Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

diacylglycerol acyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AXP3_LEIMU

TriTrypDb:

LmxM.25.1630

Length:

612

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8
GO:0005737	cytoplasm	2	1
GO:0005789	endoplasmic reticulum membrane	4	3
GO:0031090	organelle membrane	3	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AXP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXP3

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006638	neutral lipid metabolic process	4	1
GO:0006639	acylglycerol metabolic process	5	1
GO:0006641	triglyceride metabolic process	6	1
GO:0006643	membrane lipid metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019432	triglyceride biosynthetic process	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046460	neutral lipid biosynthetic process	4	1
GO:0046463	acylglycerol biosynthetic process	5	1
GO:0046467	membrane lipid biosynthetic process	4	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0008374	O-acyltransferase activity	5	9
GO:0016740	transferase activity	2	9
GO:0016746	acyltransferase activity	3	9
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	9
GO:0004144	diacylglycerol O-acyltransferase activity	7	4
GO:0016411	acylglycerol O-acyltransferase activity	6	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	403	407	PF00656	0.463
CLV_NRD_NRD_1	153	155	PF00675	0.287
CLV_NRD_NRD_1	290	292	PF00675	0.283
CLV_NRD_NRD_1	374	376	PF00675	0.286
CLV_NRD_NRD_1	447	449	PF00675	0.222
CLV_NRD_NRD_1	483	485	PF00675	0.218
CLV_NRD_NRD_1	54	56	PF00675	0.466
CLV_NRD_NRD_1	555	557	PF00675	0.441
CLV_NRD_NRD_1	590	592	PF00675	0.463
CLV_PCSK_KEX2_1	153	155	PF00082	0.336
CLV_PCSK_KEX2_1	241	243	PF00082	0.436
CLV_PCSK_KEX2_1	290	292	PF00082	0.283
CLV_PCSK_KEX2_1	373	375	PF00082	0.284
CLV_PCSK_KEX2_1	483	485	PF00082	0.227
CLV_PCSK_KEX2_1	54	56	PF00082	0.470
CLV_PCSK_KEX2_1	555	557	PF00082	0.441
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.478
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.255
CLV_PCSK_SKI1_1	153	157	PF00082	0.316
CLV_PCSK_SKI1_1	226	230	PF00082	0.354
CLV_PCSK_SKI1_1	489	493	PF00082	0.217
CLV_PCSK_SKI1_1	542	546	PF00082	0.320
CLV_Separin_Metazoa	567	571	PF03568	0.152
DEG_APCC_DBOX_1	153	161	PF00400	0.559
DEG_COP1_1	180	188	PF00400	0.570
DEG_Nend_UBRbox_2	1	3	PF02207	0.725
DOC_CKS1_1	191	196	PF01111	0.707
DOC_CKS1_1	21	26	PF01111	0.610
DOC_CKS1_1	215	220	PF01111	0.622
DOC_CKS1_1	284	289	PF01111	0.601
