Exonuclease domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXM3_LEIMU

TriTrypDb:

LmxM.25.1440

Length:

508

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXM3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXM3

Function

Biological processes
Term	Name	Level	Count
GO:0000738	obsolete DNA catabolic process, exonucleolytic	6	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006259	DNA metabolic process	4	1
GO:0006308	DNA catabolic process	5	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0046483	heterocycle metabolic process	3	1
GO:0046700	heterocycle catabolic process	4	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003824	catalytic activity	1	10
GO:0004518	nuclease activity	4	10
GO:0004527	exonuclease activity	5	10
GO:0005488	binding	1	10
GO:0008408	3'-5' exonuclease activity	6	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0004529	DNA exonuclease activity	5	1
GO:0004536	DNA nuclease activity	4	1
GO:0008296	3'-5'-DNA exonuclease activity	7	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016895	DNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0140097	catalytic activity, acting on DNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	351	355	PF00656	0.778
CLV_NRD_NRD_1	10	12	PF00675	0.556
CLV_NRD_NRD_1	135	137	PF00675	0.310
CLV_NRD_NRD_1	231	233	PF00675	0.290
CLV_NRD_NRD_1	3	5	PF00675	0.568
CLV_NRD_NRD_1	461	463	PF00675	0.773
CLV_NRD_NRD_1	482	484	PF00675	0.743
CLV_PCSK_FUR_1	479	483	PF00082	0.738
CLV_PCSK_KEX2_1	10	12	PF00082	0.535
CLV_PCSK_KEX2_1	230	232	PF00082	0.288
CLV_PCSK_KEX2_1	3	5	PF00082	0.572
CLV_PCSK_KEX2_1	478	480	PF00082	0.771
CLV_PCSK_KEX2_1	481	483	PF00082	0.754
CLV_PCSK_KEX2_1	76	78	PF00082	0.543
CLV_PCSK_PC1ET2_1	478	480	PF00082	0.782
CLV_PCSK_PC1ET2_1	481	483	PF00082	0.770
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.543
CLV_PCSK_PC7_1	226	232	PF00082	0.290
CLV_PCSK_SKI1_1	185	189	PF00082	0.296
CLV_PCSK_SKI1_1	232	236	PF00082	0.286
CLV_PCSK_SKI1_1	302	306	PF00082	0.510
CLV_PCSK_SKI1_1	42	46	PF00082	0.411
CLV_PCSK_SKI1_1	452	456	PF00082	0.810
CLV_PCSK_SKI1_1	89	93	PF00082	0.418
DEG_MDM2_SWIB_1	160	168	PF02201	0.531
DEG_Nend_Nbox_1	1	3	PF02207	0.696
DEG_SPOP_SBC_1	339	343	PF00917	0.681
DEG_SPOP_SBC_1	416	420	PF00917	0.489
DOC_AGCK_PIF_1	88	93	PF00069	0.357
DOC_CKS1_1	171	176	PF01111	0.508
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.371
DOC_MAPK_gen_1	10	17	PF00069	0.625
DOC_MAPK_gen_1	230	236	PF00069	0.527
DOC_MAPK_gen_1	76	84	PF00069	0.526
DOC_MAPK_HePTP_8	74	86	PF00069	0.525
DOC_MAPK_MEF2A_6	77	86	PF00069	0.526
DOC_PP1_RVXF_1	164	171	PF00149	0.469
DOC_PP2B_LxvP_1	84	87	PF13499	0.380
DOC_PP4_FxxP_1	97	100	PF00568	0.490
DOC_USP7_MATH_1	196	200	PF00917	0.490
DOC_USP7_MATH_1	313	317	PF00917	0.483
DOC_USP7_MATH_1	328	332	PF00917	0.710
DOC_USP7_MATH_1	339	343	PF00917	0.618
DOC_USP7_MATH_1	348	352	PF00917	0.536
DOC_USP7_MATH_1	359	363	PF00917	0.702
DOC_USP7_MATH_1	405	409	PF00917	0.663
