Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXN4_LEIMU

TriTrypDb:

LmxM.25.1540

Length:

747

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXN4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009892	negative regulation of metabolic process	4	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0009894	regulation of catabolic process	4	1
GO:0009895	negative regulation of catabolic process	5	1
GO:0009987	cellular process	1	1
GO:0010468	regulation of gene expression	5	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0010605	negative regulation of macromolecule metabolic process	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0010628	positive regulation of gene expression	6	1
GO:0016070	RNA metabolic process	5	1
GO:0016553	base conversion or substitution editing	6	1
GO:0016554	cytidine to uridine editing	7	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031324	negative regulation of cellular metabolic process	5	1
GO:0031329	regulation of cellular catabolic process	5	1
GO:0031330	negative regulation of cellular catabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043487	regulation of RNA stability	3	1
GO:0043488	regulation of mRNA stability	4	1
GO:0043489	RNA stabilization	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045934	negative regulation of nucleobase-containing compound metabolic process	6	1
GO:0046483	heterocycle metabolic process	3	1
GO:0048255	mRNA stabilization	5	1
GO:0048518	positive regulation of biological process	3	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051172	negative regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051253	negative regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0061013	regulation of mRNA catabolic process	6	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1902369	negative regulation of RNA catabolic process	7	1
GO:1902373	negative regulation of mRNA catabolic process	7	1
GO:1903311	regulation of mRNA metabolic process	6	1
GO:1903312	negative regulation of mRNA metabolic process	7	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.412
CLV_C14_Caspase3-7	30	34	PF00656	0.747
CLV_NRD_NRD_1	181	183	PF00675	0.335
CLV_NRD_NRD_1	25	27	PF00675	0.794
CLV_NRD_NRD_1	254	256	PF00675	0.335
CLV_NRD_NRD_1	259	261	PF00675	0.335
CLV_NRD_NRD_1	302	304	PF00675	0.303
CLV_NRD_NRD_1	412	414	PF00675	0.335
CLV_NRD_NRD_1	573	575	PF00675	0.477
CLV_PCSK_KEX2_1	181	183	PF00082	0.335
CLV_PCSK_KEX2_1	25	27	PF00082	0.794
CLV_PCSK_KEX2_1	254	256	PF00082	0.335
CLV_PCSK_KEX2_1	259	261	PF00082	0.335
CLV_PCSK_KEX2_1	412	414	PF00082	0.335
CLV_PCSK_KEX2_1	573	575	PF00082	0.484
CLV_PCSK_PC7_1	255	261	PF00082	0.363
CLV_PCSK_PC7_1	408	414	PF00082	0.335
CLV_PCSK_SKI1_1	102	106	PF00082	0.335
CLV_PCSK_SKI1_1	191	195	PF00082	0.468
CLV_PCSK_SKI1_1	604	608	PF00082	0.591
DEG_SCF_TRCP1_1	649	654	PF00400	0.379
DOC_ANK_TNKS_1	16	23	PF00023	0.638
DOC_CKS1_1	172	177	PF01111	0.188
DOC_CYCLIN_yCln2_LP_2	169	175	PF00134	0.305
DOC_MAPK_gen_1	259	266	PF00069	0.363
DOC_MAPK_gen_1	704	712	PF00069	0.449
DOC_MAPK_RevD_3	167	182	PF00069	0.402
DOC_MAPK_RevD_3	245	260	PF00069	0.363
DOC_PP1_RVXF_1	582	588	PF00149	0.338
DOC_PP4_FxxP_1	336	339	PF00568	0.335
DOC_PP4_FxxP_1	346	349	PF00568	0.335
DOC_PP4_FxxP_1	568	571	PF00568	0.464
DOC_USP7_MATH_1	120	124	PF00917	0.438
