Putative casein kinase I

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

casein kinase I, putative

Species:

Leishmania mexicana

UniProt:

E9AXN8_LEIMU

TriTrypDb:

LmxM.25.1580

Length:

521

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	3
GO:0005737	cytoplasm	2	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	3
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AXN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXN8

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	19
GO:0006793	phosphorus metabolic process	3	19
GO:0006796	phosphate-containing compound metabolic process	4	19
GO:0006807	nitrogen compound metabolic process	2	19
GO:0008152	metabolic process	1	19
GO:0009987	cellular process	1	19
GO:0016310	phosphorylation	5	19
GO:0019538	protein metabolic process	3	19
GO:0036211	protein modification process	4	19
GO:0043170	macromolecule metabolic process	3	19
GO:0043412	macromolecule modification	4	19
GO:0044237	cellular metabolic process	2	19
GO:0044238	primary metabolic process	2	19
GO:0071704	organic substance metabolic process	2	19
GO:1901564	organonitrogen compound metabolic process	3	19
GO:0006810	transport	3	3
GO:0006897	endocytosis	5	3
GO:0007165	signal transduction	2	3
GO:0016192	vesicle-mediated transport	4	3
GO:0018105	peptidyl-serine phosphorylation	6	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018209	peptidyl-serine modification	6	3
GO:0050789	regulation of biological process	2	3
GO:0050794	regulation of cellular process	3	3
GO:0051179	localization	1	3
GO:0051234	establishment of localization	2	3
GO:0065007	biological regulation	1	3

