WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Flagella-associated protein 251, putative

Species:

Leishmania mexicana

UniProt:

E9AXP0_LEIMU

TriTrypDb:

LmxM.25.1600

Length:

1171

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0031514	motile cilium	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AXP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXP0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	424	428	PF00656	0.662
CLV_C14_Caspase3-7	702	706	PF00656	0.438
CLV_C14_Caspase3-7	737	741	PF00656	0.426
CLV_C14_Caspase3-7	768	772	PF00656	0.556
CLV_NRD_NRD_1	114	116	PF00675	0.565
CLV_NRD_NRD_1	205	207	PF00675	0.441
CLV_NRD_NRD_1	252	254	PF00675	0.428
CLV_NRD_NRD_1	279	281	PF00675	0.408
CLV_NRD_NRD_1	301	303	PF00675	0.576
CLV_NRD_NRD_1	58	60	PF00675	0.496
CLV_PCSK_KEX2_1	113	115	PF00082	0.572
CLV_PCSK_KEX2_1	156	158	PF00082	0.583
CLV_PCSK_KEX2_1	205	207	PF00082	0.441
CLV_PCSK_KEX2_1	252	254	PF00082	0.428
CLV_PCSK_KEX2_1	279	281	PF00082	0.408
CLV_PCSK_KEX2_1	301	303	PF00082	0.576
CLV_PCSK_KEX2_1	520	522	PF00082	0.365
CLV_PCSK_KEX2_1	696	698	PF00082	0.365
CLV_PCSK_KEX2_1	978	980	PF00082	0.410
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.566
CLV_PCSK_PC1ET2_1	520	522	PF00082	0.365
CLV_PCSK_PC1ET2_1	696	698	PF00082	0.365
CLV_PCSK_PC1ET2_1	978	980	PF00082	0.410
CLV_PCSK_SKI1_1	1047	1051	PF00082	0.408
CLV_PCSK_SKI1_1	1122	1126	PF00082	0.437
CLV_PCSK_SKI1_1	280	284	PF00082	0.323
CLV_PCSK_SKI1_1	301	305	PF00082	0.459
CLV_PCSK_SKI1_1	341	345	PF00082	0.529
CLV_PCSK_SKI1_1	348	352	PF00082	0.342
CLV_PCSK_SKI1_1	521	525	PF00082	0.375
CLV_PCSK_SKI1_1	529	533	PF00082	0.384
CLV_PCSK_SKI1_1	59	63	PF00082	0.343
CLV_PCSK_SKI1_1	746	750	PF00082	0.617
CLV_PCSK_SKI1_1	80	84	PF00082	0.467
CLV_PCSK_SKI1_1	817	821	PF00082	0.326
CLV_PCSK_SKI1_1	978	982	PF00082	0.451
DEG_APCC_DBOX_1	1074	1082	PF00400	0.398
DEG_APCC_DBOX_1	520	528	PF00400	0.388
DEG_APCC_DBOX_1	978	986	PF00400	0.410
DEG_Nend_UBRbox_1	1	4	PF02207	0.621
DEG_ODPH_VHL_1	820	833	PF01847	0.470
DOC_CKS1_1	463	468	PF01111	0.558
DOC_CYCLIN_RxL_1	1118	1129	PF00134	0.438
DOC_CYCLIN_RxL_1	529	541	PF00134	0.428
DOC_MAPK_gen_1	113	122	PF00069	0.536
DOC_MAPK_gen_1	205	213	PF00069	0.407
DOC_MAPK_gen_1	520	527	PF00069	0.348
