Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXN3_LEIMU

TriTrypDb:

LmxM.25.1530

Length:

619

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.544
CLV_C14_Caspase3-7	383	387	PF00656	0.620
CLV_NRD_NRD_1	310	312	PF00675	0.660
CLV_NRD_NRD_1	601	603	PF00675	0.717
CLV_PCSK_FUR_1	308	312	PF00082	0.646
CLV_PCSK_KEX2_1	310	312	PF00082	0.683
CLV_PCSK_KEX2_1	601	603	PF00082	0.635
CLV_PCSK_KEX2_1	617	619	PF00082	0.450
CLV_PCSK_SKI1_1	188	192	PF00082	0.557
CLV_PCSK_SKI1_1	208	212	PF00082	0.386
CLV_PCSK_SKI1_1	290	294	PF00082	0.368
CLV_PCSK_SKI1_1	329	333	PF00082	0.505
CLV_PCSK_SKI1_1	336	340	PF00082	0.558
CLV_PCSK_SKI1_1	455	459	PF00082	0.424
DEG_Nend_Nbox_1	1	3	PF02207	0.570
DOC_CYCLIN_RxL_1	287	294	PF00134	0.369
DOC_MAPK_gen_1	186	195	PF00069	0.449
DOC_MAPK_gen_1	416	422	PF00069	0.542
DOC_PP1_RVXF_1	225	232	PF00149	0.401
DOC_PP1_RVXF_1	312	319	PF00149	0.444
DOC_PP1_RVXF_1	559	566	PF00149	0.549
DOC_PP4_FxxP_1	135	138	PF00568	0.579
DOC_USP7_MATH_1	23	27	PF00917	0.685
DOC_USP7_MATH_1	324	328	PF00917	0.687
DOC_USP7_MATH_1	366	370	PF00917	0.613
DOC_USP7_MATH_1	392	396	PF00917	0.440
DOC_USP7_MATH_1	526	530	PF00917	0.778
DOC_WW_Pin1_4	19	24	PF00397	0.584
DOC_WW_Pin1_4	395	400	PF00397	0.626
DOC_WW_Pin1_4	445	450	PF00397	0.693
DOC_WW_Pin1_4	87	92	PF00397	0.501
LIG_14-3-3_CanoR_1	188	196	PF00244	0.590
LIG_14-3-3_CanoR_1	290	300	PF00244	0.470
LIG_14-3-3_CanoR_1	308	318	PF00244	0.587
LIG_14-3-3_CanoR_1	427	433	PF00244	0.613
LIG_14-3-3_CanoR_1	568	576	PF00244	0.621
LIG_14-3-3_CanoR_1	604	609	PF00244	0.443
LIG_BIR_III_2	269	273	PF00653	0.434
LIG_BIR_III_2	38	42	PF00653	0.366
LIG_Clathr_ClatBox_1	339	343	PF01394	0.554
LIG_EH_1	6	10	PF12763	0.455
LIG_FHA_1	408	414	PF00498	0.571
LIG_FHA_1	456	462	PF00498	0.535
LIG_FHA_1	46	52	PF00498	0.489
LIG_FHA_1	544	550	PF00498	0.587
LIG_FHA_1	579	585	PF00498	0.659
LIG_FHA_2	115	121	PF00498	0.591
LIG_FHA_2	381	387	PF00498	0.755
LIG_FHA_2	583	589	PF00498	0.680
LIG_GBD_Chelix_1	471	479	PF00786	0.568
LIG_LIR_Apic_2	107	113	PF02991	0.352
LIG_LIR_Apic_2	133	138	PF02991	0.586
LIG_LIR_Gen_1	357	368	PF02991	0.581
LIG_LIR_Gen_1	44	55	PF02991	0.512
LIG_LIR_Nem_3	251	256	PF02991	0.457
LIG_LIR_Nem_3	357	363	PF02991	0.586
LIG_LIR_Nem_3	44	50	PF02991	0.506
LIG_LIR_Nem_3	66	72	PF02991	0.439
LIG_MYND_1	91	95	PF01753	0.368
LIG_NRBOX	287	293	PF00104	0.402
LIG_NRP_CendR_1	617	619	PF00754	0.475
LIG_Pex14_2	404	408	PF04695	0.417
LIG_Rb_pABgroove_1	12	20	PF01858	0.599
LIG_Rb_pABgroove_1	295	303	PF01858	0.454
LIG_SH2_CRK	360	364	PF00017	0.467
LIG_SH2_CRK	47	51	PF00017	0.415
LIG_SH2_CRK	476	480	PF00017	0.626
LIG_SH2_STAP1	189	193	PF00017	0.547
LIG_SH2_STAP1	360	364	PF00017	0.467
LIG_SH2_STAP1	47	51	PF00017	0.433
LIG_SH2_STAP1	490	494	PF00017	0.683
LIG_SH2_STAP1	504	508	PF00017	0.580
LIG_SH2_STAT5	246	249	PF00017	0.341
LIG_SH2_STAT5	462	465	PF00017	0.441
LIG_SH2_STAT5	47	50	PF00017	0.417
LIG_SH3_1	156	162	PF00018	0.543
LIG_SH3_3	156	162	PF00018	0.636
LIG_SH3_3	235	241	PF00018	0.566
LIG_SH3_3	360	366	PF00018	0.453
LIG_SH3_3	443	449	PF00018	0.714
LIG_SH3_3	503	509	PF00018	0.629
LIG_SH3_3	88	94	PF00018	0.404
LIG_SUMO_SIM_par_1	166	171	PF11976	0.559
LIG_SUMO_SIM_par_1	75	80	PF11976	0.421
LIG_TRAF2_1	221	224	PF00917	0.478
