Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9AXN2_LEIMU

TriTrypDb:

LmxM.25.1520

Length:

942

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXN2

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0004674	protein serine/threonine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	286	290	PF00656	0.756
CLV_C14_Caspase3-7	368	372	PF00656	0.643
CLV_NRD_NRD_1	29	31	PF00675	0.699
CLV_NRD_NRD_1	513	515	PF00675	0.394
CLV_NRD_NRD_1	921	923	PF00675	0.838
CLV_PCSK_KEX2_1	29	31	PF00082	0.699
CLV_PCSK_KEX2_1	513	515	PF00082	0.394
CLV_PCSK_KEX2_1	6	8	PF00082	0.762
CLV_PCSK_KEX2_1	721	723	PF00082	0.389
CLV_PCSK_KEX2_1	921	923	PF00082	0.775
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.762
CLV_PCSK_PC1ET2_1	721	723	PF00082	0.367
CLV_PCSK_SKI1_1	539	543	PF00082	0.402
CLV_PCSK_SKI1_1	586	590	PF00082	0.389
CLV_PCSK_SKI1_1	591	595	PF00082	0.389
CLV_Separin_Metazoa	706	710	PF03568	0.449
DEG_Nend_UBRbox_3	1	3	PF02207	0.852
DEG_SCF_TRCP1_1	368	373	PF00400	0.566
DEG_SPOP_SBC_1	70	74	PF00917	0.652
DEG_SPOP_SBC_1	761	765	PF00917	0.543
DEG_SPOP_SBC_1	813	817	PF00917	0.668
DEG_SPOP_SBC_1	860	864	PF00917	0.765
DOC_ANK_TNKS_1	89	96	PF00023	0.695
DOC_CYCLIN_RxL_1	536	546	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	235	238	PF00134	0.708
DOC_MAPK_DCC_7	604	612	PF00069	0.367
DOC_MAPK_gen_1	591	600	PF00069	0.389
DOC_MAPK_gen_1	604	612	PF00069	0.389
DOC_MAPK_gen_1	921	927	PF00069	0.830
DOC_MAPK_JIP1_4	594	600	PF00069	0.389
DOC_MAPK_MEF2A_6	604	612	PF00069	0.367
DOC_PP2B_LxvP_1	235	238	PF13499	0.740
DOC_PP2B_LxvP_1	316	319	PF13499	0.630
DOC_PP2B_LxvP_1	791	794	PF13499	0.628
DOC_PP2B_LxvP_1	875	878	PF13499	0.835
DOC_PP4_FxxP_1	534	537	PF00568	0.389
DOC_USP7_MATH_1	104	108	PF00917	0.756
DOC_USP7_MATH_1	221	225	PF00917	0.676
DOC_USP7_MATH_1	228	232	PF00917	0.755
DOC_USP7_MATH_1	291	295	PF00917	0.619
DOC_USP7_MATH_1	307	311	PF00917	0.768
DOC_USP7_MATH_1	366	370	PF00917	0.765
DOC_USP7_MATH_1	57	61	PF00917	0.724
DOC_USP7_MATH_1	696	700	PF00917	0.516
DOC_USP7_MATH_1	70	74	PF00917	0.639
DOC_USP7_MATH_1	723	727	PF00917	0.311
DOC_USP7_MATH_1	761	765	PF00917	0.645
DOC_USP7_MATH_1	782	786	PF00917	0.634
DOC_USP7_MATH_1	836	840	PF00917	0.638
DOC_USP7_MATH_1	86	90	PF00917	0.652
DOC_USP7_MATH_1	860	864	PF00917	0.704
DOC_WW_Pin1_4	152	157	PF00397	0.624
DOC_WW_Pin1_4	173	178	PF00397	0.833