DOC_MAPK_gen_1	800	808	PF00069	0.486
DOC_MAPK_gen_1	933	940	PF00069	0.492
DOC_MAPK_MEF2A_6	184	193	PF00069	0.458
DOC_MAPK_MEF2A_6	520	527	PF00069	0.348
DOC_PP1_RVXF_1	17	23	PF00149	0.383
DOC_PP1_RVXF_1	277	284	PF00149	0.324
DOC_PP1_RVXF_1	386	393	PF00149	0.329
DOC_PP1_RVXF_1	532	539	PF00149	0.324
DOC_PP2B_LxvP_1	847	850	PF13499	0.609
DOC_PP4_FxxP_1	441	444	PF00568	0.379
DOC_PP4_FxxP_1	463	466	PF00568	0.530
DOC_PP4_FxxP_1	824	827	PF00568	0.358
DOC_SPAK_OSR1_1	100	104	PF12202	0.337
DOC_USP7_MATH_1	1097	1101	PF00917	0.411
DOC_USP7_MATH_1	400	404	PF00917	0.328
DOC_USP7_MATH_1	436	440	PF00917	0.479
DOC_USP7_MATH_1	490	494	PF00917	0.418
DOC_USP7_MATH_1	590	594	PF00917	0.766
DOC_USP7_MATH_1	611	615	PF00917	0.677
DOC_USP7_MATH_1	616	620	PF00917	0.466
DOC_USP7_MATH_1	649	653	PF00917	0.509
DOC_USP7_MATH_1	753	757	PF00917	0.601
DOC_USP7_MATH_1	843	847	PF00917	0.625
DOC_USP7_MATH_1	875	879	PF00917	0.370
DOC_USP7_MATH_1	9	13	PF00917	0.479
DOC_USP7_UBL2_3	344	348	PF12436	0.434
DOC_WW_Pin1_4	191	196	PF00397	0.453
DOC_WW_Pin1_4	236	241	PF00397	0.528
DOC_WW_Pin1_4	244	249	PF00397	0.380
DOC_WW_Pin1_4	266	271	PF00397	0.239
DOC_WW_Pin1_4	292	297	PF00397	0.351
DOC_WW_Pin1_4	462	467	PF00397	0.539
DOC_WW_Pin1_4	623	628	PF00397	0.470
DOC_WW_Pin1_4	7	12	PF00397	0.561
DOC_WW_Pin1_4	704	709	PF00397	0.513
DOC_WW_Pin1_4	722	727	PF00397	0.257
DOC_WW_Pin1_4	839	844	PF00397	0.643
DOC_WW_Pin1_4	845	850	PF00397	0.647
DOC_WW_Pin1_4	919	924	PF00397	0.534
LIG_14-3-3_CanoR_1	100	110	PF00244	0.460
LIG_14-3-3_CanoR_1	302	308	PF00244	0.534
LIG_14-3-3_CanoR_1	489	495	PF00244	0.290
LIG_14-3-3_CanoR_1	688	693	PF00244	0.330
LIG_Actin_RPEL_3	514	533	PF02755	0.462
LIG_Actin_WH2_2	1074	1092	PF00022	0.434
LIG_Actin_WH2_2	372	390	PF00022	0.320
LIG_BRCT_BRCA1_1	402	406	PF00533	0.317
LIG_Clathr_ClatBox_1	1124	1128	PF01394	0.405
LIG_CSL_BTD_1	730	733	PF09270	0.507
LIG_deltaCOP1_diTrp_1	21	24	PF00928	0.316
LIG_FHA_1	1008	1014	PF00498	0.342
LIG_FHA_1	1068	1074	PF00498	0.399
LIG_FHA_1	1097	1103	PF00498	0.529
LIG_FHA_1	121	127	PF00498	0.473
LIG_FHA_1	273	279	PF00498	0.333
LIG_FHA_1	309	315	PF00498	0.314
LIG_FHA_1	356	362	PF00498	0.272
LIG_FHA_1	548	554	PF00498	0.438
LIG_FHA_1	572	578	PF00498	0.656
LIG_FHA_1	66	72	PF00498	0.339