LIG_TRAF2_1	533	536	PF00917	0.520
LIG_TYR_ITIM	45	50	PF00017	0.511
LIG_TYR_ITIM	474	479	PF00017	0.586
LIG_UBA3_1	331	336	PF00899	0.533
LIG_WRPW_2	335	338	PF00400	0.344
MOD_CK1_1	199	205	PF00069	0.610
MOD_CK1_1	234	240	PF00069	0.468
MOD_CK1_1	341	347	PF00069	0.684
MOD_CK1_1	395	401	PF00069	0.542
MOD_CK1_1	426	432	PF00069	0.642
MOD_CK1_1	440	446	PF00069	0.619
MOD_CK1_1	447	453	PF00069	0.585
MOD_CK1_1	521	527	PF00069	0.751
MOD_CK1_1	530	536	PF00069	0.713
MOD_CK1_1	557	563	PF00069	0.574
MOD_CK1_1	82	88	PF00069	0.690
MOD_CK2_1	344	350	PF00069	0.521
MOD_CK2_1	351	357	PF00069	0.646
MOD_CK2_1	514	520	PF00069	0.753
MOD_CK2_1	526	532	PF00069	0.783
MOD_CK2_1	58	64	PF00069	0.531
MOD_CK2_1	582	588	PF00069	0.638
MOD_GlcNHglycan	25	28	PF01048	0.624
MOD_GlcNHglycan	3	6	PF01048	0.446
MOD_GlcNHglycan	311	314	PF01048	0.626
MOD_GlcNHglycan	319	322	PF01048	0.619
MOD_GlcNHglycan	326	329	PF01048	0.592
MOD_GlcNHglycan	353	356	PF01048	0.548
MOD_GlcNHglycan	386	390	PF01048	0.557
MOD_GlcNHglycan	428	431	PF01048	0.621
MOD_GlcNHglycan	522	526	PF01048	0.770
MOD_GlcNHglycan	528	532	PF01048	0.806
MOD_GSK3_1	184	191	PF00069	0.533
MOD_GSK3_1	19	26	PF00069	0.655
MOD_GSK3_1	422	429	PF00069	0.650
MOD_GSK3_1	437	444	PF00069	0.539
MOD_GSK3_1	514	521	PF00069	0.670
MOD_GSK3_1	526	533	PF00069	0.637
MOD_GSK3_1	578	585	PF00069	0.615
MOD_GSK3_1	75	82	PF00069	0.602
MOD_N-GLC_1	322	327	PF02516	0.656
MOD_N-GLC_1	366	371	PF02516	0.616
MOD_NEK2_1	1	6	PF00069	0.555
MOD_NEK2_1	196	201	PF00069	0.560
MOD_NEK2_1	231	236	PF00069	0.441
MOD_NEK2_1	286	291	PF00069	0.465
MOD_NEK2_1	422	427	PF00069	0.603
MOD_NEK2_1	58	63	PF00069	0.568
MOD_PIKK_1	390	396	PF00454	0.445
MOD_PIKK_1	58	64	PF00454	0.314
MOD_PK_1	604	610	PF00069	0.443
MOD_PKA_2	304	310	PF00069	0.607
MOD_PKA_2	426	432	PF00069	0.663
MOD_PKA_2	567	573	PF00069	0.677
MOD_PKA_2	582	588	PF00069	0.560
MOD_PKB_1	186	194	PF00069	0.536
MOD_PKB_1	602	610	PF00069	0.443
MOD_Plk_1	344	350	PF00069	0.672
MOD_Plk_1	356	362	PF00069	0.617
MOD_Plk_1	366	372	PF00069	0.567
MOD_Plk_1	79	85	PF00069	0.548
MOD_Plk_2-3	114	120	PF00069	0.600
MOD_Plk_2-3	209	215	PF00069	0.586
MOD_Plk_2-3	537	543	PF00069	0.694
MOD_Plk_2-3	559	565	PF00069	0.639
MOD_Plk_4	344	350	PF00069	0.577
MOD_ProDKin_1	19	25	PF00069	0.588
MOD_ProDKin_1	395	401	PF00069	0.618
MOD_ProDKin_1	445	451	PF00069	0.683
MOD_ProDKin_1	87	93	PF00069	0.497
MOD_SUMO_rev_2	412	419	PF00179	0.482
MOD_SUMO_rev_2	485	494	PF00179	0.464
MOD_SUMO_rev_2	587	592	PF00179	0.666
MOD_SUMO_rev_2	82	91	PF00179	0.621
TRG_DiLeu_BaLyEn_6	287	292	PF01217	0.404
TRG_ENDOCYTIC_2	360	363	PF00928	0.570
TRG_ENDOCYTIC_2	47	50	PF00928	0.382
TRG_ENDOCYTIC_2	476	479	PF00928	0.615
TRG_ER_diArg_1	186	189	PF00400	0.538
TRG_ER_diArg_1	308	311	PF00400	0.646
TRG_ER_diArg_1	601	604	PF00400	0.718
TRG_ER_diArg_1	617	619	PF00400	0.450
TRG_Pf-PMV_PEXEL_1	194	198	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZM0	Leptomonas seymouri	48%	100%
A0A1X0NY83	Trypanosomatidae	29%	100%
A0A3S7WZ73	Leishmania donovani	88%	100%
A0A422NL47	Trypanosoma rangeli	31%	100%
A4HEJ9	Leishmania braziliensis	78%	100%
A4I1J9	Leishmania infantum	88%	100%
C9ZK33	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4Q9T8	Leishmania major	84%	100%