KOW domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXP4_LEIMU

TriTrypDb:

LmxM.25.1640

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	8
GO:0043226	organelle	2	8
GO:0043228	non-membrane-bounded organelle	3	8
GO:0043229	intracellular organelle	3	8
GO:0043232	intracellular non-membrane-bounded organelle	4	8
GO:0110165	cellular anatomical entity	1	8
GO:0005739	mitochondrion	5	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

E9AXP4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXP4

PDB structure(s): 7aih_O , 7am2_O , 7ane_O

Function

Biological processes
Term	Name	Level	Count
GO:0006412	translation	4	8
GO:0006518	peptide metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	8
GO:0009059	macromolecule biosynthetic process	4	8
GO:0009987	cellular process	1	8
GO:0019538	protein metabolic process	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	8
GO:0043043	peptide biosynthetic process	5	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043603	amide metabolic process	3	8
GO:0043604	amide biosynthetic process	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8
GO:1901566	organonitrogen compound biosynthetic process	4	8
GO:1901576	organic substance biosynthetic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003735	structural constituent of ribosome	2	8
GO:0005198	structural molecule activity	1	8
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	229	231	PF00675	0.520
CLV_NRD_NRD_1	279	281	PF00675	0.545
CLV_NRD_NRD_1	292	294	PF00675	0.540
CLV_NRD_NRD_1	428	430	PF00675	0.696
CLV_PCSK_KEX2_1	229	231	PF00082	0.466
CLV_PCSK_KEX2_1	279	281	PF00082	0.479
CLV_PCSK_KEX2_1	38	40	PF00082	0.495
CLV_PCSK_KEX2_1	428	430	PF00082	0.696
CLV_PCSK_PC1ET2_1	38	40	PF00082	0.495
CLV_PCSK_SKI1_1	315	319	PF00082	0.632
CLV_PCSK_SKI1_1	42	46	PF00082	0.556
DEG_APCC_DBOX_1	77	85	PF00400	0.495
DEG_Kelch_Keap1_1	220	225	PF01344	0.566
DOC_MAPK_gen_1	161	168	PF00069	0.427
DOC_MAPK_gen_1	269	278	PF00069	0.564
DOC_MAPK_gen_1	76	83	PF00069	0.555
DOC_MAPK_MEF2A_6	269	278	PF00069	0.636
DOC_PP2B_LxvP_1	239	242	PF13499	0.488
DOC_PP2B_LxvP_1	54	57	PF13499	0.545
DOC_USP7_MATH_1	348	352	PF00917	0.821
DOC_USP7_MATH_1	361	365	PF00917	0.558
DOC_USP7_UBL2_3	217	221	PF12436	0.501
DOC_USP7_UBL2_3	38	42	PF12436	0.543
DOC_WW_Pin1_4	123	128	PF00397	0.525
DOC_WW_Pin1_4	47	52	PF00397	0.616
LIG_14-3-3_CanoR_1	16	26	PF00244	0.551
LIG_14-3-3_CanoR_1	229	234	PF00244	0.493
LIG_14-3-3_CanoR_1	293	297	PF00244	0.512
LIG_14-3-3_CanoR_1	381	389	PF00244	0.682
LIG_Actin_WH2_2	277	295	PF00022	0.516
LIG_Actin_WH2_2	49	67	PF00022	0.538
LIG_CaM_IQ_9	307	322	PF13499	0.539
LIG_eIF4E_1	162	168	PF01652	0.476
LIG_FHA_1	139	145	PF00498	0.537
LIG_FHA_1	205	211	PF00498	0.508
LIG_FHA_1	221	227	PF00498	0.386
LIG_FHA_1	320	326	PF00498	0.570
LIG_FHA_1	436	442	PF00498	0.590
LIG_FHA_2	181	187	PF00498	0.518
LIG_FHA_2	411	417	PF00498	0.392
LIG_HCF-1_HBM_1	98	101	PF13415	0.500
