Clusterin-associated protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative intraflagellar transport protein A1

Species:

Leishmania mexicana

UniProt:

E9AXM2_LEIMU

TriTrypDb:

LmxM.25.1430

Length:

480

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0032991	protein-containing complex	1	1
GO:0031514	motile cilium	5	1

Expansion

Sequence features

E9AXM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXM2

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0030030	cell projection organization	4	9
GO:0071840	cellular component organization or biogenesis	2	9
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0010970	transport along microtubule	4	1
GO:0022607	cellular component assembly	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0035720	intraciliary anterograde transport	4	1
GO:0035735	intraciliary transport involved in cilium assembly	4	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	448	452	PF00656	0.708
CLV_NRD_NRD_1	179	181	PF00675	0.283
CLV_NRD_NRD_1	294	296	PF00675	0.470
CLV_NRD_NRD_1	309	311	PF00675	0.596
CLV_NRD_NRD_1	314	316	PF00675	0.734
CLV_NRD_NRD_1	378	380	PF00675	0.766
CLV_NRD_NRD_1	416	418	PF00675	0.650
CLV_PCSK_FUR_1	307	311	PF00082	0.616
CLV_PCSK_KEX2_1	179	181	PF00082	0.283
CLV_PCSK_KEX2_1	246	248	PF00082	0.184
CLV_PCSK_KEX2_1	309	311	PF00082	0.662
CLV_PCSK_KEX2_1	314	316	PF00082	0.660
CLV_PCSK_KEX2_1	377	379	PF00082	0.627
CLV_PCSK_KEX2_1	416	418	PF00082	0.708
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.184
CLV_PCSK_PC7_1	310	316	PF00082	0.667
CLV_PCSK_PC7_1	374	380	PF00082	0.516
CLV_PCSK_SKI1_1	106	110	PF00082	0.317
CLV_PCSK_SKI1_1	182	186	PF00082	0.283
CLV_PCSK_SKI1_1	419	423	PF00082	0.684
DEG_APCC_DBOX_1	181	189	PF00400	0.283
DEG_Kelch_Keap1_1	458	463	PF01344	0.678
DEG_SCF_FBW7_1	322	327	PF00400	0.675
DOC_CDC14_PxL_1	15	23	PF14671	0.283
DOC_CYCLIN_RxL_1	179	189	PF00134	0.377
DOC_CYCLIN_RxL_1	257	266	PF00134	0.377
DOC_MAPK_gen_1	76	83	PF00069	0.348
DOC_MAPK_MEF2A_6	76	83	PF00069	0.317
DOC_MAPK_NFAT4_5	76	84	PF00069	0.377
DOC_PP1_RVXF_1	258	265	PF00149	0.377
DOC_PP1_RVXF_1	60	66	PF00149	0.283
DOC_PP4_FxxP_1	27	30	PF00568	0.283
DOC_USP7_MATH_1	145	149	PF00917	0.304
DOC_USP7_MATH_1	204	208	PF00917	0.410
DOC_USP7_MATH_1	324	328	PF00917	0.682
DOC_USP7_MATH_1	441	445	PF00917	0.678
DOC_USP7_MATH_1	450	454	PF00917	0.650
DOC_USP7_MATH_2	441	447	PF00917	0.623
DOC_USP7_UBL2_3	105	109	PF12436	0.317
DOC_USP7_UBL2_3	212	216	PF12436	0.283
DOC_USP7_UBL2_3	271	275	PF12436	0.348
