Putative DNA polymerase delta subunit 2

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase delta subunit 2, putative

Species:

Leishmania mexicana

UniProt:

E9AXM0_LEIMU

TriTrypDb:

LmxM.25.1410

Length:

592

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0042575	DNA polymerase complex	3	12
GO:0043625	delta DNA polymerase complex	3	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0140513	nuclear protein-containing complex	2	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12

Expansion

Sequence features

E9AXM0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXM0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006260	DNA replication	5	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:0006271	DNA strand elongation involved in DNA replication	6	1
GO:0022616	DNA strand elongation	5	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	8
GO:0003887	DNA-directed DNA polymerase activity	5	8
GO:0005488	binding	1	12
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016779	nucleotidyltransferase activity	4	8
GO:0034061	DNA polymerase activity	4	8
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	8
GO:0140640	catalytic activity, acting on a nucleic acid	2	8
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	431	435	PF00656	0.379
CLV_PCSK_SKI1_1	185	189	PF00082	0.339
CLV_PCSK_SKI1_1	218	222	PF00082	0.440
CLV_PCSK_SKI1_1	25	29	PF00082	0.390
CLV_PCSK_SKI1_1	315	319	PF00082	0.313
CLV_PCSK_SKI1_1	510	514	PF00082	0.512
CLV_PCSK_SKI1_1	523	527	PF00082	0.666
CLV_PCSK_SKI1_1	95	99	PF00082	0.383
CLV_Separin_Metazoa	110	114	PF03568	0.339
DEG_APCC_DBOX_1	184	192	PF00400	0.320
DEG_APCC_DBOX_1	24	32	PF00400	0.417
DEG_APCC_DBOX_1	268	276	PF00400	0.425
DEG_SPOP_SBC_1	577	581	PF00917	0.226
DOC_CYCLIN_RxL_1	21	32	PF00134	0.426
DOC_MAPK_FxFP_2	480	483	PF00069	0.320
DOC_MAPK_gen_1	267	274	PF00069	0.339
DOC_MAPK_gen_1	291	300	PF00069	0.425
DOC_MAPK_gen_1	312	319	PF00069	0.304
DOC_MAPK_gen_1	352	361	PF00069	0.451
DOC_MAPK_gen_1	385	394	PF00069	0.316
DOC_MAPK_gen_1	550	560	PF00069	0.383
DOC_MAPK_HePTP_8	349	361	PF00069	0.320
DOC_MAPK_MEF2A_6	195	204	PF00069	0.425
DOC_MAPK_MEF2A_6	267	276	PF00069	0.322
DOC_MAPK_MEF2A_6	352	361	PF00069	0.320
DOC_MAPK_MEF2A_6	568	577	PF00069	0.418
DOC_MAPK_NFAT4_5	269	277	PF00069	0.361
DOC_PP2B_LxvP_1	381	384	PF13499	0.329
DOC_PP4_FxxP_1	480	483	PF00568	0.320
DOC_PP4_FxxP_1	525	528	PF00568	0.617
DOC_PP4_FxxP_1	589	592	PF00568	0.573
DOC_USP7_MATH_1	244	248	PF00917	0.394
DOC_USP7_MATH_1	254	258	PF00917	0.577
DOC_USP7_MATH_1	268	272	PF00917	0.357
DOC_USP7_MATH_1	332	336	PF00917	0.445
DOC_USP7_MATH_1	450	454	PF00917	0.425
DOC_USP7_UBL2_3	312	316	PF12436	0.310
DOC_WW_Pin1_4	236	241	PF00397	0.485
DOC_WW_Pin1_4	492	497	PF00397	0.389
LIG_14-3-3_CanoR_1	267	273	PF00244	0.341
LIG_14-3-3_CanoR_1	352	358	PF00244	0.367
LIG_14-3-3_CanoR_1	510	515	PF00244	0.524
