_1	67	76	PF00069	0.388
DOC_MAPK_MEF2A_6	67	76	PF00069	0.388
DOC_PP2B_LxvP_1	150	153	PF13499	0.378
DOC_USP7_MATH_1	117	121	PF00917	0.678
DOC_USP7_MATH_1	127	131	PF00917	0.599
DOC_USP7_MATH_1	219	223	PF00917	0.534
DOC_USP7_MATH_1	249	253	PF00917	0.405
DOC_USP7_MATH_1	3	7	PF00917	0.527
DOC_USP7_MATH_1	51	55	PF00917	0.574
DOC_USP7_UBL2_3	247	251	PF12436	0.426
DOC_WW_Pin1_4	113	118	PF00397	0.642
DOC_WW_Pin1_4	119	124	PF00397	0.634
DOC_WW_Pin1_4	169	174	PF00397	0.457
DOC_WW_Pin1_4	46	51	PF00397	0.649
LIG_14-3-3_CanoR_1	228	234	PF00244	0.483
LIG_14-3-3_CanoR_1	4	8	PF00244	0.555
LIG_14-3-3_CanoR_1	40	46	PF00244	0.601
LIG_BRCT_BRCA1_1	202	206	PF00533	0.461
LIG_DLG_GKlike_1	41	49	PF00625	0.591
LIG_FHA_1	270	276	PF00498	0.225
LIG_LIR_Gen_1	267	275	PF02991	0.355
LIG_LIR_Nem_3	267	271	PF02991	0.370
LIG_PTB_Apo_2	141	148	PF02174	0.371
LIG_PTB_Phospho_1	141	147	PF10480	0.368
LIG_REV1ctd_RIR_1	63	71	PF16727	0.389
LIG_SH2_CRK	83	87	PF00017	0.460
LIG_SH2_GRB2like	142	145	PF00017	0.372
LIG_SH2_GRB2like	83	86	PF00017	0.512
LIG_SH2_NCK_1	142	146	PF00017	0.382
LIG_SH2_SRC	142	145	PF00017	0.390
LIG_SH2_STAP1	142	146	PF00017	0.407
LIG_SH2_STAT5	159	162	PF00017	0.333
LIG_SH2_STAT5	245	248	PF00017	0.429
LIG_SH2_STAT5	270	273	PF00017	0.334
LIG_SH2_STAT5	62	65	PF00017	0.421
LIG_SH3_3	195	201	PF00018	0.621
LIG_SH3_3	47	53	PF00018	0.583
LIG_TRAF2_1	176	179	PF00917	0.404
MOD_CK1_1	130	136	PF00069	0.564
MOD_CK1_1	172	178	PF00069	0.572
MOD_CK1_1	44	50	PF00069	0.767
MOD_CK2_1	172	178	PF00069	0.452
MOD_CK2_1	219	225	PF00069	0.395
MOD_GlcNHglycan	174	177	PF01048	0.602
MOD_GSK3_1	113	120	PF00069	0.666
MOD_GSK3_1	126	133	PF00069	0.599
MOD_GSK3_1	134	141	PF00069	0.562
MOD_GSK3_1	266	273	PF00069	0.482
MOD_GSK3_1	40	47	PF00069	0.640
MOD_N-GLC_1	130	135	PF02516	0.566
MOD_NEK2_1	126	131	PF00069	0.702
MOD_NEK2_1	45	50	PF00069	0.470
MOD_NEK2_2	146	151	PF00069	0.390
MOD_NEK2_2	3	8	PF00069	0.524
MOD_PIKK_1	33	39	PF00454	0.470
MOD_PKA_1	40	46	PF00069	0.589
MOD_PKA_2	3	9	PF00069	0.413
MOD_PKA_2	40	46	PF00069	0.776
MOD_PKB_1	156	164	PF00069	0.479
MOD_Plk_1	137	143	PF00069	0.434
MOD_Plk_1	266	272	PF00069	0.367
MOD_Plk_4	3	9	PF00069	0.708
MOD_ProDKin_1	113	119	PF00069	0.642
MOD_ProDKin_1	169	175	PF00069	0.457
MOD_ProDKin_1	46	52	PF00069	0.649
MOD_SUMO_for_1	164	167	PF00179	0.440
MOD_SUMO_rev_2	167	172	PF00179	0.380
TRG_DiLeu_BaEn_1	178	183	PF01217	0.426
TRG_ENDOCYTIC_2	147	150	PF00928	0.357
TRG_ENDOCYTIC_2	62	65	PF00928	0.385
TRG_ENDOCYTIC_2	83	86	PF00928	0.453
TRG_ER_diArg_1	11	13	PF00400	0.591
TRG_ER_diArg_1	156	159	PF00400	0.431

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K0	Leptomonas seymouri	62%	100%
A0A1X0NZR6	Trypanosomatidae	41%	100%
A0A3S7WZD6	Leishmania donovani	89%	100%
A0A422NGH8	Trypanosoma rangeli	42%	100%
A4HEH4	Leishmania braziliensis	77%	98%
A4I1L6	Leishmania infantum	89%	100%
C9ZK58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q9S1	Leishmania major	91%	98%
V5BHV1	Trypanosoma cruzi	41%	90%