TAP42-like family protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TAP42-like family, putative

Species:

Leishmania mexicana

UniProt:

E9AXL6_LEIMU

TriTrypDb:

LmxM.25.1370

Length:

473

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AXL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AXL6

Function

Biological processes
Term	Name	Level	Count
GO:0009966	regulation of signal transduction	4	10
GO:0010646	regulation of cell communication	4	10
GO:0023051	regulation of signaling	3	10
GO:0048583	regulation of response to stimulus	3	10
GO:0050789	regulation of biological process	2	10
GO:0050794	regulation of cellular process	3	10
GO:0065007	biological regulation	1	10
GO:0019220	regulation of phosphate metabolic process	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0035303	regulation of dephosphorylation	7	1
GO:0051174	regulation of phosphorus metabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019902	phosphatase binding	4	1
GO:0019903	protein phosphatase binding	5	1
GO:0051721	protein phosphatase 2A binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	314	318	PF00656	0.488
CLV_NRD_NRD_1	244	246	PF00675	0.273
CLV_NRD_NRD_1	320	322	PF00675	0.284
CLV_PCSK_FUR_1	240	244	PF00082	0.288
CLV_PCSK_KEX2_1	100	102	PF00082	0.343
CLV_PCSK_KEX2_1	242	244	PF00082	0.253
CLV_PCSK_KEX2_1	320	322	PF00082	0.260
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.288
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.243
CLV_PCSK_PC7_1	240	246	PF00082	0.288
CLV_PCSK_SKI1_1	184	188	PF00082	0.308
CLV_PCSK_SKI1_1	198	202	PF00082	0.242
CLV_PCSK_SKI1_1	226	230	PF00082	0.285
DEG_APCC_DBOX_1	436	444	PF00400	0.371
DEG_MDM2_SWIB_1	52	59	PF02201	0.525
DOC_CKS1_1	82	87	PF01111	0.442
DOC_CYCLIN_yCln2_LP_2	82	88	PF00134	0.442
DOC_MAPK_gen_1	320	326	PF00069	0.460
DOC_MAPK_MEF2A_6	178	187	PF00069	0.563
DOC_PP1_RVXF_1	182	188	PF00149	0.525
DOC_PP1_RVXF_1	273	279	PF00149	0.442
DOC_USP7_MATH_1	102	106	PF00917	0.485
DOC_USP7_MATH_1	372	376	PF00917	0.493
DOC_WW_Pin1_4	63	68	PF00397	0.459
DOC_WW_Pin1_4	81	86	PF00397	0.355
LIG_14-3-3_CanoR_1	220	226	PF00244	0.530
LIG_14-3-3_CanoR_1	328	332	PF00244	0.477
LIG_14-3-3_CanoR_1	57	65	PF00244	0.525
LIG_APCC_ABBA_1	183	188	PF00400	0.525
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_CSL_BTD_1	82	85	PF09270	0.459
LIG_deltaCOP1_diTrp_1	451	457	PF00928	0.484
LIG_DLG_GKlike_1	292	300	PF00625	0.488
LIG_eIF4E_1	86	92	PF01652	0.589
LIG_FHA_1	201	207	PF00498	0.484
LIG_FHA_1	328	334	PF00498	0.446
LIG_FHA_1	350	356	PF00498	0.532
LIG_FHA_1	401	407	PF00498	0.442
LIG_FHA_1	74	80	PF00498	0.442
LIG_FHA_1	82	88	PF00498	0.466
LIG_FHA_2	258	264	PF00498	0.484
LIG_FHA_2	403	409	PF00498	0.459
LIG_FHA_2	75	81	PF00498	0.484
LIG_HOMEOBOX	187	190	PF00046	0.525
LIG_LIR_Gen_1	179	190	PF02991	0.506
LIG_LIR_Gen_1	330	339	PF02991	0.474
LIG_LIR_Gen_1	408	417	PF02991	0.460
LIG_LIR_Gen_1	51	59	PF02991	0.481
LIG_LIR_Gen_1	90	99	PF02991	0.459
LIG_LIR_Nem_3	179	185	PF02991	0.473
LIG_LIR_Nem_3	330	334	PF02991	0.474
LIG_LIR_Nem_3	408	412	PF02991	0.488
LIG_LIR_Nem_3	51	55	PF02991	0.516
LIG_LIR_Nem_3	80	86	PF02991	0.459