DOC_USP7_MATH_1	230	234	PF00917	0.480
DOC_USP7_MATH_1	321	325	PF00917	0.322
DOC_USP7_MATH_1	439	443	PF00917	0.327
DOC_USP7_MATH_1	545	549	PF00917	0.434
DOC_USP7_MATH_1	563	567	PF00917	0.564
DOC_USP7_MATH_1	572	576	PF00917	0.472
DOC_USP7_MATH_1	85	89	PF00917	0.430
DOC_WW_Pin1_4	113	118	PF00397	0.399
DOC_WW_Pin1_4	157	162	PF00397	0.425
DOC_WW_Pin1_4	171	176	PF00397	0.249
DOC_WW_Pin1_4	335	340	PF00397	0.334
DOC_WW_Pin1_4	418	423	PF00397	0.335
LIG_14-3-3_CanoR_1	107	112	PF00244	0.475
LIG_14-3-3_CanoR_1	219	223	PF00244	0.205
LIG_14-3-3_CanoR_1	343	347	PF00244	0.427
LIG_14-3-3_CanoR_1	573	577	PF00244	0.538
LIG_14-3-3_CanoR_1	738	743	PF00244	0.466
LIG_Actin_WH2_2	690	708	PF00022	0.463
LIG_AP2alpha_2	132	134	PF02296	0.335
LIG_APCC_ABBA_1	270	275	PF00400	0.466
LIG_APCC_ABBAyCdc20_2	574	580	PF00400	0.539
LIG_BIR_II_1	1	5	PF00653	0.648
LIG_BIR_III_4	226	230	PF00653	0.188
LIG_BIR_III_4	440	444	PF00653	0.335
LIG_BRCT_BRCA1_1	122	126	PF00533	0.415
LIG_Clathr_ClatBox_1	83	87	PF01394	0.402
LIG_deltaCOP1_diTrp_1	238	245	PF00928	0.402
LIG_EH1_1	495	503	PF00400	0.374
LIG_EH1_1	504	512	PF00400	0.335
LIG_FHA_1	106	112	PF00498	0.378
LIG_FHA_1	219	225	PF00498	0.249
LIG_FHA_1	343	349	PF00498	0.378
LIG_FHA_1	394	400	PF00498	0.394
LIG_FHA_1	458	464	PF00498	0.480
LIG_FHA_1	490	496	PF00498	0.322
LIG_FHA_2	172	178	PF00498	0.341
LIG_FHA_2	624	630	PF00498	0.554
LIG_HP1_1	82	86	PF01393	0.402
LIG_LIR_Apic_2	345	349	PF02991	0.331
LIG_LIR_Apic_2	565	571	PF02991	0.488
LIG_LIR_Gen_1	123	134	PF02991	0.363
LIG_LIR_Gen_1	237	247	PF02991	0.426
LIG_LIR_Gen_1	396	405	PF02991	0.408
LIG_LIR_Gen_1	692	699	PF02991	0.297
LIG_LIR_Gen_1	96	104	PF02991	0.400
LIG_LIR_Nem_3	123	129	PF02991	0.363
LIG_LIR_Nem_3	237	243	PF02991	0.426
LIG_LIR_Nem_3	396	400	PF02991	0.408
LIG_LIR_Nem_3	580	585	PF02991	0.434
LIG_LIR_Nem_3	692	697	PF02991	0.404
LIG_LIR_Nem_3	96	101	PF02991	0.413
LIG_PCNA_yPIPBox_3	486	495	PF02747	0.432
LIG_Pex14_1	240	244	PF04695	0.480
LIG_PTB_Apo_2	423	430	PF02174	0.335
LIG_PTB_Phospho_1	423	429	PF10480	0.480
LIG_Rb_pABgroove_1	642	650	PF01858	0.376
LIG_SH2_CRK	98	102	PF00017	0.436
LIG_SH2_NCK_1	387	391	PF00017	0.355
LIG_SH2_SRC	31	34	PF00017	0.764
LIG_SH2_SRC	718	721	PF00017	0.433
LIG_SH2_STAP1	31	35	PF00017	0.749
LIG_SH2_STAP1	578	582	PF00017	0.547
LIG_SH2_STAT3	52	55	PF00017	0.645
LIG_SH2_STAT5	244	247	PF00017	0.480
LIG_SH2_STAT5	519	522	PF00017	0.335
LIG_SH2_STAT5	718	721	PF00017	0.392
LIG_SH3_3	130	136	PF00018	0.335
LIG_SH3_3	139	145	PF00018	0.335
LIG_SH3_3	169	175	PF00018	0.460
LIG_SH3_3	244	250	PF00018	0.335
LIG_SH3_3	396	402	PF00018	0.355
LIG_SH3_3	76	82	PF00018	0.636
LIG_Sin3_3	150	157	PF02671	0.266
LIG_SUMO_SIM_anti_2	508	514	PF11976	0.335
LIG_SUMO_SIM_anti_2	524	530	PF11976	0.335
LIG_SUMO_SIM_par_1	459	469	PF11976	0.331
LIG_SUMO_SIM_par_1	82	88	PF11976	0.402
LIG_TRFH_1	568	572	PF08558	0.540
LIG_WRC_WIRS_1	86	91	PF05994	0.447
LIG_WW_2	79	82	PF00397	0.624
LIG_WW_3	570	574	PF00397	0.567
MOD_CK1_1	156	162	PF00069	0.391
MOD_CK1_1	233	239	PF00069	0.285
MOD_CK1_1	329	335	PF00069	0.353
MOD_CK1_1	338	344	PF00069	0.347
MOD_CK1_1	351	357	PF00069	0.305
MOD_CK1_1	36	42	PF00069	0.653
MOD_CK1_1	442	448	PF00069	0.351
MOD_CK1_1	54	60	PF00069	0.788
MOD_CK1_1	689	695	PF00069	0.441
MOD_CK1_1	96	102	PF00069	0.490
MOD_CK2_1	623	629	PF00069	0.402
MOD_Cter_Amidation	252	255	PF01082	0.335