DOC_USP7_UBL2_3	296	300	PF12436	0.579
DOC_USP7_UBL2_3	76	80	PF12436	0.305
DOC_WW_Pin1_4	320	325	PF00397	0.752
LIG_14-3-3_CanoR_1	170	177	PF00244	0.283
LIG_14-3-3_CanoR_1	247	256	PF00244	0.184
LIG_14-3-3_CanoR_1	62	66	PF00244	0.380
LIG_14-3-3_CanoR_1	7	16	PF00244	0.440
LIG_Actin_WH2_2	287	302	PF00022	0.572
LIG_Actin_WH2_2	90	107	PF00022	0.283
LIG_BIR_II_1	1	5	PF00653	0.413
LIG_BRCT_BRCA1_1	147	151	PF00533	0.286
LIG_BRCT_BRCA1_1	460	464	PF00533	0.702
LIG_Clathr_ClatBox_1	21	25	PF01394	0.283
LIG_EH1_1	91	99	PF00400	0.348
LIG_FHA_1	10	16	PF00498	0.391
LIG_FHA_1	187	193	PF00498	0.294
LIG_FHA_1	248	254	PF00498	0.238
LIG_FHA_1	51	57	PF00498	0.377
LIG_FHA_2	109	115	PF00498	0.312
LIG_FHA_2	358	364	PF00498	0.725
LIG_FHA_2	42	48	PF00498	0.304
LIG_GBD_Chelix_1	100	108	PF00786	0.283
LIG_Integrin_RGD_1	161	163	PF01839	0.348
LIG_LIR_Apic_2	25	30	PF02991	0.283
LIG_LIR_Gen_1	115	126	PF02991	0.317
LIG_LIR_Nem_3	115	121	PF02991	0.317
LIG_LIR_Nem_3	148	154	PF02991	0.283
LIG_LIR_Nem_3	2	6	PF02991	0.392
LIG_LIR_Nem_3	250	255	PF02991	0.282
LIG_LIR_Nem_3	257	262	PF02991	0.377
LIG_LIR_Nem_3	64	69	PF02991	0.348
LIG_LYPXL_yS_3	18	21	PF13949	0.283
LIG_MLH1_MIPbox_1	148	152	PF16413	0.317
LIG_NRBOX	180	186	PF00104	0.377
LIG_PDZ_Class_1	475	480	PF00595	0.580
LIG_PTB_Apo_2	231	238	PF02174	0.377
LIG_PTB_Apo_2	258	265	PF02174	0.283
LIG_REV1ctd_RIR_1	63	71	PF16727	0.286
LIG_SH2_GRB2like	241	244	PF00017	0.377
LIG_SH2_SRC	241	244	PF00017	0.377
LIG_SH2_SRC	46	49	PF00017	0.283
LIG_SH2_STAT3	255	258	PF00017	0.283
LIG_SH2_STAT5	255	258	PF00017	0.283
LIG_TRAF2_1	93	96	PF00917	0.283
LIG_TYR_ITIM	16	21	PF00017	0.283
LIG_UBA3_1	97	105	PF00899	0.283
LIG_WRC_WIRS_1	24	29	PF05994	0.283
LIG_WRC_WIRS_1	6	11	PF05994	0.346
MOD_CK1_1	141	147	PF00069	0.283
MOD_CK1_1	169	175	PF00069	0.298
MOD_CK1_1	23	29	PF00069	0.296
MOD_CK1_1	387	393	PF00069	0.666
MOD_CK1_1	444	450	PF00069	0.644
MOD_CK1_1	453	459	PF00069	0.680
MOD_CK1_1	466	472	PF00069	0.572
MOD_CK2_1	108	114	PF00069	0.312
MOD_CK2_1	200	206	PF00069	0.329
MOD_CK2_1	23	29	PF00069	0.283
MOD_CK2_1	324	330	PF00069	0.828
MOD_CK2_1	352	358	PF00069	0.645
MOD_CK2_1	41	47	PF00069	0.359
MOD_CK2_1	443	449	PF00069	0.824
MOD_CK2_1	457	463	PF00069	0.665
MOD_CK2_1	5	11	PF00069	0.349
MOD_Cter_Amidation	312	315	PF01082	0.753
MOD_GlcNHglycan	202	205	PF01048	0.412
MOD_GlcNHglycan	228	231	PF01048	0.414
MOD_GlcNHglycan	311	314	PF01048	0.813
MOD_GlcNHglycan	351	357	PF01048	0.674
MOD_GlcNHglycan	360	363	PF01048	0.611
MOD_GlcNHglycan	460	463	PF01048	0.658
