Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AXL7_LEIMU

TriTrypDb:

LmxM.25.1380

Length:

236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXL7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXL7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.689
CLV_NRD_NRD_1	115	117	PF00675	0.431
CLV_NRD_NRD_1	226	228	PF00675	0.719
CLV_NRD_NRD_1	41	43	PF00675	0.593
CLV_PCSK_KEX2_1	115	117	PF00082	0.431
CLV_PCSK_KEX2_1	225	227	PF00082	0.613
CLV_PCSK_KEX2_1	41	43	PF00082	0.593
CLV_PCSK_SKI1_1	116	120	PF00082	0.438
CLV_PCSK_SKI1_1	137	141	PF00082	0.541
CLV_PCSK_SKI1_1	70	74	PF00082	0.574
DEG_Nend_UBRbox_1	1	4	PF02207	0.667
DOC_ANK_TNKS_1	225	232	PF00023	0.696
DOC_MAPK_MEF2A_6	103	110	PF00069	0.483
DOC_MAPK_MEF2A_6	213	222	PF00069	0.652
DOC_USP7_MATH_1	118	122	PF00917	0.450
DOC_USP7_MATH_1	29	33	PF00917	0.596
DOC_USP7_MATH_1	99	103	PF00917	0.467
DOC_WW_Pin1_4	139	144	PF00397	0.585
DOC_WW_Pin1_4	201	206	PF00397	0.677
LIG_14-3-3_CanoR_1	137	142	PF00244	0.543
LIG_14-3-3_CanoR_1	42	52	PF00244	0.607
LIG_14-3-3_CanoR_1	54	59	PF00244	0.538
LIG_14-3-3_CterR_2	233	236	PF00244	0.740
LIG_BRCT_BRCA1_1	96	100	PF00533	0.635
LIG_deltaCOP1_diTrp_1	128	134	PF00928	0.442
LIG_FHA_2	168	174	PF00498	0.593
LIG_LIR_Gen_1	26	33	PF02991	0.574
LIG_LIR_Gen_1	85	94	PF02991	0.600
LIG_LIR_Nem_3	204	209	PF02991	0.657
LIG_LIR_Nem_3	26	30	PF02991	0.506
LIG_LIR_Nem_3	4	9	PF02991	0.614
LIG_LIR_Nem_3	85	91	PF02991	0.421
LIG_Pex14_1	130	134	PF04695	0.431
LIG_SH2_CRK	9	13	PF00017	0.590
LIG_TRAF2_1	181	184	PF00917	0.579
MOD_CK2_1	201	207	PF00069	0.663
MOD_CK2_1	29	35	PF00069	0.669
MOD_GlcNHglycan	70	73	PF01048	0.577
MOD_GSK3_1	106	113	PF00069	0.467
MOD_GSK3_1	25	32	PF00069	0.662
MOD_N-GLC_1	33	38	PF02516	0.532
MOD_NEK2_1	1	6	PF00069	0.599
MOD_NEK2_1	106	111	PF00069	0.460
MOD_NEK2_1	126	131	PF00069	0.247
MOD_NEK2_1	33	38	PF00069	0.551
MOD_NEK2_1	68	73	PF00069	0.543
MOD_PIKK_1	161	167	PF00454	0.731
MOD_PIKK_1	43	49	PF00454	0.583
MOD_PKA_2	1	7	PF00069	0.632
MOD_Plk_1	25	31	PF00069	0.537
MOD_Plk_1	33	39	PF00069	0.515
MOD_Plk_4	33	39	PF00069	0.317
MOD_ProDKin_1	139	145	PF00069	0.582
MOD_ProDKin_1	201	207	PF00069	0.673
TRG_DiLeu_BaLyEn_6	60	65	PF01217	0.519
TRG_ENDOCYTIC_2	9	12	PF00928	0.660
TRG_ER_diArg_1	114	116	PF00400	0.429
TRG_ER_diArg_1	224	227	PF00400	0.706
TRG_ER_diArg_1	40	42	PF00400	0.524
TRG_Pf-PMV_PEXEL_1	124	128	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	42	47	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	63	67	PF00026	0.562

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4H8	Leptomonas seymouri	63%	100%
A0A1X0NMP7	Trypanosomatidae	45%	91%
A0A3Q8ICI7	Leishmania donovani	95%	100%
A4HE54	Leishmania braziliensis	80%	97%
A4I1I2	Leishmania infantum	94%	100%
C9ZJY6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	96%
Q4Q9V5	Leishmania major	93%	100%
V5D3X1	Trypanosoma cruzi	50%	95%