Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania mexicana

UniProt:

E9AXN6_LEIMU

TriTrypDb:

Length:

808

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXN6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXN6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0019538	protein metabolic process	3	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0004674	protein serine/threonine kinase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	355	359	PF00656	0.700
CLV_NRD_NRD_1	136	138	PF00675	0.602
CLV_NRD_NRD_1	401	403	PF00675	0.556
CLV_NRD_NRD_1	463	465	PF00675	0.692
CLV_NRD_NRD_1	783	785	PF00675	0.391
CLV_PCSK_FUR_1	341	345	PF00082	0.661
CLV_PCSK_KEX2_1	136	138	PF00082	0.575
CLV_PCSK_KEX2_1	343	345	PF00082	0.664
CLV_PCSK_KEX2_1	400	402	PF00082	0.596
CLV_PCSK_KEX2_1	463	465	PF00082	0.656
CLV_PCSK_KEX2_1	471	473	PF00082	0.584
CLV_PCSK_KEX2_1	481	483	PF00082	0.728
CLV_PCSK_KEX2_1	783	785	PF00082	0.357
CLV_PCSK_KEX2_1	792	794	PF00082	0.357
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.665
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.792
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.728
CLV_PCSK_PC1ET2_1	792	794	PF00082	0.438
CLV_PCSK_PC7_1	397	403	PF00082	0.388
CLV_PCSK_SKI1_1	137	141	PF00082	0.616
CLV_PCSK_SKI1_1	191	195	PF00082	0.561
CLV_PCSK_SKI1_1	215	219	PF00082	0.500
CLV_PCSK_SKI1_1	334	338	PF00082	0.573
CLV_PCSK_SKI1_1	414	418	PF00082	0.337
CLV_PCSK_SKI1_1	692	696	PF00082	0.391
CLV_PCSK_SKI1_1	783	787	PF00082	0.357
CLV_PCSK_SKI1_1	792	796	PF00082	0.357
DEG_SPOP_SBC_1	512	516	PF00917	0.497
DEG_SPOP_SBC_1	89	93	PF00917	0.772
DOC_ANK_TNKS_1	540	547	PF00023	0.707
DOC_CDC14_PxL_1	772	780	PF14671	0.438
DOC_CKS1_1	23	28	PF01111	0.755
DOC_MAPK_gen_1	497	506	PF00069	0.774
DOC_MAPK_MEF2A_6	448	456	PF00069	0.502
DOC_MAPK_MEF2A_6	625	633	PF00069	0.391
DOC_PP2B_LxvP_1	408	411	PF13499	0.444
DOC_PP2B_LxvP_1	657	660	PF13499	0.438
DOC_PP2B_PxIxI_1	269	275	PF00149	0.705
DOC_PP4_FxxP_1	298	301	PF00568	0.418
DOC_SPAK_OSR1_1	297	301	PF12202	0.420
DOC_USP7_MATH_1	158	162	PF00917	0.659
DOC_USP7_MATH_1	17	21	PF00917	0.673
DOC_USP7_MATH_1	548	552	PF00917	0.710
DOC_USP7_MATH_1	88	92	PF00917	0.735
DOC_USP7_MATH_1	95	99	PF00917	0.696
DOC_WW_Pin1_4	137	142	PF00397	0.575
DOC_WW_Pin1_4	154	159	PF00397	0.512
DOC_WW_Pin1_4	198	203	PF00397	0.691
DOC_WW_Pin1_4	22	27	PF00397	0.790
DOC_WW_Pin1_4	246	251	PF00397	0.503
DOC_WW_Pin1_4	266	271	PF00397	0.737
DOC_WW_Pin1_4	470	475	PF00397	0.605
DOC_WW_Pin1_4	507	512	PF00397	0.673
DOC_WW_Pin1_4	513	518	PF00397	0.652
DOC_WW_Pin1_4	532	537	PF00397	0.547
DOC_WW_Pin1_4	560	565	PF00397	0.645
DOC_WW_Pin1_4	623	628	PF00397	0.417
LIG_14-3-3_CanoR_1	154	158	PF00244	0.677
LIG_14-3-3_CanoR_1	262	272	PF00244	0.647