MOD_GlcNHglycan	47	51	PF01048	0.323
MOD_GlcNHglycan	471	475	PF01048	0.591
MOD_GSK3_1	141	148	PF00069	0.289
MOD_GSK3_1	200	207	PF00069	0.410
MOD_GSK3_1	226	233	PF00069	0.417
MOD_GSK3_1	305	312	PF00069	0.629
MOD_GSK3_1	320	327	PF00069	0.698
MOD_GSK3_1	352	359	PF00069	0.607
MOD_GSK3_1	441	448	PF00069	0.657
MOD_GSK3_1	449	456	PF00069	0.635
MOD_GSK3_1	458	465	PF00069	0.627
MOD_GSK3_1	46	53	PF00069	0.377
MOD_GSK3_1	466	473	PF00069	0.524
MOD_GSK3_1	5	12	PF00069	0.344
MOD_N-GLC_1	128	133	PF02516	0.377
MOD_N-GLC_1	186	191	PF02516	0.339
MOD_N-GLC_1	200	205	PF02516	0.289
MOD_N-GLC_1	444	449	PF02516	0.504
MOD_NEK2_1	455	460	PF00069	0.681
MOD_NEK2_1	9	14	PF00069	0.346
MOD_PIKK_1	186	192	PF00454	0.296
MOD_PIKK_1	247	253	PF00454	0.248
MOD_PKA_1	309	315	PF00069	0.689
MOD_PKA_2	169	175	PF00069	0.283
MOD_PKA_2	309	315	PF00069	0.699
MOD_PKA_2	387	393	PF00069	0.717
MOD_PKA_2	61	67	PF00069	0.386
MOD_PKB_1	164	172	PF00069	0.283
MOD_PKB_1	307	315	PF00069	0.506
MOD_PKB_1	417	425	PF00069	0.807
MOD_Plk_1	116	122	PF00069	0.317
MOD_Plk_1	407	413	PF00069	0.702
MOD_Plk_1	431	437	PF00069	0.748
MOD_Plk_1	50	56	PF00069	0.394
MOD_Plk_2-3	363	369	PF00069	0.778
MOD_Plk_2-3	463	469	PF00069	0.705
MOD_Plk_2-3	5	11	PF00069	0.349
MOD_Plk_4	146	152	PF00069	0.317
MOD_Plk_4	195	201	PF00069	0.377
MOD_Plk_4	387	393	PF00069	0.511
MOD_Plk_4	407	413	PF00069	0.702
MOD_Plk_4	61	67	PF00069	0.377
MOD_ProDKin_1	320	326	PF00069	0.754
MOD_SUMO_rev_2	131	136	PF00179	0.377
MOD_SUMO_rev_2	205	213	PF00179	0.283
MOD_SUMO_rev_2	281	287	PF00179	0.496
MOD_SUMO_rev_2	292	302	PF00179	0.609
TRG_DiLeu_BaEn_1	11	16	PF01217	0.348
TRG_DiLeu_BaEn_1	407	412	PF01217	0.702
TRG_DiLeu_BaEn_1	432	437	PF01217	0.643
TRG_DiLeu_LyEn_5	11	16	PF01217	0.348
TRG_DiLeu_LyEn_5	432	437	PF01217	0.643
TRG_ENDOCYTIC_2	18	21	PF00928	0.356
TRG_ENDOCYTIC_2	259	262	PF00928	0.331
TRG_ER_diArg_1	164	167	PF00400	0.283
TRG_ER_diArg_1	179	182	PF00400	0.283
TRG_ER_diArg_1	307	310	PF00400	0.765
TRG_ER_diArg_1	344	347	PF00400	0.694
TRG_ER_diArg_1	377	379	PF00400	0.735
TRG_ER_diArg_1	415	417	PF00400	0.714
TRG_ER_diArg_1	433	436	PF00400	0.716
TRG_Pf-PMV_PEXEL_1	179	183	PF00026	0.283

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKV6	Leptomonas seymouri	75%	100%
A0A3S7WZA7	Leishmania donovani	94%	99%
A0A422N0X8	Trypanosoma rangeli	66%	96%
A4HEE7	Leishmania braziliensis	88%	100%
A4I1I7	Leishmania infantum	94%	99%
C9ZJX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
Q4Q9V0	Leishmania major	93%	100%