Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXN1_LEIMU

TriTrypDb:

LmxM.25.1510

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXN1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.432
CLV_C14_Caspase3-7	333	337	PF00656	0.661
CLV_C14_Caspase3-7	409	413	PF00656	0.625
CLV_C14_Caspase3-7	506	510	PF00656	0.509
CLV_NRD_NRD_1	227	229	PF00675	0.537
CLV_NRD_NRD_1	31	33	PF00675	0.347
CLV_NRD_NRD_1	425	427	PF00675	0.634
CLV_NRD_NRD_1	428	430	PF00675	0.629
CLV_NRD_NRD_1	46	48	PF00675	0.461
CLV_PCSK_KEX2_1	229	231	PF00082	0.561
CLV_PCSK_KEX2_1	31	33	PF00082	0.347
CLV_PCSK_KEX2_1	46	48	PF00082	0.461
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.517
CLV_PCSK_PC7_1	225	231	PF00082	0.546
CLV_PCSK_SKI1_1	124	128	PF00082	0.416
DEG_APCC_DBOX_1	123	131	PF00400	0.583
DEG_Nend_UBRbox_2	1	3	PF02207	0.548
DEG_SCF_TRCP1_1	485	490	PF00400	0.606
DEG_SPOP_SBC_1	3	7	PF00917	0.387
DEG_SPOP_SBC_1	320	324	PF00917	0.712
DEG_SPOP_SBC_1	404	408	PF00917	0.705
DEG_SPOP_SBC_1	497	501	PF00917	0.621
DOC_CDC14_PxL_1	71	79	PF14671	0.366
DOC_CKS1_1	362	367	PF01111	0.730
DOC_MAPK_gen_1	426	436	PF00069	0.628
DOC_MAPK_MEF2A_6	9	18	PF00069	0.452
DOC_PP2B_LxvP_1	461	464	PF13499	0.505
DOC_PP2B_LxvP_1	72	75	PF13499	0.394
DOC_PP2B_PxIxI_1	392	398	PF00149	0.609
DOC_PP4_FxxP_1	11	14	PF00568	0.413
DOC_PP4_MxPP_1	348	351	PF00568	0.700
DOC_USP7_MATH_1	206	210	PF00917	0.529
DOC_USP7_MATH_1	299	303	PF00917	0.619
DOC_USP7_MATH_1	365	369	PF00917	0.695
DOC_USP7_MATH_1	4	8	PF00917	0.397
DOC_USP7_MATH_1	403	407	PF00917	0.705
DOC_USP7_MATH_1	467	471	PF00917	0.766
DOC_USP7_MATH_1	483	487	PF00917	0.542
DOC_USP7_MATH_1	61	65	PF00917	0.370
DOC_WW_Pin1_4	303	308	PF00397	0.705
DOC_WW_Pin1_4	346	351	PF00397	0.622
DOC_WW_Pin1_4	361	366	PF00397	0.645
DOC_WW_Pin1_4	371	376	PF00397	0.557
DOC_WW_Pin1_4	389	394	PF00397	0.611
LIG_14-3-3_CanoR_1	167	173	PF00244	0.261
LIG_14-3-3_CanoR_1	329	335	PF00244	0.630
LIG_14-3-3_CanoR_1	382	386	PF00244	0.651
LIG_14-3-3_CanoR_1	459	464	PF00244	0.514
LIG_14-3-3_CanoR_1	90	96	PF00244	0.297
LIG_AP2alpha_2	398	400	PF02296	0.631
LIG_BIR_III_2	279	283	PF00653	0.578
LIG_EH1_1	81	89	PF00400	0.391
LIG_EVH1_1	314	318	PF00568	0.542
LIG_FHA_1	111	117	PF00498	0.541
LIG_FHA_1	325	331	PF00498	0.537
LIG_FHA_1	431	437	PF00498	0.653
LIG_FHA_1	439	445	PF00498	0.490
LIG_FHA_1	473	479	PF00498	0.704
LIG_FHA_2	142	148	PF00498	0.451
LIG_FHA_2	448	454	PF00498	0.577
LIG_FHA_2	92	98	PF00498	0.482
LIG_LIR_Apic_2	10	14	PF02991	0.423
LIG_LIR_Gen_1	259	270	PF02991	0.685
LIG_LIR_Gen_1	509	518	PF02991	0.402
LIG_LIR_Nem_3	259	265	PF02991	0.678
LIG_LIR_Nem_3	509	514	PF02991	0.541
LIG_MAD2	47	55	PF02301	0.485
LIG_MYND_1	389	393	PF01753	0.636
LIG_SH2_NCK_1	262	266	PF00017	0.610
LIG_SH2_SRC	194	197	PF00017	0.420
LIG_SH2_STAT3	182	185	PF00017	0.434
LIG_SH2_STAT5	140	143	PF00017	0.425
LIG_SH2_STAT5	179	182	PF00017	0.459
LIG_SH2_STAT5	194	197	PF00017	0.446
LIG_SH2_STAT5	528	531	PF00017	0.478
LIG_SH2_STAT5	65	68	PF00017	0.335
LIG_SH2_STAT5	70	73	PF00017	0.375
LIG_SH3_3	269	275	PF00018	0.621
LIG_SH3_3	278	284	PF00018	0.644
LIG_SH3_3	301	307	PF00018	0.648
LIG_SH3_3	312	318	PF00018	0.545
LIG_SH3_3	383	389	PF00018	0.679
LIG_SH3_3	393	399	PF00018	0.559
LIG_SUMO_SIM_par_1	266	274	PF11976	0.676