LIG_14-3-3_CanoR_1	69	79	PF00244	0.736
LIG_14-3-3_CanoR_1	703	709	PF00244	0.492
LIG_14-3-3_CanoR_1	793	800	PF00244	0.360
LIG_Actin_WH2_2	409	427	PF00022	0.225
LIG_APCC_ABBA_1	218	223	PF00400	0.497
LIG_APCC_ABBAyCdc20_2	123	129	PF00400	0.592
LIG_APCC_ABBAyCdc20_2	430	436	PF00400	0.391
LIG_BIR_III_2	138	142	PF00653	0.588
LIG_deltaCOP1_diTrp_1	229	235	PF00928	0.512
LIG_EVH1_1	387	391	PF00568	0.691
LIG_FHA_1	157	163	PF00498	0.687
LIG_FHA_1	2	8	PF00498	0.715
LIG_FHA_1	282	288	PF00498	0.575
LIG_FHA_1	457	463	PF00498	0.507
LIG_FHA_1	464	470	PF00498	0.752
LIG_FHA_1	53	59	PF00498	0.712
LIG_FHA_1	555	561	PF00498	0.586
LIG_FHA_1	78	84	PF00498	0.678
LIG_FHA_2	247	253	PF00498	0.512
LIG_FHA_2	353	359	PF00498	0.786
LIG_FHA_2	597	603	PF00498	0.438
LIG_FHA_2	635	641	PF00498	0.438
LIG_FHA_2	741	747	PF00498	0.475
LIG_FHA_2	765	771	PF00498	0.378
LIG_FHA_2	793	799	PF00498	0.357
LIG_LIR_Apic_2	20	26	PF02991	0.682
LIG_LIR_Apic_2	4	9	PF02991	0.785
LIG_LIR_Apic_2	621	627	PF02991	0.438
LIG_LIR_Gen_1	140	149	PF02991	0.569
LIG_LIR_Gen_1	188	197	PF02991	0.478
LIG_LIR_Gen_1	229	238	PF02991	0.457
LIG_LIR_Gen_1	268	279	PF02991	0.628
LIG_LIR_Gen_1	358	368	PF02991	0.694
LIG_LIR_Gen_1	422	427	PF02991	0.406
LIG_LIR_Nem_3	121	127	PF02991	0.691
LIG_LIR_Nem_3	140	145	PF02991	0.330
LIG_LIR_Nem_3	169	175	PF02991	0.495
LIG_LIR_Nem_3	188	192	PF02991	0.313
LIG_LIR_Nem_3	229	235	PF02991	0.464
LIG_LIR_Nem_3	268	274	PF02991	0.626
LIG_LIR_Nem_3	422	426	PF02991	0.367
LIG_LIR_Nem_3	615	619	PF02991	0.376
LIG_LIR_Nem_3	701	705	PF02991	0.438
LIG_MAD2	191	199	PF02301	0.595
LIG_Pex14_2	596	600	PF04695	0.438
LIG_Pex14_2	702	706	PF04695	0.357
LIG_Pex14_2	715	719	PF04695	0.357
LIG_REV1ctd_RIR_1	802	808	PF16727	0.492
LIG_SH2_CRK	23	27	PF00017	0.739
LIG_SH2_CRK	405	409	PF00017	0.415
LIG_SH2_CRK	418	422	PF00017	0.357
LIG_SH2_CRK	616	620	PF00017	0.357
LIG_SH2_NCK_1	609	613	PF00017	0.457
LIG_SH2_NCK_1	616	620	PF00017	0.419
LIG_SH2_PTP2	271	274	PF00017	0.688
LIG_SH2_PTP2	575	578	PF00017	0.528
LIG_SH2_SRC	227	230	PF00017	0.520
LIG_SH2_SRC	6	9	PF00017	0.785
LIG_SH2_SRC	609	612	PF00017	0.415
LIG_SH2_STAP1	116	120	PF00017	0.717
LIG_SH2_STAP1	131	135	PF00017	0.409
LIG_SH2_STAP1	175	179	PF00017	0.504
LIG_SH2_STAP1	180	184	PF00017	0.459
LIG_SH2_STAP1	458	462	PF00017	0.580
LIG_SH2_STAT5	178	181	PF00017	0.421
LIG_SH2_STAT5	227	230	PF00017	0.520
LIG_SH2_STAT5	271	274	PF00017	0.688
LIG_SH2_STAT5	291	294	PF00017	0.241
LIG_SH2_STAT5	304	307	PF00017	0.533
LIG_SH2_STAT5	458	461	PF00017	0.469
LIG_SH2_STAT5	575	578	PF00017	0.528
LIG_SH2_STAT5	6	9	PF00017	0.785
LIG_SH2_STAT5	705	708	PF00017	0.369
LIG_SH2_STAT5	761	764	PF00017	0.357
LIG_SH3_3	159	165	PF00018	0.678
LIG_SH3_3	196	202	PF00018	0.660
LIG_SH3_3	240	246	PF00018	0.560
LIG_SH3_3	302	308	PF00018	0.489