DOC_WW_Pin1_4	226	231	PF00397	0.750
DOC_WW_Pin1_4	251	256	PF00397	0.791
DOC_WW_Pin1_4	339	344	PF00397	0.696
DOC_WW_Pin1_4	36	41	PF00397	0.695
DOC_WW_Pin1_4	425	430	PF00397	0.756
DOC_WW_Pin1_4	43	48	PF00397	0.673
DOC_WW_Pin1_4	432	437	PF00397	0.716
DOC_WW_Pin1_4	443	448	PF00397	0.521
DOC_WW_Pin1_4	645	650	PF00397	0.365
DOC_WW_Pin1_4	728	733	PF00397	0.389
DOC_WW_Pin1_4	783	788	PF00397	0.710
DOC_WW_Pin1_4	798	803	PF00397	0.701
DOC_WW_Pin1_4	866	871	PF00397	0.819
DOC_WW_Pin1_4	914	919	PF00397	0.669
LIG_14-3-3_CanoR_1	222	227	PF00244	0.799
LIG_14-3-3_CanoR_1	276	283	PF00244	0.673
LIG_14-3-3_CanoR_1	356	360	PF00244	0.696
LIG_14-3-3_CanoR_1	697	705	PF00244	0.367
LIG_14-3-3_CanoR_1	722	732	PF00244	0.311
LIG_14-3-3_CanoR_1	808	812	PF00244	0.575
LIG_14-3-3_CterR_2	940	942	PF00244	0.568
LIG_Actin_WH2_2	473	490	PF00022	0.389
LIG_APCC_ABBAyCdc20_2	586	592	PF00400	0.389
LIG_BRCT_BRCA1_1	309	313	PF00533	0.792
LIG_BRCT_BRCA1_1	434	438	PF00533	0.577
LIG_CtBP_PxDLS_1	183	187	PF00389	0.809
LIG_eIF4E_1	339	345	PF01652	0.768
LIG_eIF4E_1	637	643	PF01652	0.399
LIG_EVH1_2	317	321	PF00568	0.783
LIG_FHA_1	186	192	PF00498	0.643
LIG_FHA_1	564	570	PF00498	0.389
LIG_FHA_1	578	584	PF00498	0.389
LIG_FHA_1	615	621	PF00498	0.394
LIG_FHA_1	630	636	PF00498	0.389
LIG_FHA_1	870	876	PF00498	0.613
LIG_FHA_1	927	933	PF00498	0.689
LIG_FHA_2	33	39	PF00498	0.830
LIG_FHA_2	415	421	PF00498	0.840
LIG_FHA_2	679	685	PF00498	0.311
LIG_FHA_2	745	751	PF00498	0.479
LIG_FHA_2	826	832	PF00498	0.778
LIG_FHA_2	847	853	PF00498	0.667
LIG_LIR_Apic_2	391	395	PF02991	0.773
LIG_LIR_Apic_2	533	537	PF02991	0.389
LIG_LIR_Apic_2	634	640	PF02991	0.389
LIG_LIR_Nem_3	176	181	PF02991	0.802
LIG_LIR_Nem_3	213	217	PF02991	0.769
LIG_LIR_Nem_3	310	316	PF02991	0.728
LIG_LIR_Nem_3	466	470	PF02991	0.402
LIG_LIR_Nem_3	810	814	PF02991	0.572
LIG_MLH1_MIPbox_1	309	313	PF16413	0.792
LIG_MYND_1	233	237	PF01753	0.777
LIG_MYND_1	40	44	PF01753	0.720
LIG_PAM2_1	562	574	PF00658	0.389
LIG_PTAP_UEV_1	329	334	PF05743	0.545
LIG_SH2_CRK	172	176	PF00017	0.782
LIG_SH2_CRK	178	182	PF00017	0.745
LIG_SH2_CRK	467	471	PF00017	0.389
LIG_SH2_GRB2like	656	659	PF00017	0.389
LIG_SH2_NCK_1	547	551	PF00017	0.516
LIG_SH2_PTP2	392	395	PF00017	0.777
LIG_SH2_SRC	656	659	PF00017	0.516
LIG_SH2_STAP1	390	394	PF00017	0.706
LIG_SH2_STAT5	258	261	PF00017	0.851
LIG_SH2_STAT5	297	300	PF00017	0.801
LIG_SH2_STAT5	312	315	PF00017	0.558