LIG_SUMO_SIM_par_1	373	380	PF11976	0.528
LIG_TRAF2_1	158	161	PF00917	0.371
LIG_TRAF2_1	234	237	PF00917	0.488
LIG_TRAF2_1	413	416	PF00917	0.657
LIG_WRC_WIRS_1	8	13	PF05994	0.427
MOD_CK1_1	199	205	PF00069	0.517
MOD_CK1_1	287	293	PF00069	0.655
MOD_CK1_1	302	308	PF00069	0.539
MOD_CK1_1	324	330	PF00069	0.536
MOD_CK1_1	406	412	PF00069	0.661
MOD_CK1_1	439	445	PF00069	0.540
MOD_CK1_1	462	468	PF00069	0.612
MOD_CK1_1	470	476	PF00069	0.656
MOD_CK1_1	486	492	PF00069	0.591
MOD_CK1_1	495	501	PF00069	0.592
MOD_CK1_1	7	13	PF00069	0.432
MOD_CK2_1	141	147	PF00069	0.408
MOD_CK2_1	168	174	PF00069	0.374
MOD_CK2_1	217	223	PF00069	0.489
MOD_CK2_1	334	340	PF00069	0.580
MOD_CK2_1	53	59	PF00069	0.403
MOD_CK2_1	7	13	PF00069	0.482
MOD_CK2_1	91	97	PF00069	0.467
MOD_GlcNHglycan	107	110	PF01048	0.650
MOD_GlcNHglycan	136	139	PF01048	0.459
MOD_GlcNHglycan	144	147	PF01048	0.349
MOD_GlcNHglycan	219	222	PF01048	0.559
MOD_GlcNHglycan	286	289	PF01048	0.572
MOD_GlcNHglycan	368	371	PF01048	0.705
MOD_GlcNHglycan	383	386	PF01048	0.574
MOD_GlcNHglycan	461	464	PF01048	0.665
MOD_GlcNHglycan	465	468	PF01048	0.719
MOD_GlcNHglycan	485	488	PF01048	0.516
MOD_GlcNHglycan	495	498	PF01048	0.632
MOD_GlcNHglycan	531	534	PF01048	0.357
MOD_GlcNHglycan	55	58	PF01048	0.403
MOD_GSK3_1	196	203	PF00069	0.553
MOD_GSK3_1	287	294	PF00069	0.685
MOD_GSK3_1	299	306	PF00069	0.664
MOD_GSK3_1	3	10	PF00069	0.485
MOD_GSK3_1	319	326	PF00069	0.701
MOD_GSK3_1	330	337	PF00069	0.608
MOD_GSK3_1	361	368	PF00069	0.605
MOD_GSK3_1	459	466	PF00069	0.615
MOD_GSK3_1	467	474	PF00069	0.612
MOD_GSK3_1	483	490	PF00069	0.616
MOD_GSK3_1	492	499	PF00069	0.610
MOD_N-GLC_1	334	339	PF02516	0.769
MOD_NEK2_1	141	146	PF00069	0.376
MOD_NEK2_1	168	173	PF00069	0.524
MOD_NEK2_1	217	222	PF00069	0.410
MOD_NEK2_1	529	534	PF00069	0.352
MOD_NEK2_1	91	96	PF00069	0.405
MOD_NEK2_2	4	9	PF00069	0.400
MOD_NEK2_2	454	459	PF00069	0.640
MOD_PIKK_1	291	297	PF00454	0.538
MOD_PIKK_1	308	314	PF00454	0.537
MOD_PKA_2	381	387	PF00069	0.655
MOD_Plk_1	200	206	PF00069	0.396
MOD_Plk_1	334	340	PF00069	0.655
MOD_Plk_1	439	445	PF00069	0.525
MOD_Plk_1	50	56	PF00069	0.315
MOD_Plk_2-3	196	202	PF00069	0.390
MOD_Plk_4	200	206	PF00069	0.396
MOD_Plk_4	430	436	PF00069	0.665
MOD_Plk_4	439	445	PF00069	0.473
MOD_Plk_4	7	13	PF00069	0.442
MOD_Plk_4	91	97	PF00069	0.420
MOD_ProDKin_1	303	309	PF00069	0.704
MOD_ProDKin_1	346	352	PF00069	0.626
MOD_ProDKin_1	361	367	PF00069	0.647
MOD_ProDKin_1	371	377	PF00069	0.556
MOD_ProDKin_1	389	395	PF00069	0.611
MOD_SUMO_for_1	102	105	PF00179	0.582
TRG_DiLeu_BaEn_1	239	244	PF01217	0.524
TRG_DiLeu_BaEn_1	456	461	PF01217	0.631
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.370
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.390
TRG_DiLeu_LyEn_5	456	461	PF01217	0.519
TRG_ENDOCYTIC_2	262	265	PF00928	0.609
TRG_ER_diArg_1	31	33	PF00400	0.335
TRG_ER_diArg_1	45	47	PF00400	0.457
TRG_NES_CRM1_1	13	27	PF08389	0.360
TRG_NLS_MonoExtC_3	425	430	PF00514	0.703
TRG_NLS_MonoExtN_4	423	430	PF00514	0.702
TRG_Pf-PMV_PEXEL_1	516	521	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYY1	Leptomonas seymouri	38%	100%
A0A3Q8ICE6	Leishmania donovani	86%	100%
A4HEK1	Leishmania braziliensis	70%	99%
A4I1J7	Leishmania infantum	86%	100%
Q4Q9U0	Leishmania major	86%	100%