SURP motif domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Surp module, putative

Species:

Leishmania mexicana

UniProt:

E9AXL9_LEIMU

TriTrypDb:

LmxM.25.1400

Length:

395

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0140513	nuclear protein-containing complex	2	12
GO:1990904	ribonucleoprotein complex	2	12
GO:0005654	nucleoplasm	2	1
GO:0005684	U2-type spliceosomal complex	4	1
GO:0005686	U2 snRNP	5	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0071004	U2-type prespliceosome	5	1
GO:0071010	prespliceosome	4	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9AXL9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXL9

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	12
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	12
GO:0000398	mRNA splicing, via spliceosome	8	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006396	RNA processing	6	12
GO:0006397	mRNA processing	7	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008380	RNA splicing	7	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0016071	mRNA metabolic process	6	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0045292	mRNA cis splicing, via spliceosome	9	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.539
CLV_NRD_NRD_1	136	138	PF00675	0.589
CLV_NRD_NRD_1	150	152	PF00675	0.595
CLV_NRD_NRD_1	207	209	PF00675	0.253
CLV_NRD_NRD_1	215	217	PF00675	0.461
CLV_NRD_NRD_1	257	259	PF00675	0.436
CLV_NRD_NRD_1	33	35	PF00675	0.443
CLV_NRD_NRD_1	85	87	PF00675	0.509
CLV_PCSK_KEX2_1	136	138	PF00082	0.531
CLV_PCSK_KEX2_1	215	217	PF00082	0.461
CLV_PCSK_KEX2_1	247	249	PF00082	0.505
CLV_PCSK_KEX2_1	256	258	PF00082	0.400
CLV_PCSK_KEX2_1	33	35	PF00082	0.454
CLV_PCSK_KEX2_1	380	382	PF00082	0.653
CLV_PCSK_KEX2_1	48	50	PF00082	0.489
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.328
CLV_PCSK_PC1ET2_1	380	382	PF00082	0.653
CLV_PCSK_PC1ET2_1	48	50	PF00082	0.538
CLV_PCSK_SKI1_1	215	219	PF00082	0.398
CLV_PCSK_SKI1_1	248	252	PF00082	0.431
CLV_PCSK_SKI1_1	258	262	PF00082	0.333
CLV_Separin_Metazoa	126	130	PF03568	0.552
DEG_Nend_UBRbox_2	1	3	PF02207	0.705
DEG_SCF_FBW7_2	10	16	PF00400	0.467
DEG_SPOP_SBC_1	165	169	PF00917	0.538
DEG_SPOP_SBC_1	315	319	PF00917	0.688
DOC_CKS1_1	10	15	PF01111	0.467
DOC_CYCLIN_RxL_1	213	224	PF00134	0.583
DOC_MAPK_gen_1	151	158	PF00069	0.586
DOC_MAPK_gen_1	280	289	PF00069	0.542
DOC_MAPK_gen_1	48	55	PF00069	0.398
DOC_PP1_RVXF_1	214	221	PF00149	0.475
DOC_PP1_RVXF_1	268	274	PF00149	0.413
DOC_PP2B_LxvP_1	352	355	PF13499	0.570
DOC_PP4_FxxP_1	311	314	PF00568	0.731
DOC_USP7_MATH_1	315	319	PF00917	0.730
DOC_USP7_MATH_1	337	341	PF00917	0.668
DOC_USP7_MATH_1	358	362	PF00917	0.744
DOC_USP7_MATH_1	92	96	PF00917	0.616
DOC_USP7_UBL2_3	175	179	PF12436	0.436
DOC_USP7_UBL2_3	247	251	PF12436	0.461
DOC_WW_Pin1_4	310	315	PF00397	0.715
DOC_WW_Pin1_4	331	336	PF00397	0.682
DOC_WW_Pin1_4	356	361	PF00397	0.574
DOC_WW_Pin1_4	9	14	PF00397	0.492
LIG_14-3-3_CanoR_1	215	221	PF00244	0.332
LIG_14-3-3_CanoR_1	283	289	PF00244	0.591
LIG_14-3-3_CanoR_1	323	330	PF00244	0.487
LIG_14-3-3_CanoR_1	347	352	PF00244	0.607
LIG_AP2alpha_2	141	143	PF02296	0.434
LIG_BRCT_BRCA1_1	358	362	PF00533	0.706
LIG_BRCT_BRCA1_1	57	61	PF00533	0.486