LIG_SH2_STAT5	392	395	PF00017	0.777
LIG_SH2_STAT5	455	458	PF00017	0.403
LIG_SH2_STAT5	471	474	PF00017	0.403
LIG_SH2_STAT5	498	501	PF00017	0.389
LIG_SH2_STAT5	556	559	PF00017	0.389
LIG_SH2_STAT5	571	574	PF00017	0.389
LIG_SH2_STAT5	656	659	PF00017	0.403
LIG_SH2_STAT5	675	678	PF00017	0.394
LIG_SH3_1	37	43	PF00018	0.764
LIG_SH3_1	874	880	PF00018	0.840
LIG_SH3_3	140	146	PF00018	0.739
LIG_SH3_3	150	156	PF00018	0.652
LIG_SH3_3	205	211	PF00018	0.754
LIG_SH3_3	227	233	PF00018	0.667
LIG_SH3_3	298	304	PF00018	0.741
LIG_SH3_3	327	333	PF00018	0.594
LIG_SH3_3	37	43	PF00018	0.764
LIG_SH3_3	771	777	PF00018	0.738
LIG_SH3_3	874	880	PF00018	0.823
LIG_SUMO_SIM_anti_2	839	846	PF11976	0.813
LIG_SUMO_SIM_par_1	182	189	PF11976	0.675
LIG_SUMO_SIM_par_1	331	338	PF11976	0.688
LIG_SUMO_SIM_par_1	60	69	PF11976	0.564
LIG_SUMO_SIM_par_1	848	855	PF11976	0.710
LIG_SUMO_SIM_par_1	929	937	PF11976	0.819
LIG_TRAF2_1	156	159	PF00917	0.679
LIG_TRAF2_1	239	242	PF00917	0.694
LIG_TRFH_1	359	363	PF08558	0.768
LIG_TYR_ITIM	569	574	PF00017	0.389
LIG_UBA3_1	714	721	PF00899	0.403
LIG_UBA3_1	737	743	PF00899	0.664
LIG_WRC_WIRS_1	906	911	PF05994	0.608
LIG_WW_3	145	149	PF00397	0.571
LIG_WW_3	606	610	PF00397	0.389
LIG_WW_3	772	776	PF00397	0.721
LIG_WW_3	876	880	PF00397	0.833
MOD_CDC14_SPxK_1	919	922	PF00782	0.753
MOD_CDK_SPK_2	251	256	PF00069	0.695
MOD_CDK_SPK_2	344	349	PF00069	0.774
MOD_CDK_SPK_2	645	650	PF00069	0.378
MOD_CDK_SPK_2	916	921	PF00069	0.746
MOD_CDK_SPxK_1	916	922	PF00069	0.750
MOD_CDK_SPxxK_3	173	180	PF00069	0.805
MOD_CDK_SPxxK_3	914	921	PF00069	0.748
MOD_CK1_1	173	179	PF00069	0.761
MOD_CK1_1	185	191	PF00069	0.623
MOD_CK1_1	275	281	PF00069	0.773
MOD_CK1_1	32	38	PF00069	0.802
MOD_CK1_1	373	379	PF00069	0.671
MOD_CK1_1	414	420	PF00069	0.770
MOD_CK1_1	430	436	PF00069	0.713
MOD_CK1_1	46	52	PF00069	0.694
MOD_CK1_1	549	555	PF00069	0.393
MOD_CK1_1	629	635	PF00069	0.389
MOD_CK1_1	69	75	PF00069	0.782
MOD_CK1_1	760	766	PF00069	0.726
MOD_CK1_1	783	789	PF00069	0.585
MOD_CK1_1	807	813	PF00069	0.729
MOD_CK1_1	815	821	PF00069	0.671
MOD_CK1_1	846	852	PF00069	0.665
MOD_CK1_1	862	868	PF00069	0.762
MOD_CK1_1	869	875	PF00069	0.743
MOD_CK1_1	886	892	PF00069	0.570
MOD_CK1_1	908	914	PF00069	0.685
MOD_CK2_1	152	158	PF00069	0.591
MOD_CK2_1	32	38	PF00069	0.699
MOD_CK2_1	414	420	PF00069	0.833
MOD_CK2_1	521	527	PF00069	0.389
MOD_CK2_1	678	684	PF00069	0.333
MOD_CK2_1	825	831	PF00069	0.784
MOD_CK2_1	837	843	PF00069	0.634
MOD_DYRK1A_RPxSP_1	152	156	PF00069	0.590
MOD_GlcNHglycan	131	134	PF01048	0.757
MOD_GlcNHglycan	143	146	PF01048	0.631
MOD_GlcNHglycan	172	175	PF01048	0.765
MOD_GlcNHglycan	293	296	PF01048	0.712
MOD_GlcNHglycan	330	333	PF01048	0.724
MOD_GlcNHglycan	368	371	PF01048	0.853
MOD_GlcNHglycan	372	375	PF01048	0.631
MOD_GlcNHglycan	376	379	PF01048	0.685
MOD_GlcNHglycan	548	551	PF01048	0.396
MOD_GlcNHglycan	60	63	PF01048	0.701
MOD_GlcNHglycan	627	631	PF01048	0.394
MOD_GlcNHglycan	68	71	PF01048	0.822
MOD_GlcNHglycan	698	701	PF01048	0.516
MOD_GlcNHglycan	759	762	PF01048	0.725
MOD_GlcNHglycan	764	767	PF01048	0.740
MOD_GlcNHglycan	84	87	PF01048	0.602
MOD_GlcNHglycan	845	848	PF01048	0.804
MOD_GSK3_1	113	120	PF00069	0.665
MOD_GSK3_1	137	144	PF00069	0.626
MOD_GSK3_1	222	229	PF00069	0.698
MOD_GSK3_1	272	279	PF00069	0.689
MOD_GSK3_1	32	39	PF00069	0.810
MOD_GSK3_1	366	373	PF00069	0.606
MOD_GSK3_1	396	403	PF00069	0.831
MOD_GSK3_1	427	434	PF00069	0.690
MOD_GSK3_1	494	501	PF00069	0.556
MOD_GSK3_1	573	580	PF00069	0.490
MOD_GSK3_1	610	617	PF00069	0.392
MOD_GSK3_1	645	652	PF00069	0.394
MOD_GSK3_1	65	72	PF00069	0.674
MOD_GSK3_1	661	668	PF00069	0.389
MOD_GSK3_1	757	764	PF00069	0.522
MOD_GSK3_1	792	799	PF00069	0.752
MOD_GSK3_1	82	89	PF00069	0.757
MOD_GSK3_1	859	866	PF00069	0.834
MOD_GSK3_1	879	886	PF00069	0.569
MOD_GSK3_1	898	905	PF00069	0.714
MOD_GSK3_1	908	915	PF00069	0.623
MOD_LATS_1	28	34	PF00433	0.791
MOD_N-GLC_1	291	296	PF02516	0.755
MOD_N-GLC_1	562	567	PF02516	0.499
MOD_N-GLC_1	825	830	PF02516	0.634
MOD_N-GLC_1	866	871	PF02516	0.770
MOD_N-GLC_1	909	914	PF02516	0.711
MOD_NEK2_1	128	133	PF00069	0.679
MOD_NEK2_1	272	277	PF00069	0.747
MOD_NEK2_1	283	288	PF00069	0.810
MOD_NEK2_1	572	577	PF00069	0.389
MOD_NEK2_1	642	647	PF00069	0.516
MOD_NEK2_1	65	70	PF00069	0.714
MOD_NEK2_1	678	683	PF00069	0.311
MOD_NEK2_1	733	738	PF00069	0.629
MOD_NEK2_1	759	764	PF00069	0.688
MOD_NEK2_1	837	842	PF00069	0.698
MOD_NEK2_1	845	850	PF00069	0.684
MOD_NEK2_1	909	914	PF00069	0.683
MOD_PIKK_1	104	110	PF00454	0.638
MOD_PIKK_1	237	243	PF00454	0.741
MOD_PIKK_1	396	402	PF00454	0.732
MOD_PIKK_1	744	750	PF00454	0.635
MOD_PIKK_1	815	821	PF00454	0.761
MOD_PIKK_1	883	889	PF00454	0.792
MOD_PIKK_1	909	915	PF00454	0.678
MOD_PKA_1	29	35	PF00069	0.691
MOD_PKA_2	17	23	PF00069	0.696
MOD_PKA_2	221	227	PF00069	0.798
MOD_PKA_2	275	281	PF00069	0.753
MOD_PKA_2	29	35	PF00069	0.838
MOD_PKA_2	355	361	PF00069	0.598
MOD_PKA_2	463	469	PF00069	0.395
MOD_PKA_2	649	655	PF00069	0.349
MOD_PKA_2	696	702	PF00069	0.449
MOD_PKA_2	723	729	PF00069	0.311
MOD_PKA_2	807	813	PF00069	0.640
MOD_Plk_1	562	568	PF00069	0.449
MOD_Plk_1	744	750	PF00069	0.609
MOD_Plk_1	909	915	PF00069	0.645
MOD_Plk_2-3	792	798	PF00069	0.820
MOD_Plk_4	210	216	PF00069	0.816
MOD_Plk_4	317	323	PF00069	0.790
MOD_Plk_4	376	382	PF00069	0.797
MOD_Plk_4	388	394	PF00069	0.615
MOD_Plk_4	494	500	PF00069	0.409
MOD_Plk_4	521	527	PF00069	0.389
MOD_Plk_4	71	77	PF00069	0.661
MOD_Plk_4	733	739	PF00069	0.507
MOD_Plk_4	846	852	PF00069	0.651
MOD_ProDKin_1	152	158	PF00069	0.624
MOD_ProDKin_1	173	179	PF00069	0.834
MOD_ProDKin_1	226	232	PF00069	0.753
MOD_ProDKin_1	251	257	PF00069	0.791
MOD_ProDKin_1	339	345	PF00069	0.696
MOD_ProDKin_1	36	42	PF00069	0.698
MOD_ProDKin_1	425	431	PF00069	0.755
MOD_ProDKin_1	43	49	PF00069	0.677
MOD_ProDKin_1	432	438	PF00069	0.716
MOD_ProDKin_1	443	449	PF00069	0.508
MOD_ProDKin_1	645	651	PF00069	0.365
MOD_ProDKin_1	728	734	PF00069	0.389
MOD_ProDKin_1	783	789	PF00069	0.708
MOD_ProDKin_1	798	804	PF00069	0.703
MOD_ProDKin_1	866	872	PF00069	0.820
MOD_ProDKin_1	914	920	PF00069	0.662
MOD_SUMO_rev_2	155	163	PF00179	0.671
TRG_DiLeu_BaEn_1	706	711	PF01217	0.389
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.766
TRG_DiLeu_LyEn_5	706	711	PF01217	0.449
TRG_ENDOCYTIC_2	10	13	PF00928	0.858
TRG_ENDOCYTIC_2	178	181	PF00928	0.686
TRG_ENDOCYTIC_2	199	202	PF00928	0.789
TRG_ENDOCYTIC_2	390	393	PF00928	0.770
TRG_ENDOCYTIC_2	467	470	PF00928	0.389
TRG_ENDOCYTIC_2	571	574	PF00928	0.389
TRG_ENDOCYTIC_2	675	678	PF00928	0.516
TRG_ER_diArg_1	29	31	PF00400	0.699
TRG_ER_diArg_1	512	514	PF00400	0.394
TRG_ER_diArg_1	920	922	PF00400	0.753
TRG_NES_CRM1_1	706	718	PF08389	0.389
TRG_NLS_MonoCore_2	720	725	PF00514	0.367
TRG_NLS_MonoExtN_4	719	725	PF00514	0.449
TRG_Pf-PMV_PEXEL_1	507	511	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	591	596	PF00026	0.389
TRG_Pf-PMV_PEXEL_1	609	614	PF00026	0.389

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I119	Leptomonas seymouri	48%	99%
A0A3Q8IFC6	Leishmania donovani	88%	100%
A4HEK0	Leishmania braziliensis	72%	99%
A4I1J8	Leishmania infantum	88%	100%
Q4Q9T9	Leishmania major	87%	100%