LeishMANIAdb
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Tim10/DDP zinc finger family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Tim10/DDP zinc finger family protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AXN5_LEIMU
TriTrypDb:
LmxM.25.1550
Length:
102

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AXN5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXN5

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 39 43 PF00082 0.442
DEG_Nend_UBRbox_3 1 3 PF02207 0.613
DOC_MAPK_gen_1 65 74 PF00069 0.564
DOC_USP7_MATH_1 6 10 PF00917 0.687
LIG_BIR_III_2 47 51 PF00653 0.672
LIG_FHA_2 12 18 PF00498 0.598
LIG_LIR_Gen_1 88 99 PF02991 0.574
LIG_PTB_Apo_2 27 34 PF02174 0.561
LIG_PTB_Apo_2 65 72 PF02174 0.524
LIG_PTB_Phospho_1 65 71 PF10480 0.519
LIG_SH2_STAT5 35 38 PF00017 0.533
LIG_SH3_3 47 53 PF00018 0.522
MOD_CK2_1 11 17 PF00069 0.652
MOD_GlcNHglycan 85 88 PF01048 0.630
MOD_NEK2_1 11 16 PF00069 0.707
MOD_NEK2_1 34 39 PF00069 0.526
MOD_PIKK_1 11 17 PF00454 0.652
MOD_Plk_4 6 12 PF00069 0.725
MOD_SUMO_rev_2 75 84 PF00179 0.501
TRG_ENDOCYTIC_2 71 74 PF00928 0.534
TRG_ENDOCYTIC_2 91 94 PF00928 0.369

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IBG3 Leptomonas seymouri 72% 100%
A0A1X0NYW6 Trypanosomatidae 60% 98%
A0A3Q8ICJ9 Leishmania donovani 98% 100%
A0A3S5IRE3 Trypanosoma rangeli 59% 100%
A4HEJ7 Leishmania braziliensis 88% 100%
A4I1K1 Leishmania infantum 98% 100%
C9ZK35 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 100%
Q4Q9T6 Leishmania major 98% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS