S5A_REDUCTASE domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 23

Species:

Leishmania mexicana

UniProt:

E9AXM5_LEIMU

TriTrypDb:

LmxM.25.1445

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005739	mitochondrion	5	1
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9AXM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXM5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	10
GO:0008152	metabolic process	1	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016491	oxidoreductase activity	2	10
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors	3	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	176	178	PF00675	0.490
CLV_NRD_NRD_1	19	21	PF00675	0.392
CLV_NRD_NRD_1	32	34	PF00675	0.334
DOC_CYCLIN_RxL_1	98	107	PF00134	0.333
DOC_MAPK_gen_1	30	38	PF00069	0.542
DOC_MAPK_MEF2A_6	109	116	PF00069	0.351
DOC_PP1_RVXF_1	99	106	PF00149	0.353
DOC_PP2B_LxvP_1	224	227	PF13499	0.292
DOC_PP4_FxxP_1	105	108	PF00568	0.302
DOC_USP7_MATH_1	142	146	PF00917	0.496
DOC_USP7_MATH_1	205	209	PF00917	0.252
DOC_USP7_MATH_1	234	238	PF00917	0.443
LIG_14-3-3_CanoR_1	210	215	PF00244	0.248
LIG_APCC_ABBAyCdc20_2	101	107	PF00400	0.266
LIG_BIR_II_1	1	5	PF00653	0.787
LIG_BRCT_BRCA1_1	202	206	PF00533	0.290
LIG_BRCT_BRCA1_1	42	46	PF00533	0.546
LIG_BRCT_BRCA1_1	76	80	PF00533	0.581
LIG_FHA_1	64	70	PF00498	0.557
LIG_FHA_2	11	17	PF00498	0.656
LIG_LIR_Gen_1	211	220	PF02991	0.330
LIG_LIR_Gen_1	39	47	PF02991	0.507
LIG_LIR_Gen_1	85	94	PF02991	0.269
LIG_LIR_Nem_3	203	207	PF02991	0.290
LIG_LIR_Nem_3	211	217	PF02991	0.268
LIG_LIR_Nem_3	219	224	PF02991	0.269
LIG_LIR_Nem_3	37	41	PF02991	0.544
LIG_LIR_Nem_3	43	47	PF02991	0.544
LIG_LIR_Nem_3	85	90	PF02991	0.308
LIG_Pex14_1	131	135	PF04695	0.268
LIG_Pex14_1	221	225	PF04695	0.268
LIG_PTB_Apo_2	180	187	PF02174	0.298
LIG_PTB_Apo_2	188	195	PF02174	0.281
LIG_PTB_Phospho_1	188	194	PF10480	0.329
LIG_REV1ctd_RIR_1	183	191	PF16727	0.234
LIG_RPA_C_Fungi	205	217	PF08784	0.170
LIG_SH2_CRK	135	139	PF00017	0.295
LIG_SH2_CRK	87	91	PF00017	0.268
LIG_SH2_STAT5	156	159	PF00017	0.226
LIG_SH2_STAT5	171	174	PF00017	0.362
LIG_SH2_STAT5	194	197	PF00017	0.292
LIG_SH2_STAT5	245	248	PF00017	0.323
LIG_SH2_STAT5	41	44	PF00017	0.357
LIG_SH2_STAT5	87	90	PF00017	0.304
LIG_SH2_STAT5	99	102	PF00017	0.396
LIG_SH3_3	123	129	PF00018	0.268
LIG_SUMO_SIM_anti_2	211	219	PF11976	0.471
LIG_SUMO_SIM_par_1	211	219	PF11976	0.330
LIG_TYR_ITIM	133	138	PF00017	0.302
LIG_WRC_WIRS_1	201	206	PF05994	0.268
LIG_WRC_WIRS_1	41	46	PF05994	0.234
MOD_CK1_1	208	214	PF00069	0.379
MOD_CK2_1	10	16	PF00069	0.717
MOD_GlcNHglycan	1	4	PF01048	0.774
MOD_GlcNHglycan	10	13	PF01048	0.563
MOD_GlcNHglycan	117	120	PF01048	0.308
MOD_GlcNHglycan	70	73	PF01048	0.435
MOD_GlcNHglycan	76	79	PF01048	0.412
MOD_GlcNHglycan	80	83	PF01048	0.323
MOD_GSK3_1	205	212	PF00069	0.402
MOD_GSK3_1	36	43	PF00069	0.466
MOD_GSK3_1	74	81	PF00069	0.393
MOD_N-GLC_1	78	83	PF02516	0.268
MOD_NEK2_1	186	191	PF00069	0.382
MOD_NEK2_1	206	211	PF00069	0.150
MOD_NEK2_1	42	47	PF00069	0.449
MOD_NEK2_1	68	73	PF00069	0.365
MOD_NEK2_1	74	79	PF00069	0.319
MOD_NEK2_1	80	85	PF00069	0.232
MOD_NEK2_1	90	95	PF00069	0.227
MOD_PKA_2	209	215	PF00069	0.287
MOD_PKA_2	234	240	PF00069	0.419
MOD_PKB_1	6	14	PF00069	0.578
MOD_Plk_4	150	156	PF00069	0.305
MOD_Plk_4	210	216	PF00069	0.425
MOD_Plk_4	225	231	PF00069	0.338
MOD_Plk_4	23	29	PF00069	0.495
MOD_Plk_4	63	69	PF00069	0.307
TRG_DiLeu_BaEn_1	176	181	PF01217	0.346
TRG_ENDOCYTIC_2	130	133	PF00928	0.268
TRG_ENDOCYTIC_2	135	138	PF00928	0.291
TRG_ENDOCYTIC_2	171	174	PF00928	0.315
TRG_ENDOCYTIC_2	201	204	PF00928	0.268
TRG_ENDOCYTIC_2	41	44	PF00928	0.237
TRG_ENDOCYTIC_2	87	90	PF00928	0.268
TRG_ER_diArg_1	6	9	PF00400	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7H2	Leptomonas seymouri	68%	98%
A0A0S4JBK7	Bodo saltans	60%	100%
A0A3R7KQ16	Trypanosoma rangeli	58%	100%
A0A3S7WZ53	Leishmania donovani	93%	100%
A4HE76	Leishmania braziliensis	81%	100%
A4I1J0	Leishmania infantum	93%	100%
C9ZJX6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
Q4Q9U7	Leishmania major	93%	100%
V5B3K3	Trypanosoma cruzi	61%	90%