LeishMANIAdb
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Peptide chain release factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Peptide chain release factor-like protein
Gene product:
Peptide chain release factor 1, mitochondrial, putative
Species:
Leishmania mexicana
UniProt:
E9AXM6_LEIMU
TriTrypDb:
LmxM.25.1450
Length:
439

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 10
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AXM6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXM6

Function

Biological processes
Term Name Level Count
GO:0006415 translational termination 6 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022411 cellular component disassembly 4 1
GO:0032984 protein-containing complex disassembly 5 1
GO:0043933 protein-containing complex organization 4 1
GO:0071840 cellular component organization or biogenesis 2 1
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 11
GO:0003747 translation release factor activity 5 11
GO:0005488 binding 1 11
GO:0008079 translation termination factor activity 4 11
GO:0008135 translation factor activity, RNA binding 3 11
GO:0045182 translation regulator activity 1 11
GO:0090079 translation regulator activity, nucleic acid binding 2 11
GO:0097159 organic cyclic compound binding 2 11
GO:1901363 heterocyclic compound binding 2 11

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 166 168 PF00675 0.203
CLV_PCSK_KEX2_1 166 168 PF00082 0.203
CLV_PCSK_KEX2_1 60 62 PF00082 0.341
CLV_PCSK_PC1ET2_1 60 62 PF00082 0.400
CLV_PCSK_PC7_1 56 62 PF00082 0.327
CLV_PCSK_SKI1_1 330 334 PF00082 0.214
CLV_PCSK_SKI1_1 429 433 PF00082 0.453
CLV_PCSK_SKI1_1 7 11 PF00082 0.509
DEG_APCC_KENBOX_2 34 38 PF00400 0.354
DEG_Nend_Nbox_1 1 3 PF02207 0.620
DOC_ANK_TNKS_1 296 303 PF00023 0.414
DOC_MAPK_gen_1 97 104 PF00069 0.352
DOC_PP1_RVXF_1 290 296 PF00149 0.427
DOC_PP1_RVXF_1 5 11 PF00149 0.540
DOC_USP7_MATH_1 228 232 PF00917 0.488
DOC_USP7_MATH_1 396 400 PF00917 0.487
DOC_USP7_MATH_1 72 76 PF00917 0.372
DOC_WW_Pin1_4 84 89 PF00397 0.654
LIG_14-3-3_CanoR_1 206 215 PF00244 0.494
LIG_14-3-3_CanoR_1 256 266 PF00244 0.403
LIG_14-3-3_CanoR_1 385 391 PF00244 0.406
LIG_BIR_III_4 261 265 PF00653 0.470
LIG_BRCT_BRCA1_1 230 234 PF00533 0.449
LIG_BRCT_BRCA1_1 85 89 PF00533 0.459
LIG_CaM_IQ_9 12 28 PF13499 0.556
LIG_FHA_1 148 154 PF00498 0.489
LIG_FHA_1 36 42 PF00498 0.412
LIG_FHA_1 422 428 PF00498 0.414
LIG_FHA_1 49 55 PF00498 0.288
LIG_FHA_2 118 124 PF00498 0.445
LIG_FHA_2 146 152 PF00498 0.532
LIG_LIR_Apic_2 378 382 PF02991 0.414
LIG_LIR_Gen_1 270 281 PF02991 0.582
LIG_LIR_Nem_3 203 208 PF02991 0.452
LIG_LIR_Nem_3 86 92 PF02991 0.449
LIG_MYND_1 277 281 PF01753 0.385
LIG_PDZ_Class_1 434 439 PF00595 0.443
LIG_Pex14_1 94 98 PF04695 0.379
LIG_RPA_C_Fungi 162 174 PF08784 0.312
LIG_SH2_CRK 379 383 PF00017 0.225
LIG_SH2_STAP1 208 212 PF00017 0.297
LIG_SH2_STAT5 29 32 PF00017 0.500
LIG_SH2_STAT5 53 56 PF00017 0.268
LIG_SH2_STAT5 91 94 PF00017 0.492
LIG_SH3_3 275 281 PF00018 0.383
LIG_SUMO_SIM_par_1 280 285 PF11976 0.331
LIG_UBA3_1 138 143 PF00899 0.383
LIG_UBA3_1 427 432 PF00899 0.483
LIG_UBA3_1 54 60 PF00899 0.430
LIG_WRC_WIRS_1 397 402 PF05994 0.377
MOD_CK1_1 129 135 PF00069 0.248
MOD_CK1_1 320 326 PF00069 0.252