LIG_14-3-3_CanoR_1	523	528	PF00244	0.675
LIG_AP2alpha_2	488	490	PF02296	0.304
LIG_BRCT_BRCA1_1	29	33	PF00533	0.530
LIG_BRCT_BRCA1_1	368	372	PF00533	0.339
LIG_BRCT_BRCA1_1	395	399	PF00533	0.435
LIG_BRCT_BRCA1_1	480	484	PF00533	0.309
LIG_BRCT_BRCA1_1	539	543	PF00533	0.449
LIG_BRCT_BRCA1_2	539	545	PF00533	0.448
LIG_Clathr_ClatBox_1	111	115	PF01394	0.304
LIG_Clathr_ClatBox_1	572	576	PF01394	0.369
LIG_EH_1	396	400	PF12763	0.425
LIG_EH1_1	53	61	PF00400	0.276
LIG_eIF4E_1	94	100	PF01652	0.339
LIG_FAT_LD_1	272	280	PF03623	0.160
LIG_FHA_1	128	134	PF00498	0.246
LIG_FHA_1	196	202	PF00498	0.304
LIG_FHA_1	306	312	PF00498	0.317
LIG_FHA_1	354	360	PF00498	0.339
LIG_FHA_1	389	395	PF00498	0.425
LIG_FHA_1	408	414	PF00498	0.415
LIG_FHA_1	582	588	PF00498	0.463
LIG_FHA_2	346	352	PF00498	0.433
LIG_FHA_2	455	461	PF00498	0.330
LIG_FHA_2	511	517	PF00498	0.466
LIG_LIR_Apic_2	478	483	PF02991	0.320
LIG_LIR_Apic_2	524	528	PF02991	0.609
LIG_LIR_Apic_2	588	592	PF02991	0.475
LIG_LIR_Gen_1	224	235	PF02991	0.496
LIG_LIR_Gen_1	239	249	PF02991	0.420
LIG_LIR_Gen_1	508	517	PF02991	0.461
LIG_LIR_Nem_3	224	230	PF02991	0.518
LIG_LIR_Nem_3	239	245	PF02991	0.394
LIG_LIR_Nem_3	508	514	PF02991	0.388
LIG_MYND_1	380	384	PF01753	0.320
LIG_NRBOX	345	351	PF00104	0.425
LIG_PCNA_yPIPBox_3	121	135	PF02747	0.160
LIG_Pex14_2	480	484	PF04695	0.320
LIG_PTAP_UEV_1	472	477	PF05743	0.304
LIG_SH2_CRK	205	209	PF00017	0.425
LIG_SH2_STAP1	49	53	PF00017	0.417
LIG_SH2_STAT5	242	245	PF00017	0.416
LIG_SH3_3	227	233	PF00018	0.448
LIG_SH3_3	371	377	PF00018	0.295
LIG_SH3_3	392	398	PF00018	0.304
LIG_SH3_3	470	476	PF00018	0.304
LIG_SH3_3	69	75	PF00018	0.441
LIG_SH3_3	80	86	PF00018	0.387
LIG_SUMO_SIM_anti_2	271	277	PF11976	0.342
LIG_SUMO_SIM_anti_2	358	363	PF11976	0.320
LIG_SUMO_SIM_par_1	355	360	PF11976	0.335
LIG_SUMO_SIM_par_1	463	468	PF11976	0.451
LIG_SUMO_SIM_par_1	571	576	PF11976	0.383
LIG_TRAF2_1	513	516	PF00917	0.572
LIG_WRC_WIRS_1	563	568	PF05994	0.377
LIG_WRC_WIRS_1	586	591	PF05994	0.500
MOD_CK1_1	3	9	PF00069	0.663
MOD_CK1_1	335	341	PF00069	0.454
MOD_CK1_1	532	538	PF00069	0.730
MOD_CK1_1	585	591	PF00069	0.511
MOD_CK2_1	170	176	PF00069	0.361
MOD_CK2_1	254	260	PF00069	0.538
MOD_CK2_1	345	351	PF00069	0.439
MOD_CK2_1	510	516	PF00069	0.467
MOD_CK2_1	577	583	PF00069	0.227
MOD_GlcNHglycan	122	127	PF01048	0.397
MOD_GlcNHglycan	134	138	PF01048	0.236
MOD_GlcNHglycan	14	17	PF01048	0.514
MOD_GlcNHglycan	172	175	PF01048	0.346
MOD_GlcNHglycan	180	185	PF01048	0.271
MOD_GlcNHglycan	221	224	PF01048	0.509
MOD_GlcNHglycan	246	249	PF01048	0.373
MOD_GlcNHglycan	256	259	PF01048	0.503
MOD_GlcNHglycan	338	341	PF01048	0.327
MOD_GlcNHglycan	441	444	PF01048	0.343
MOD_GlcNHglycan	467	470	PF01048	0.361
MOD_GlcNHglycan	50	53	PF01048	0.380
MOD_GlcNHglycan	539	542	PF01048	0.720
MOD_GlcNHglycan	568	571	PF01048	0.450
MOD_GlcNHglycan	6	9	PF01048	0.648
MOD_GSK3_1	157	164	PF00069	0.339