LIG_CtBP_PxDLS_1	14	20	PF00389	0.441
LIG_eIF4E_1	366	372	PF01652	0.695
LIG_FHA_1	153	159	PF00498	0.528
LIG_FHA_1	279	285	PF00498	0.547
LIG_FHA_1	55	61	PF00498	0.510
LIG_FHA_2	113	119	PF00498	0.743
LIG_FHA_2	217	223	PF00498	0.527
LIG_FHA_2	225	231	PF00498	0.584
LIG_FHA_2	239	245	PF00498	0.281
LIG_FHA_2	261	267	PF00498	0.417
LIG_FHA_2	323	329	PF00498	0.666
LIG_LIR_Nem_3	205	210	PF02991	0.489
LIG_LIR_Nem_3	212	217	PF02991	0.512
LIG_LIR_Nem_3	359	365	PF02991	0.616
LIG_LIR_Nem_3	58	64	PF02991	0.384
LIG_LYPXL_S_1	61	65	PF13949	0.330
LIG_MYND_1	76	80	PF01753	0.511
LIG_PCNA_yPIPBox_3	268	279	PF02747	0.551
LIG_Pex14_2	61	65	PF04695	0.352
LIG_PTB_Apo_2	188	195	PF02174	0.486
LIG_RPA_C_Fungi	22	34	PF08784	0.465
LIG_SH2_CRK	214	218	PF00017	0.368
LIG_SH2_NCK_1	249	253	PF00017	0.394
LIG_SH2_STAP1	172	176	PF00017	0.397
LIG_SH2_STAP1	249	253	PF00017	0.394
LIG_SH2_STAT5	138	141	PF00017	0.431
LIG_SH2_STAT5	172	175	PF00017	0.306
LIG_SH2_STAT5	237	240	PF00017	0.483
LIG_SH2_STAT5	64	67	PF00017	0.382
LIG_SH3_3	77	83	PF00018	0.610
LIG_SUMO_SIM_par_1	154	159	PF11976	0.519
LIG_TRAF2_1	263	266	PF00917	0.448
LIG_WRC_WIRS_1	217	222	PF05994	0.345
LIG_WRC_WIRS_1	279	284	PF05994	0.512
MOD_CK1_1	67	73	PF00069	0.512
MOD_CK2_1	216	222	PF00069	0.489
MOD_CK2_1	224	230	PF00069	0.474
MOD_CK2_1	238	244	PF00069	0.274
MOD_CK2_1	260	266	PF00069	0.431
MOD_CK2_1	322	328	PF00069	0.694
MOD_Cter_Amidation	378	381	PF01082	0.739
MOD_GlcNHglycan	28	31	PF01048	0.447
MOD_GlcNHglycan	339	342	PF01048	0.609
MOD_GSK3_1	104	111	PF00069	0.663
MOD_GSK3_1	152	159	PF00069	0.592
MOD_GSK3_1	166	173	PF00069	0.464
MOD_GSK3_1	274	281	PF00069	0.502
MOD_GSK3_1	310	317	PF00069	0.658
MOD_GSK3_1	337	344	PF00069	0.677
MOD_NEK2_1	112	117	PF00069	0.708
MOD_NEK2_1	166	171	PF00069	0.290
MOD_NEK2_1	210	215	PF00069	0.326
MOD_NEK2_1	238	243	PF00069	0.536
MOD_NEK2_1	316	321	PF00069	0.667
MOD_NEK2_1	367	372	PF00069	0.569
MOD_NEK2_1	43	48	PF00069	0.481
MOD_NEK2_1	54	59	PF00069	0.327
MOD_NEK2_2	99	104	PF00069	0.558
MOD_PIKK_1	231	237	PF00454	0.475
MOD_PKA_2	26	32	PF00069	0.538
MOD_PKA_2	282	288	PF00069	0.562
MOD_PKA_2	322	328	PF00069	0.546
MOD_Plk_1	156	162	PF00069	0.537
MOD_Plk_1	55	61	PF00069	0.380
MOD_Plk_4	233	239	PF00069	0.494
MOD_Plk_4	347	353	PF00069	0.670
MOD_Plk_4	367	373	PF00069	0.587
MOD_Plk_4	6	12	PF00069	0.652
MOD_ProDKin_1	310	316	PF00069	0.719
MOD_ProDKin_1	331	337	PF00069	0.683
MOD_ProDKin_1	356	362	PF00069	0.574
MOD_ProDKin_1	9	15	PF00069	0.491
MOD_SUMO_rev_2	148	153	PF00179	0.658
TRG_ENDOCYTIC_2	214	217	PF00928	0.360
TRG_ENDOCYTIC_2	62	65	PF00928	0.363
TRG_ER_diArg_1	136	138	PF00400	0.611
TRG_ER_diArg_1	214	216	PF00400	0.446
TRG_ER_diArg_1	256	258	PF00400	0.529
TRG_ER_diArg_1	267	270	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.431
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXM6	Leptomonas seymouri	71%	100%
A0A0S4IPX0	Bodo saltans	34%	86%
A0A1X0NNP0	Trypanosomatidae	43%	80%
A0A3R7KXN8	Trypanosoma rangeli	47%	88%
A0A3S7WZ46	Leishmania donovani	94%	100%
A4HEF0	Leishmania braziliensis	88%	100%
A4I1I4	Leishmania infantum	94%	100%
C9ZJY4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4Q9V3	Leishmania major	94%	100%
V5BCN7	Trypanosoma cruzi	47%	81%