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	19
GO:0003824	catalytic activity	1	19
GO:0004672	protein kinase activity	3	19
GO:0005488	binding	1	19
GO:0005524	ATP binding	5	19
GO:0016301	kinase activity	4	19
GO:0016740	transferase activity	2	19
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	19
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	19
GO:0017076	purine nucleotide binding	4	19
GO:0030554	adenyl nucleotide binding	5	19
GO:0032553	ribonucleotide binding	3	19
GO:0032555	purine ribonucleotide binding	4	19
GO:0032559	adenyl ribonucleotide binding	5	19
GO:0035639	purine ribonucleoside triphosphate binding	4	19
GO:0036094	small molecule binding	2	19
GO:0043167	ion binding	2	19
GO:0043168	anion binding	3	19
GO:0097159	organic cyclic compound binding	2	19
GO:0097367	carbohydrate derivative binding	2	19
GO:0140096	catalytic activity, acting on a protein	2	19
GO:1901265	nucleoside phosphate binding	3	19
GO:1901363	heterocyclic compound binding	2	19
GO:0004674	protein serine/threonine kinase activity	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	489	493	PF00656	0.547
CLV_NRD_NRD_1	172	174	PF00675	0.332
CLV_NRD_NRD_1	266	268	PF00675	0.388
CLV_NRD_NRD_1	344	346	PF00675	0.506
CLV_NRD_NRD_1	412	414	PF00675	0.786
CLV_NRD_NRD_1	53	55	PF00675	0.522
CLV_PCSK_KEX2_1	172	174	PF00082	0.321
CLV_PCSK_KEX2_1	266	268	PF00082	0.388
CLV_PCSK_KEX2_1	344	346	PF00082	0.472
CLV_PCSK_KEX2_1	352	354	PF00082	0.487
CLV_PCSK_KEX2_1	412	414	PF00082	0.786
CLV_PCSK_KEX2_1	450	452	PF00082	0.528
CLV_PCSK_KEX2_1	456	458	PF00082	0.572
CLV_PCSK_KEX2_1	506	508	PF00082	0.554
CLV_PCSK_PC1ET2_1	352	354	PF00082	0.502
CLV_PCSK_PC1ET2_1	450	452	PF00082	0.525
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.568
CLV_PCSK_PC1ET2_1	506	508	PF00082	0.554
CLV_PCSK_PC7_1	348	354	PF00082	0.413
CLV_PCSK_SKI1_1	177	181	PF00082	0.434
CLV_PCSK_SKI1_1	201	205	PF00082	0.345
CLV_PCSK_SKI1_1	21	25	PF00082	0.414
CLV_PCSK_SKI1_1	245	249	PF00082	0.362
CLV_PCSK_SKI1_1	298	302	PF00082	0.468
CLV_PCSK_SKI1_1	306	310	PF00082	0.414
CLV_PCSK_SKI1_1	320	324	PF00082	0.442
CLV_PCSK_SKI1_1	344	348	PF00082	0.418
CLV_PCSK_SKI1_1	507	511	PF00082	0.641
CLV_PCSK_SKI1_1	85	89	PF00082	0.480
DEG_APCC_DBOX_1	172	180	PF00400	0.406
DEG_APCC_DBOX_1	266	274	PF00400	0.442
DEG_SCF_FBW7_2	307	313	PF00400	0.262
DOC_CKS1_1	307	312	PF01111	0.406
DOC_CKS1_1	417	422	PF01111	0.553
DOC_CYCLIN_RxL_1	327	335	PF00134	0.430
DOC_CYCLIN_RxL_1	348	357	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	382	388	PF00134	0.586
DOC_MAPK_gen_1	213	221	PF00069	0.374
DOC_MAPK_gen_1	234	241	PF00069	0.332
DOC_MAPK_gen_1	352	358	PF00069	0.580
DOC_MAPK_gen_1	42	52	PF00069	0.418
DOC_MAPK_MEF2A_6	43	52	PF00069	0.416
DOC_PP1_RVXF_1	226	232	PF00149	0.406
DOC_PP1_RVXF_1	328	335	PF00149	0.426
DOC_PP2B_LxvP_1	356	359	PF13499	0.406
DOC_PP2B_LxvP_1	382	385	PF13499	0.566
DOC_PP4_FxxP_1	417	420	PF00568	0.682
DOC_PP4_FxxP_1	510	513	PF00568	0.555
DOC_USP7_MATH_1	102	106	PF00917	0.559
DOC_USP7_MATH_1	2	6	PF00917	0.589
DOC_USP7_MATH_1	376	380	PF00917	0.733
DOC_USP7_MATH_1	386	390	PF00917	0.684