LIG_FHA_1	708	714	PF00498	0.495
LIG_FHA_1	887	893	PF00498	0.445
LIG_FHA_2	102	108	PF00498	0.470
LIG_FHA_2	1051	1057	PF00498	0.428
LIG_FHA_2	1082	1088	PF00498	0.420
LIG_FHA_2	1158	1164	PF00498	0.620
LIG_FHA_2	412	418	PF00498	0.634
LIG_FHA_2	440	446	PF00498	0.469
LIG_FHA_2	559	565	PF00498	0.436
LIG_FHA_2	632	638	PF00498	0.457
LIG_FHA_2	749	755	PF00498	0.528
LIG_FHA_2	891	897	PF00498	0.464
LIG_GBD_Chelix_1	379	387	PF00786	0.433
LIG_Integrin_RGD_1	769	771	PF01839	0.656
LIG_Integrin_RGD_1	872	874	PF01839	0.475
LIG_LIR_Apic_2	439	444	PF02991	0.385
LIG_LIR_Apic_2	823	827	PF02991	0.359
LIG_LIR_Gen_1	1035	1044	PF02991	0.305
LIG_LIR_Gen_1	259	270	PF02991	0.510
LIG_LIR_Gen_1	3	13	PF02991	0.621
LIG_LIR_Gen_1	541	549	PF02991	0.502
LIG_LIR_Gen_1	700	708	PF02991	0.368
LIG_LIR_Gen_1	727	733	PF02991	0.392
LIG_LIR_Gen_1	924	930	PF02991	0.496
LIG_LIR_Nem_3	1035	1039	PF02991	0.313
LIG_LIR_Nem_3	1058	1064	PF02991	0.370
LIG_LIR_Nem_3	1076	1082	PF02991	0.366
LIG_LIR_Nem_3	182	188	PF02991	0.332
LIG_LIR_Nem_3	259	265	PF02991	0.448
LIG_LIR_Nem_3	3	8	PF02991	0.639
LIG_LIR_Nem_3	526	531	PF02991	0.374
LIG_LIR_Nem_3	541	547	PF02991	0.409
LIG_LIR_Nem_3	657	661	PF02991	0.410
LIG_LIR_Nem_3	700	704	PF02991	0.376
LIG_LIR_Nem_3	727	732	PF02991	0.401
LIG_LIR_Nem_3	801	807	PF02991	0.443
LIG_LIR_Nem_3	924	929	PF02991	0.494
LIG_LIR_Nem_3	961	965	PF02991	0.363
LIG_NRBOX	1077	1083	PF00104	0.426
LIG_NRBOX	791	797	PF00104	0.462
LIG_PALB2_WD40_1	388	396	PF16756	0.349
LIG_PCNA_PIPBox_1	376	385	PF02747	0.354
LIG_PCNA_PIPBox_1	956	965	PF02747	0.353
LIG_PDZ_Class_1	1166	1171	PF00595	0.620
LIG_REV1ctd_RIR_1	746	756	PF16727	0.400
LIG_RPA_C_Fungi	1113	1125	PF08784	0.484
LIG_SH2_CRK	1046	1050	PF00017	0.342
LIG_SH2_CRK	185	189	PF00017	0.348
LIG_SH2_CRK	294	298	PF00017	0.370
LIG_SH2_CRK	72	76	PF00017	0.364
LIG_SH2_CRK	87	91	PF00017	0.365
LIG_SH2_CRK	965	969	PF00017	0.345
LIG_SH2_GRB2like	1043	1046	PF00017	0.293
LIG_SH2_NCK_1	1011	1015	PF00017	0.347
LIG_SH2_NCK_1	701	705	PF00017	0.392
LIG_SH2_NCK_1	72	76	PF00017	0.378
LIG_SH2_NCK_1	87	91	PF00017	0.314
LIG_SH2_PTP2	5	8	PF00017	0.318
LIG_SH2_SRC	315	318	PF00017	0.466
LIG_SH2_SRC	644	647	PF00017	0.431
LIG_SH2_STAT3	1017	1020	PF00017	0.246
LIG_SH2_STAT3	802	805	PF00017	0.420
LIG_SH2_STAT3	964	967	PF00017	0.336