LIG_LIR_Apic_2	34	40	PF02991	0.468
LIG_LIR_Gen_1	401	406	PF02991	0.570
LIG_LIR_Nem_3	401	405	PF02991	0.569
LIG_PCNA_yPIPBox_3	163	177	PF02747	0.448
LIG_SH2_GRB2like	101	104	PF00017	0.492
LIG_SH2_PTP2	402	405	PF00017	0.572
LIG_SH2_SRC	296	299	PF00017	0.519
LIG_SH2_SRC	96	99	PF00017	0.509
LIG_SH2_STAT3	101	104	PF00017	0.492
LIG_SH2_STAT5	124	127	PF00017	0.536
LIG_SH2_STAT5	287	290	PF00017	0.446
LIG_SH2_STAT5	402	405	PF00017	0.572
LIG_SH2_STAT5	68	71	PF00017	0.535
LIG_SH3_3	173	179	PF00018	0.483
LIG_SH3_3	386	392	PF00018	0.717
LIG_SH3_3	438	444	PF00018	0.608
LIG_SUMO_SIM_anti_2	140	146	PF11976	0.493
LIG_SUMO_SIM_anti_2	401	410	PF11976	0.552
LIG_SUMO_SIM_anti_2	79	86	PF11976	0.549
LIG_SUMO_SIM_par_1	140	146	PF11976	0.449
LIG_SUMO_SIM_par_1	401	410	PF11976	0.358
LIG_TRAF2_1	243	246	PF00917	0.620
LIG_UBA3_1	53	60	PF00899	0.516
LIG_UBA3_1	63	72	PF00899	0.487
LIG_WRC_WIRS_1	310	315	PF05994	0.557
MOD_CK1_1	232	238	PF00069	0.490
MOD_CK1_1	346	352	PF00069	0.770
MOD_CK1_1	364	370	PF00069	0.592
MOD_CK2_1	180	186	PF00069	0.518
MOD_CK2_1	410	416	PF00069	0.613
MOD_GlcNHglycan	145	148	PF01048	0.517
MOD_GlcNHglycan	234	237	PF01048	0.496
MOD_GlcNHglycan	345	348	PF01048	0.723
MOD_GlcNHglycan	383	386	PF01048	0.471
MOD_GSK3_1	15	22	PF00069	0.496
MOD_GSK3_1	288	295	PF00069	0.477
MOD_GSK3_1	339	346	PF00069	0.730
MOD_N-GLC_1	47	52	PF02516	0.616
MOD_NEK2_1	19	24	PF00069	0.637
MOD_NEK2_1	254	259	PF00069	0.602
MOD_NEK2_1	288	293	PF00069	0.476
MOD_NEK2_1	398	403	PF00069	0.633
MOD_NEK2_1	83	88	PF00069	0.542
MOD_PIKK_1	19	25	PF00454	0.470
MOD_PIKK_1	339	345	PF00454	0.730
MOD_PIKK_1	349	355	PF00454	0.618
MOD_PKA_1	229	235	PF00069	0.464
MOD_PKA_2	15	21	PF00069	0.565
MOD_PKA_2	229	235	PF00069	0.478
MOD_PKA_2	292	298	PF00069	0.532
MOD_PKA_2	319	325	PF00069	0.565
MOD_PKB_1	29	37	PF00069	0.507
MOD_Plk_1	244	250	PF00069	0.603
MOD_Plk_1	263	269	PF00069	0.378
MOD_Plk_1	97	103	PF00069	0.488
MOD_Plk_2-3	263	269	PF00069	0.539
MOD_Plk_2-3	410	416	PF00069	0.590
MOD_Plk_2-3	447	453	PF00069	0.677
MOD_Plk_4	367	373	PF00069	0.639
MOD_Plk_4	398	404	PF00069	0.562
MOD_ProDKin_1	123	129	PF00069	0.522
MOD_ProDKin_1	47	53	PF00069	0.616
MOD_SUMO_for_1	376	379	PF00179	0.675
MOD_SUMO_rev_2	126	133	PF00179	0.511
TRG_DiLeu_BaEn_1	234	239	PF01217	0.493
TRG_DiLeu_BaEn_1	272	277	PF01217	0.501
TRG_DiLeu_BaEn_1	79	84	PF01217	0.546
TRG_DiLeu_BaLyEn_6	271	276	PF01217	0.560
TRG_ENDOCYTIC_2	122	125	PF00928	0.458
TRG_ENDOCYTIC_2	402	405	PF00928	0.572
TRG_ER_diArg_1	10	13	PF00400	0.750
TRG_ER_diArg_1	198	201	PF00400	0.584
TRG_ER_diArg_1	229	231	PF00400	0.501
TRG_ER_diArg_1	278	280	PF00400	0.554
TRG_ER_diArg_1	30	33	PF00400	0.498
TRG_NES_CRM1_1	209	222	PF08389	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I882	Leptomonas seymouri	71%	100%
A0A1X0NY95	Trypanosomatidae	71%	100%
A0A3Q8IDE3	Leishmania donovani	92%	100%
A4HEI0	Leishmania braziliensis	83%	98%
A4I1L0	Leishmania infantum	92%	100%
Q4Q9S7	Leishmania major	91%	100%