DOC_USP7_MATH_1	395	399	PF00917	0.616
DOC_USP7_MATH_1	502	506	PF00917	0.719
DOC_USP7_MATH_1	89	93	PF00917	0.477
DOC_USP7_UBL2_3	316	320	PF12436	0.592
DOC_USP7_UBL2_3	51	55	PF12436	0.512
DOC_WW_Pin1_4	106	111	PF00397	0.536
DOC_WW_Pin1_4	306	311	PF00397	0.427
DOC_WW_Pin1_4	391	396	PF00397	0.655
DOC_WW_Pin1_4	416	421	PF00397	0.616
DOC_WW_Pin1_4	509	514	PF00397	0.625
LIG_14-3-3_CanoR_1	129	137	PF00244	0.450
LIG_14-3-3_CanoR_1	172	177	PF00244	0.371
LIG_14-3-3_CanoR_1	330	335	PF00244	0.428
LIG_14-3-3_CanoR_1	353	359	PF00244	0.402
LIG_14-3-3_CanoR_1	399	404	PF00244	0.767
LIG_14-3-3_CanoR_1	412	416	PF00244	0.584
LIG_14-3-3_CanoR_1	478	484	PF00244	0.637
LIG_14-3-3_CanoR_1	507	513	PF00244	0.515
LIG_Actin_WH2_2	269	284	PF00022	0.415
LIG_AP2alpha_1	33	37	PF02296	0.392
LIG_APCC_ABBAyCdc20_2	196	202	PF00400	0.347
LIG_BIR_II_1	1	5	PF00653	0.529
LIG_BRCT_BRCA1_1	271	275	PF00533	0.291
LIG_BRCT_BRCA1_1	364	368	PF00533	0.493
LIG_BRCT_BRCA1_1	413	417	PF00533	0.722
LIG_BRCT_BRCA1_1	499	503	PF00533	0.541
LIG_deltaCOP1_diTrp_1	442	448	PF00928	0.512
LIG_FHA_1	297	303	PF00498	0.378
LIG_FHA_1	509	515	PF00498	0.697
LIG_FHA_2	1	7	PF00498	0.770
LIG_FHA_2	307	313	PF00498	0.356
LIG_FHA_2	428	434	PF00498	0.662
LIG_FHA_2	493	499	PF00498	0.713
LIG_FHA_2	9	15	PF00498	0.624
LIG_GBD_Chelix_1	273	281	PF00786	0.226
LIG_LIR_Apic_2	414	420	PF02991	0.722
LIG_LIR_Gen_1	148	158	PF02991	0.427
LIG_LIR_Gen_1	272	281	PF02991	0.320
LIG_LIR_Gen_1	339	347	PF02991	0.389
LIG_LIR_Gen_1	442	453	PF02991	0.557
LIG_LIR_Nem_3	227	233	PF02991	0.327
LIG_LIR_Nem_3	272	278	PF02991	0.355
LIG_LIR_Nem_3	284	290	PF02991	0.359
LIG_LIR_Nem_3	32	36	PF02991	0.478
LIG_LIR_Nem_3	321	325	PF02991	0.418
LIG_LIR_Nem_3	339	343	PF02991	0.302
LIG_LIR_Nem_3	442	448	PF02991	0.522
LIG_LIR_Nem_3	66	72	PF02991	0.461
LIG_LYPXL_yS_3	59	62	PF13949	0.502
LIG_MYND_3	428	432	PF01753	0.544
LIG_Pex14_2	33	37	PF04695	0.479
LIG_PTB_Apo_2	27	34	PF02174	0.413
LIG_SH2_CRK	340	344	PF00017	0.416
LIG_SH2_CRK	69	73	PF00017	0.444
LIG_SH2_STAP1	441	445	PF00017	0.519
LIG_SH2_STAP1	64	68	PF00017	0.410
LIG_SH2_STAT5	144	147	PF00017	0.383
LIG_SH2_STAT5	169	172	PF00017	0.324
LIG_SH2_STAT5	192	195	PF00017	0.413
LIG_SH2_STAT5	220	223	PF00017	0.374
LIG_SH2_STAT5	253	256	PF00017	0.373
LIG_SH2_STAT5	279	282	PF00017	0.378
LIG_SH2_STAT5	325	328	PF00017	0.405
LIG_SH3_2	513	518	PF14604	0.507
LIG_SH3_3	134	140	PF00018	0.482
LIG_SH3_3	375	381	PF00018	0.729
LIG_SH3_3	510	516	PF00018	0.634
LIG_SUMO_SIM_par_1	178	184	PF11976	0.464
LIG_SUMO_SIM_par_1	396	408	PF11976	0.563
LIG_TRAF2_1	310	313	PF00917	0.483
LIG_UBA3_1	346	352	PF00899	0.386
MOD_CK1_1	105	111	PF00069	0.537
MOD_CK1_1	131	137	PF00069	0.444
MOD_CK1_1	175	181	PF00069	0.369
MOD_CK1_1	402	408	PF00069	0.773
MOD_CK1_1	411	417	PF00069	0.612
MOD_CK1_1	477	483	PF00069	0.728
MOD_CK1_1	63	69	PF00069	0.413
MOD_CK1_1	92	98	PF00069	0.570
MOD_CK2_1	306	312	PF00069	0.369
MOD_CK2_1	8	14	PF00069	0.709
MOD_Cter_Amidation	350	353	PF01082	0.333
MOD_GlcNHglycan	117	120	PF01048	0.522
MOD_GlcNHglycan	364	367	PF01048	0.668
MOD_GlcNHglycan	500	503	PF01048	0.649