MOD_GSK3_1	166	173	PF00069	0.353
MOD_GSK3_1	27	34	PF00069	0.499
MOD_GSK3_1	280	287	PF00069	0.395
MOD_GSK3_1	301	308	PF00069	0.345
MOD_GSK3_1	332	339	PF00069	0.366
MOD_GSK3_1	450	457	PF00069	0.335
MOD_GSK3_1	471	478	PF00069	0.304
MOD_GSK3_1	506	513	PF00069	0.423
MOD_GSK3_1	523	530	PF00069	0.502
MOD_GSK3_1	562	569	PF00069	0.377
MOD_GSK3_1	577	584	PF00069	0.405
MOD_N-GLC_1	284	289	PF02516	0.413
MOD_N-GLC_1	3	8	PF02516	0.549
MOD_N-GLC_1	577	582	PF02516	0.334
MOD_N-GLC_2	211	213	PF02516	0.178
MOD_NEK2_1	179	184	PF00069	0.376
MOD_NEK2_1	225	230	PF00069	0.432
MOD_NEK2_1	234	239	PF00069	0.533
MOD_NEK2_1	31	36	PF00069	0.454
MOD_NEK2_1	399	404	PF00069	0.413
MOD_NEK2_1	438	443	PF00069	0.306
MOD_NEK2_1	566	571	PF00069	0.354
MOD_NEK2_1	582	587	PF00069	0.373
MOD_NEK2_2	284	289	PF00069	0.421
MOD_NEK2_2	529	534	PF00069	0.489
MOD_PIKK_1	31	37	PF00454	0.418
MOD_PKA_2	254	260	PF00069	0.644
MOD_PKA_2	268	274	PF00069	0.385
MOD_PKA_2	450	456	PF00069	0.304
MOD_Plk_1	284	290	PF00069	0.413
MOD_Plk_1	577	583	PF00069	0.459
MOD_Plk_2-3	414	420	PF00069	0.276
MOD_Plk_4	204	210	PF00069	0.389
MOD_Plk_4	345	351	PF00069	0.421
MOD_Plk_4	475	481	PF00069	0.382
MOD_Plk_4	582	588	PF00069	0.449
MOD_ProDKin_1	236	242	PF00069	0.473
MOD_ProDKin_1	492	498	PF00069	0.389
MOD_SUMO_for_1	544	547	PF00179	0.436
MOD_SUMO_rev_2	304	313	PF00179	0.389
MOD_SUMO_rev_2	323	332	PF00179	0.239
MOD_SUMO_rev_2	546	552	PF00179	0.649
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.478
TRG_DiLeu_BaLyEn_6	377	382	PF01217	0.339
TRG_DiLeu_BaLyEn_6	556	561	PF01217	0.395
TRG_ENDOCYTIC_2	205	208	PF00928	0.425
TRG_ENDOCYTIC_2	242	245	PF00928	0.315
TRG_ENDOCYTIC_2	37	40	PF00928	0.323
TRG_ENDOCYTIC_2	511	514	PF00928	0.512
TRG_ENDOCYTIC_2	94	97	PF00928	0.327
TRG_ER_diArg_1	41	44	PF00400	0.379
TRG_NES_CRM1_1	347	360	PF08389	0.425
TRG_NLS_MonoExtC_3	313	318	PF00514	0.320
TRG_NLS_MonoExtC_3	425	431	PF00514	0.427
TRG_NLS_MonoExtN_4	312	319	PF00514	0.320
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.320
TRG_Pf-PMV_PEXEL_1	185	189	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.425

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P663	Leptomonas seymouri	70%	100%
A0A0S4IRV7	Bodo saltans	38%	100%
A0A1X0NMG0	Trypanosomatidae	47%	100%
A0A3Q8ING8	Leishmania donovani	92%	100%
A0A422P247	Trypanosoma rangeli	47%	100%
A4HEE9	Leishmania braziliensis	86%	100%
A4I1I5	Leishmania infantum	93%	100%
C9ZJY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
O35654	Mus musculus	27%	100%
O48520	Arabidopsis thaliana	25%	100%
O93610	Xenopus laevis	26%	100%
P46957	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%
P87324	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q4Q9V2	Leishmania major	92%	100%
Q6AXY4	Rattus norvegicus	26%	100%
Q9LRE5	Oryza sativa subsp. japonica	27%	100%
Q9W088	Drosophila melanogaster	26%	100%
V5B3K0	Trypanosoma cruzi	46%	100%