cAMP response protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cAMP response protein, putative

Species:

Leishmania mexicana

UniProt:

E9AXM7_LEIMU

TriTrypDb:

LmxM.25.1460

Length:

773

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 31
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	5
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0005819	spindle	5	3
GO:0005930	axoneme	2	3
GO:0043228	non-membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043232	intracellular non-membrane-bounded organelle	4	3
GO:0072686	mitotic spindle	6	3

Expansion

Sequence features

E9AXM7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXM7

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	3
GO:0000281	mitotic cytokinesis	4	3
GO:0000910	cytokinesis	3	3
GO:0001539	cilium or flagellum-dependent cell motility	3	3
GO:0006996	organelle organization	4	3
GO:0007010	cytoskeleton organization	5	3
GO:0007017	microtubule-based process	2	3
GO:0007051	spindle organization	3	3
GO:0007052	mitotic spindle organization	4	3
GO:0009987	cellular process	1	3
GO:0016043	cellular component organization	3	3
GO:0022402	cell cycle process	2	3
GO:0048870	cell motility	2	3
GO:0060285	cilium-dependent cell motility	4	3
GO:0061640	cytoskeleton-dependent cytokinesis	4	3
GO:0071840	cellular component organization or biogenesis	2	3
GO:1902850	microtubule cytoskeleton organization involved in mitosis	4	3
GO:1903047	mitotic cell cycle process	3	3