MOD_Cter_Amidation	257	260	PF01082	0.335
MOD_GlcNHglycan	155	158	PF01048	0.483
MOD_GlcNHglycan	203	206	PF01048	0.353
MOD_GlcNHglycan	226	230	PF01048	0.430
MOD_GlcNHglycan	328	331	PF01048	0.403
MOD_GlcNHglycan	350	353	PF01048	0.335
MOD_GlcNHglycan	355	358	PF01048	0.335
MOD_GlcNHglycan	433	436	PF01048	0.424
MOD_GlcNHglycan	440	444	PF01048	0.325
MOD_GlcNHglycan	465	471	PF01048	0.438
MOD_GlcNHglycan	515	518	PF01048	0.342
MOD_GlcNHglycan	56	59	PF01048	0.793
MOD_GlcNHglycan	564	568	PF01048	0.499
MOD_GlcNHglycan	601	604	PF01048	0.642
MOD_GlcNHglycan	608	611	PF01048	0.399
MOD_GlcNHglycan	649	652	PF01048	0.526
MOD_GSK3_1	105	112	PF00069	0.340
MOD_GSK3_1	153	160	PF00069	0.406
MOD_GSK3_1	206	213	PF00069	0.450
MOD_GSK3_1	230	237	PF00069	0.480
MOD_GSK3_1	334	341	PF00069	0.350
MOD_GSK3_1	418	425	PF00069	0.428
MOD_GSK3_1	431	438	PF00069	0.263
MOD_GSK3_1	439	446	PF00069	0.150
MOD_GSK3_1	647	654	PF00069	0.456
MOD_GSK3_1	738	745	PF00069	0.495
MOD_N-GLC_1	201	206	PF02516	0.439
MOD_N-GLC_1	431	436	PF02516	0.474
MOD_N-GLC_1	505	510	PF02516	0.188
MOD_N-GLC_1	623	628	PF02516	0.553
MOD_N-GLC_1	689	694	PF02516	0.511
MOD_N-GLC_1	96	101	PF02516	0.420
MOD_NEK2_1	153	158	PF00069	0.434
MOD_NEK2_1	225	230	PF00069	0.220
MOD_NEK2_1	342	347	PF00069	0.324
MOD_NEK2_1	457	462	PF00069	0.447
MOD_NEK2_1	556	561	PF00069	0.602
MOD_NEK2_1	647	652	PF00069	0.500
MOD_NEK2_1	742	747	PF00069	0.528
MOD_NEK2_2	120	125	PF00069	0.480
MOD_NEK2_2	206	211	PF00069	0.363
MOD_PIKK_1	135	141	PF00454	0.335
MOD_PIKK_1	210	216	PF00454	0.335
MOD_PIKK_1	443	449	PF00454	0.328
MOD_PIKK_1	484	490	PF00454	0.484
MOD_PIKK_1	51	57	PF00454	0.638
MOD_PIKK_1	586	592	PF00454	0.666
MOD_PIKK_1	96	102	PF00454	0.480
MOD_PKA_2	218	224	PF00069	0.237
MOD_PKA_2	27	33	PF00069	0.803
MOD_PKA_2	342	348	PF00069	0.425
MOD_PKA_2	572	578	PF00069	0.540
MOD_PKB_1	51	59	PF00069	0.752
MOD_Plk_1	431	437	PF00069	0.447
MOD_Plk_1	505	511	PF00069	0.289
MOD_Plk_1	563	569	PF00069	0.481
MOD_Plk_1	623	629	PF00069	0.420
MOD_Plk_1	692	698	PF00069	0.245
MOD_Plk_1	96	102	PF00069	0.420
MOD_Plk_4	329	335	PF00069	0.419
MOD_Plk_4	362	368	PF00069	0.355
MOD_Plk_4	374	380	PF00069	0.335
MOD_Plk_4	458	464	PF00069	0.466
MOD_Plk_4	623	629	PF00069	0.393
MOD_Plk_4	668	674	PF00069	0.550
MOD_Plk_4	85	91	PF00069	0.419
MOD_ProDKin_1	113	119	PF00069	0.399
MOD_ProDKin_1	157	163	PF00069	0.425
MOD_ProDKin_1	171	177	PF00069	0.249
MOD_ProDKin_1	335	341	PF00069	0.334
MOD_ProDKin_1	418	424	PF00069	0.335
TRG_ENDOCYTIC_2	244	247	PF00928	0.447
TRG_ENDOCYTIC_2	387	390	PF00928	0.355
TRG_ENDOCYTIC_2	519	522	PF00928	0.402
TRG_ENDOCYTIC_2	98	101	PF00928	0.385
TRG_ER_diArg_1	181	183	PF00400	0.336
TRG_ER_diArg_1	25	28	PF00400	0.789
TRG_ER_diArg_1	254	256	PF00400	0.335
TRG_ER_diArg_1	259	261	PF00400	0.335
TRG_ER_diArg_1	572	574	PF00400	0.498
TRG_NES_CRM1_1	636	649	PF08389	0.476
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.393

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT36	Leptomonas seymouri	63%	100%
A0A1X0NYA6	Trypanosomatidae	53%	100%
A0A3R7MPK5	Trypanosoma rangeli	51%	100%
A0A3S7WZ63	Leishmania donovani	93%	100%
A4HEJ8	Leishmania braziliensis	86%	100%
A4I1K0	Leishmania infantum	92%	100%
C9ZK34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
Q4Q9T7	Leishmania major	93%	100%
V5BHU4	Trypanosoma cruzi	51%	100%