MOD_CK2_1 145 151 PF00069 0.228
MOD_CK2_1 227 233 PF00069 0.182
MOD_CK2_1 365 371 PF00069 0.297
MOD_CK2_1 396 402 PF00069 0.438
MOD_GlcNHglycan 22 25 PF01048 0.443
MOD_GlcNHglycan 236 239 PF01048 0.238
MOD_GlcNHglycan 298 301 PF01048 0.252
MOD_GlcNHglycan 319 322 PF01048 0.252
MOD_GlcNHglycan 330 333 PF01048 0.252
MOD_GlcNHglycan 368 371 PF01048 0.252
MOD_GlcNHglycan 4 7 PF01048 0.477
MOD_GlcNHglycan 404 407 PF01048 0.497
MOD_GlcNHglycan 69 73 PF01048 0.388
MOD_GSK3_1 223 230 PF00069 0.301
MOD_GSK3_1 267 274 PF00069 0.237
MOD_GSK3_1 313 320 PF00069 0.252
MOD_GSK3_1 366 373 PF00069 0.262
MOD_GSK3_1 68 75 PF00069 0.546
MOD_N-GLC_1 117 122 PF02516 0.258
MOD_N-GLC_1 355 360 PF02516 0.252
MOD_NEK2_1 173 178 PF00069 0.280
MOD_NEK2_1 2 7 PF00069 0.640
MOD_NEK2_1 204 209 PF00069 0.301
MOD_NEK2_1 266 271 PF00069 0.237
MOD_NEK2_1 306 311 PF00069 0.252
MOD_NEK2_1 41 46 PF00069 0.336
MOD_PIKK_1 12 18 PF00454 0.462
MOD_PKA_1 20 26 PF00069 0.459
MOD_PKA_2 296 302 PF00069 0.243
MOD_PKA_2 384 390 PF00069 0.252
MOD_PKA_2 402 408 PF00069 0.365
MOD_Plk_1 117 123 PF00069 0.372
MOD_Plk_1 192 198 PF00069 0.237
MOD_Plk_1 355 361 PF00069 0.252
MOD_Plk_2-3 117 123 PF00069 0.418
MOD_Plk_2-3 145 151 PF00069 0.288
MOD_Plk_2-3 280 286 PF00069 0.331
MOD_Plk_4 192 198 PF00069 0.238
MOD_Plk_4 396 402 PF00069 0.380
MOD_ProDKin_1 84 90 PF00069 0.647
MOD_SUMO_for_1 25 28 PF00179 0.431
MOD_SUMO_rev_2 285 293 PF00179 0.282
TRG_DiLeu_BaEn_1 151 156 PF01217 0.369
TRG_DiLeu_BaEn_3 136 142 PF01217 0.193
TRG_DiLeu_BaLyEn_6 4 9 PF01217 0.551
TRG_DiLeu_LyEn_5 151 156 PF01217 0.138
TRG_ENDOCYTIC_2 242 245 PF00928 0.237
TRG_ER_diArg_1 130 133 PF00400 0.258
TRG_ER_diArg_1 166 168 PF00400 0.238
TRG_NES_CRM1_1 144 159 PF08389 0.302
TRG_Pf-PMV_PEXEL_1 113 117 PF00026 0.356
TRG_Pf-PMV_PEXEL_1 154 159 PF00026 0.284

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I5V4 Leptomonas seymouri 77% 100%
A0A0S4JC65 Bodo saltans 39% 100%
A0A1X0NM55 Trypanosomatidae 62% 98%
A0A3R7K1X0 Trypanosoma rangeli 60% 96%
A0A3S7WZ74 Leishmania donovani 96% 100%
A0LYL5 Gramella forsetii (strain KT0803) 32% 100%
A0RRK4 Campylobacter fetus subsp. fetus (strain 82-40) 32% 100%
A1BJT9 Chlorobium phaeobacteroides (strain DSM 266) 35% 100%
A1QYZ0 Borrelia turicatae (strain 91E135) 33% 100%
A1SHH9 Nocardioides sp. (strain ATCC BAA-499 / JS614) 33% 100%
A1URS5 Bartonella bacilliformis (strain ATCC 35685 / NCTC 12138 / KC583) 31% 100%
A3M6N7 Acinetobacter baumannii (strain ATCC 17978 / CIP 53.77 / LMG 1025 / NCDC KC755 / 5377) 30% 100%
A4HE77 Leishmania braziliensis 91% 100%
A4I1J1 Leishmania infantum 95% 100%
A4SCF1 Chlorobium phaeovibrioides (strain DSM 265 / 1930) 32% 100%
A5CYC3 Pelotomaculum thermopropionicum (strain DSM 13744 / JCM 10971 / SI) 31% 100%
A5FHI8 Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / JCM 8514 / NBRC 14942 / NCIMB 11054 / UW101) 33% 100%
A5N3J7 Clostridium kluyveri (strain ATCC 8527 / DSM 555 / NCIMB 10680) 35% 100%
A5WFG1 Psychrobacter sp. (strain PRwf-1) 33% 100%
A6H0W3 Flavobacterium psychrophilum (strain ATCC 49511 / DSM 21280 / CIP 103535 / JIP02/86) 32% 100%
A6UCF2 Sinorhizobium medicae (strain WSM419) 29% 100%
A6WXQ3 Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37) 31% 100%