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	19
GO:0005509	calcium ion binding	5	18
GO:0043167	ion binding	2	18
GO:0043169	cation binding	3	18
GO:0046872	metal ion binding	4	18
GO:0005515	protein binding	2	3
GO:0008092	cytoskeletal protein binding	3	3
GO:0015631	tubulin binding	4	3
GO:0043014	alpha-tubulin binding	5	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	545	549	PF00656	0.483
CLV_C14_Caspase3-7	765	769	PF00656	0.327
CLV_NRD_NRD_1	124	126	PF00675	0.237
CLV_NRD_NRD_1	158	160	PF00675	0.229
CLV_NRD_NRD_1	244	246	PF00675	0.468
CLV_NRD_NRD_1	315	317	PF00675	0.234
CLV_NRD_NRD_1	41	43	PF00675	0.516
CLV_NRD_NRD_1	50	52	PF00675	0.537
CLV_NRD_NRD_1	512	514	PF00675	0.256
CLV_NRD_NRD_1	539	541	PF00675	0.347
CLV_NRD_NRD_1	683	685	PF00675	0.435
CLV_NRD_NRD_1	697	699	PF00675	0.443
CLV_PCSK_KEX2_1	158	160	PF00082	0.226
CLV_PCSK_KEX2_1	197	199	PF00082	0.456
CLV_PCSK_KEX2_1	235	237	PF00082	0.540
CLV_PCSK_KEX2_1	246	248	PF00082	0.362
CLV_PCSK_KEX2_1	315	317	PF00082	0.221
CLV_PCSK_KEX2_1	539	541	PF00082	0.294
CLV_PCSK_KEX2_1	683	685	PF00082	0.454
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.516
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.518
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.339
CLV_PCSK_PC7_1	154	160	PF00082	0.158
CLV_PCSK_SKI1_1	204	208	PF00082	0.445
CLV_PCSK_SKI1_1	236	240	PF00082	0.465
CLV_PCSK_SKI1_1	269	273	PF00082	0.268
CLV_PCSK_SKI1_1	302	306	PF00082	0.287
CLV_PCSK_SKI1_1	353	357	PF00082	0.259
CLV_PCSK_SKI1_1	457	461	PF00082	0.289
CLV_PCSK_SKI1_1	464	468	PF00082	0.294
CLV_PCSK_SKI1_1	540	544	PF00082	0.237
CLV_PCSK_SKI1_1	560	564	PF00082	0.269
CLV_PCSK_SKI1_1	604	608	PF00082	0.397
CLV_PCSK_SKI1_1	688	692	PF00082	0.446
DEG_APCC_DBOX_1	683	691	PF00400	0.407
DEG_APCC_DBOX_1	723	731	PF00400	0.357
DEG_COP1_1	205	214	PF00400	0.313
DEG_Nend_UBRbox_1	1	4	PF02207	0.598
DEG_ODPH_VHL_1	592	603	PF01847	0.395
DOC_CKS1_1	523	528	PF01111	0.506
DOC_CYCLIN_yClb5_NLxxxL_5	289	296	PF00134	0.427
DOC_CYCLIN_yCln2_LP_2	465	471	PF00134	0.476
DOC_MAPK_gen_1	121	129	PF00069	0.452
DOC_MAPK_gen_1	163	173	PF00069	0.508
DOC_MAPK_gen_1	392	399	PF00069	0.385
DOC_MAPK_gen_1	42	49	PF00069	0.548
DOC_MAPK_gen_1	430	439	PF00069	0.432
DOC_MAPK_gen_1	566	574	PF00069	0.310
DOC_MAPK_gen_1	683	693	PF00069	0.374
DOC_MAPK_gen_1	717	727	PF00069	0.304
DOC_MAPK_MEF2A_6	123	131	PF00069	0.468
DOC_MAPK_MEF2A_6	566	574	PF00069	0.314
DOC_MAPK_MEF2A_6	575	582	PF00069	0.330
DOC_MAPK_NFAT4_5	575	583	PF00069	0.381
DOC_MAPK_RevD_3	301	316	PF00069	0.468
DOC_PP1_RVXF_1	455	462	PF00149	0.366
DOC_PP4_FxxP_1	418	421	PF00568	0.450
DOC_PP4_FxxP_1	492	495	PF00568	0.459
DOC_SPAK_OSR1_1	189	193	PF12202	0.328
DOC_USP7_MATH_1	218	222	PF00917	0.509
DOC_USP7_MATH_1	230	234	PF00917	0.443
DOC_USP7_MATH_1	317	321	PF00917	0.443
DOC_USP7_MATH_1	335	339	PF00917	0.354
DOC_USP7_MATH_1	675	679	PF00917	0.558
DOC_USP7_UBL2_3	269	273	PF12436	0.483
DOC_USP7_UBL2_3	460	464	PF12436	0.548
DOC_USP7_UBL2_3	681	685	PF12436	0.479
DOC_WW_Pin1_4	522	527	PF00397	0.425
DOC_WW_Pin1_4	624	629	PF00397	0.530