DOC_WW_Pin1_4	116	121	PF00397	0.490
DOC_WW_Pin1_4	170	175	PF00397	0.508
DOC_WW_Pin1_4	252	257	PF00397	0.438
DOC_WW_Pin1_4	284	289	PF00397	0.413
DOC_WW_Pin1_4	32	37	PF00397	0.545
DOC_WW_Pin1_4	381	386	PF00397	0.623
DOC_WW_Pin1_4	412	417	PF00397	0.494
DOC_WW_Pin1_4	443	448	PF00397	0.715
LIG_14-3-3_CanoR_1	10	16	PF00244	0.601
LIG_14-3-3_CanoR_1	268	272	PF00244	0.561
LIG_14-3-3_CanoR_1	3	7	PF00244	0.595
LIG_14-3-3_CanoR_1	350	359	PF00244	0.789
LIG_14-3-3_CanoR_1	400	410	PF00244	0.602
LIG_14-3-3_CanoR_1	69	78	PF00244	0.509
LIG_14-3-3_CanoR_1	89	94	PF00244	0.171
LIG_AP2alpha_1	373	377	PF02296	0.677
LIG_BRCT_BRCA1_1	214	218	PF00533	0.531
LIG_BRCT_BRCA1_1	84	88	PF00533	0.376
LIG_Clathr_ClatBox_1	368	372	PF01394	0.708
LIG_Clathr_ClatBox_1	63	67	PF01394	0.427
LIG_deltaCOP1_diTrp_1	162	170	PF00928	0.531
LIG_FHA_1	107	113	PF00498	0.546
LIG_FHA_1	219	225	PF00498	0.516
LIG_FHA_1	253	259	PF00498	0.508
LIG_FHA_1	322	328	PF00498	0.687
LIG_FHA_1	33	39	PF00498	0.537
LIG_FHA_1	364	370	PF00498	0.727
LIG_FHA_1	422	428	PF00498	0.688
LIG_FHA_1	443	449	PF00498	0.731
LIG_FHA_1	500	506	PF00498	0.800
LIG_FHA_1	73	79	PF00498	0.438
LIG_FHA_2	285	291	PF00498	0.401
LIG_FHA_2	456	462	PF00498	0.523
LIG_LIR_Apic_2	94	100	PF02991	0.490
LIG_LIR_Gen_1	123	133	PF02991	0.486
LIG_LIR_Gen_1	162	171	PF02991	0.508
LIG_LIR_Gen_1	270	279	PF02991	0.532
LIG_LIR_Gen_1	370	377	PF02991	0.589
LIG_LIR_Gen_1	5	13	PF02991	0.605
LIG_LIR_Gen_1	81	91	PF02991	0.368
LIG_LIR_Nem_3	123	129	PF02991	0.509
LIG_LIR_Nem_3	162	167	PF02991	0.508
LIG_LIR_Nem_3	242	246	PF02991	0.522
LIG_LIR_Nem_3	270	274	PF02991	0.508
LIG_LIR_Nem_3	343	349	PF02991	0.674
LIG_LIR_Nem_3	370	376	PF02991	0.591
LIG_LIR_Nem_3	5	9	PF02991	0.517
LIG_LIR_Nem_3	81	86	PF02991	0.383
LIG_PDZ_Class_2	503	508	PF00595	0.749
LIG_Pex14_1	271	275	PF04695	0.395
LIG_Pex14_2	160	164	PF04695	0.490
LIG_Pex14_2	373	377	PF04695	0.577
LIG_Pex14_2	93	97	PF04695	0.490
LIG_PTAP_UEV_1	384	389	PF05743	0.496
LIG_SH2_CRK	118	122	PF00017	0.539
LIG_SH2_CRK	275	279	PF00017	0.518
LIG_SH2_CRK	6	10	PF00017	0.464
LIG_SH2_STAP1	80	84	PF00017	0.477
LIG_SH2_STAT5	83	86	PF00017	0.377
LIG_SH3_1	382	388	PF00018	0.487
LIG_SH3_2	447	452	PF14604	0.514
LIG_SH3_3	168	174	PF00018	0.561
LIG_SH3_3	253	259	PF00018	0.474
LIG_SH3_3	33	39	PF00018	0.583
LIG_SH3_3	382	388	PF00018	0.487
LIG_SH3_3	444	450	PF00018	0.512
LIG_SUMO_SIM_anti_2	182	190	PF11976	0.561
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.412
LIG_SUMO_SIM_par_1	182	190	PF11976	0.500
LIG_SUMO_SIM_par_1	232	237	PF11976	0.531
LIG_SUMO_SIM_par_1	366	372	PF11976	0.753
LIG_TRAF2_1	388	391	PF00917	0.764
LIG_UBA3_1	186	194	PF00899	0.490
LIG_WRC_WIRS_1	90	95	PF05994	0.362
MOD_CDK_SPK_2	284	289	PF00069	0.413
MOD_CK1_1	353	359	PF00069	0.784
MOD_CK1_1	408	414	PF00069	0.726
MOD_CK1_1	417	423	PF00069	0.769
MOD_CK1_1	467	473	PF00069	0.818
MOD_CK1_1	5	11	PF00069	0.682
MOD_CK2_1	284	290	PF00069	0.412
MOD_CK2_1	455	461	PF00069	0.523
MOD_Cter_Amidation	134	137	PF01082	0.308