LIG_SH3_3	314	320	PF00018	0.376
LIG_SH3_3	383	389	PF00018	0.759
LIG_SH3_3	573	579	PF00018	0.495
LIG_SH3_3	80	86	PF00018	0.765
LIG_SUMO_SIM_par_1	144	150	PF11976	0.428
LIG_SUMO_SIM_par_1	445	453	PF11976	0.438
LIG_SUMO_SIM_par_1	556	563	PF11976	0.598
LIG_SUMO_SIM_par_1	777	782	PF11976	0.438
LIG_TRAF2_1	249	252	PF00917	0.736
LIG_TRAF2_1	750	753	PF00917	0.422
LIG_TRAF2_1	795	798	PF00917	0.422
LIG_TRAF2_2	564	569	PF00917	0.695
LIG_TRFH_1	706	710	PF08558	0.492
LIG_TYR_ITIM	403	408	PF00017	0.434
LIG_TYR_ITIM	416	421	PF00017	0.357
LIG_TYR_ITIM	614	619	PF00017	0.357
LIG_WRC_WIRS_1	420	425	PF05994	0.438
LIG_WRC_WIRS_1	597	602	PF05994	0.438
LIG_WRC_WIRS_1	699	704	PF05994	0.438
MOD_CDK_SPxxK_3	137	144	PF00069	0.585
MOD_CDK_SPxxK_3	560	567	PF00069	0.700
MOD_CK1_1	150	156	PF00069	0.717
MOD_CK1_1	273	279	PF00069	0.619
MOD_CK1_1	359	365	PF00069	0.751
MOD_CK1_1	515	521	PF00069	0.699
MOD_CK1_1	54	60	PF00069	0.711
MOD_CK1_1	549	555	PF00069	0.678
MOD_CK1_1	64	70	PF00069	0.593
MOD_CK1_1	73	79	PF00069	0.650
MOD_CK1_1	737	743	PF00069	0.390
MOD_CK1_1	91	97	PF00069	0.524
MOD_CK2_1	246	252	PF00069	0.506
MOD_CK2_1	472	478	PF00069	0.754
MOD_CK2_1	489	495	PF00069	0.771
MOD_CK2_1	532	538	PF00069	0.759
MOD_CK2_1	792	798	PF00069	0.357
MOD_GlcNHglycan	149	152	PF01048	0.593
MOD_GlcNHglycan	162	165	PF01048	0.699
MOD_GlcNHglycan	208	211	PF01048	0.644
MOD_GlcNHglycan	350	353	PF01048	0.702
MOD_GlcNHglycan	358	361	PF01048	0.780
MOD_GlcNHglycan	368	371	PF01048	0.575
MOD_GlcNHglycan	379	382	PF01048	0.651
MOD_GlcNHglycan	474	477	PF01048	0.772
MOD_GlcNHglycan	519	522	PF01048	0.638
MOD_GlcNHglycan	551	554	PF01048	0.558
MOD_GlcNHglycan	637	640	PF01048	0.357
MOD_GlcNHglycan	684	687	PF01048	0.415
MOD_GlcNHglycan	736	739	PF01048	0.428
MOD_GlcNHglycan	93	96	PF01048	0.635
MOD_GSK3_1	150	157	PF00069	0.655
MOD_GSK3_1	18	25	PF00069	0.686
MOD_GSK3_1	233	240	PF00069	0.498
MOD_GSK3_1	262	269	PF00069	0.653
MOD_GSK3_1	330	337	PF00069	0.515
MOD_GSK3_1	344	351	PF00069	0.540
MOD_GSK3_1	352	359	PF00069	0.685
MOD_GSK3_1	444	451	PF00069	0.408
MOD_GSK3_1	470	477	PF00069	0.751
MOD_GSK3_1	50	57	PF00069	0.724
MOD_GSK3_1	507	514	PF00069	0.670
MOD_GSK3_1	549	556	PF00069	0.756
MOD_GSK3_1	58	65	PF00069	0.671
MOD_GSK3_1	619	626	PF00069	0.357
MOD_GSK3_1	67	74	PF00069	0.547
MOD_GSK3_1	682	689	PF00069	0.404
MOD_GSK3_1	690	697	PF00069	0.426
MOD_GSK3_1	7	14	PF00069	0.751
MOD_GSK3_1	760	767	PF00069	0.492
MOD_GSK3_1	89	96	PF00069	0.669
MOD_LATS_1	342	348	PF00433	0.678
MOD_N-GLC_1	51	56	PF02516	0.509
MOD_N-GLC_1	635	640	PF02516	0.492
MOD_N-GLC_1	660	665	PF02516	0.438
MOD_N-GLC_2	354	356	PF02516	0.576
MOD_NEK2_1	1	6	PF00069	0.796
MOD_NEK2_1	11	16	PF00069	0.624
MOD_NEK2_1	174	179	PF00069	0.529
MOD_NEK2_1	280	285	PF00069	0.588
MOD_NEK2_1	368	373	PF00069	0.593