DOC_CYCLIN_yClb5_NLxxxL_5	422	429	PF00134	0.432
DOC_MAPK_gen_1	226	234	PF00069	0.552
DOC_MAPK_gen_1	290	297	PF00069	0.515
DOC_MAPK_gen_1	356	366	PF00069	0.360
DOC_MAPK_gen_1	473	482	PF00069	0.433
DOC_MAPK_gen_1	483	492	PF00069	0.405
DOC_MAPK_gen_1	555	562	PF00069	0.241
DOC_MAPK_HePTP_8	480	492	PF00069	0.484
DOC_MAPK_MEF2A_6	290	299	PF00069	0.464
DOC_MAPK_MEF2A_6	359	368	PF00069	0.377
DOC_MAPK_MEF2A_6	409	418	PF00069	0.458
DOC_MAPK_MEF2A_6	422	429	PF00069	0.427
DOC_MAPK_MEF2A_6	483	492	PF00069	0.419
DOC_MAPK_MEF2A_6	555	562	PF00069	0.217
DOC_PP2B_LxvP_1	183	186	PF13499	0.652
DOC_PP2B_LxvP_1	35	38	PF13499	0.570
DOC_PP2B_LxvP_1	366	369	PF13499	0.417
DOC_PP2B_LxvP_1	425	428	PF13499	0.484
DOC_PP2B_LxvP_1	566	569	PF13499	0.284
DOC_PP4_FxxP_1	336	339	PF00568	0.345
DOC_PP4_FxxP_1	534	537	PF00568	0.252
DOC_USP7_MATH_1	172	176	PF00917	0.669
DOC_USP7_MATH_1	208	212	PF00917	0.697
DOC_USP7_MATH_1	31	35	PF00917	0.662
DOC_USP7_MATH_1	442	446	PF00917	0.441
DOC_USP7_MATH_1	455	459	PF00917	0.412
DOC_USP7_MATH_1	466	470	PF00917	0.399
DOC_USP7_MATH_2	195	201	PF00917	0.595
DOC_USP7_UBL2_3	485	489	PF12436	0.484
DOC_WW_Pin1_4	190	195	PF00397	0.754
DOC_WW_Pin1_4	20	25	PF00397	0.717
DOC_WW_Pin1_4	214	219	PF00397	0.626
DOC_WW_Pin1_4	242	247	PF00397	0.615
DOC_WW_Pin1_4	26	31	PF00397	0.719
DOC_WW_Pin1_4	283	288	PF00397	0.606
DOC_WW_Pin1_4	493	498	PF00397	0.441
LIG_14-3-3_CanoR_1	142	152	PF00244	0.560
LIG_14-3-3_CanoR_1	15	22	PF00244	0.685
LIG_14-3-3_CanoR_1	266	272	PF00244	0.539
LIG_14-3-3_CanoR_1	290	296	PF00244	0.489
LIG_14-3-3_CanoR_1	320	324	PF00244	0.284
LIG_14-3-3_CanoR_1	448	452	PF00244	0.441
LIG_14-3-3_CanoR_1	94	101	PF00244	0.596
LIG_ActinCP_TwfCPI_2	336	345	PF01115	0.345
LIG_APCC_Cbox_2	141	147	PF00515	0.435
LIG_BIR_III_4	272	276	PF00653	0.502
LIG_BRCT_BRCA1_1	267	271	PF00533	0.602
LIG_BRCT_BRCA1_1	66	70	PF00533	0.637
LIG_DLG_GKlike_1	291	299	PF00625	0.484
LIG_eIF4E_1	361	367	PF01652	0.417
LIG_FHA_1	311	317	PF00498	0.362
LIG_FHA_1	413	419	PF00498	0.457
LIG_FHA_1	494	500	PF00498	0.441
LIG_FHA_1	61	67	PF00498	0.639
LIG_FHA_2	205	211	PF00498	0.578
LIG_FHA_2	267	273	PF00498	0.541
LIG_FHA_2	44	50	PF00498	0.652
LIG_FHA_2	573	579	PF00498	0.217
LIG_LIR_Apic_2	210	215	PF02991	0.663
LIG_LIR_Apic_2	319	324	PF02991	0.273
LIG_LIR_Apic_2	335	339	PF02991	0.204
LIG_LIR_Gen_1	298	308	PF02991	0.258
LIG_LIR_Gen_1	322	333	PF02991	0.323
LIG_LIR_Gen_1	67	77	PF02991	0.642
LIG_LIR_LC3C_4	458	463	PF02991	0.441
LIG_LIR_Nem_3	279	283	PF02991	0.572