LIG_SH2_STAT5	1043	1046	PF00017	0.293
LIG_SH2_STAT5	1159	1162	PF00017	0.619
LIG_SH2_STAT5	199	202	PF00017	0.334
LIG_SH2_STAT5	315	318	PF00017	0.466
LIG_SH2_STAT5	370	373	PF00017	0.295
LIG_SH2_STAT5	5	8	PF00017	0.574
LIG_SH2_STAT5	517	520	PF00017	0.361
LIG_SH2_STAT5	63	66	PF00017	0.337
LIG_SH2_STAT5	646	649	PF00017	0.527
LIG_SH2_STAT5	807	810	PF00017	0.424
LIG_SH2_STAT5	962	965	PF00017	0.360
LIG_SH3_3	311	317	PF00018	0.407
LIG_SH3_3	495	501	PF00018	0.382
LIG_SH3_3	816	822	PF00018	0.329
LIG_SH3_3	833	839	PF00018	0.425
LIG_SH3_3	935	941	PF00018	0.485
LIG_SUMO_SIM_anti_2	164	170	PF11976	0.213
LIG_SUMO_SIM_par_1	521	526	PF11976	0.378
LIG_SUMO_SIM_par_1	793	799	PF11976	0.405
LIG_TRAF2_1	414	417	PF00917	0.610
LIG_TRAF2_1	561	564	PF00917	0.396
LIG_TRAF2_1	619	622	PF00917	0.459
LIG_TRAF2_1	682	685	PF00917	0.386
LIG_TYR_ITIM	1044	1049	PF00017	0.326
LIG_TYR_ITIM	699	704	PF00017	0.370
LIG_TYR_ITIM	70	75	PF00017	0.341
LIG_WRC_WIRS_1	262	267	PF05994	0.455
MOD_CK1_1	266	272	PF00069	0.232
MOD_CK1_1	439	445	PF00069	0.508
MOD_CK1_1	626	632	PF00069	0.451
MOD_CK1_1	650	656	PF00069	0.574
MOD_CK1_1	707	713	PF00069	0.540
MOD_CK1_1	721	727	PF00069	0.363
MOD_CK1_1	809	815	PF00069	0.362
MOD_CK1_1	842	848	PF00069	0.608
MOD_CK1_1	88	94	PF00069	0.368
MOD_CK1_1	887	893	PF00069	0.420
MOD_CK2_1	101	107	PF00069	0.462
MOD_CK2_1	1081	1087	PF00069	0.399
MOD_CK2_1	282	288	PF00069	0.320
MOD_CK2_1	411	417	PF00069	0.641
MOD_CK2_1	558	564	PF00069	0.386
MOD_CK2_1	598	604	PF00069	0.556
MOD_CK2_1	616	622	PF00069	0.503
MOD_CK2_1	703	709	PF00069	0.470
MOD_CK2_1	748	754	PF00069	0.652
MOD_CK2_1	9	15	PF00069	0.460
MOD_CK2_1	919	925	PF00069	0.516
MOD_CK2_1	999	1005	PF00069	0.346
MOD_GlcNHglycan	1155	1158	PF01048	0.679
MOD_GlcNHglycan	323	326	PF01048	0.319
MOD_GlcNHglycan	44	47	PF01048	0.697
MOD_GlcNHglycan	508	511	PF01048	0.324
MOD_GlcNHglycan	539	543	PF01048	0.387
MOD_GlcNHglycan	594	597	PF01048	0.618
MOD_GlcNHglycan	649	652	PF01048	0.590
MOD_GlcNHglycan	761	766	PF01048	0.769
MOD_GlcNHglycan	786	789	PF01048	0.654
MOD_GSK3_1	1081	1088	PF00069	0.492
MOD_GSK3_1	1153	1160	PF00069	0.645
MOD_GSK3_1	187	194	PF00069	0.436
MOD_GSK3_1	227	234	PF00069	0.638
MOD_GSK3_1	355	362	PF00069	0.325
MOD_GSK3_1	432	439	PF00069	0.577
