Rab3 GTPase-activating protein catalytic subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Rab3 GTPase-activating protein catalytic subunit, putative

Species:

Leishmania mexicana

UniProt:

E9AXN0_LEIMU

TriTrypDb:

LmxM.25.1490

Length:

1244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

E9AXN0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXN0

Function

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Biological processes
Term	Name	Level	Count
GO:0043085	positive regulation of catalytic activity	4	7
GO:0043087	regulation of GTPase activity	5	7
GO:0043547	positive regulation of GTPase activity	6	7
GO:0044093	positive regulation of molecular function	3	7
GO:0050790	regulation of catalytic activity	3	7
GO:0051336	regulation of hydrolase activity	4	7
GO:0051345	positive regulation of hydrolase activity	5	7
GO:0065007	biological regulation	1	7
GO:0065009	regulation of molecular function	2	7

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Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.503
CLV_C14_Caspase3-7	607	611	PF00656	0.564
CLV_NRD_NRD_1	213	215	PF00675	0.717
CLV_NRD_NRD_1	405	407	PF00675	0.681
CLV_NRD_NRD_1	488	490	PF00675	0.663
CLV_NRD_NRD_1	532	534	PF00675	0.830
CLV_NRD_NRD_1	584	586	PF00675	0.570
CLV_NRD_NRD_1	705	707	PF00675	0.674
CLV_NRD_NRD_1	72	74	PF00675	0.755
CLV_NRD_NRD_1	959	961	PF00675	0.385

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRU4	Leptomonas seymouri	50%	99%
A0A3Q8IBT0	Leishmania donovani	89%	100%
A4HDZ6	Leishmania braziliensis	75%	98%
A4I1J5	Leishmania infantum	89%	100%
Q4Q9U2	Leishmania major	88%	100%

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