MOD_GlcNHglycan	315	318	PF01048	0.357
MOD_GlcNHglycan	332	335	PF01048	0.743
MOD_GlcNHglycan	346	349	PF01048	0.627
MOD_GlcNHglycan	350	353	PF01048	0.751
MOD_GlcNHglycan	354	358	PF01048	0.741
MOD_GlcNHglycan	361	364	PF01048	0.727
MOD_GlcNHglycan	385	388	PF01048	0.713
MOD_GlcNHglycan	403	406	PF01048	0.716
MOD_GlcNHglycan	407	410	PF01048	0.726
MOD_GlcNHglycan	458	461	PF01048	0.752
MOD_GlcNHglycan	466	469	PF01048	0.811
MOD_GlcNHglycan	484	487	PF01048	0.696
MOD_GSK3_1	106	113	PF00069	0.561
MOD_GSK3_1	313	320	PF00069	0.542
MOD_GSK3_1	328	335	PF00069	0.678
MOD_GSK3_1	340	347	PF00069	0.675
MOD_GSK3_1	359	366	PF00069	0.680
MOD_GSK3_1	401	408	PF00069	0.698
MOD_GSK3_1	410	417	PF00069	0.746
MOD_GSK3_1	418	425	PF00069	0.729
MOD_GSK3_1	488	495	PF00069	0.642
MOD_NEK2_1	122	127	PF00069	0.551
MOD_NEK2_1	187	192	PF00069	0.490
MOD_NEK2_1	2	7	PF00069	0.556
MOD_NEK2_1	218	223	PF00069	0.481
MOD_NEK2_1	274	279	PF00069	0.511
MOD_NEK2_1	321	326	PF00069	0.679
MOD_NEK2_1	410	415	PF00069	0.776
MOD_NEK2_1	82	87	PF00069	0.457
MOD_NEK2_1	95	100	PF00069	0.428
MOD_PIKK_1	25	31	PF00454	0.435
MOD_PIKK_1	69	75	PF00454	0.459
MOD_PK_1	11	17	PF00069	0.686
MOD_PKA_1	11	17	PF00069	0.647
MOD_PKA_1	482	488	PF00069	0.764
MOD_PKA_2	2	8	PF00069	0.573
MOD_PKA_2	267	273	PF00069	0.561
MOD_PKA_2	399	405	PF00069	0.585
MOD_PKA_2	482	488	PF00069	0.779
MOD_PKB_1	230	238	PF00069	0.531
MOD_Plk_1	122	128	PF00069	0.500
MOD_Plk_1	143	149	PF00069	0.498
MOD_Plk_1	196	202	PF00069	0.490
MOD_Plk_1	339	345	PF00069	0.751
MOD_Plk_2-3	106	112	PF00069	0.490
MOD_Plk_2-3	488	494	PF00069	0.527
MOD_Plk_4	11	17	PF00069	0.681
MOD_Plk_4	196	202	PF00069	0.490
MOD_Plk_4	212	218	PF00069	0.490
MOD_Plk_4	274	280	PF00069	0.519
MOD_Plk_4	321	327	PF00069	0.682
MOD_ProDKin_1	116	122	PF00069	0.490
MOD_ProDKin_1	170	176	PF00069	0.508
MOD_ProDKin_1	252	258	PF00069	0.438
MOD_ProDKin_1	284	290	PF00069	0.412
MOD_ProDKin_1	32	38	PF00069	0.540
MOD_ProDKin_1	381	387	PF00069	0.624
MOD_ProDKin_1	412	418	PF00069	0.493
MOD_ProDKin_1	443	449	PF00069	0.710
MOD_SUMO_rev_2	298	304	PF00179	0.492
MOD_SUMO_rev_2	54	64	PF00179	0.462
TRG_DiLeu_BaEn_1	183	188	PF01217	0.490
TRG_DiLeu_BaEn_1	300	305	PF01217	0.494
TRG_DiLeu_BaEn_2	155	161	PF01217	0.563
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.561
TRG_ENDOCYTIC_2	118	121	PF00928	0.539
TRG_ENDOCYTIC_2	275	278	PF00928	0.395
TRG_ENDOCYTIC_2	6	9	PF00928	0.614
TRG_ENDOCYTIC_2	83	86	PF00928	0.377
TRG_ER_diArg_1	2	4	PF00400	0.598
TRG_ER_diArg_1	230	232	PF00400	0.490
TRG_ER_diArg_1	9	11	PF00400	0.513
TRG_NES_CRM1_1	143	156	PF08389	0.536
TRG_NLS_MonoExtN_4	478	485	PF00514	0.749

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P667	Leptomonas seymouri	64%	100%
A0A3R7N9L3	Trypanosoma rangeli	54%	100%
A0A3S7WZ67	Leishmania donovani	92%	100%
A4HEE6	Leishmania braziliensis	79%	98%
A4I1I8	Leishmania infantum	92%	100%
C9ZJX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
Q4Q9U9	Leishmania major	91%	100%
V5B841	Trypanosoma cruzi	56%	100%