LIG_LIR_Nem_3	90	95	PF02991	0.459
LIG_Pex14_1	182	186	PF04695	0.459
LIG_Pex14_2	52	56	PF04695	0.509
LIG_RPA_C_Fungi	215	227	PF08784	0.341
LIG_SH2_CRK	331	335	PF00017	0.291
LIG_SH2_STAP1	74	78	PF00017	0.394
LIG_SH2_STAT3	387	390	PF00017	0.335
LIG_SH2_STAT5	238	241	PF00017	0.300
LIG_SH2_STAT5	25	28	PF00017	0.410
LIG_SH2_STAT5	331	334	PF00017	0.276
LIG_SH2_STAT5	86	89	PF00017	0.342
LIG_SH3_3	341	347	PF00018	0.322
LIG_SH3_3	358	364	PF00018	0.223
LIG_SUMO_SIM_anti_2	191	197	PF11976	0.297
LIG_TRAF2_1	171	174	PF00917	0.327
LIG_TRAF2_1	256	259	PF00917	0.393
LIG_TRAF2_1	405	408	PF00917	0.278
LIG_UBA3_1	91	100	PF00899	0.275
MOD_CK1_1	2	8	PF00069	0.579
MOD_CK1_1	33	39	PF00069	0.344
MOD_CK2_1	121	127	PF00069	0.494
MOD_CK2_1	158	164	PF00069	0.348
MOD_CK2_1	168	174	PF00069	0.250
MOD_CK2_1	257	263	PF00069	0.421
MOD_CK2_1	276	282	PF00069	0.291
MOD_CK2_1	287	293	PF00069	0.248
MOD_CK2_1	402	408	PF00069	0.300
MOD_CK2_1	74	80	PF00069	0.349
MOD_CMANNOS	454	457	PF00535	0.335
MOD_GlcNHglycan	123	126	PF01048	0.428
MOD_GlcNHglycan	152	155	PF01048	0.416
MOD_GlcNHglycan	357	360	PF01048	0.407
MOD_GlcNHglycan	451	454	PF01048	0.335
MOD_GlcNHglycan	59	62	PF01048	0.403
MOD_GSK3_1	146	153	PF00069	0.373
MOD_GSK3_1	17	24	PF00069	0.360
MOD_GSK3_1	288	295	PF00069	0.341
MOD_GSK3_1	29	36	PF00069	0.238
MOD_GSK3_1	355	362	PF00069	0.379
MOD_GSK3_1	367	374	PF00069	0.249
MOD_N-GLC_1	155	160	PF02516	0.297
MOD_N-GLC_1	2	7	PF02516	0.608
MOD_N-GLC_1	30	35	PF02516	0.344
MOD_NEK2_1	176	181	PF00069	0.276
MOD_NEK2_1	200	205	PF00069	0.261
MOD_NEK2_1	21	26	PF00069	0.433
MOD_NEK2_1	218	223	PF00069	0.490
MOD_NEK2_1	276	281	PF00069	0.349
MOD_NEK2_1	287	292	PF00069	0.334
MOD_PIKK_1	210	216	PF00454	0.319
MOD_PKA_2	135	141	PF00069	0.420
MOD_PKA_2	327	333	PF00069	0.308
MOD_PKA_2	350	356	PF00069	0.286
MOD_PKA_2	378	384	PF00069	0.243
MOD_Plk_1	264	270	PF00069	0.431
MOD_Plk_1	292	298	PF00069	0.341
MOD_Plk_1	30	36	PF00069	0.355
MOD_Plk_1	322	328	PF00069	0.302
MOD_Plk_1	37	43	PF00069	0.343
MOD_Plk_4	21	27	PF00069	0.352
MOD_Plk_4	292	298	PF00069	0.362
MOD_Plk_4	329	335	PF00069	0.276
MOD_ProDKin_1	63	69	PF00069	0.300
MOD_ProDKin_1	81	87	PF00069	0.155
MOD_SUMO_for_1	229	232	PF00179	0.341
MOD_SUMO_rev_2	191	201	PF00179	0.297
MOD_SUMO_rev_2	232	236	PF00179	0.393
TRG_DiLeu_BaEn_1	191	196	PF01217	0.297
TRG_DiLeu_BaEn_4	165	171	PF01217	0.341
TRG_DiLeu_BaEn_4	263	269	PF01217	0.323
TRG_DiLeu_BaEn_4	433	439	PF01217	0.300
TRG_ENDOCYTIC_2	331	334	PF00928	0.291
TRG_ER_diArg_1	243	245	PF00400	0.285
TRG_ER_diArg_1	268	271	PF00400	0.311
TRG_ER_diArg_1	319	321	PF00400	0.335
TRG_NLS_MonoCore_2	241	246	PF00514	0.300
TRG_NLS_MonoExtN_4	240	246	PF00514	0.309
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.441
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	247	252	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCB4	Leptomonas seymouri	71%	100%
A0A0S4JC44	Bodo saltans	36%	100%
A0A1X0NM51	Trypanosomatidae	46%	100%
A0A3S7WZ42	Leishmania donovani	93%	100%
A4HE53	Leishmania braziliensis	82%	100%
A4I1I1	Leishmania infantum	93%	100%
C9ZJY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
Q4Q9V6	Leishmania major	92%	100%