MOD_GSK3_1	102	109	PF00069	0.540
MOD_GSK3_1	127	134	PF00069	0.712
MOD_GSK3_1	302	309	PF00069	0.320
MOD_GSK3_1	328	335	PF00069	0.321
MOD_GSK3_1	386	393	PF00069	0.699
MOD_GSK3_1	395	402	PF00069	0.724
MOD_GSK3_1	404	411	PF00069	0.584
MOD_GSK3_1	467	474	PF00069	0.625
MOD_GSK3_1	498	505	PF00069	0.742
MOD_GSK3_1	88	95	PF00069	0.550
MOD_N-GLC_1	106	111	PF02516	0.529
MOD_N-GLC_1	29	34	PF02516	0.414
MOD_N-GLC_1	371	376	PF02516	0.621
MOD_N-GLC_1	92	97	PF02516	0.535
MOD_N-GLC_2	168	170	PF02516	0.313
MOD_N-GLC_2	367	369	PF02516	0.520
MOD_NEK2_1	22	27	PF00069	0.503
MOD_NEK2_1	247	252	PF00069	0.384
MOD_NEK2_1	262	267	PF00069	0.345
MOD_NEK2_1	281	286	PF00069	0.360
MOD_NEK2_1	332	337	PF00069	0.440
MOD_NEK2_1	354	359	PF00069	0.546
MOD_NEK2_1	368	373	PF00069	0.696
MOD_NEK2_1	491	496	PF00069	0.760
MOD_NEK2_1	88	93	PF00069	0.732
MOD_PIKK_1	332	338	PF00454	0.545
MOD_PIKK_1	41	47	PF00454	0.332
MOD_PIKK_1	467	473	PF00454	0.495
MOD_PK_1	399	405	PF00069	0.566
MOD_PKA_1	172	178	PF00069	0.358
MOD_PKA_1	234	240	PF00069	0.415
MOD_PKA_2	128	134	PF00069	0.491
MOD_PKA_2	172	178	PF00069	0.344
MOD_PKA_2	281	287	PF00069	0.419
MOD_PKA_2	411	417	PF00069	0.727
MOD_PKA_2	477	483	PF00069	0.688
MOD_Plk_1	131	137	PF00069	0.437
MOD_Plk_1	405	411	PF00069	0.654
MOD_Plk_1	491	497	PF00069	0.631
MOD_Plk_1	92	98	PF00069	0.521
MOD_Plk_2-3	492	498	PF00069	0.491
MOD_Plk_4	131	137	PF00069	0.432
MOD_Plk_4	175	181	PF00069	0.468
MOD_Plk_4	399	405	PF00069	0.566
MOD_Plk_4	92	98	PF00069	0.512
MOD_ProDKin_1	106	112	PF00069	0.536
MOD_ProDKin_1	306	312	PF00069	0.427
MOD_ProDKin_1	391	397	PF00069	0.656
MOD_ProDKin_1	416	422	PF00069	0.615
MOD_ProDKin_1	509	515	PF00069	0.627
MOD_SUMO_for_1	203	206	PF00179	0.364
MOD_SUMO_for_1	50	53	PF00179	0.439
MOD_SUMO_rev_2	35	44	PF00179	0.350
MOD_SUMO_rev_2	454	463	PF00179	0.567
MOD_SUMO_rev_2	63	68	PF00179	0.391
TRG_DiLeu_BaEn_2	270	276	PF01217	0.313
TRG_DiLeu_BaLyEn_6	396	401	PF01217	0.564
TRG_ENDOCYTIC_2	151	154	PF00928	0.407
TRG_ENDOCYTIC_2	230	233	PF00928	0.285
TRG_ENDOCYTIC_2	340	343	PF00928	0.385
TRG_ENDOCYTIC_2	59	62	PF00928	0.502
TRG_ENDOCYTIC_2	69	72	PF00928	0.448
TRG_ER_diArg_1	172	174	PF00400	0.323
TRG_ER_diArg_1	343	345	PF00400	0.491
TRG_NLS_Bipartite_1	42	59	PF00514	0.365
TRG_NLS_MonoExtN_4	54	59	PF00514	0.417
TRG_Pf-PMV_PEXEL_1	344	349	PF00026	0.467
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F5	Leptomonas seymouri	39%	100%
A0A1X0NZS9	Trypanosomatidae	45%	100%
A0A3Q8IJ66	Leishmania donovani	45%	100%
A0A3R7K1Y6	Trypanosoma rangeli	28%	78%
A0A3S7WZA2	Leishmania donovani	93%	100%
A0A422NL83	Trypanosoma rangeli	49%	100%
A4HEI6	Leishmania braziliensis	76%	98%
A4HFV0	Leishmania braziliensis	31%	93%
A4HMD1	Leishmania braziliensis	45%	100%
A4I1K4	Leishmania infantum	93%	100%
A4IAZ8	Leishmania infantum	45%	100%
C9ZK43	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
C9ZM31	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	75%
E9B5Y1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	100%
Q4Q6U1	Leishmania major	42%	100%
Q4Q9T3	Leishmania major	90%	97%
Q8BN21	Mus musculus	27%	100%
Q9NHE1	Leishmania major	45%	100%