MOD_GSK3_1	446	453	PF00069	0.473
MOD_GSK3_1	462	469	PF00069	0.578
MOD_GSK3_1	572	579	PF00069	0.670
MOD_GSK3_1	586	593	PF00069	0.760
MOD_GSK3_1	61	68	PF00069	0.361
MOD_GSK3_1	703	710	PF00069	0.388
MOD_GSK3_1	718	725	PF00069	0.374
MOD_GSK3_1	748	755	PF00069	0.671
MOD_GSK3_1	757	764	PF00069	0.739
MOD_GSK3_1	839	846	PF00069	0.578
MOD_GSK3_1	85	92	PF00069	0.388
MOD_GSK3_1	886	893	PF00069	0.344
MOD_GSK3_1	921	928	PF00069	0.322
MOD_N-GLC_1	308	313	PF02516	0.330
MOD_N-GLC_1	35	40	PF02516	0.395
MOD_N-GLC_1	572	577	PF02516	0.661
MOD_N-GLC_1	680	685	PF02516	0.369
MOD_N-GLC_1	809	814	PF02516	0.490
MOD_NEK2_1	1034	1039	PF00069	0.337
MOD_NEK2_1	1050	1055	PF00069	0.386
MOD_NEK2_1	1081	1086	PF00069	0.326
MOD_NEK2_1	122	127	PF00069	0.618
MOD_NEK2_1	179	184	PF00069	0.420
MOD_NEK2_1	272	277	PF00069	0.294
MOD_NEK2_1	303	308	PF00069	0.417
MOD_NEK2_1	321	326	PF00069	0.319
MOD_NEK2_1	363	368	PF00069	0.361
MOD_NEK2_1	446	451	PF00069	0.355
MOD_NEK2_1	631	636	PF00069	0.438
MOD_NEK2_1	703	708	PF00069	0.441
MOD_NEK2_1	713	718	PF00069	0.367
MOD_NEK2_1	748	753	PF00069	0.650
MOD_NEK2_1	993	998	PF00069	0.482
MOD_NEK2_2	436	441	PF00069	0.468
MOD_PIKK_1	1034	1040	PF00454	0.316
MOD_PIKK_1	1081	1087	PF00454	0.263
MOD_PIKK_1	120	126	PF00454	0.572
MOD_PIKK_1	130	136	PF00454	0.675
MOD_PIKK_1	214	220	PF00454	0.516
MOD_PIKK_1	263	269	PF00454	0.483
MOD_PIKK_1	308	314	PF00454	0.330
MOD_PIKK_1	718	724	PF00454	0.361
MOD_PIKK_1	740	746	PF00454	0.490
MOD_PIKK_1	75	81	PF00454	0.330
MOD_PIKK_1	864	870	PF00454	0.444
MOD_PIKK_1	985	991	PF00454	0.326
MOD_PK_1	688	694	PF00069	0.348
MOD_PKA_2	1067	1073	PF00069	0.437
MOD_PKA_2	85	91	PF00069	0.413
MOD_Plk_1	1034	1040	PF00069	0.457
MOD_Plk_1	258	264	PF00069	0.429
MOD_Plk_1	346	352	PF00069	0.394
MOD_Plk_1	35	41	PF00069	0.432
MOD_Plk_1	564	570	PF00069	0.544
MOD_Plk_1	572	578	PF00069	0.712
MOD_Plk_2-3	558	564	PF00069	0.405
MOD_Plk_2-3	734	740	PF00069	0.432
MOD_Plk_2-3	757	763	PF00069	0.562
MOD_Plk_4	1097	1103	PF00069	0.510
MOD_Plk_4	161	167	PF00069	0.286
MOD_Plk_4	258	264	PF00069	0.524
MOD_Plk_4	316	322	PF00069	0.361
MOD_Plk_4	346	352	PF00069	0.390
MOD_Plk_4	359	365	PF00069	0.270
MOD_Plk_4	436	442	PF00069	0.549
MOD_Plk_4	450	456	PF00069	0.479
MOD_Plk_4	523	529	PF00069	0.355
MOD_Plk_4	626	632	PF00069	0.467