MOD_NEK2_1	443	448	PF00069	0.438
MOD_NEK2_1	489	494	PF00069	0.728
MOD_NEK2_1	504	509	PF00069	0.634
MOD_NEK2_1	537	542	PF00069	0.618
MOD_NEK2_1	596	601	PF00069	0.438
MOD_NEK2_1	60	65	PF00069	0.718
MOD_NEK2_1	751	756	PF00069	0.498
MOD_NEK2_1	779	784	PF00069	0.438
MOD_NEK2_2	270	275	PF00069	0.703
MOD_PIKK_1	203	209	PF00454	0.699
MOD_PIKK_1	25	31	PF00454	0.814
MOD_PIKK_1	562	568	PF00454	0.616
MOD_PIKK_1	58	64	PF00454	0.783
MOD_PK_1	448	454	PF00069	0.513
MOD_PKA_1	463	469	PF00069	0.654
MOD_PKA_1	480	486	PF00069	0.760
MOD_PKA_1	792	798	PF00069	0.357
MOD_PKA_2	153	159	PF00069	0.732
MOD_PKA_2	337	343	PF00069	0.640
MOD_PKA_2	463	469	PF00069	0.676
MOD_PKA_2	70	76	PF00069	0.678
MOD_PKA_2	792	798	PF00069	0.357
MOD_PKB_1	69	77	PF00069	0.685
MOD_Plk_1	17	23	PF00069	0.799
MOD_Plk_1	180	186	PF00069	0.533
MOD_Plk_1	233	239	PF00069	0.472
MOD_Plk_1	568	574	PF00069	0.572
MOD_Plk_1	601	607	PF00069	0.438
MOD_Plk_1	660	666	PF00069	0.438
MOD_Plk_1	751	757	PF00069	0.438
MOD_Plk_4	1	7	PF00069	0.737
MOD_Plk_4	174	180	PF00069	0.508
MOD_Plk_4	18	24	PF00069	0.627
MOD_Plk_4	318	324	PF00069	0.450
MOD_Plk_4	419	425	PF00069	0.438
MOD_Plk_4	601	607	PF00069	0.391
MOD_Plk_4	721	727	PF00069	0.492
MOD_ProDKin_1	137	143	PF00069	0.562
MOD_ProDKin_1	154	160	PF00069	0.513
MOD_ProDKin_1	198	204	PF00069	0.685
MOD_ProDKin_1	22	28	PF00069	0.789
MOD_ProDKin_1	246	252	PF00069	0.506
MOD_ProDKin_1	266	272	PF00069	0.725
MOD_ProDKin_1	470	476	PF00069	0.604
MOD_ProDKin_1	507	513	PF00069	0.669
MOD_ProDKin_1	532	538	PF00069	0.583
MOD_ProDKin_1	560	566	PF00069	0.637
MOD_ProDKin_1	623	629	PF00069	0.417
MOD_SUMO_for_1	437	440	PF00179	0.357
MOD_SUMO_rev_2	483	489	PF00179	0.786
MOD_SUMO_rev_2	714	720	PF00179	0.451
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.482
TRG_ENDOCYTIC_2	124	127	PF00928	0.496
TRG_ENDOCYTIC_2	271	274	PF00928	0.670
TRG_ENDOCYTIC_2	405	408	PF00928	0.420
TRG_ENDOCYTIC_2	418	421	PF00928	0.297
TRG_ENDOCYTIC_2	575	578	PF00928	0.528
TRG_ENDOCYTIC_2	609	612	PF00928	0.379
TRG_ENDOCYTIC_2	616	619	PF00928	0.330
TRG_ENDOCYTIC_2	705	708	PF00928	0.391
TRG_ENDOCYTIC_2	788	791	PF00928	0.357
TRG_ER_diArg_1	135	137	PF00400	0.529
TRG_ER_diArg_1	400	402	PF00400	0.528
TRG_ER_diArg_1	462	464	PF00400	0.656
TRG_ER_diArg_1	783	785	PF00400	0.357
TRG_NES_CRM1_1	698	709	PF08389	0.492
TRG_NLS_Bipartite_1	463	484	PF00514	0.692
TRG_NLS_MonoExtC_3	342	348	PF00514	0.664
TRG_NLS_MonoExtC_3	479	485	PF00514	0.739
TRG_NLS_MonoExtN_4	341	347	PF00514	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK2	Leptomonas seymouri	65%	92%
A0A3S7WZ58	Leishmania donovani	92%	94%
A0A422NL22	Trypanosoma rangeli	34%	100%
A4HEJ6	Leishmania braziliensis	82%	100%
A4I1K2	Leishmania infantum	92%	100%
Q4Q9T5	Leishmania major	90%	100%
V5B2C1	Trypanosoma cruzi	33%	100%