LIG_LIR_Nem_3	298	303	PF02991	0.415
LIG_LIR_Nem_3	360	364	PF02991	0.431
LIG_LIR_Nem_3	379	385	PF02991	0.484
LIG_LIR_Nem_3	393	397	PF02991	0.441
LIG_LIR_Nem_3	518	523	PF02991	0.440
LIG_LIR_Nem_3	67	73	PF02991	0.625
LIG_NRBOX	311	317	PF00104	0.191
LIG_Pex14_1	332	336	PF04695	0.345
LIG_Pex14_1	582	586	PF04695	0.217
LIG_Pex14_2	330	334	PF04695	0.202
LIG_Pex14_2	349	353	PF04695	0.526
LIG_PTB_Apo_2	543	550	PF02174	0.345
LIG_PTB_Phospho_1	543	549	PF10480	0.345
LIG_SH2_CRK	321	325	PF00017	0.337
LIG_SH2_CRK	549	553	PF00017	0.284
LIG_SH2_NCK_1	321	325	PF00017	0.273
LIG_SH2_NCK_1	510	514	PF00017	0.468
LIG_SH2_PTP2	426	429	PF00017	0.463
LIG_SH2_SRC	129	132	PF00017	0.447
LIG_SH2_STAT5	143	146	PF00017	0.562
LIG_SH2_STAT5	261	264	PF00017	0.520
LIG_SH2_STAT5	321	324	PF00017	0.323
LIG_SH2_STAT5	329	332	PF00017	0.224
LIG_SH2_STAT5	361	364	PF00017	0.449
LIG_SH2_STAT5	382	385	PF00017	0.450
LIG_SH2_STAT5	426	429	PF00017	0.484
LIG_SH2_STAT5	523	526	PF00017	0.473
LIG_SH2_STAT5	531	534	PF00017	0.244
LIG_SH2_STAT5	586	589	PF00017	0.217
LIG_SH3_3	16	22	PF00018	0.694
LIG_SH3_3	183	189	PF00018	0.721
LIG_SH3_3	212	218	PF00018	0.666
LIG_SH3_3	27	33	PF00018	0.600
LIG_SH3_3	336	342	PF00018	0.253
LIG_SH3_3	382	388	PF00018	0.559
LIG_SH3_3	494	500	PF00018	0.441
LIG_SH3_3	559	565	PF00018	0.224
LIG_SH3_3	566	572	PF00018	0.208
LIG_SUMO_SIM_anti_2	313	319	PF11976	0.260
LIG_SUMO_SIM_anti_2	458	463	PF11976	0.419
LIG_SUMO_SIM_par_1	294	301	PF11976	0.290
LIG_SUMO_SIM_par_1	313	319	PF11976	0.140
LIG_SUMO_SIM_par_1	558	564	PF11976	0.241
LIG_TRAF2_1	116	119	PF00917	0.571
LIG_TRAF2_1	491	494	PF00917	0.417
LIG_TRFH_1	549	553	PF08558	0.268
LIG_UBA3_1	524	529	PF00899	0.477
LIG_WRC_WIRS_1	299	304	PF05994	0.359
LIG_WRC_WIRS_1	333	338	PF05994	0.328
LIG_WRC_WIRS_1	391	396	PF05994	0.441
LIG_WW_3	23	27	PF00397	0.627
MOD_CDK_SPK_2	242	247	PF00069	0.615
MOD_CDK_SPxK_1	190	196	PF00069	0.706
MOD_CDK_SPxK_1	20	26	PF00069	0.667
MOD_CDK_SPxxK_3	283	290	PF00069	0.594
MOD_CK1_1	177	183	PF00069	0.655
MOD_CK1_1	235	241	PF00069	0.667
MOD_CK1_1	267	273	PF00069	0.689
MOD_CK1_1	279	285	PF00069	0.510
MOD_CK1_1	298	304	PF00069	0.445
MOD_CK1_1	319	325	PF00069	0.263
MOD_CK1_1	64	70	PF00069	0.661
MOD_CK1_1	78	84	PF00069	0.565
MOD_CK2_1	112	118	PF00069	0.583
MOD_CK2_1	204	210	PF00069	0.576
MOD_CK2_1	508	514	PF00069	0.460
MOD_Cter_Amidation	239	242	PF01082	0.461
MOD_DYRK1A_RPxSP_1	20	24	PF00069	0.718
MOD_GlcNHglycan	176	179	PF01048	0.442
MOD_GlcNHglycan	180	183	PF01048	0.441
MOD_GlcNHglycan	218	221	PF01048	0.446