MOD_Plk_4	734	740	PF00069	0.542
MOD_Plk_4	815	821	PF00069	0.345
MOD_Plk_4	85	91	PF00069	0.391
MOD_Plk_4	887	893	PF00069	0.469
MOD_Plk_4	925	931	PF00069	0.423
MOD_ProDKin_1	191	197	PF00069	0.454
MOD_ProDKin_1	236	242	PF00069	0.526
MOD_ProDKin_1	244	250	PF00069	0.375
MOD_ProDKin_1	266	272	PF00069	0.232
MOD_ProDKin_1	292	298	PF00069	0.357
MOD_ProDKin_1	462	468	PF00069	0.549
MOD_ProDKin_1	623	629	PF00069	0.470
MOD_ProDKin_1	7	13	PF00069	0.549
MOD_ProDKin_1	704	710	PF00069	0.514
MOD_ProDKin_1	722	728	PF00069	0.252
MOD_ProDKin_1	839	845	PF00069	0.644
MOD_ProDKin_1	919	925	PF00069	0.534
MOD_SUMO_rev_2	106	112	PF00179	0.414
MOD_SUMO_rev_2	28	32	PF00179	0.511
TRG_AP2beta_CARGO_1	1058	1068	PF09066	0.429
TRG_DiLeu_BaEn_1	685	690	PF01217	0.436
TRG_DiLeu_BaEn_1	709	714	PF01217	0.509
TRG_DiLeu_BaLyEn_6	478	483	PF01217	0.499
TRG_DiLeu_BaLyEn_6	694	699	PF01217	0.385
TRG_DiLeu_LyEn_5	685	690	PF01217	0.446
TRG_ENDOCYTIC_2	1046	1049	PF00928	0.334
TRG_ENDOCYTIC_2	185	188	PF00928	0.339
TRG_ENDOCYTIC_2	5	8	PF00928	0.493
TRG_ENDOCYTIC_2	644	647	PF00928	0.461
TRG_ENDOCYTIC_2	701	704	PF00928	0.368
TRG_ENDOCYTIC_2	72	75	PF00928	0.352
TRG_ENDOCYTIC_2	87	90	PF00928	0.369
TRG_ENDOCYTIC_2	965	968	PF00928	0.340
TRG_ER_diArg_1	112	115	PF00400	0.514
TRG_ER_diArg_1	251	253	PF00400	0.429
TRG_ER_diArg_1	278	280	PF00400	0.433
TRG_ER_diArg_1	301	303	PF00400	0.576
TRG_ER_diArg_1	479	482	PF00400	0.471
TRG_ER_diArg_1	913	916	PF00400	0.467
TRG_Pf-PMV_PEXEL_1	1062	1067	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	114	118	PF00026	0.529
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.592
TRG_Pf-PMV_PEXEL_1	481	485	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	534	539	PF00026	0.324
TRG_Pf-PMV_PEXEL_1	696	700	PF00026	0.356

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1H7	Leptomonas seymouri	68%	97%
A0A0S4ILG2	Bodo saltans	43%	100%
A0A1X0NYM6	Trypanosomatidae	49%	100%
A0A3R7KE52	Trypanosoma rangeli	51%	100%
A0A3S5H7E9	Leishmania donovani	93%	100%
A4HEI4	Leishmania braziliensis	83%	99%
A4I1K6	Leishmania infantum	93%	94%
A8IRK7	Chlamydomonas reinhardtii	27%	100%
C9ZK47	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
Q4Q9T1	Leishmania major	94%	100%
V5B2C6	Trypanosoma cruzi	51%	100%