A7GV79 Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98) 35% 100%
A7ZB10 Campylobacter concisus (strain 13826) 30% 100%
A8EQZ4 Aliarcobacter butzleri (strain RM4018) 33% 100%
A8GXI1 Rickettsia bellii (strain OSU 85-389) 32% 100%
A9IER8 Bordetella petrii (strain ATCC BAA-461 / DSM 12804 / CCUG 43448) 32% 100%
A9M8K5 Brucella canis (strain ATCC 23365 / NCTC 10854) 32% 100%
A9NEP7 Acholeplasma laidlawii (strain PG-8A) 35% 100%
A9VSC7 Bacillus mycoides (strain KBAB4) 33% 100%
B0CIC3 Brucella suis (strain ATCC 23445 / NCTC 10510) 32% 100%
B0TX37 Francisella philomiragia subsp. philomiragia (strain ATCC 25017 / FSC 153 / O#319-036) 33% 100%
B0V7E0 Acinetobacter baumannii (strain AYE) 30% 100%
B0VM26 Acinetobacter baumannii (strain SDF) 30% 100%
B1AHY9 Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736) 33% 100%
B1GZI5 Endomicrobium trichonymphae 33% 100%
B1V950 Phytoplasma australiense 34% 100%
B1XJH8 Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) 35% 100%
B2HU82 Acinetobacter baumannii (strain ACICU) 30% 100%
B2RZQ6 Borrelia hermsii (strain HS1 / DAH) 35% 100%
B2S1Z9 Treponema pallidum subsp. pallidum (strain SS14) 32% 100%
B2S825 Brucella abortus (strain S19) 32% 100%
B2UDM7 Ralstonia pickettii (strain 12J) 32% 100%
B2URQ8 Helicobacter pylori (strain Shi470) 33% 100%
B3EE55 Chlorobium limicola (strain DSM 245 / NBRC 103803 / 6330) 32% 100%
B3PJP4 Cellvibrio japonicus (strain Ueda107) 31% 100%
B3QRH7 Chlorobaculum parvum (strain DSM 263 / NCIMB 8327) 35% 100%
B4SAR5 Pelodictyon phaeoclathratiforme (strain DSM 5477 / BU-1) 33% 100%
B5Z680 Helicobacter pylori (strain G27) 33% 100%
B5ZAH6 Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western) 33% 100%
B5ZRR4 Rhizobium leguminosarum bv. trifolii (strain WSM2304) 31% 100%
B6JPI0 Helicobacter pylori (strain P12) 32% 100%
B7H0L9 Acinetobacter baumannii (strain AB307-0294) 30% 100%
B7IBA1 Acinetobacter baumannii (strain AB0057) 30% 100%
B8E003 Dictyoglomus turgidum (strain DSM 6724 / Z-1310) 35% 100%
B8G7K1 Chloroflexus aggregans (strain MD-66 / DSM 9485) 33% 100%
B8J4R4 Desulfovibrio desulfuricans (strain ATCC 27774 / DSM 6949 / MB) 38% 100%
B8ZR31 Mycobacterium leprae (strain Br4923) 36% 100%
B9DMD1 Staphylococcus carnosus (strain TM300) 34% 100%
B9E8G1 Macrococcus caseolyticus (strain JCSC5402) 32% 100%
B9IRW2 Bacillus cereus (strain Q1) 34% 100%
B9JB75 Agrobacterium radiobacter (strain K84 / ATCC BAA-868) 31% 100%
C0QWA1 Brachyspira hyodysenteriae (strain ATCC 49526 / WA1) 32% 100%
C0RFB5 Brucella melitensis biotype 2 (strain ATCC 23457) 32% 100%
C5BSZ6 Teredinibacter turnerae (strain ATCC 39867 / T7901) 31% 100%
C9ZJX5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 61% 96%
O83090 Treponema pallidum (strain Nichols) 32% 100%
P45833 Mycobacterium leprae (strain TN) 36% 100%
P45872 Bacillus subtilis (strain 168) 36% 100%
P55998 Helicobacter pylori (strain ATCC 700392 / 26695) 33% 100%
Q03QX7 Levilactobacillus brevis (strain ATCC 367 / BCRC 12310 / CIP 105137 / JCM 1170 / LMG 11437 / NCIMB 947 / NCTC 947) 35% 100%
Q11E04 Chelativorans sp. (strain BNC1) 33% 100%
Q11NS4 Cytophaga hutchinsonii (strain ATCC 33406 / DSM 1761 / CIP 103989 / NBRC 15051 / NCIMB 9469 / D465) 35% 100%