MOD_GlcNHglycan	223	226	PF01048	0.401
MOD_GlcNHglycan	441	445	PF01048	0.227
MOD_GlcNHglycan	452	455	PF01048	0.254
MOD_GlcNHglycan	76	80	PF01048	0.461
MOD_GSK3_1	174	181	PF00069	0.624
MOD_GSK3_1	195	202	PF00069	0.797
MOD_GSK3_1	204	211	PF00069	0.726
MOD_GSK3_1	279	286	PF00069	0.587
MOD_GSK3_1	291	298	PF00069	0.383
MOD_GSK3_1	60	67	PF00069	0.653
MOD_GSK3_1	84	91	PF00069	0.733
MOD_LATS_1	110	116	PF00433	0.699
MOD_N-GLC_1	264	269	PF02516	0.265
MOD_NEK2_1	295	300	PF00069	0.252
MOD_NEK2_1	310	315	PF00069	0.345
MOD_NEK2_1	316	321	PF00069	0.451
MOD_NEK2_1	603	608	PF00069	0.284
MOD_NEK2_1	62	67	PF00069	0.584
MOD_OFUCOSY	439	446	PF10250	0.284
MOD_PIKK_1	14	20	PF00454	0.677
MOD_PIKK_1	81	87	PF00454	0.785
MOD_PKA_1	54	60	PF00069	0.612
MOD_PKA_2	14	20	PF00069	0.630
MOD_PKA_2	166	172	PF00069	0.508
MOD_PKA_2	235	241	PF00069	0.637
MOD_PKA_2	265	271	PF00069	0.524
MOD_PKA_2	319	325	PF00069	0.284
MOD_PKA_2	337	343	PF00069	0.484
MOD_PKA_2	447	453	PF00069	0.417
MOD_PKA_2	54	60	PF00069	0.659
MOD_PKA_2	89	95	PF00069	0.655
MOD_Plk_1	196	202	PF00069	0.718
MOD_Plk_1	405	411	PF00069	0.376
MOD_Plk_1	466	472	PF00069	0.484
MOD_Plk_4	291	297	PF00069	0.400
MOD_Plk_4	455	461	PF00069	0.429
MOD_Plk_4	466	472	PF00069	0.399
MOD_Plk_4	54	60	PF00069	0.542
MOD_ProDKin_1	190	196	PF00069	0.755
MOD_ProDKin_1	20	26	PF00069	0.719
MOD_ProDKin_1	214	220	PF00069	0.622
MOD_ProDKin_1	242	248	PF00069	0.604
MOD_ProDKin_1	283	289	PF00069	0.602
MOD_ProDKin_1	493	499	PF00069	0.441
MOD_SUMO_rev_2	146	152	PF00179	0.577
TRG_DiLeu_BaLyEn_6	250	255	PF01217	0.542
TRG_ENDOCYTIC_2	361	364	PF00928	0.404
TRG_ENDOCYTIC_2	382	385	PF00928	0.417
TRG_ENDOCYTIC_2	426	429	PF00928	0.484
TRG_ENDOCYTIC_2	523	526	PF00928	0.456
TRG_ENDOCYTIC_2	531	534	PF00928	0.228
TRG_ENDOCYTIC_2	549	552	PF00928	0.309
TRG_ER_diArg_1	152	154	PF00400	0.502
TRG_ER_diArg_1	290	292	PF00400	0.483
TRG_ER_diArg_1	372	375	PF00400	0.484
TRG_ER_diArg_1	539	542	PF00400	0.398
TRG_ER_diArg_1	54	56	PF00400	0.625
TRG_ER_diArg_1	555	557	PF00400	0.190
TRG_Pf-PMV_PEXEL_1	591	596	PF00026	0.463
TRG_Pf-PMV_PEXEL_1	598	602	PF00026	0.417

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE36	Leptomonas seymouri	58%	94%
A0A3R7NQK7	Trypanosoma rangeli	45%	100%
A0A3S7WZ82	Leishmania donovani	90%	100%
A4HEI1	Leishmania braziliensis	77%	99%
A4I1K9	Leishmania infantum	89%	100%
C9ZK51	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q08650	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
Q4Q9S8	Leishmania major	88%	100%