LIG_14-3-3_CanoR_1	236	243	PF00244	0.450
LIG_14-3-3_CanoR_1	38	42	PF00244	0.486
LIG_14-3-3_CanoR_1	51	57	PF00244	0.463
LIG_14-3-3_CanoR_1	613	621	PF00244	0.313
LIG_14-3-3_CanoR_1	720	724	PF00244	0.358
LIG_Actin_WH2_2	567	583	PF00022	0.472
LIG_Actin_WH2_2	656	674	PF00022	0.484
LIG_APCC_ABBA_1	301	306	PF00400	0.442
LIG_BRCT_BRCA1_1	382	386	PF00533	0.376
LIG_BRCT_BRCA1_1	474	478	PF00533	0.394
LIG_BRCT_BRCA1_1	744	748	PF00533	0.384
LIG_BRCT_BRCA1_1	90	94	PF00533	0.522
LIG_BRCT_BRCA1_2	90	96	PF00533	0.369
LIG_eIF4E_1	538	544	PF01652	0.518
LIG_EVH1_1	419	423	PF00568	0.448
LIG_EVH1_2	422	426	PF00568	0.470
LIG_FHA_1	109	115	PF00498	0.467
LIG_FHA_1	232	238	PF00498	0.499
LIG_FHA_1	260	266	PF00498	0.421
LIG_FHA_1	307	313	PF00498	0.396
LIG_FHA_1	368	374	PF00498	0.440
LIG_FHA_1	484	490	PF00498	0.428
LIG_FHA_1	549	555	PF00498	0.498
LIG_FHA_1	556	562	PF00498	0.421
LIG_FHA_1	628	634	PF00498	0.394
LIG_FHA_1	655	661	PF00498	0.522
LIG_FHA_1	720	726	PF00498	0.292
LIG_FHA_2	237	243	PF00498	0.440
LIG_FHA_2	523	529	PF00498	0.411
LIG_FHA_2	543	549	PF00498	0.367
LIG_FHA_2	6	12	PF00498	0.687
LIG_FHA_2	613	619	PF00498	0.431
LIG_FHA_2	664	670	PF00498	0.436
LIG_FHA_2	674	680	PF00498	0.380
LIG_FHA_2	71	77	PF00498	0.620
LIG_FHA_2	93	99	PF00498	0.484
LIG_GBD_Chelix_1	570	578	PF00786	0.348
LIG_LIR_Apic_2	320	326	PF02991	0.376
LIG_LIR_Apic_2	358	362	PF02991	0.452
LIG_LIR_Apic_2	415	421	PF02991	0.555
LIG_LIR_Apic_2	490	495	PF02991	0.427
LIG_LIR_Apic_2	536	541	PF02991	0.518
LIG_LIR_Gen_1	281	288	PF02991	0.428
LIG_LIR_Gen_1	295	305	PF02991	0.459
LIG_LIR_Gen_1	393	403	PF02991	0.465
LIG_LIR_Gen_1	434	444	PF02991	0.485
LIG_LIR_Gen_1	597	607	PF02991	0.340
LIG_LIR_Gen_1	637	645	PF02991	0.406
LIG_LIR_LC3C_4	618	623	PF02991	0.241
LIG_LIR_Nem_3	281	285	PF02991	0.444
LIG_LIR_Nem_3	295	301	PF02991	0.430
LIG_LIR_Nem_3	350	354	PF02991	0.417
LIG_LIR_Nem_3	369	374	PF02991	0.482
LIG_LIR_Nem_3	393	398	PF02991	0.416
LIG_LIR_Nem_3	434	439	PF02991	0.478
LIG_LIR_Nem_3	587	592	PF02991	0.385
LIG_LIR_Nem_3	597	603	PF02991	0.332
LIG_LIR_Nem_3	637	642	PF02991	0.402
LIG_LIR_Nem_3	704	709	PF02991	0.361
LIG_LIR_Nem_3	745	751	PF02991	0.514
LIG_LIR_Nem_3	757	763	PF02991	0.407
LIG_MAD2	154	162	PF02301	0.483
LIG_NRBOX	569	575	PF00104	0.415
LIG_NRBOX	742	748	PF00104	0.406
LIG_Pex14_1	86	90	PF04695	0.434
LIG_Pex14_2	478	482	PF04695	0.408
LIG_Pex14_2	90	94	PF04695	0.582
LIG_PTB_Apo_2	84	91	PF02174	0.687
LIG_Rb_pABgroove_1	742	750	PF01858	0.364
LIG_REV1ctd_RIR_1	129	138	PF16727	0.376
LIG_SH2_CRK	298	302	PF00017	0.518
LIG_SH2_CRK	351	355	PF00017	0.518
LIG_SH2_CRK	374	378	PF00017	0.459
LIG_SH2_CRK	395	399	PF00017	0.450
LIG_SH2_CRK	538	542	PF00017	0.518
LIG_SH2_PTP2	600	603	PF00017	0.373
LIG_SH2_SRC	395	398	PF00017	0.333
LIG_SH2_STAP1	636	640	PF00017	0.398
LIG_SH2_STAT5	109	112	PF00017	0.435
LIG_SH2_STAT5	191	194	PF00017	0.437
LIG_SH2_STAT5	202	205	PF00017	0.372
LIG_SH2_STAT5	257	260	PF00017	0.429
LIG_SH2_STAT5	282	285	PF00017	0.486
LIG_SH2_STAT5	298	301	PF00017	0.410
LIG_SH2_STAT5	359	362	PF00017	0.420
LIG_SH2_STAT5	379	382	PF00017	0.390
LIG_SH2_STAT5	390	393	PF00017	0.366
LIG_SH2_STAT5	600	603	PF00017	0.297
LIG_SH2_STAT5	61	64	PF00017	0.556
LIG_SH3_3	414	420	PF00018	0.478
LIG_SH3_3	437	443	PF00018	0.493
LIG_SH3_3	520	526	PF00018	0.472
LIG_SUMO_SIM_anti_2	169	176	PF11976	0.362
LIG_SUMO_SIM_anti_2	615	624	PF11976	0.344
LIG_SUMO_SIM_anti_2	739	749	PF11976	0.444
LIG_SUMO_SIM_par_1	169	176	PF11976	0.402
LIG_SUMO_SIM_par_1	308	314	PF11976	0.429
LIG_SUMO_SIM_par_1	641	649	PF11976	0.545
LIG_TRAF2_1	615	618	PF00917	0.373
LIG_TRAF2_1	677	680	PF00917	0.342
LIG_TRAF2_1	701	704	PF00917	0.417
LIG_TYR_ITIM	280	285	PF00017	0.512
LIG_TYR_ITIM	296	301	PF00017	0.403
LIG_TYR_ITIM	598	603	PF00017	0.340
LIG_WRC_WIRS_1	479	484	PF05994	0.427
MOD_CK1_1	115	121	PF00069	0.467
MOD_CK1_1	627	633	PF00069	0.444
MOD_CK1_1	646	652	PF00069	0.401
MOD_CK1_1	654	660	PF00069	0.456
MOD_CK1_1	710	716	PF00069	0.451
MOD_CK1_1	726	732	PF00069	0.481
MOD_CK2_1	114	120	PF00069	0.438
MOD_CK2_1	136	142	PF00069	0.453
MOD_CK2_1	425	431	PF00069	0.483
MOD_CK2_1	5	11	PF00069	0.684
MOD_CK2_1	612	618	PF00069	0.385
MOD_CK2_1	646	652	PF00069	0.530
MOD_CK2_1	673	679	PF00069	0.418
MOD_CK2_1	698	704	PF00069	0.450
MOD_CK2_1	70	76	PF00069	0.623
MOD_CMANNOS	86	89	PF00535	0.635
MOD_GlcNHglycan	116	120	PF01048	0.291
MOD_GlcNHglycan	147	150	PF01048	0.234
MOD_GlcNHglycan	292	295	PF01048	0.230
MOD_GlcNHglycan	318	322	PF01048	0.233
MOD_GlcNHglycan	337	340	PF01048	0.240
MOD_GlcNHglycan	454	457	PF01048	0.288
MOD_GlcNHglycan	461	464	PF01048	0.239
MOD_GlcNHglycan	498	501	PF01048	0.237
MOD_GlcNHglycan	711	715	PF01048	0.515
MOD_GSK3_1	1	8	PF00069	0.543
MOD_GSK3_1	108	115	PF00069	0.458
MOD_GSK3_1	150	157	PF00069	0.438
MOD_GSK3_1	251	258	PF00069	0.485
MOD_GSK3_1	335	342	PF00069	0.497
MOD_GSK3_1	37	44	PF00069	0.497
MOD_GSK3_1	380	387	PF00069	0.376
MOD_GSK3_1	425	432	PF00069	0.483
MOD_GSK3_1	518	525	PF00069	0.426
MOD_GSK3_1	608	615	PF00069	0.358
MOD_GSK3_1	671	678	PF00069	0.431
MOD_GSK3_1	719	726	PF00069	0.491
MOD_GSK3_1	88	95	PF00069	0.475
MOD_N-GLC_1	290	295	PF02516	0.268
MOD_N-GLC_1	306	311	PF02516	0.148
MOD_N-GLC_1	36	41	PF02516	0.633
MOD_N-GLC_1	517	522	PF02516	0.283
MOD_N-GLC_1	624	629	PF02516	0.455
MOD_N-GLC_1	663	668	PF02516	0.429
MOD_NEK2_1	1	6	PF00069	0.596
MOD_NEK2_1	150	155	PF00069	0.423
MOD_NEK2_1	341	346	PF00069	0.470
MOD_NEK2_1	41	46	PF00069	0.521
MOD_NEK2_1	478	483	PF00069	0.374
MOD_NEK2_1	542	547	PF00069	0.527
MOD_NEK2_1	580	585	PF00069	0.388
MOD_NEK2_1	671	676	PF00069	0.459
MOD_NEK2_1	68	73	PF00069	0.625
MOD_NEK2_1	723	728	PF00069	0.372
MOD_PIKK_1	339	345	PF00454	0.496
MOD_PIKK_1	407	413	PF00454	0.570
MOD_PIKK_1	5	11	PF00454	0.562
MOD_PIKK_1	548	554	PF00454	0.496
MOD_PK_1	413	419	PF00069	0.600
MOD_PK_1	698	704	PF00069	0.538
MOD_PKA_1	412	418	PF00069	0.606
MOD_PKA_1	698	704	PF00069	0.430
MOD_PKA_2	145	151	PF00069	0.477
MOD_PKA_2	231	237	PF00069	0.510
MOD_PKA_2	37	43	PF00069	0.490
MOD_PKA_2	429	435	PF00069	0.537
MOD_PKA_2	452	458	PF00069	0.302
MOD_PKA_2	50	56	PF00069	0.533
MOD_PKA_2	612	618	PF00069	0.377
MOD_PKA_2	719	725	PF00069	0.405
MOD_Plk_1	134	140	PF00069	0.432
MOD_Plk_1	306	312	PF00069	0.405
MOD_Plk_1	36	42	PF00069	0.687
MOD_Plk_1	651	657	PF00069	0.448
MOD_Plk_1	739	745	PF00069	0.461
MOD_Plk_1	756	762	PF00069	0.317
MOD_Plk_2-3	136	142	PF00069	0.408
MOD_Plk_2-3	306	312	PF00069	0.408
MOD_Plk_4	278	284	PF00069	0.442
MOD_Plk_4	367	373	PF00069	0.422
MOD_Plk_4	413	419	PF00069	0.555
MOD_Plk_4	435	441	PF00069	0.560
MOD_Plk_4	726	732	PF00069	0.464
MOD_Plk_4	739	745	PF00069	0.291
MOD_ProDKin_1	522	528	PF00069	0.425
MOD_ProDKin_1	624	630	PF00069	0.529
MOD_SUMO_rev_2	240	248	PF00179	0.411
MOD_SUMO_rev_2	44	53	PF00179	0.639
MOD_SUMO_rev_2	481	489	PF00179	0.369
TRG_DiLeu_BaEn_1	617	622	PF01217	0.314
TRG_DiLeu_BaEn_1	704	709	PF01217	0.378
TRG_DiLeu_BaEn_2	473	479	PF01217	0.427
TRG_DiLeu_LyEn_5	704	709	PF01217	0.378
TRG_ENDOCYTIC_2	282	285	PF00928	0.485
TRG_ENDOCYTIC_2	298	301	PF00928	0.455
TRG_ENDOCYTIC_2	351	354	PF00928	0.518
TRG_ENDOCYTIC_2	395	398	PF00928	0.450
TRG_ENDOCYTIC_2	600	603	PF00928	0.398
TRG_ENDOCYTIC_2	636	639	PF00928	0.378
TRG_ENDOCYTIC_2	760	763	PF00928	0.417
TRG_ER_diArg_1	315	317	PF00400	0.459
TRG_ER_diArg_1	331	334	PF00400	0.425
TRG_ER_diArg_1	538	540	PF00400	0.527
TRG_NES_CRM1_1	169	181	PF08389	0.518
TRG_NES_CRM1_1	295	306	PF08389	0.464
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.419
TRG_Pf-PMV_PEXEL_1	707	711	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5H4	Leptomonas seymouri	25%	92%
A0A0N1HZ98	Leptomonas seymouri	73%	100%
A0A0N1I3M2	Leptomonas seymouri	25%	100%
A0A0N1PBW1	Leptomonas seymouri	25%	100%
A0A0S4IJW8	Bodo saltans	26%	94%
A0A0S4IQM0	Bodo saltans	24%	100%
A0A0S4J8J7	Bodo saltans	40%	84%
A0A1X0NEV8	Trypanosomatidae	25%	97%
A0A1X0NLI2	Trypanosomatidae	25%	100%
A0A1X0NMQ3	Trypanosomatidae	56%	99%
A0A1X0P419	Trypanosomatidae	27%	100%
A0A3Q8IDH4	Leishmania donovani	95%	100%
A0A3Q8IPU3	Leishmania donovani	25%	100%
A0A3R7KM50	Trypanosoma rangeli	27%	97%
A0A3R7L048	Trypanosoma rangeli	26%	100%
A0A3S5H688	Leishmania donovani	23%	89%
A0A3S7XC76	Leishmania donovani	27%	100%
A0A422N0Z6	Trypanosoma rangeli	55%	99%
A0A422NK00	Trypanosoma rangeli	23%	100%
A4HE78	Leishmania braziliensis	90%	100%
A4HFK9	Leishmania braziliensis	25%	100%
A4HQF8	Leishmania braziliensis	26%	100%
A4HTP5	Leishmania infantum	23%	89%
A4I1J2	Leishmania infantum	95%	100%
A4IC94	Leishmania infantum	27%	100%
C9ZJX4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	96%
C9ZPE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	99%
D0A3K7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
D0A5T5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AD64	Leishmania major	25%	100%
E9AHF6	Leishmania infantum	25%	100%
E9AI34	Leishmania braziliensis	25%	100%
E9AMI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AU74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AYY9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
Q4Q0C0	Leishmania major	25%	100%
Q4Q9U5	Leishmania major	94%	100%
Q4QI57	Leishmania major	24%	100%
Q5JST6	Homo sapiens	25%	100%
V5ASV2	Trypanosoma cruzi	24%	100%
V5D3X9	Trypanosoma cruzi	55%	99%
V5DA42	Trypanosoma cruzi	27%	100%