Q13TU2 Paraburkholderia xenovorans (strain LB400) 31% 100%
Q17VT1 Helicobacter acinonychis (strain Sheeba) 32% 100%
Q180Y2 Clostridioides difficile (strain 630) 33% 100%
Q1CV77 Helicobacter pylori (strain HPAG1) 33% 100%
Q1GPK3 Sphingopyxis alaskensis (strain DSM 13593 / LMG 18877 / RB2256) 32% 100%
Q1MBB2 Rhizobium leguminosarum bv. viciae (strain 3841) 32% 100%
Q1RJT5 Rickettsia bellii (strain RML369-C) 32% 100%
Q2K3T1 Rhizobium etli (strain CFN 42 / ATCC 51251) 31% 100%
Q2KI15 Bos taurus 34% 100%
Q2N5U6 Erythrobacter litoralis (strain HTCC2594) 34% 100%
Q2YLN8 Brucella abortus (strain 2308) 32% 100%
Q30X18 Oleidesulfovibrio alaskensis (strain ATCC BAA-1058 / DSM 17464 / G20) 34% 100%
Q31IN8 Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2) 30% 100%
Q3B6R6 Chlorobium luteolum (strain DSM 273 / BCRC 81028 / 2530) 33% 100%
Q3IK95 Pseudoalteromonas translucida (strain TAC 125) 31% 100%
Q49Z65 Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41) 33% 100%
Q4A8M6 Mesomycoplasma hyopneumoniae (strain 7448) 34% 100%
Q4AAJ5 Mesomycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110) 34% 100%
Q4Q9U6 Leishmania major 95% 100%
Q4V7E5 Rattus norvegicus 34% 100%
Q57B22 Brucella abortus biovar 1 (strain 9-941) 32% 100%
Q5P7G7 Aromatoleum aromaticum (strain EbN1) 35% 100%
Q601F9 Mesomycoplasma hyopneumoniae (strain 232) 34% 100%
Q630R9 Bacillus cereus (strain ZK / E33L) 34% 100%
Q662G9 Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi) 34% 100%
Q6F9S2 Acinetobacter baylyi (strain ATCC 33305 / BD413 / ADP1) 32% 100%
Q6G0R0 Bartonella quintana (strain Toulouse) 32% 100%
Q6HAV4 Bacillus thuringiensis subsp. konkukian (strain 97-27) 34% 100%
Q6MRK9 Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100) 33% 100%
Q72XC2 Bacillus cereus (strain ATCC 10987 / NRS 248) 34% 100%
Q73JU6 Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104) 31% 100%
Q7MMY6 Vibrio vulnificus (strain YJ016) 32% 100%
Q7MXT5 Porphyromonas gingivalis (strain ATCC BAA-308 / W83) 36% 100%
Q7VFA0 Helicobacter hepaticus (strain ATCC 51449 / 3B1) 33% 100%
Q812I4 Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711) 34% 100%
Q81JX1 Bacillus anthracis 34% 100%
Q831F6 Enterococcus faecalis (strain ATCC 700802 / V583) 34% 100%
Q88UT2 Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1) 36% 100%
Q8BJU9 Mus musculus 33% 100%
Q8DFF9 Vibrio vulnificus (strain CMCP6) 32% 100%
Q8FYK3 Brucella suis biovar 1 (strain 1330) 32% 100%
Q8KG45 Chlorobaculum tepidum (strain ATCC 49652 / DSM 12025 / NBRC 103806 / TLS) 35% 100%
Q8RX79 Arabidopsis thaliana 33% 100%
Q8XVD0 Ralstonia solanacearum (strain GMI1000) 32% 100%
Q8YJ95 Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094) 32% 100%
Q92MK5 Rhizobium meliloti (strain 1021) 29% 100%
Q98G93 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) 32% 100%
Q9K6F4 Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125) 37% 100%
Q9PRE0 Ureaplasma parvum serovar 3 (strain ATCC 700970) 33% 100%
Q9UGC7 Homo sapiens 33% 100%
Q9ZD21 Rickettsia prowazekii (strain Madrid E) 30% 100%
Q9ZMZ0 Helicobacter pylori (strain J99 / ATCC 700824) 33% 100%
V5AN72 Trypanosoma cruzi 60% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS