Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U1 small nuclear ribonucleoprotein 24 kDa

Species:

Leishmania mexicana

UniProt:

E9AXM4_LEIMU

TriTrypDb:

LmxM.25.1443

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005685	U1 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9AXM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXM4

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0045292	mRNA cis splicing, via spliceosome	9	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.521
CLV_NRD_NRD_1	216	218	PF00675	0.592
CLV_NRD_NRD_1	250	252	PF00675	0.453
CLV_NRD_NRD_1	38	40	PF00675	0.392
CLV_NRD_NRD_1	83	85	PF00675	0.600
CLV_PCSK_KEX2_1	117	119	PF00082	0.547
CLV_PCSK_KEX2_1	216	218	PF00082	0.595
CLV_PCSK_KEX2_1	250	252	PF00082	0.473
CLV_PCSK_KEX2_1	38	40	PF00082	0.378
CLV_PCSK_KEX2_1	82	84	PF00082	0.622
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.624
CLV_PCSK_SKI1_1	190	194	PF00082	0.579
CLV_PCSK_SKI1_1	39	43	PF00082	0.398
CLV_PCSK_SKI1_1	90	94	PF00082	0.445
DOC_CKS1_1	153	158	PF01111	0.379
DOC_CYCLIN_yCln2_LP_2	186	189	PF00134	0.456
DOC_CYCLIN_yCln2_LP_2	75	81	PF00134	0.676
DOC_MAPK_DCC_7	99	108	PF00069	0.549
DOC_MAPK_JIP1_4	195	201	PF00069	0.584
DOC_MAPK_MEF2A_6	195	203	PF00069	0.582
DOC_PP1_RVXF_1	82	89	PF00149	0.666
DOC_PP2B_LxvP_1	186	189	PF13499	0.456
DOC_USP7_MATH_1	129	133	PF00917	0.712
DOC_USP7_MATH_1	61	65	PF00917	0.669
DOC_WW_Pin1_4	122	127	PF00397	0.693
DOC_WW_Pin1_4	152	157	PF00397	0.382
LIG_14-3-3_CanoR_1	190	199	PF00244	0.596
LIG_14-3-3_CanoR_1	216	223	PF00244	0.666
LIG_14-3-3_CanoR_1	251	259	PF00244	0.503
LIG_14-3-3_CanoR_1	82	87	PF00244	0.683
LIG_CtBP_PxDLS_1	105	109	PF00389	0.508
LIG_deltaCOP1_diTrp_1	241	247	PF00928	0.507
LIG_eIF4E_1	69	75	PF01652	0.645
LIG_FHA_1	181	187	PF00498	0.500
LIG_FHA_2	208	214	PF00498	0.536
LIG_LIR_Gen_1	30	36	PF02991	0.396
LIG_LIR_Gen_1	85	96	PF02991	0.682
LIG_LIR_Nem_3	12	17	PF02991	0.501
LIG_LIR_Nem_3	30	34	PF02991	0.391
LIG_LIR_Nem_3	85	91	PF02991	0.631
LIG_MYND_1	101	105	PF01753	0.535
LIG_PCNA_yPIPBox_3	68	82	PF02747	0.679
LIG_SH2_CRK	14	18	PF00017	0.547
LIG_SH2_GRB2like	200	203	PF00017	0.535
LIG_SH2_SRC	146	149	PF00017	0.398
LIG_SH2_STAT5	113	116	PF00017	0.554
LIG_SH2_STAT5	146	149	PF00017	0.382
LIG_SH2_STAT5	16	19	PF00017	0.422
LIG_SH2_STAT5	160	163	PF00017	0.415
LIG_SH2_STAT5	200	203	PF00017	0.535
LIG_SH2_STAT5	69	72	PF00017	0.681
LIG_SH3_3	153	159	PF00018	0.380
LIG_SH3_3	30	36	PF00018	0.507
LIG_SUMO_SIM_anti_2	166	172	PF11976	0.491
LIG_TRAF2_1	210	213	PF00917	0.625
LIG_TRAF2_1	235	238	PF00917	0.602
LIG_TYR_ITIM	198	203	PF00017	0.535
LIG_WRC_WIRS_1	222	227	PF05994	0.628
LIG_WRC_WIRS_1	93	98	PF05994	0.705
LIG_WW_3	187	191	PF00397	0.625
MOD_CDK_SPxK_1	152	158	PF00069	0.495
MOD_CK1_1	224	230	PF00069	0.709
MOD_CK1_1	60	66	PF00069	0.663
MOD_CK1_1	95	101	PF00069	0.585
MOD_CK2_1	207	213	PF00069	0.613
MOD_CK2_1	231	237	PF00069	0.632
MOD_CK2_1	45	51	PF00069	0.593
MOD_CMANNOS	244	247	PF00535	0.500
MOD_GlcNHglycan	139	142	PF01048	0.633
MOD_GlcNHglycan	190	193	PF01048	0.624
MOD_GlcNHglycan	233	236	PF01048	0.584
MOD_GlcNHglycan	47	50	PF01048	0.591
MOD_GlcNHglycan	59	62	PF01048	0.703
MOD_GSK3_1	221	228	PF00069	0.674
MOD_GSK3_1	45	52	PF00069	0.572
MOD_GSK3_1	57	64	PF00069	0.677
MOD_NEK2_1	225	230	PF00069	0.733
MOD_NEK2_1	249	254	PF00069	0.572
MOD_PIKK_1	190	196	PF00454	0.566
MOD_PIKK_1	252	258	PF00454	0.641
MOD_PIKK_1	69	75	PF00454	0.679
MOD_PK_1	130	136	PF00069	0.680
MOD_PKA_1	216	222	PF00069	0.626
MOD_PKA_1	82	88	PF00069	0.667
MOD_PKA_2	129	135	PF00069	0.771
MOD_PKA_2	215	221	PF00069	0.615
MOD_PKA_2	249	255	PF00069	0.654
MOD_PKA_2	82	88	PF00069	0.667
MOD_Plk_1	130	136	PF00069	0.684
MOD_Plk_1	181	187	PF00069	0.446
MOD_Plk_1	61	67	PF00069	0.681
MOD_Plk_4	130	136	PF00069	0.535
MOD_Plk_4	6	12	PF00069	0.615
MOD_Plk_4	61	67	PF00069	0.681
MOD_ProDKin_1	122	128	PF00069	0.697
MOD_ProDKin_1	152	158	PF00069	0.383
TRG_DiLeu_BaEn_1	182	187	PF01217	0.448
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.430
TRG_ENDOCYTIC_2	14	17	PF00928	0.542
TRG_ENDOCYTIC_2	146	149	PF00928	0.470
TRG_ENDOCYTIC_2	200	203	PF00928	0.535
TRG_ER_diArg_1	116	119	PF00400	0.540
TRG_ER_diArg_1	215	217	PF00400	0.633
TRG_ER_diArg_1	249	251	PF00400	0.494
TRG_ER_diArg_1	81	84	PF00400	0.622

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN1	Leptomonas seymouri	55%	100%
A0A1X0NM21	Trypanosomatidae	27%	100%
A0A3S5H7E8	Leishmania donovani	91%	100%
A0A422N0Z0	Trypanosoma rangeli	30%	100%
A4HE80	Leishmania braziliensis	86%	100%
A4I1I9	Leishmania infantum	90%	100%
C9ZJX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
Q4Q9U8	Leishmania major	92%	100%
V5BCP1	Trypanosoma cruzi	27%	100%